The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms

2017 ◽  
Vol 124 (5) ◽  
pp. 559-568 ◽  
Author(s):  
Feng Zhang ◽  
Rujia Zhong ◽  
Song Li ◽  
Raymond Chuen-Chung Chang ◽  
Weidong Le
Keyword(s):  
Sleep Disorders ◽  
Missing Link ◽  
Age Related

scholarly journals Mr. Potato Head

2019 ◽  
pp. 468-487
Author(s):  
Nancy Foldvary-Schaefer ◽  
Thapanee Somboon ◽  
Zahreddin Alsheikhtaha
Keyword(s):  
Sleep Apnea ◽  
Sleep Disorders ◽  
Developmental Delay ◽  
Epileptic Encephalopathy ◽  
Electrode Placement ◽  
Age Related ◽  
Generalized Epilepsy ◽  
Patients With Epilepsy ◽  
Spike Wave

This case illustrates diagnostic challenges in patients with epilepsy and suspected sleep disorders. Specifically, the symptomatic generalized epilepsy Lennox-Gastaut syndrome is an age-related epileptic encephalopathy characterized by developmental delay; multiple seizure types, including tonic seizures in drowsiness and sleep; and generalized slow spike-wave complexes on electroencephalography (EEG). Tonic seizures in sleep can be unrecognized or can be confused with sleep disorders such as sleep apnea. The case demonstrates how to identify generalized epileptic abnormalities and seizures on the limited EEG montage used in routine polysomnography and expanded EEG using the 10-20 system of electrode placement.

AGING AND COGNITIVE DISORDERS FROM THE SOMNOLOGY’S VIEWPOINT

2021 ◽  
pp. 195-201
Author(s):  
И.М. Мадаева ◽  
Н.В. Семенова ◽  
Л.И. Колесникова ◽  
С.И. Колесников
Keyword(s):  
Sleep Disorders ◽  
Cognitive Dysfunction ◽  
Functional State ◽  
Aging Process ◽  
Cognitive Disorders ◽  
Biologically Active ◽  
Cell Markers ◽  
Social Burden ◽  
Pathological Aging ◽  
Age Related

Высокое социальное бремя возрастзависимых заболеваний делает актуальным разработку и внедрение комплекса медицинских технологий донозологической диагностики, лечения и профилактики различных нарушений функциональных состояний жизнедеятельности человека в процессе старения. Возрастное снижение активности функционального состояния мозга и его взаимообусловленность с континуумом сон-бодрствование приводит к преждевременному (патологическому) старению с проявлениями нейродегенерации. Хотя нарушения функционирования цикла сон-бодрствование являются характерными для процесса старения, но возрастные изменения не всегда сопровождаются когнитивной дисфункцией. Сложная архитектура сна претерпевает выраженные изменения в течение всей жизни человека. В литературе активно дискутируется взаимосвязь нарушений циркадной ритмики при старении и развития когнитивной дисфункции. В то же время встречается достаточное количество исследований, посвященных изменениям организма на молекулярном уровне при возрастных нарушениях сна. Гетерогенность патогенетических механизмов старения, ассоциаций нарушений сна и процессов когнитивной дисфункции включает также изменение метаболизма. В регуляцию процессов сна вовлечены различные нейромедиаторы и другие биологически активные вещества, так называемые «sleep-promoting substances». Насущная необходимость дальнейших научных изысканий в поиске молекулярно-клеточных маркеров и диагностических паттернов нарушений сна при старении является перспективным и внесет значительный вклад в развитие прорывных технологий в профилактике патологического старения. Подход с позиции современной нейробиологии, сомнологии и медицины сна представляется крайне актуальным и своевременным. Этот обзор посвящен некоторым аспектам научных изысканий, посвященных возрастным изменениям сна и их молекулярно-клеточным маркерам. Age-dependent diseases high social burden makes relevant medical technologies development and implementation of human aging process functional state various disorders prenosological diagnosis, treatment and prevention. Age-related activity decrease of the brain functional state and its interdependence with the sleep-wake continuum leads to premature (pathological) aging with manifestations of neurodegeneration. Although disturbances of the sleep-wake cycle functioning are characteristic for the aging process, age-related changes are not always accompanied by cognitive dysfunction. There are sufficient number studies on the molecular level changes in age-related sleep disorders. Aging, sleep disorders and processes of cognitive dysfunction association pathogenetic mechanisms heterogeneity also include metabolism changes. Various neurotransmitters and other biologically active substances, so-called «sleep-promoting substances» are involved in the regulation of sleep processes. The urgent need for molecular-cell markers and diagnostic patterns of sleep disorders further scientific search in aging process is promising and will make a significant contribution to the breakthrough technologies development in the pathological aging prevention. The complex architecture of sleep undergoes pronounced changes throughout a person’s life. In the literature, the relationship of circadian rhythm disturbances during aging and the development of cognitive dysfunction is actively debated. Approach from the positions of the modern neurobiology, somnology and sleep medicine perspectives seems extremely relevant and timely. This review is devoted to some aspects of age-related in sleep and their molecular-cell markers changes modern scientific research and our own data analysis.

Orexin: a Missing Link Between Sleep Disorders and Heart Failure?

2017 ◽  
Vol 14 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Stephen Pan ◽  
Carolina S. Cabral ◽  
Euan A. Ashley ◽  
Marco V. Perez
Keyword(s):  
Heart Failure ◽  
Sleep Disorders ◽  
Orexin A ◽  
Missing Link

Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?

2000 ◽  
Vol 29 (12) ◽  
pp. 1302-1306 ◽  
Author(s):  
Francesco S Facchini ◽  
Nancy W Hua ◽  
Gerald M Reaven ◽  
Riccardo A Stoohs
Keyword(s):  
Oxidative Stress ◽  
Missing Link ◽  
Age Related

Sleep disorders in neurodegenerative diseases other than Parkinson disease and multiple system atrophy

2017 ◽  
Author(s):  
Raffaele Manni ◽  
Michele Terzaghi
Keyword(s):  
Neurodegenerative Diseases ◽  
Sleep Disorders ◽  
Neurodegenerative Disorders ◽  
Sleep Problems ◽  
Lewy Bodies ◽  
Corticobasal Degeneration ◽  
Spinocerebellar Ataxias ◽  
Age Related ◽  
Key Points ◽  
Sleep Alterations

This chapter examines sleep–wake disturbances occurring in the most common neurodegenerative disorders. It reviews sleep alterations in Alzheimer disease and dementia with Lewy bodies. It also discusses sleep problems in progressive supranuclear palsy, corticobasal degeneration, Huntington disease, and spinocerebellar ataxias. Status dissociatus as an extreme form of sleep alteration in advanced neurodegenerative diseases is also considered. The chapter reviews the key points for the treatment of disrupted sleep in neurodegenerative disorders, with a focus on pharmacological and nonpharmacological interventions to improve sleep continuity. It also summarizes paraphysiological age-related changes in sleep patterns and discusses indications and procedures for clinical and instrumental assessment of sleep disorders in neurodegenerative disorders.

SMC1β-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction

2005 ◽  
Vol 37 (12) ◽  
pp. 1351-1355 ◽  
Author(s):  
Craig A Hodges ◽  
Ekaterina Revenkova ◽  
Rolf Jessberger ◽  
Terry J Hassold ◽  
Patricia A Hunt
Keyword(s):  
Missing Link ◽  
Female Mice ◽  
Age Related

Sleep and Sleep Disorders in Old Age

2018 ◽  
pp. 303-325
Author(s):  
Garima Srivastava ◽  
Rakesh Kumar Tripathi
Keyword(s):  
Sleep Disorders ◽  
Eye Movement ◽  
Old Age ◽  
Physiological Age ◽  
Rapid Eye Movement ◽  
Behaviour Therapy ◽  
Sleep Complaints ◽  
Age Related ◽  
Cognitive Behaviour ◽  
A New Technique

Sleep complaints are prevalent among older adults. Sleep quality and quantity changes with advancing age. There are changes in sleep patterns that are normal with ageing but many changes are the sign of disordered sleep. Sleep can be divided into rapid eye movement (REM) sleep and non-rapid eye movement sleep (NREM). Each has unique characteristics that are differentiated by their waveforms on the electroencephalogram (EEG) and by other physiological signals; several physiological age-related changes are thought to produce alterations in circadian rhythms. While there are numerous psychological and social factors contributing to quality and quantity of sleep, specific sleep disorders more prevalent in old age are insomnia, sleep apnea, and rapid eye movement disorder. Non-pharmacological treatment is effective in management of sleep disorders. Cognitive behaviour therapy is most effective to tackle insomnia. Cognitive behavior therapy along with meditation is beneficial for other sleep disorders and a new technique is also emerging: mindfulness.

scholarly journals The Effect of Aerobic Training and Vitamin D Supplements on the Neurocognitive Functions of Elderly Women with Sleep Disorders

2018 ◽  
Author(s):  
morteza taheri
Keyword(s):  
Vitamin D ◽  
Mental Disorders ◽  
Sleep Disorders ◽  
Aerobic Training ◽  
Elderly Women ◽  
The Elderly ◽  
Economic Costs ◽  
Neurocognitive Functions ◽  
Age Related ◽  
Vitamin D Supplements

<p>The age-related physical and mental disorders in the elderly are issues that endure social and economic costs. The aim of the present study was to examine the effect of aerobic training and vitamin D supplements on the neurocognitive functions of elderly women with sleep disorders.</p>

scholarly journals MODES OF USE OF THE CELL PHONE AND HEALTH OF SCHOOLCHILDREN

2019 ◽  
Vol 98 (8) ◽  
pp. 857-862 ◽  
Author(s):  
Olga A. Vyatleva ◽  
A. M. Kurgansky
Keyword(s):  
Sleep Disorders ◽  
Age Differences ◽  
Radiation Intensity ◽  
Health Indicators ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Relative Risks ◽  
Age Related ◽  
Age Dependent ◽  
The Impact

Introduction. The broad spread of cell phones (CP) among schoolchildren and the absence of age standards for their safe use determined the purpose of the study: to reveal the regimens of CP use, critical for the health of children and adolescents. Material and methods. In a cross-sectional study in 2008-2010, by the questionnaire data of 2,137 schoolchildren aged 6-15 years there was assessed the impact of CP usage indices (daily number of calls - CN, call duration - CD, and total daily duration of calls - TCDD) on health (the incidence of headaches and sleep disorders, number of colds). Student and Mann-Whitney criteria and assessment of relative risks were used. Results. The study revealed age-dependent critical values of usage indices (in 6-10 years: CN=2, TCDD=6 minutes.; in 11-13 years: CN=6; in 14-15 years CN=6, CD=3 minutes., TCDD=4 -10 min.), the exceeding of which due to risks: in 6-10 years - to have more than 4 colds a year (OR 2.25, 95% CI 1.09-4.62); in 11-13 years to have several headaches per week (OR 1.61, 95% CI 1.12-2.30); in 14-15 years - to have several headaches (OR 1.79, 95% CI 1.27-2.54) and several sleep disorders (OR 1.66, 95% CI 1.17-2.37) per week. Discussion. Age differences in critical modes of CP use and in health violations, as well as the importance of radiation intensity are discussed. Conclusions. Age-related CP use regimens, critical for health, were established. It was shown the need to develop more precise age criteria for safe CP use with taking into account a wider range of health indicators and radiation intensity.

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