scholarly journals Assessment of the tau protein concentration in patients with tick-borne encephalitis

2019 ◽  
Vol 38 (3) ◽  
pp. 479-483 ◽  
Author(s):  
Piotr Czupryna ◽  
Barbara Mroczko ◽  
Sławomir Pancewicz ◽  
Paweł Muszynski ◽  
Sambor Grygorczuk ◽  
...  
Keyword(s):  
Tau Protein ◽  
Protein Concentration ◽  
Tick Borne Encephalitis

High CSF Tau-protein concentration in delirium induced by high dose psychiatric medication

2006 ◽  
Vol 40 (11-12) ◽  
pp. 1039-1041 ◽  
Author(s):  
Anja Windhagen ◽  
Ulrich Wurster ◽  
Stefan Kropp ◽  
Marc Ziegenbein
Keyword(s):  
Tau Protein ◽  
Protein Concentration ◽  
High Dose ◽  
Psychiatric Medication

scholarly journals Mutation in microtubule-associated protein tau MAPT coding gene and its correlation with Alzheimer’s disease

2020 ◽  
Vol 11 (4) ◽  
pp. 5150-5157
Author(s):  
Sabah Subhi Ismael ◽  
Sarab D. Al-Shamaa
Keyword(s):  
Alzheimer’S Disease ◽  
Family History ◽  
Patient Group ◽  
Tau Protein ◽  
Protein Concentration ◽  
Positive Family History ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau ◽  
Pcr Product ◽  
Healthy Control

Alzheimer's disease (AD) is a progressive irreversible neuronal dysfunction characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in daily activities. Disturbances in microtubule-associated protein tau (MAPT) gene expression result in disruption of the neuronal cytoskeleton and formation of neurofibrillary tangles. The study aims are to highlight the correlation between MAPT gene's exons mutations and AD. Beside the possibility of utilizing serum's tau protein concentration as an indicator for AD due to the accumulation of intracellular neurofibrillary filaments of highly phosphorylated Tau in AD patient's brain. DNA had been extracted from participant's blood that divided into three groups 30 participants in each ,AD patients ,Positive family history and healthy or control groups. The results of this research showed that serum's Tau protein concentration in AD patient group was significantly higher than healthy control and positive family history group and according to this result serum's tau concentration could be utilized as a good indicator for AD .Beside mutation in each 1,9 and 13 exons had been identified by PCR product analysis utilizing specific primers for each , Amplification PCR products in exon (1) showed 428bp band in AD patients group does not exist in 26.66% and in positive family history for AD group does not exist in 23.33%, In exon (9) PCR product of 604bp band in AD patients group does not exist in 53.33%, and in positive family history group does not exist in 43.33%. While amplification PCR product of exon 13 showed 299bps band in all healthy control and positive family history but not in AD patient group instead it band in 263bp had been appeared in 36.66%. These results confirmed the important role of tau protein and its coding gene in the pathology of AD.

Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis

2011 ◽  
Vol 18 (5) ◽  
pp. 592-599 ◽  
Author(s):  
J Frederiksen ◽  
K Kristensen ◽  
JMC Bahl ◽  
M Christiansen
Keyword(s):  
Multiple Sclerosis ◽  
Prognostic Factor ◽  
Optic Neuritis ◽  
Tau Protein ◽  
Protein Concentration ◽  
Protein A ◽  
Neurological Impairment ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Risk Of Progression

Background: Tau protein has been proposed as biomarker of axonal damage leading to irreversible neurological impairment in MS. CSF concentrations may be useful when determining risk of progression from ON to MS. Objective: To investigate the association between tau protein concentration and 14-3-3 protein in the cerebrospinal fluid (CSF) of patients with monosymptomatic optic neuritis (ON) versus patients with monosymptomatic onset who progressed to multiple sclerosis (MS). To evaluate results against data found in a complete literature review. Methods: A total of 66 patients with MS and/or ON from the Department of Neurology of Glostrup Hospital, University of Copenhagen, Denmark, were included. CSF samples were analysed for tau protein and 14-3-3 protein, and clinical and paraclinical information was obtained from medical records. Results: The study shows a significantly increased concentration of tau protein in CSF from patients with relapsing–remitting MS and patients monosymptomatic at onset who progressed to MS, but interestingly no increased tau protein concentration in monosymptomatic ON. The concentration of tau protein was significantly correlated to Expanded Disability Status Scale score. No 14-3-3 protein was detected in any CSF sample. Conclusions: The results of this study invite further exploration of the possible role of tau protein as a prognostic factor to predict progression from ON to MS in future studies.

scholarly journals Sequelae of tick-borne encephalitis in retrospective analysis of 1072 patients

2018 ◽  
Vol 146 (13) ◽  
pp. 1663-1670 ◽  
Author(s):  
Piotr Czupryna ◽  
Sambor Grygorczuk ◽  
Katarzyna Krawczuk ◽  
Sławomir Pancewicz ◽  
Joanna Zajkowska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Analysis ◽  
Protein Concentration ◽  
Neurological Complications ◽  
Tick Borne Encephalitis ◽  
Potential Risk Factors ◽  
Vector Borne ◽  
Subjective Complaints ◽  
The Moment

AbstractTick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe. The aim of the study was to evaluate sequelae and to analyse the potential risk factors predisposing to sequelae development. We performed a retrospective analysis of medical records of 1072 patients who received a 1-month follow-up appointment after hospital discharge. Medical data, such as patients’ age, gender, place of living, subjective complaints, neurological and psychiatric sequelae were evaluated twice: at the moment of discharge and at follow-up visits 1 month after discharge. We observed that sequelae may affect 20.6% of TBE patients. Subjective sequelae were more frequent than subjective complaints during the hospitalisation (P < 0.001), while objective neurological symptoms during the hospitalisation were more pronounced than neurological sequelae (P < 0.001). Patients with meningoencephalomyelitis were predisposed to neurological complications, while subjective symptoms were more common in meningoencephalitis. Independent risk factors for sequelae development were: age and cerebrospinal fluid (CSF) protein concentration. The risk of late neurological complications persisting was increased in patients with higher CSF protein concentration. Based on the results of our study we concluded that, there is a need for a better vaccination program, which would prevent the development of sequelae.

Effects of Gene and Plasma Tau on Cognitive Impairment in Rural Chinese Population

2021 ◽  
Vol 18 ◽  
Author(s):  
Xu Tang ◽  
Shuzhen Liu ◽  
Jiansheng Cai ◽  
Quanhui Chen ◽  
Xia Xu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Tau Protein ◽  
Chinese Population ◽  
Protein Concentration ◽  
Mmse Score ◽  
Rural China ◽  
Control Group ◽  
Blood Samples ◽  
Protein Tau ◽  
And Control

Background: Sufficient attention was not paid to the effects of microtubule-associated protein tau (MAPT) and plasma tau protein on cognition. Objective: A total of 3072 people in rural China were recruited. They were provided with question-naires, and blood samples were obtained. Methods: The MMSE score was used to divide the population into cognitive impairment group and control group. First, logistic regression analysis was used to explore the possible factors influenc- ing cognitive function. Second, 1837 samples were selected for SNP detection through stratified sampling. Third, 288 samples were selected to test three plasma biomarkers (tau, phosphorylated tau, and Aβ-42). Results: For the MAPT rs242557, people with AG genotypes were 1.32 times more likely to devel- op cognitive impairment than those with AA genotypes, and people with GG genotypes were 1.47 times more likely to develop cognitive impairment than those with AG phenotypes. The plasma tau protein concentration was also increased in the population carrying G (P = 0.020). The plasma tau protein was negatively correlated with the MMSE score (P = 0.004). Conclusion: The mutation of MAPT rs242557 (A > G) increased the risk of cognitive impairment and the concentration of plasma tau protein.

Albumin-Induced Endocytic Vacuoles in Tetrahymena Pyrijormis

1975 ◽  
Vol 33 ◽  
pp. 694-695
Author(s):  
L. J. Brenner ◽  
D. G. Osborne ◽  
B. L. Schumaker
Keyword(s):  
Electron Microscopy ◽  
Bovine Serum Albumin ◽  
Bovine Serum ◽  
Protein Concentration ◽  
Tetrahymena Pyriformis ◽  
Sequence Of Events ◽  
Cytoplasmic Bodies ◽  
Food Vacuoles ◽  
Mouse Ascites ◽  
Normal Human

Exposure of the ciliate, Tetrahymena pyriformis, strain WH6, to normal human or rabbit sera or mouse ascites fluids induces the formation of large cytoplasmic bodies. By electron microscopy these (LB) are observed to be membrane-bounded structures, generally spherical and varying in size (Fig. 1), which do not resemble the food vacuoles of cells grown in proteinaceous broth. The possibility exists that the large bodies represent endocytic vacuoles containing material concentrated from the highly nutritive proteins and lipoproteins of the sera or ascites fluids. Tetrahymena mixed with bovine serum albumin or ovalbumin solutions having about the same protein concentration (7g/100 ml) as serum form endocytic vacuoles which bear little resemblance to the serum-induced LB. The albumin-induced structures (Fig. 2) are irregular in shape, rarely spherical, and have contents which vary in density and consistency. In this paper an attempt is made to formulate the sequence of events which might occur in the formation of the albumin-induced vacuoles.

Was unterscheidet die Subtypen der Creutzfeldt-Jakob-Krankheit von anderen Demenzen mit initialen psychiatrischen Auffälligkeiten?

2003 ◽  
Vol 01 (01) ◽  
pp. 24-29
Author(s):  
H. Wormstall ◽  
M. Bartels ◽  
G.W. Eschweiler
Keyword(s):  
Tau Protein ◽  
Fur Protein ◽  
T2 Mri ◽  
Codon 129

ZusammenfassungSeit dem Nachweis boviner spongiformer Enzephalopathie (BSE) unter Rindern in Deutschland im November 2000 ist die Gefahr, an der neuen Variante der Creutzfeld-Jakob-Krankheit (vCJD) zu erkranken, auch hierzulande größer geworden. Diese Übersicht schildert die Differenzialdiagnostik von Demenzerkrankungen mit initialen psychiatrischen Auffälligkeiten im jüngeren und höheren Alter. Besonderer Wert wird auf die Unterschiede zwischen der sporadischen Creutzfeld-Jakob-Krankheit (sCJD) und der vCJD gelegt. Neben den klinischen und initial meist psychiatrisch geprägten Verläufen werden neuere laborchemische, molekulargenetische und neuroradiologische Aspekte dieser beiden Prionkrankheiten dargestellt. Der Liquor ist in den meisten Fällen positiv für Protein 14-3-3, Tau-Protein und Neuron-spezifische Enolase (NSE). Nur bei bestimmten molekulargenetisch am Codon 129 des Prionproteins determinierten Subgruppen der sCJD-Patienten, nicht aber bei vCJD-Patienten, finden sich im EEG periodische scharfe Wellen. In der Frühdiagnostik der sCJD kann vor allem die diffusionsgewichtete MRI eingesetzt werden. Bei den jüngeren vCJD-Patienten findet man neben den psychiatrischen Symptomen Parästhesien, erst später eine Demenz und Ataxie von mehr als 6 Monaten Dauer sowie T2-MRI-Signalhyperintensitäten im Pulvinar. Als weitere Differenzialdiagnosen der verschiedenen CJD-Subtypen wird auch die wenig bekannte Hashimoto-Enzephalopathie näher beschrieben.

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