Paracetamol Pharmacokinetics are Independent of Caloric Intake and Physical Activity

1994 ◽  
Vol 8 (6) ◽  
pp. 361-368 ◽  
Author(s):  
C. A. Yiamouyiannis ◽  
A. Harris ◽  
R. A. Sanders ◽  
B. J. Martin ◽  
J. B. Watkins
1986 ◽  
Vol 25 (6) ◽  
pp. 1131-1136 ◽  
Author(s):  
Deborah J. Bowen ◽  
Sharon E. Eury ◽  
Neil E. Grunberg

2021 ◽  
Vol 22 (4) ◽  
Author(s):  
Jorge F. Elgart ◽  
◽  
Luis Flores ◽  
Analía G. Abraham ◽  
Graciela L. Garrote ◽  
...  

ABSTRACT Introduction: the confinement imposed to reduce the spread of COVID-19 induces changes in habits and unhealthy lifestyles. Objectives: to verify changes associated with confinement in eating habits and lifestyle in the Argentine population and their differences between the metropolitan area of Buenos Aires (AMBA) and the rest of the country. Materials and methods: cross-sectional, descriptive, and analytical study, through an “online” survey (December 2020) carried out on adults residing in Argentina. Age, gender and place of residence were surveyed, as well as the changes registered regarding weight, eating habits, physical activity, desire to eat and quality of sleep. A descriptive analysis of the valid surveys received (N=1,536) was carried out, verifying differences between the regions using parametric and nonparametric tests, considering significant p<0.05. Results: 75.1% of the participants were women (38.8±13.1 years), 60.5% from the AMBA and 39.5% from the rest of the country. Isolation was associated with changes that impacted on the psychological, stress, healthy habits, and sleep, with some significant regional differences. However, the common end result between AMBA and the rest of the country was the greater increase in caloric intake and the decrease in physical activity that led to 39.7% of the participants increasing their weight (mean 4.8±2,8 kg). Conclusions: isolation was associated with undesirable side effects, which could be diminished through the virtual promotion of healthy habits that would simultaneously decrease the growth of obesity and diabetes. Key words: COVID-19; social isolation; eating habits; lifestyle; physical activity.


2020 ◽  
Vol 9 (9) ◽  
pp. 2782 ◽  
Author(s):  
Philibert Duriez ◽  
Lauralee Robichon ◽  
Roland Dardennes ◽  
Guillaume Lavoisy ◽  
Dominique Grouselle ◽  
...  

Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl—(AG) and desacyl—(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, n = 29), half—(T1) and total (T2) weight recovery, and one month after discharge (T3, n = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short—(15 days) or long—(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sung Jun Chung ◽  
Hwan Il Kim ◽  
Bumhee Yang ◽  
Taehee Kim ◽  
Yun Su Sim ◽  
...  

AbstractThe general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who participated in the Korea National Health and Nutrition Examination Survey 2007–2016 according to severity of RSP. Participants were classified as subjects with normal spirometry, those with mild-to-moderate RSP, and those with severe RSP. Poor quality of life was defined as 25th percentile value on the EuroQoL five dimensions (Eq5D) questionnaire index, i.e., 0.90. This study included 23,615 subjects composed of 20,742 with normal spirometry, 2758 with mild-to-moderate RSP, and 115 with severe RSP. The subjects with severe RSP were more likely to have attained lower education levels, had a lower total caloric intake, had less physical activity, had experienced a higher prevalence of comorbidities, and poorer quality of life than those with normal spirometry (P < 0.001 for all). In multivariable analysis, subjects with a mild-to-moderate RSP and severe RSP were more likely to show decreased total calories (coefficient for change in calorie = − 56.6 kcal and − 286.7 kcal, respectively) than those with normal spirometry; subjects with mild-to-moderate RSP and those with severe RSP were 1.26 times and 1.96 times more likely, respectively, to have a poorer quality of life than those with normal spirometry. Additionally, subjects with mild-to-moderate RSP and those with severe RSP were 0.84 times and 0.36 times less likely, respectively, to have high-intensity physical activity than those with normal spirometry in univariable analysis. The trends of a poorer quality of life and physical activity were only significant in the male subgroups. In conclusion, our study revealed that the severity of general health problems and quality of life reductions are correlated with the severity of RSP, especially in males.


2013 ◽  
Vol 26 (2) ◽  
pp. 283-289 ◽  
Author(s):  
C. J. Homko ◽  
L. C. Zamora ◽  
G. Boden ◽  
H. P. Parkman

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Hermann L. Müller

Childhood craniopharyngiomas are rare embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. The overall survival rates after neurosurgical intervention and/or irradiation are high (92%). However, the quality of survival is frequently impaired due to endocrine deficiencies, sleep disturbances, daytime sleepiness, and severe obesity caused by hypothalamic lesions. Based on self-assessment using nutritional diaries, caloric intake was similar in patients and BMI-matched controls. Analyses of physical activity by accelerometric measurements showed a markedly lower level of physical activity. Significant daytime sleepiness and disturbances of circadian rhythms have been demonstrated in obese childhood craniopharyngioma patients. Daytime sleepiness and obesity in these patients were both correlated with low nocturnal and early morning melatonin levels. Polysomnographic studies in patients with severe daytime sleepiness revealed sleeping patterns typical for secondary narcolepsy. Reports on a beneficial effect of treatment with central stimulating agents supported the hypothesis that secondary narcolepsy should be considered as a rare cause for severe daytime sleepiness in patients with childhood craniopharyngioma.


Author(s):  
Shari Eli ◽  
Nicholas Li

Abstract Total energy expenditures for the Indian population between 1983 and 2012 are estimated to shed light on the debate concerning falling measured caloric intake during the period (A. Deaton and J. Drèze. 2009. “Food and Nutrition in India: Facts and Interpretations.” Economic and Political Weekly 44(7): 42–65). Anthropometric, time-use, and detailed employment surveys are used to estimate the separate components of total energy expenditure related to metabolism and physical activity levels. Despite a significant drop in adult physical activity levels, total energy expenditures are flat overall between 1983 and 2012. Rising metabolic requirements due to increases in weight dampened the effect of falling activity levels on total energy expenditure. In addition, the 10 percent decline in the population share of children in the period raised average total energy expenditures considerably as children have much lower metabolic requirements and activity levels than adults.


2020 ◽  
Vol 44 (2) ◽  
pp. 180-187
Author(s):  
Natalie Bennion ◽  
Lori Andersen Spruance ◽  
Jay E. Maddock

Objectives: Childhood obesity rates remain high. The youth sports environment is an opportunity to combat obesity. The purpose of this study was to determine the types of beverages/ snacks provided at youth sports and determine associations between energy consumption and expenditure. Methods: This cross-sectional study observed 4 different sports in a youth sports league (N = 189). The System for Observing Fitness Instruction Time (SOFIT) was used to quantify physical activity. Food environmental scans were used to quantify caloric intake. A t-test was conducted to examine differences between energy consumption and expenditure. We conducted a separate analysis for games that did not offer snacks/beverages. Results: The average energy expenditure was 170.3 calories per game; males were more physically active than females. The average caloric content was 213.3 calories for games that did not offer snacks/beverages and average sugar provided was 26.4 grams per game. The majority of sugar came from sugar-sweetened beverages. Conclusions: Calorie intake was higher than expenditure. Children were consuming more sugar in one game than daily recommendations. Youth sports would benefit from an intervention aimed at the food environment.


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