scholarly journals Does daily wear time of Twin Block reliably predict its efficiency of class II treatment?

2021 ◽  
Author(s):  
Michal Sarul ◽  
Marek Nahajowski ◽  
Grzegorz Gawin ◽  
Joanna Antoszewska-Smith
Keyword(s):  
Statistical Significance ◽  
Characteristic Curve ◽  
Class Ii ◽  
Class I ◽  
Rank Test ◽  
Treatment Efficiency ◽  
Significance Level ◽  
Twin Block ◽  
Wear Time ◽  
Class Ii Treatment

Abstract Purpose The objective of this study was to investigate how daily wear time (DWT) influences class II malocclusion treatment efficiency. Materials and methods The study group consisted of 55 patients (mean age 10.4 years) diagnosed with a class II/1 malocclusion. Twin block appliances, with built-in Theramon® microsensors (MC Technology, Hargelsberg, Austria) to monitor patients’ cooperation (daily wear time assessment), were used for treatment. Cephalograms were taken and the following initial and final measurements were compared: Co-Gn, Co-Go, Co-Olp, Pg-Olp, WITS, SNA, SNB, ANB, Co-Go-Me, overjet, molar and canine relationships. The Shapiro–Wilk test, Wilcoxon signed-rank test, Student’s t-test, Levene’s test, Mann–Whitney U test, Kruskal–Wallis test, χ2 test, and Spearman’s rank correlation coefficient with p < 0.05 set as the statistical significance level were used to determine the correlation of the outcomes with DWT; a ROC (receiver operating characteristic) curve was calculated to illustrate diagnostic ability of the binary classifier system. Results DWT was very highly positively correlated with change of the Pg-Olp parameter and highly with an improvement in the ANB, SNA, and SNB angles, an increase in the WITS parameter and an increase in Co-Gn distance. DWTs < 7.5 h correlated with significantly less improvement of the investigated variables. However, DWT > 7.5 h did not significantly correlate with the improvement of the overjet and most of the linear parameters in the mandible. The ROC curve and its AUC (area under curve) allowed the determination of a DWT of 7 h and 48 min to be capable of establishing a class I relationship with 83% probability. Conclusions Class II treatment efficiency was influenced by DWT; an 8 h threshold value had an 83% probability of establishing a class I relationship.

scholarly journals Cross-sectional study on the weight and length of infants in the interior of the State of São Paulo, Brazil: associations with sociodemographic variables and breastfeeding

2009 ◽  
Vol 127 (4) ◽  
pp. 198-205 ◽  
Author(s):  
Julia Laura Delbue Bernardi ◽  
Regina Esteves Jordão ◽  
Antônio de Azevedo Barros Filho
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Statistical Significance ◽  
Randomized Study ◽  
The Body ◽  
Nutrition Status ◽  
Rank Test ◽  
Cross Sectional ◽  
Sociodemographic Variables ◽  
Significance Level

CONTEXT AND OBJECTIVE: Increasing obesity is starting to occur among Brazilians. The aim of this study was to investigate the weight and length of children under two years of age in relation to sociodemographic variables and according to whether they were breastfed. DESIGN AND SETTING: Cross-sectional randomized study conducted in 2004-2005, based on the declaration of live births (SINASC) in Campinas, Brazil. METHODS: 2,857 mothers of newborns were interviewed and answered a questionnaire seeking socioeconomic and breastfeeding information. The newborns' weights and lengths were measured at the end of the interviews and the body mass index was calculated. Percentiles (< 15 and > 85) and Z-scores (< -1 and > +1) were used for classification based on the new growth charts recommended by WHO (2006). The log-rank test, multiple linear regression and binomial test (Z) were used. The statistical significance level used was 5%. RESULTS: The predominant social level was class C. The median for exclusive breastfeeding was 90 days; 61.25% of the children were between P15 and P85 for body mass index and 61.12% for length, respectively. Children whose mothers studied for nine to eleven years and children whose mothers were unemployed presented lower weight. Children whose mothers worked in health-related professions presented lower length when correlated with breastfeeding. CONCLUSION: The breastfeeding, maternal schooling and maternal occupation levels had an influence on nutrition status and indicated that obesity is occurring in early childhood among the infants living in the municipality.

scholarly journals Orthopedic cervical headgear in Class II treatment: case report

2003 ◽  
Vol 14 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Carla Enoki ◽  
Mírian Aiko Nakane Matsumoto ◽  
José Tarcísio Lima Ferreira
Keyword(s):  
Case Report ◽  
Growth Pattern ◽  
Class Ii ◽  
Mixed Dentition ◽  
Class I ◽  
Cephalometric Analysis ◽  
Class Ii Malocclusion ◽  
Class Ii Treatment ◽  
Division 1 ◽  
Downward Displacement

Early treatment for Class II malocclusion was undertaken with the objective of correcting skeletal disproportion by altering the growth pattern. A case of Class II, Division 1 malocclusion in the mixed dentition was corrected to Class I molar relationship using orthopedic cervical headgear, with nonextraction edgewise therapy. Cephalometric analysis indicated a reduction in the maxillomandibular discrepancy (ANB) correcting the Class II malocclusion to Class I malocclusion. The treatment showed that this was achieved by downward displacement and inhibition of the forward growth of the maxilla and growth of the mandible. There was no downward rotation of the mandible nor maxillary first molar extrusion. There was improvement in the jaw relationship.

Comparison of Class I and Class II Treatment Duration Among Three Different Orthodontic Practices

2006 ◽  
Vol 12 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Kurt Popowich ◽  
Carlos Flores-Mir ◽  
Brian Nebbe ◽  
Giseon Heo ◽  
Paul W. Major
Keyword(s):  
Treatment Duration ◽  
Class Ii ◽  
Class I ◽  
Class Ii Treatment

scholarly journals Construction and efficacy evaluation of novel swine leukocyte antigen (SLA) class I and class II allele-specific poly-T cell epitope vaccines against porcine reproductive and respiratory syndrome virus

2020 ◽  
Vol 101 (11) ◽  
pp. 1191-1201
Author(s):  
Debin Tian ◽  
Sakthivel Subramaniam ◽  
C. Lynn Heffron ◽  
Hassan M. Mahsoub ◽  
Harini Sooryanarain ◽  
...  
Keyword(s):  
T Cell ◽  
Statistical Significance ◽  
Cell Epitope ◽  
Class Ii ◽  
Class I ◽  
Respiratory Syndrome Virus ◽  
T Cell Epitope ◽  
T Cell Epitopes ◽  
Efficacy Evaluation ◽  
Allele Specific

Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically important global swine disease. Here we report the development of subunit PRRSV-2 vaccines by expressing swine leucocyte antigen (SLA) class I and class II allele-specific epitope antigens in a robust adenovirus vector. SLA I-specific CD8 and SLA II-specific CD4 T cell epitopes of PRRSV-2 NADC20 were predicted in silico. Stable murine leukaemia cell lines (RMA-S), which are TAP-deficient and lacking endogenous class I epitope loading, were established to express different SLA I alleles. The binding stability of PRRSV T cell epitope peptides with SLA I alleles expressed on RMA-S cells was characterized. Two PRRSV poly-T cell epitope peptides were designed. NADC20-PP1 included 39 class I epitopes, consisting of 8 top-ranked epitopes specific to each of 5 SLA I alleles, and fused to 5 class II epitopes specific to SLA II alleles. NADC20-PP2, a subset of PP1, included two top-ranked class I epitopes specific to each of the five SLA I alleles. Two vaccine candidates, Ad-NADC20-PP1 and Ad-NADC20-PP2, were constructed by expressing the polytope peptides in a replication-incompetent human adenovirus 5 vector. A vaccination and challenge study in 30 piglets showed that animals vaccinated with the vaccines had numerically lower gross and histopathology lung lesions, and numerically lower PRRSV RNA loads in lung and serum after challenge compared to the controls, although there was no statistical significance. The results suggested that the Ad-NADC20-PP1 and Ad-NADC20-PP2 vaccines provided little or no protection, further highlighting the tremendous challenges faced in developing an effective subunit PRRSV-2 vaccine.

scholarly journals The Difference of Students’ Mathematical Communication Ability Taught by Cooperative Learning Model Think Talk Write Type and Numbered Head Together Type

2018 ◽  
Vol 8 (3) ◽  
pp. 231-242 ◽  
Author(s):  
Meiva Marthaulina Lestari Siahaan ◽  
E. Elvis Napitupulu
Keyword(s):  
Data Analysis ◽  
Cooperative Learning ◽  
Class Ii ◽  
Learning Model ◽  
Posttest Score ◽  
Class I ◽  
Mathematical Communication ◽  
Significance Level ◽  
Communication Ability ◽  
The Difference

The purpose of this research was to know there was any difference in student’s mathematical communication ability in cooperative learning Think TalkWrite (TTW) type and Numbered Head Together (NHT) type. The population was all students at SMP Negeri 1 Lubuk Pakam. The sample was two classes which each consist of 36 students, VII A as experimental class I which taught by TTW and VII B as experimental class II which taught by NHT. The sample was taken by cluster random sampling. Collecting data technique of this research was mathematical comunication ability essay test that was given in the end of learning either in experimental class I or experimental class II. From the data analysis of each of experimental class were obtained that the average of posttest score in TTW classroom was higher than in NHT classroom. It was also obtained that score of mathematical communication indicators in TTW classroom was higher than in NHT classroom. From the data analysis of posttest score by using t-test with significance level α = 0.05, it was obtained that tcount = 4.687 and ttable = 1.667. It means that tcount > ttable then H0 was rejected and Ha was accepted. So, it can be concluded that there was difference of student’s mathematical communication ability who taught by cooperative learning model type TTW with NHT at SMP Negeri 1 Lubuk Pakam.

scholarly journals The Effect of Damask Rose and Orange Blossom on Anxiety in Older Adults

2021 ◽  
Vol 11 (1) ◽  
pp. 20-29
Author(s):  
Zahra Khalili ◽  
◽  
Zohreh Taraghi ◽  
Ehteram Sadat Ilali ◽  
◽  
...  
Keyword(s):  
Older Adults ◽  
Essential Oil ◽  
Essential Oils ◽  
Human Life ◽  
Statistical Significance ◽  
The Elderly ◽  
T Test ◽  
Rank Test ◽  
Significance Level ◽  
Damask Rose

Objective: Anxiety is often one of the biggest problems in human life and its consequences are quite noticeable. The use of medications for its control can cause side effects or drug dependence. Anxiety management, which is one of the most important nursing practices, can be done by non-pharmaceutical methods such as aromatherapy. This study aims to compare the effects of aromatherapy using the essential oils of damask rose and orange blossom on anxiety in older adults. Methods: This quasi-experimental study was conducted on 60 older adults who were selected by using random numbers generated by RANDBETWEEN function in Excel. After obtaining a written informed consent from them, they were asked to inhale %10 damask rose essence for three nights. After one month, they underwent aromatherapy with %10 orange blossom essential oil. In each period, anxiety was measured by the Geriatric Anxiety Scale (GAS). The collected data were analyzed using paired t-test, independent t-test, and Wilcoxon Signed-Rank test in SPSS v. 25 software considering a statistical significance level of P<0.05. Results: Although the GAS score was reduced after aromatherapy with both essential oil (P<0.001), the changes in GAS score were not significantly different in the two periods using damask rose and orange blossom essential oils (P=0.729). Conclusion: Aromatherapy with both damask rose and orange blossom essential oils can reduce anxiety in the elderly.

scholarly journals Cervical Posture and Skeletal Malocclusions – Is there a Link?

2019 ◽  
Vol 15 (1) ◽  
pp. 5-9
Author(s):  
Sanam Tauheed ◽  
Attiya Shaikh ◽  
Mubassar Fida
Keyword(s):  
Statistical Significance ◽  
Class I ◽  
Class Iii ◽  
Weak Correlation ◽  
Pearson’S Correlation ◽  
Significance Level ◽  
Skeletal Class ◽  
Pearson's Correlation ◽  
One Way Anova ◽  
Cervical Posture

Background: The present study was conducted in order to determine cervical posture in different skeletal sagittal malocclusions as well as to assess whether a correlation existed between cervical posture and skeletal relationships. Methods: Cervical curvature and inclination of 63 subjects was assessed using their lateral cephalometric radiographs. Cervical inclination was assessed using the cervicohorizontal postural variables namely OPT/HOR and CVT/HOR whereas cervical curvature was determined by measuring the angle OPT/CVT. Sagittally, the subjects were also categorized into skeletal Class I, II and III based on the angle ANB. One way ANOVA was used for the comparison of cervical posture in different skeletal sagittal malocclusions. Pearson’s correlation was used to evaluate the correlation of cervical posture with different skeletal sagittal jaw relations. Statistical significance level was set at p≤0.05. Results: Statistically significant differences were found between the different skeletal malocclusions for the cervical curvature angle OPT/CVT (p=0.025). A weak correlation of cervical curvature angle OPT/CVT (r=0.305, p=0.016) with sagittal malocclusion was found.  Conclusions: Skeletal sagittal malocclusions differ in their cervical postures, especially  cervical curvature. Skeletal Class III subjects have significantly straighter cervical columns than skeletal Class I subjects. Cervical curvature is correlated with sagittal jaw relations.  Keywords: cervical curvature; cervical posture; skeletal sagittal malocclusions .  

Class II treatment with the Runner in adolescent patients: Combining Twin Block efficiency with aligner aesthetics

2014 ◽  
Vol 3 (2) ◽  
pp. e71-e79 ◽  
Author(s):  
Angela Arreghini ◽  
Ilaria Carletti ◽  
Maria Cristina Ceccarelli ◽  
Luca Lombardo ◽  
Giuseppe Siciliani
Keyword(s):  
Class Ii ◽  
Twin Block ◽  
Class Ii Treatment ◽  
Adolescent Patients

Assessment of BRAF class I/II/III mutations, demographics, and treatment outcomes in NSCLC.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e21016-e21016
Author(s):  
Julian Andres Marin-Acevedo ◽  
James Kevin Hicks ◽  
Ram Thapa ◽  
Dung-Tsa Chen ◽  
ErinMarie Kimbrough ◽  
...  
Keyword(s):  
Demographic Data ◽  
Pairwise Comparison ◽  
Class Ii ◽  
Class I ◽  
Smoking History ◽  
Rank Test ◽  
Class Iii ◽  
Braf Mutations ◽  
Kaplan Meier ◽  
Braf Mutant

e21016 Background: BRAF mutations are grouped (class I, II or III) according to kinase activity, dependence on RAS, and dimerization. BRAF class I mutations are targeted with BRAF/MEK inhibitors. The management of class II/III mutations has not been fully elucidated. We aimed to further characterize BRAF-mutant NSCLC. Methods: Moffitt patients with BRAF-mutant NSCLC were identified through retrospective review of a clinical molecular database and electronic health record from 1/1/2012 - 03/31/2020. Demographics, PD-L1 expression, responses to chemotherapy/immunotherapy, and overall survival were collected. The correlation between BRAF mutation classes and these variables was determined using a pairwise comparison of p-values and corrected for testing using the Benjamini-Hochberg method. For survival analysis, we used the Kaplan-Meier method with log-rank test. Results: 153 patients were included. Table summarizes the demographic data. 14 evaluable patients with class I mutations received anti-BRAF therapy. The DCR was 79% (11/14) and 83% when PD-L1 ≥1% (5/6). 36 response-evaluable patients received immunotherapy. The DCR was 79% (11/14) for patients with class I, 69% (9/13) for class II, and 78% (7/9) for class III mutations (p=0.89). The DCR was 73% in those with PD-L1 ≥1% (22/30) and 44% in those with PD-L1 <1% (7/16; p= 0.02). 43 response-evaluable patients received chemotherapy. The DCR was 86% (18/21) for patients with class I, 69% (9/13) for class II, and 78% (7/9) for class III mutations (p=0.49). The mOS was 26.2 months for all patients. The mOS was 31.2 months for class I, 15.6 months for class II, 28.8 months for class III, 34.8 months for AMP, and 24 months for VUS (p=0.6). Conclusions: To our knowledge, this is the largest retrospective study of patients with BRAF-mutant NSCLC. BRAFmutations were more common in patients with adenocarcinoma and those with a smoking history. PD-L1 levels ≥1% were seen more frequently in all BRAF-mutant patients. Class I mutations were significantly more common than other mutations and responded well to BRAF-targeted therapy, particularly when PD-L1 ≥1%. All BRAF-mutant classes responded similarly to immunotherapy and better responses were seen among those with PD-L1 ≥1%. Responses to chemotherapy were similar across all classes. Improved OS in class I-mutant disease was seen. These findings were not statistically significant. Additional research is needed to better characterize these patients to individualize management and improve outcomes.[Table: see text]

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