scholarly journals Comprehensive coagulation and fibrinolytic potential in the acute phase of pediatric patients with idiopathic nephrotic syndrome evaluated by whole blood-based rotational thromboelastometry

2022 ◽  
Author(s):  
Tomoaki Ishikawa ◽  
Yuto Nakajima ◽  
Takashi Omae ◽  
Kenichi Ogiwara ◽  
Keiji Nogami
Keyword(s):  
Nephrotic Syndrome ◽  
Acute Phase ◽  
Whole Blood ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Rotational Thromboelastometry ◽  
Fibrinolytic Potential

ALBUMIN VERSUS FRESH FROZEN PLASMA IN MANAGING DIURETIC RESISTANT EDEMA IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Vishwajeet Singh ◽  
P K Berwal ◽  
T C Saini ◽  
Narender Mishra
Keyword(s):  
Nephrotic Syndrome ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Dry Weight ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Double Number ◽  
Group A ◽  
Group B ◽  
Frozen Plasma

Background: This study was carried out to compare the efficacy and outcome of albumin with fresh frozen plasma (FFP) in the treatment of diuretic resistant edema in nephrotic syndrome Methods: Sixty patients with idiopathic NS were enrolled in this prospective analytic study. Patients with moderate to severe edema with serum albumin <1.5 gm/dl were given albumin and FFP dividing into two groups. Group-A, received intravenous albumin- 1 gm/kg/day and Group-B intravenous FFP 15ml/kg/day. Total number of albumin and FFP infusion were determined by edema reduction. Results: Diagnosis of NS and biochemical parameters were same in both groups. Dry weight was achieved in Group-A in 6.62± 3.15 days and in Group-B 6.65 ± 3.18 days. In GroupA the number of albumin infusion required was 1.42±0.62 and Group-B FFP infusion required was 3.11± 1.05 (p=0.0001). No significant complications were observed in both the groups. Conclusion: FFP cost half than albumin and same duration required to reduce edema but with double number of infusion and it is safe in pediatric patients with NS presenting with moderate to severe edema. Keywords: NS, Oedema, FFP, Albumin

Circulating blood cells influence the fibrinolytic capacity of clots generated in the presence of detergent sclerosants

2019 ◽  
Vol 35 (4) ◽  
pp. 273-280
Author(s):  
Tom Li ◽  
David Connor ◽  
Kurosh Parsi
Keyword(s):  
Whole Blood ◽  
Blood Cells ◽  
Sample Type ◽  
Rotational Thromboelastometry ◽  
Blood Samples ◽  
Platelet Poor Plasma ◽  
Low Concentrations ◽  
Sodium Tetradecyl Sulphate ◽  
Fibrinolytic Potential ◽  
Fibrinolytic Capacity

Objectives To investigate the effects of sodium tetradecyl sulphate and polidocanol on fibrinolytic potential of sclerosant-incubated clots. Methods Serial dilutions of sodium tetradecyl sulphate and polidocanol were incubated with platelet poor plasma and whole blood samples. Rotational thromboelastometry was used to determine the lysis of sclerosant-incubated clots in whole blood. Fibrin generation and fibrinolysis were quantified using an overall haemostatic potential assay on platelet poor plasma. Results Rotational thromboelastometry analysis of whole blood revealed increased maximum lysis in the presence of sodium tetradecyl sulphate but decreased maximum lysis at low concentrations of polidocanol. Clots generated using platelet poor plasma in the overall haemostatic potential assay demonstrated no significant change in fibrinolysis for both sclerosants at all concentrations measured. Discussion Sodium tetradecyl sulphate and polidocanol produce differing effects on the fibrinolytic potential depending on sample type and concentration. In whole blood, sodium tetradecyl sulphate produces clots more sensitive to lysis while polidocanol produced fibrinolytic-resistant clots.

scholarly journals Persistent Abnormalities of Fatty Acids Profile in Children With Idiopathic Nephrotic Syndrome in Stable Remission

2021 ◽  
Vol 8 ◽  
Author(s):  
Stefano Turolo ◽  
Alberto C. Edefonti ◽  
William Morello ◽  
Marie-Louise Syren ◽  
Valentina De Cosmi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Nephrotic Syndrome ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Cell Communication ◽  
Fatty Acids Profile ◽  
Filtration Barrier ◽  
Omega 6 ◽  
Steroid Sensitive Nephrotic Syndrome

Steroid-sensitive nephrotic syndrome is an immunological disorder mediated by still poorly defined circulating factor(s) that target the podocyte and damage the filtration barrier. Fatty acids (FA) have several biological roles and, in particular, are strictly involved in cell to cell communication, inflammatory processes and regulation of lymphocyte pools. Studies of FAs during INS have been mainly focused on biochemical changes during the phase of proteinuria; while no information is available about FA profile in patients with idiopathic nephrotic syndrome (INS) on stable remission. Aim of this study is to assess differences in blood FA profile between pediatric patients with INS during the phase of stable remission. Blood fatty acid profile of 47 pediatric patients on stable remission and 47 matched healthy controls were evaluated with gas chromatography. Patients with INS on stable remission had significantly higher levels of PUFA and omega-6 than controls (40.17 vs. 37.91% and 36.95 vs. 34.79%), lower levels of SFA and MUFA. Considering the single fatty acids, levels of omega-6 18:2n6 linoleic acid and omega-6 20:4n6 arachidonic acid were significantly higher in patients with INS than in controls (23.01 vs. 21.55%, p-value 0.003 and 10.37 vs. 9.65%, p-value 0.01). Moreover, patients with INS showed lower levels of SFA 14:0 (0.74 vs. 0.92%) and 18:0 (10.74 vs. 11.74%) and MUFA 18:1n9 oleic acid (18.50 vs. 19.83%). To the best of our knowledge this is the first study assessing FAs profile in children with INS in stable remission. In a population of 47 patients, we were able to demonstrate a higher blood level of linoleic and arachidonic acid, and consequently of omega-6 and PUFA, compared to controls. Persistently higher than normal levels of either linoleic or arachidonic acid, could be viewed as candidate biomarker for a state of risk of relapse in children with idiopathic nephrotic syndrome.

Glomerular permeability activity: Prevalence and prognostic value in pediatric patients with idiopathic nephrotic syndrome

2004 ◽  
Vol 44 (4) ◽  
pp. 604-610 ◽  
Author(s):  
Howard Trachtman ◽  
Laurence A. Greenbaum ◽  
Ellen T. McCarthy ◽  
Mukut Sharma ◽  
Bernard G. Gauthier ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Prognostic Value ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Glomerular Permeability

RESULTS OF TREATMENT OF CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME AT BAC NINH OBSTETRIC AND CHILDREN'S HOSPITAL

2021 ◽  
Vol 62 (5) ◽  
Author(s):  
Vu Thi Chi ◽  
Ta Thi Thanh Phuong ◽  
Pham Trung Kien
Keyword(s):  
Nephrotic Syndrome ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Blood Protein ◽  
Creatinine Ratio ◽  
Treatment Results ◽  
Laboratory Findings ◽  
Results Of Treatment ◽  
Severe Reduction ◽  
Male To Female

Objectives: describe the clinical characteristics, laboratory findings and evaluate the results of treatment of idiopathic nephrotic syndrome in pediatric patients at Bac Ninh Obstetrics and Children’sHospital. Method: descriptive study. From January 1, 2020 to June 30, 2021.Result: Fiffty two children were recruited into the study sample. Males got involed in this disease more than females with a ratio male to female of 2.05/1 (there were 17 women and 35 men). The meanage was 6,75 years (from 1 to 15 years old), 55,8% of them were under 5 years old. The percentages of severe edema was 7,7%; increased blood pressure was 9.6%; anuria was 19.2%. The average 24-hour proteinuria was 143.46 mg/kg/day; average protein/creatinine ratio was 878.08 mg/mmol. The percentages of patient with good treatment results is 76.9%. Proteinuria, protein/creatinine in urinedecreased significantly after treatment (p<0.05). Blood albumin increased and cholesterol decreased significantly after treatment (p<0.05).Conclusion: Children with idiopathic nephrotic syndrome most were males, young age, severe edema, severe reduction in blood protein and proteinuria. The disease was completely treatable and monitored locally

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