Overview of natural hydrogels for regenerative medicine applications

Abstract Hydrogels from different materials can be used in biomedical field as an innovative approach in regenerative medicine. Depending on the origin source, hydrogels can be synthetized through chemical and physical methods. Hydrogel can be characterized through several physical parameters, such as size, elastic modulus, swelling and degradation rate. Lately, research is focused on hydrogels derived from biologic materials. These hydrogels can be derived from protein polymers, such as collage, elastin, and polysaccharide polymers like glycosaminoglycans or alginate among others. Introduction of decellularized tissues into hydrogels synthesis displays several advantages compared to natural or synthetic based hydrogels. Preservation of natural molecules such as growth factors, glycans, bioactive cryptic peptides and natural proteins can promote cell growth, function, differentiation, angiogenesis, anti-angiogenesis, antimicrobial effects, and chemotactic effects. Versatility of hydrogels make possible multiple applications and combinations with several molecules on order to obtain the adequate characteristic for each scope. In this context, a lot of molecules such as cross link agents, drugs, grow factors or cells can be used. This review focuses on the recent progress of hydrogels synthesis and applications in order to classify the most recent and relevant matters in biomedical field.

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Nanoparticles combined with growth factors: recent progress and applications

RSC Advances ◽

10.1039/c6ra13636b ◽

2016 ◽

Vol 6 (93) ◽

pp. 90856-90872 ◽

Cited By ~ 11

Author(s):

Chenyu Chu ◽

Jia Deng ◽

Li Liu ◽

Yubin Cao ◽

Xiawei Wei ◽

...

Keyword(s):

Growth Factors ◽

Regenerative Medicine ◽

Recent Progress

Increasing attention has been focused on the applications of nanoparticles combined with growth factors (NPs/GFs) due to the substantial functions of GFs in regenerative medicine and disease treatments.

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Biochemical Regulation of Regenerative Processes by Growth Factors and Cytokines: Basic Mechanisms and Relevance for Regenerative Medicine

Biochemistry (Moscow) ◽

10.1134/s0006297920010022 ◽

2020 ◽

Vol 85 (1) ◽

pp. 11-26 ◽

Cited By ~ 3

Author(s):

P. I. Makarevich ◽

A. Yu. Efimenko ◽

V. A. Tkachuk

Keyword(s):

Growth Factors ◽

Regenerative Medicine ◽

Regenerative Processes ◽

Biochemical Regulation

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Recent Advances in Nanocomposites Based on Aliphatic Polyesters: Design, Synthesis, and Applications in Regenerative Medicine

Applied Sciences ◽

10.3390/app8091452 ◽

2018 ◽

Vol 8 (9) ◽

pp. 1452 ◽

Cited By ~ 6

Author(s):

Ilaria Armentano ◽

Matteo Gigli ◽

Francesco Morena ◽

Chiara Argentati ◽

Luigi Torre ◽

...

Keyword(s):

Stem Cell ◽

Regenerative Medicine ◽

Polymer Nanocomposites ◽

Recent Progress ◽

Polymer Nanocomposite ◽

Synthesis Methods ◽

Aliphatic Polyester ◽

Aliphatic Polyesters ◽

Design Synthesis ◽

Matrix Properties

In the last decade, biopolymer matrices reinforced with nanofillers have attracted great research efforts thanks to the synergistic characteristics derived from the combination of these two components. In this framework, this review focuses on the fundamental principles and recent progress in the field of aliphatic polyester-based nanocomposites for regenerative medicine applications. Traditional and emerging polymer nanocomposites are described in terms of polymer matrix properties and synthesis methods, used nanofillers, and nanocomposite processing and properties. Special attention has been paid to the most recent nanocomposite systems developed by combining alternative copolymerization strategies with specific nanoparticles. Thermal, electrical, biodegradation, and surface properties have been illustrated and correlated with the nanoparticle kind, content, and shape. Finally, cell-polymer (nanocomposite) interactions have been described by reviewing analysis methodologies such as primary and stem cell viability, adhesion, morphology, and differentiation processes.

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Laser-induced deposition of copper from deep eutectic solvents: optimization of chemical and physical parameters

New Journal of Chemistry ◽

10.1039/d1nj04158d ◽

2021 ◽

Author(s):

Andrey Shishov ◽

Dmitry Gordeychuk ◽

Lev Logunov ◽

Elena Danilova ◽

Aleksandra Levshakova ◽

...

Keyword(s):

Deep Eutectic Solvents ◽

Dielectric Materials ◽

Physical Parameters ◽

Physical Methods

Fabrication of the conductive copper structures on the surface of various dielectric materials is quite important for many fields of science. There are a lot of chemical and physical methods...

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Aerogels for Biomedical Applications

Aerogels II - Materials Research Foundations ◽

10.21741/9781644901298-2 ◽

2021 ◽

pp. 23-42

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Regenerative Medicine ◽

Bone Regeneration ◽

Biomedical Applications ◽

Implantable Devices ◽

Strategic Development ◽

The World ◽

Biomedical Field ◽

Materials Used

The researchers across the world are actively engaged in strategic development of new porous aerogel materials for possible application of these extraordinary materials in the biomedical field. Due to their excellent porosity and established biocompatibility, aerogels are now emerging as viable solutions for drug delivery and other biomedical applications. This chapter aims to cover the diverse aerogel materials used across the globe for different biomedical applications including drug delivery, implantable devices, regenerative medicine encompassing tissue engineering and bone regeneration, and biosensing.

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Improving the Color Stability of Naturally Colored Silk by Cross-Linking the Sericin with Phytic Acid

International Journal of Polymer Science ◽

10.1155/2019/6936437 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Mingbo Ma ◽

Pirah Ayaz ◽

Wanhui Jin ◽

Wenlong Zhou

Keyword(s):

Phytic Acid ◽

Color Stability ◽

Constant Level ◽

Cross Linking ◽

Color Fastness ◽

Cross Link ◽

Biomedical Field ◽

The Cross

The color of naturally colored silk (NCS) fades easily during home washing due to the loss of pigment accompanied by dissolution of the sericin. In this study, phytic acid was used to cross-link the sericin of NCS and reduce its solubility, aiming at improving the color fastness of NCS to repeated washing. It was found that the sericin-fixing effect increased as the concentration of phytic acid to 1.0 wt% and the cross-linking time to 5 h increased and then reached a constant level. Cross-linking at pH 7.0-8.5 and temperature 30-40°C could obtain relatively good sericin-fixing effects. The cross-linked NCS showed low sericin loss during the degumming and had much better color fastness to repeated washing as compared with the samples before cross-linking. The cross-linking method proposed in this study may be not only a kind of solution for improving the color fastness of NCS with high practicality but also an alternative for cross-linking sericin-based materials in the biomedical field.

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Shape-changing polymers for biomedical applications

Journal of Materials Chemistry B ◽

10.1039/c8tb02579g ◽

2019 ◽

Vol 7 (10) ◽

pp. 1597-1624 ◽

Cited By ~ 32

Author(s):

Alina Kirillova ◽

Leonid Ionov

Keyword(s):

Biomedical Applications ◽

Recent Progress ◽

Smart Polymers ◽

Shape Morphing ◽

Shape Transformations ◽

Biomedical Field ◽

External Stimuli ◽

Significant Attention

Smart polymers that are capable of controlled shape transformations under external stimuli have attracted significant attention in the recent years due to the resemblance of this behavior to the biological intelligence observed in nature. In this review, we focus on the recent progress in the field of shape-morphing polymers, highlighting their most promising applications in the biomedical field.

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PEG Cross-Linked Alginate Hydrogels with Controlled Mechanical Properties

MRS Proceedings ◽

10.1557/proc-530-37 ◽

1998 ◽

Vol 530 ◽

Cited By ~ 2

Author(s):

Petra Eiselt ◽

Jon A. Rowley ◽

David J. Mooney

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Molecular Weight ◽

Elastic Modulus ◽

Cell Transplantation ◽

Cross Linking ◽

Cross Link ◽

Link Density ◽

A Cell ◽

Cross Link Density

AbstractReconstruction of tissues and organs utilizing cell transplantation offers an attractive approach for the treatment of patients suffering from organ failure or loss. Highly porous synthetic materials are often used to mimic the function of the extracellular matrix (ECM) in tissue engineering, and serve as a cell delivery vehicle for the formation of tissues in vivo. Alginate, a linear copolysaccharide composed of D-mannuronic acid (M) and L-guluronic acid (G) units is widely used as a cell transplantation matrix. Alginate is considered to be biocompatible, and hydrogels are formed in the presence of divalent cations such as Ca2+, Ba2+ and Sr2+. However, ionically cross-linked alginate gels continuously lose their mechanical properties over time with uncontrollable degradation behavior. We have modified alginate via covalent coupling of cross-linking molecules to expand and stabilize the mechanical property ranges of these gels. Several diamino PEG molecules of varying molecular weight (200, 400, 1000, 3400) were synthesized utilizing carbodiimide chemistry. Sodium alginate was covalently cross-linked with these cross-linking molecules, and mechanical properties of the resulting hydrogels were determined. The elastic modulus of the cross-linked alginates depended on the molecular weight of the cross-linking molecules, and ranged from 10-110 kPa. The theoretical cross-link density in the hydrogels was also varied from 3 to 47% (relative to the carboxylic groups in the alginate) and the mechanical properties were measured. The elastic modulus increased gradually and reached a maximum at a cross-link density of 15%. In summary, covalently coupled hydrogels can be synthesized which exhibit a wide range of mechanical properties, and these materials may be useful in a number of tissue engineering applications.

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Analysis on Functionally Graded Material Coating Interface Crack

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.602-604.1596 ◽

2012 ◽

Vol 602-604 ◽

pp. 1596-1599

Author(s):

Bo He ◽

Chang Qing Sun

Keyword(s):

Elastic Modulus ◽

Stress Intensity ◽

Intensity Factor ◽

Interface Crack ◽

Functionally Graded ◽

Physical Parameters ◽

Mode I ◽

Modulus Ratio ◽

Functionally Graded Coating ◽

Graded Coating

It is assumed that the physical parameters of functionally graded coating material accords with the variation of degree n polynomial, and based on this material model, the behavior of crack fracture on the interface of functionally graded coating is studied. The results show that when the functionally graded coating structure bears a tension load, stress intensity factors of mode I and mode II exist at the same time generally, and the intensity factor of mode I occupies a leading position all along. Besides, when the elastic modulus ratio of the base to the functionally graded coating top is 5 and the elastic modulus of functionally graded coating varies linearly, the stress intensity factor of interface crack is the smallest, and with the increasing of elastic modulus ratio, the optimal non-uniform parameter tends to be larger than 1.

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