scholarly journals PREVALENCE OF VITAMIN D3 DEFICIENCY AMONG PEDIATRIC PATIENTS WITH IDIOPATHIC NEPHROTIC SYNDROME IN REMISSION - A CROSS-SECTIONAL OBSERVATIONAL STUDY FROM VADODARA, GUJARAT

2018 ◽  
Vol 05 (07) ◽  
pp. 481-483
Author(s):  
Jayesh R Solanki ◽  
Shruthy Sudhakaran ◽  
Kalpita S Shringarpure
Keyword(s):  
Nephrotic Syndrome ◽  
Observational Study ◽  
Vitamin D3 ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Cross Sectional ◽  
Vitamin D3 Deficiency

scholarly journals Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Roberta da Silva Filha ◽  
Sérgio Veloso Brant Pinheiro ◽  
Thiago Macedo e Cordeiro ◽  
Victor Feracin ◽  
Érica Leandro Marciano Vieira ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Ang Ii ◽  
Cross Sectional ◽  
Angiotensin Converting Enzyme 2 ◽  
Inflammatory Molecules

AbstractIntroduction: Renin angiotensin system (RAS) plays a role in idiopathic nephrotic syndrome (INS). Most studies investigated only the classical RAS axis. Therefore, the aims of the present study were to evaluate urinary levels of RAS molecules related to classical and to counter-regulatory axes in pediatric patients with INS, to compare the measurements with levels in healthy controls and to search for associations with inflammatory molecules, proteinuria and disease treatment. Subjects and methods: This cross-sectional study included 31 patients with INS and 19 healthy controls, matched for age and sex. Patients and controls were submitted to urine collection for measurement of RAS molecules [Ang II, Ang-(1-7), ACE and ACE2] by enzyme immunoassay and cytokines by Cytometric Bead Array. Findings in INS patients were compared according to proteinuria: absent (<150 mg/dl, n = 15) and present (≥150 mg/dl, n = 16). Results: In comparison to controls, INS patients had increased Ang II, Ang-(1-7) and ACE, levels while ACE2 was reduced. INS patients with proteinuria had lower levels of ACE2 than those without proteinuria. ACE2 levels were negatively correlated with 24-h-proteinuria. Urinary concentrations of MCP-1/CCL2 were significantly higher in INS patients, positively correlated with Ang II and negatively with Ang-(1-7). ACE2 concentrations were negatively correlated with IP-10/CXCL-10 levels, which, in turn, were positively correlated with 24-h-proteinuria. Conclusion: INS patients exhibited changes in RAS molecules and in chemokines. Proteinuria was associated with low levels of ACE2 and high levels of inflammatory molecules.

ALBUMIN VERSUS FRESH FROZEN PLASMA IN MANAGING DIURETIC RESISTANT EDEMA IN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Vishwajeet Singh ◽  
P K Berwal ◽  
T C Saini ◽  
Narender Mishra
Keyword(s):  
Nephrotic Syndrome ◽  
Pediatric Patients ◽  
Idiopathic Nephrotic Syndrome ◽  
Dry Weight ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Double Number ◽  
Group A ◽  
Group B ◽  
Frozen Plasma

Background: This study was carried out to compare the efficacy and outcome of albumin with fresh frozen plasma (FFP) in the treatment of diuretic resistant edema in nephrotic syndrome Methods: Sixty patients with idiopathic NS were enrolled in this prospective analytic study. Patients with moderate to severe edema with serum albumin <1.5 gm/dl were given albumin and FFP dividing into two groups. Group-A, received intravenous albumin- 1 gm/kg/day and Group-B intravenous FFP 15ml/kg/day. Total number of albumin and FFP infusion were determined by edema reduction. Results: Diagnosis of NS and biochemical parameters were same in both groups. Dry weight was achieved in Group-A in 6.62± 3.15 days and in Group-B 6.65 ± 3.18 days. In GroupA the number of albumin infusion required was 1.42±0.62 and Group-B FFP infusion required was 3.11± 1.05 (p=0.0001). No significant complications were observed in both the groups. Conclusion: FFP cost half than albumin and same duration required to reduce edema but with double number of infusion and it is safe in pediatric patients with NS presenting with moderate to severe edema. Keywords: NS, Oedema, FFP, Albumin

scholarly journals Vitamin D3 Deficiency in Non-Alcoholic Fatty Liver Disease

2020 ◽  
Author(s):  
Mohammad Mahdi Hayatbakhsh Abbasi ◽  
Mohammad Javad Zahedi ◽  
Sodaif Darvish Moghadam ◽  
Fereshteh Arab Ghahestani ◽  
Fatemeh Karami Robati
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Vitamin D3 ◽  
Fatty Liver Disease ◽  
Demographic Data ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver ◽  
Vitamin D3 Deficiency ◽  
Alcoholic Fatty Liver Disease

Regarding the importance of non-alcoholic fatty liver disease (NAFLD) and the high prevalence of vitamin D3 deficiency in different societies. This study aimed to evaluate the distribution of Vit D3 deficiency in individuals with non-alcoholic fatty liver disease. In this cross-sectional study, 122 individuals with nonalcoholic fatty liver disease were selected by a simple sampling method. After collecting demographic data, serum Vit 25(OH) D3 level was measured by the ELFA method. Blood lipids level (TG, cholesterol, HDL, LDL), FBS, AST, ALT, alkaline phosphatase, total and direct bilirubin, albumin, and PT were measured by the enzymatic method. To analyze the data, descriptive and analytical methods and SPSS software version 16 were used. The study cases are comprised of 122 individuals (57.4% male). The average age of cases was 42.4±11.7 years, and the mean of serum Vit D3 level was 19.8±22 ng/dl (3-220 ng/dl). Regarding the serum 25(OH) D3 levels data showed 66.4% of cases were Vit D3 deficient (Vit D3 level< 20 ng/dl), 18% had insufficient level (Vit D3 level=20-30 ng/dl), and the remained 15.6% had sufficient level (Vit D3 level> 30 ng/dl). HDL level was higher in individuals with 25(OH) D3 sufficiency compared to those with 25(OH) D3 insufficiency and Vit D3 deficiency (P=0.019). There was no significant relationship between serum Vit D3 level and other investigated variables. The results of this study indicated that most individuals with non-alcoholic fatty liver disease had Vit D3 deficiency. Further studies are suggested.

scholarly journals Vitamin D3 – does it correlate with exercise tolerance in stable COPD?

2019 ◽  
Vol 14 (1) ◽  
pp. 14-20
Author(s):  
Samia Hassan ◽  
Taskina Ali ◽  
Kazi Saifuddin Bennoor ◽  
Md Ali Hossain ◽  
Mustafizur Rahman ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Exercise Tolerance ◽  
Cross Sectional Study ◽  
Urgent Care ◽  
Male Smoker ◽  
Skeletal Health ◽  
Cross Sectional ◽  
Copd Patients ◽  
The Status ◽  
Vitamin D3 Deficiency

Background: Though the classic function of vitamin D3 in skeletal health is established, but its new role has been discovered in tissues and organs other than bones. Vitamin D3 deficiency has been found in patients with various morbid conditions, such as cardiovascular diseases, autoimmune diseases, infectious diseases, Diabetes mellitus and malignancies including respiratory ailments. Objectives: This cross sectional study was designed to evaluate the status of this fat soluble vitamin D3 and its correlation with exercise tolerance in stable COPD patients. Methods: For this purpose, 47 male, smoker (>4 pack years), stable (who has not experienced any acute exacerbation, hospitalizations, urgent care visits, or changes in routine medications within 4 weeks prior to study), COPD patients (post bronchodilator FEV1/FVC<0.70; duration >4 years) of >40 years of age, were selected from the Out Patient Department of National Institute of Diseases of Chest and Hospital (NIDCH), Dhaka. For the assessment of vitamin D3 status, their serum 25-hydroxycholecalciferol [25(OH)D], for exercise tolerance, 6 min walk distance [6MWD; by 6 min walk test], peripheral capillary oxygen saturation (SpO2) [by pulse oximetry], level of dyspnea and fatigue [by Modified BORG scale], were measured. The data were expressed as percentage and mean ±SEM and were statistically analyzed by Pearson’s correlation coefficient test, where p<0.05 was accepted as significant. Results: Out of 47 stable COPD patients, 46 (97.8%) were with serum 25(OH) D < 30 ng/ml. In addition, 6MWD was positively (p£0.05) and dyspnea (p£0.001) along with fatigue (p£0.05) score were negatively correlated with serum 25(OH)D level in these stable COPD patients. Conclusion: This study result concluded that, majority patients with stable COPD had D3 deficiency and this D3 deficiency showed significant correlation with decrement of exercise tolerance. J Bangladesh Soc Physiol. 2019, June; 14(1): 14-20

scholarly journals Oral health conditions in children with idiopathic nephrotic syndrome: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Urszula Kaczmarek ◽  
Alina Wrzyszcz-Kowalczyk ◽  
Katarzyna Jankowska ◽  
Katarzyna Prościak ◽  
Monika Mysiak-Dębska ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Oral Health ◽  
Idiopathic Nephrotic Syndrome ◽  
Cross Sectional Study ◽  
Health Conditions ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Ocular and extra-ocular complications following long-term steroid consumption in children with idiopathic nephrotic syndrome

2020 ◽  
Vol 11 (1) ◽  
pp. 7-10
Author(s):  
Gulshan Nigar Chaudhury ◽  
Tarannum Khandaker ◽  
Tahmina Ferdous ◽  
Rifat Asma Chowdhury ◽  
Shireen Afroz ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Intraocular Pressure ◽  
Bone Pain ◽  
Idiopathic Nephrotic Syndrome ◽  
Epigastric Pain ◽  
Cross Sectional Study ◽  
High Dose ◽  
Ocular Complications ◽  
Cross Sectional ◽  
The Mean

Background: High dose of corticosteroids are required by patients with idiopathic nephrotic syndrome for long duration due to repeated relapse. The aims of this study were to analyze the ocular and extra-ocular complications of steroids on children with nephrotic syndrome. Methods: This cross-sectional study was conducted at Dhaka Shishu (Children) Hospital from September 2017 to September 2019. Children with nephrotic syndrome between 1-16 years of age, who received steroid for at least three months, participated in this study. Total 70 children were enrolled. Detailed history was taken from parents regarding initial episode, drug history, visual problem, headache, hypertension, weight gain, psychosis, bone pain, epigastric pain and excessive growth of body hair. Comprehensive opthalmologic assessment including visual acquity, intraocular pressure and cataract were performed. Detail of renal histopathology and treatment regimen in each patient was noted. Results: A total of 70 patients were included, 61.4% were male and 38.6% were female. Median age at the time of examination was 60 months (range 17 to 216 months). The mean duration of disease was 33.71±21.12 months. The mean cumulative steroid dose at the time of examination was 8485.91±7326.83 mg. Fourteen (20%) patients had posterior subcapsular cataract. Among 70 patients, we could do visual acuity for 25 (35.7%) patients, intraocular pressure (IOP) in mm for 51 (72.85%) patients. Among them raised IOP was found in five (9.8%) patients. In right eye mean IOP was 14.16±3.57 and for left eye 14.77±3.55 mm. Renal biopsy was performed in 15 (21.43%) cases. Among the biopsy report, it was found that mesangial proliferative glomerulonephritis (MPGN) in 8 (53.33%), focal segmental glomerulonephritis (FSGS) in 2 (13.33%) and minimal change in 5 (33.34%) cases. Among all cases, 12 (17.14%) patients developed Cushingoid facies, 3 (4.2%) patients had hypertrichosis, 3 (4.2%) patients had central obesity and 4 (5.7%) patients had buffalo hump but none had hypertension, diabetes mellitus, epigastric pain, bone pain or psychosis. Conclusion: Cataract formation was the most frequent ocular complication after large dose of oral corticosteroid therapy. The present study emphasizes the need for regular eye screening. Cushingoid facies was the most frequent among extra-ocular complications. Birdem Med J 2021; 11(1): 7-10

scholarly journals Treatment of idiopathic nephrotic syndrome with two steroid dosing regimens – one-year observational study

2021 ◽  
Author(s):  
Małgorzata Pańczyk-Tomaszewska ◽  
Piotr Skrzypczyk ◽  
Kacper Mroczkowski ◽  
Beata Leszczyńska ◽  
Małgorzata Mizerska-Wasiak
Keyword(s):  
Nephrotic Syndrome ◽  
Observational Study ◽  
Idiopathic Nephrotic Syndrome ◽  
Dosing Regimens ◽  
One Year
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