Lipid Emulsion Enriched in Omega-3 PUFA Accelerates Wound Healing: A Placebo-Controlled Animal Study

2017 ◽  
Vol 42 (6) ◽  
pp. 1714-1720 ◽  
Author(s):  
Yi-Chi Peng ◽  
Fwu-Lin Yang ◽  
Yi-Maun Subeq ◽  
Chin-Chieh Tien ◽  
Yann-Fen C. Chao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Study ◽  
Lipid Emulsion ◽  
Omega 3

scholarly journals The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats

2017 ◽  
Vol 22 (2) ◽  
pp. 97 ◽  
Author(s):  
Fransisca Daisa ◽  
Mohamad Andrie ◽  
Wintari Taurina
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Negative Control ◽  
Stage Ii ◽  
Male Rats ◽  
Wound Healing Process ◽  
Omega 3 ◽  
Significant Difference ◽  
Healing Power ◽  
Channa Striata

The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control), ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open stage II and observation until day 16 injury. The area of the wound was measured with the image J program Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a significant difference in the negative group with ointment concentration of 20% (p <0.05). The treatment group phase ointment fish oil extract is effective for wound healing is best to have a concentration of 20% for percentage of wound healing power of 97.157% and the average AUC value of 865.683% of the day.

Topical application of omega-3-, omega-6-, and omega-9-rich oil emulsions for cutaneous wound healing in rats

2018 ◽  
Vol 9 (2) ◽  
pp. 418-433 ◽  
Author(s):  
Wan Maznah Wan Ishak ◽  
Haliza Katas ◽  
Ng Pei Yuen ◽  
Maizaton Atmadini Abdullah ◽  
Mohd Hanif Zulfakar
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Cutaneous Wound Healing ◽  
Omega 3 ◽  
Cutaneous Wound ◽  
Omega 6 ◽  
3 Omega ◽  
Oil Emulsions

scholarly journals Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection

2014 ◽  
Vol 3 (11) ◽  
pp. 682-690 ◽  
Author(s):  
J. Wesley Alexander ◽  
Dorothy M. Supp
Keyword(s):  
Fatty Acids ◽  
Wound Healing ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Pro-Resolution Potency of Resolvins D1, D2 and E1 on Neutrophil Migration and in Dermal Wound Healing

Nano LIFE ◽  
2017 ◽  
Vol 07 (01) ◽  
pp. 1750002 ◽  
Author(s):  
Riyesh Menon ◽  
Paulina Krzyszczyk ◽  
François Berthiaume
Keyword(s):  
Wound Healing ◽  
Neutrophil Migration ◽  
Treated Group ◽  
Omega 3 ◽  
Excessive Pressure ◽  
Macrophage Phagocytosis ◽  
Strong Linear Correlation ◽  
Excisional Wound

An exuberant inflammatory response may exacerbate the primary tissue damage caused by injuries to the skin due to burns, surgery, excessive pressure, and other etiologies, thus increasing the time to heal. We hypothesized that application of factors that decrease inflammation would allow the skin to more quickly restore its barrier function, and promote the return to homeostasis. Resolvins are endogenous, pro-resolving lipid mediators derived from omega-3 fatty acids that serve to inhibit neutrophil migration and enhance macrophage phagocytosis, thus promoting the resolution of inflammation and the beginning of the proliferative phase of wound healing. Resolvins are derived either from docosahexaenoic (D-series) or eicosapentaenoic (E-series) acid. Herein, we compare the effects of resolvins D1 (RvD1), D2 (RvD2) and E1 (RvE1) on their abilities to inhibit neutrophil migration in vitro and to promote wound healing in vivo. In Transwell experiments, all resolvins inhibited neutrophil migration, with RvE1 being the most effective at a 2000[Formula: see text]nM concentration. In an in vivo murine excisional wound (1[Formula: see text]cm[Formula: see text][Formula: see text][Formula: see text]1[Formula: see text]cm) healing model, topically applied resolvins accelerated wound closure. RvE1-treated wounds healed by 19.4[Formula: see text][Formula: see text][Formula: see text]1.5 days post-wounding, which was significantly shorter than the RvD2-treated and RvD1-treated groups ([Formula: see text]0.05), which closed by an average of 22.8[Formula: see text][Formula: see text][Formula: see text]1.8 and 24.4[Formula: see text][Formula: see text][Formula: see text]2.2 days, respectively. Furthermore, all resolvin-treated groups healed faster than vehicle controls ([Formula: see text]0.05), which closed at 28.6[Formula: see text][Formula: see text][Formula: see text]1.5 days. There was a strong linear correlation ([Formula: see text]0.9384) between each resolvin’s potency in inhibiting neutrophil migration in vitro versus accelerating wound healing in vivo. Furthermore, upon histological analysis, the RvE1-treated group exhibited more mature collagen organization and re-epithelialization.

Bedside to Bench: The Risk of Bleeding with Parenteral Omega-3 Lipid Emulsion Therapy

2014 ◽  
Vol 164 (3) ◽  
pp. 652-654 ◽  
Author(s):  
Bryan J. Dicken ◽  
Aisha Bruce ◽  
Tarah M. Samuel ◽  
Paul W. Wales ◽  
Susan Nahirniak ◽  
...  
Keyword(s):  
Lipid Emulsion ◽  
Omega 3 ◽  
Risk Of Bleeding

scholarly journals The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients

2016 ◽  
Vol 112 ◽  
pp. 1-11 ◽  
Author(s):  
Thomas C. Hall ◽  
Dilraj K. Bilku ◽  
Christopher P. Neal ◽  
Jill Cooke ◽  
Helena L. Fisk ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Critically Ill ◽  
Lipid Emulsion ◽  
Fatty Acid Profiles ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
The Impact

scholarly journals PENGARUH PEMBERIAN MINYAK IKAN LEMURU (Sardinella Longiceps) SECARA SISTEMIK TERHADAP JUMLAH OSTEOBLAS PADA PROSES PENYEMBUHAN SOKET GIGI

DENTA ◽  
2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Eddy Hermanto ◽  
Soemartono Soemartono ◽  
Dwi Surya Sudrajat
Keyword(s):  
Wound Healing ◽  
Fish Oil ◽  
Tooth Extraction ◽  
Control Group ◽  
Omega 3 ◽  
Control Group Design ◽  
Tooth Socket ◽  
Post Test ◽  
Socket Healing ◽  
Sardinella Longiceps

<pre><em><strong>Background</strong>: Sockets healing is a dynamic, continuous and overlapping process. Osteoblasts are important cells in healing sockets that will mineralize into bone until the injured tissue heals. Lemuru fish oil (Sardinella longiceps) contains omega 3 which can increase the number of osteoblasts so that it accelerates the process of socket healing after tooth extraction. <strong>Objective</strong>: To determine the effect lemuru fish oil that given systemically in increasing the number of osteoblasts in post-extraction tooth socket wound healing. <strong>Materials and methods</strong>: Experimental research laboratories with post test only control group design. Samples of 33 male Wistar mice were divided randomly into 3 groups. Group K as a control group that was not given lemuru fish oil, group P1 as a group given lemuru fish oil 1.5ml / 200g BB, and P2 group as a group given 1 ml / 200g BB lemuru fish oil. Extraction of left mandibular first incisor was carried out, then extract was given once a day for 7 days with gastric sonde. Observations were made on the 14th day after tooth extraction by calculating the number of osteoblasts in the histology sample using HE (Hematoxylin Eosin). <strong>Results</strong>: In each treatment group there were significant differences (P &lt;0.05) and significant comparisons (P&gt; 0, 05). <strong>Conclusion</strong>: Giving lemuru fish oil can increase the number of osteoblasts to post-extraction tooth socket wound healing.</em></pre><p><em> </em></p>

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