scholarly journals Bioactive glasses incorporating less-common ions to improve biological and physical properties

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Usanee Pantulap ◽  
Marcela Arango-Ospina ◽  
Aldo R. Boccaccini
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Physical Properties ◽  
Functional Properties ◽  
Tissue Repair ◽  
Biomedical Applications ◽  
Therapeutic Effects ◽  
Metallic Ions ◽  
Bioactive Glasses ◽  
Anti Inflammatory

AbstractBioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

Bioactive glasses in wound healing: hope or hype?

2017 ◽  
Vol 5 (31) ◽  
pp. 6167-6174 ◽  
Author(s):  
Shiva Naseri ◽  
William C. Lepry ◽  
Showan N. Nazhat
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Great Promise ◽  
Mineralized Tissue ◽  
Bioactive Glasses ◽  
Soft Tissue Repair ◽  
Potential Applications

Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications in soft tissue repair, and in particular wound healing, have demonstrated great promise.

Synthesis and characterization of biodegradable lysine-based waterborne polyurethane for soft tissue engineering applications

2016 ◽  
Vol 4 (11) ◽  
pp. 1682-1690 ◽  
Author(s):  
Hongye Hao ◽  
Jingyu Shao ◽  
Ya Deng ◽  
Shan He ◽  
Feng Luo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Repair ◽  
Waterborne Polyurethane ◽  
Synthesis And Characterization ◽  
Soft Tissue Repair ◽  
Waterborne Polyurethanes ◽  
Soft Tissue Engineering

Light-crosslinking waterborne polyurethanes (LWPUs) based on lysine possess appropriate elasticity for soft tissue repair, and can induce macrophages into a wound healing phenotype.

scholarly journals Bioactive Materials for Soft Tissue Repair

2021 ◽  
Vol 9 ◽  
Author(s):  
Elisa Mazzoni ◽  
Maria Rosa Iaquinta ◽  
Carmen Lanzillotti ◽  
Chiara Mazziotta ◽  
Martina Maritati ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
Soft Tissues ◽  
High Efficiency ◽  
Calcium Phosphates ◽  
Tissue Growth ◽  
Tissue Healing ◽  
Soft Tissue Engineering

Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. In tissue engineering, several types of biomaterials are employed, such as bioceramics including calcium phosphates, bioactive glasses, and glass–ceramics. These scaffolds seem to have a high potential as biomaterials in regenerative medicine. In addition, in conjunction with other materials, such as polymers, ceramic scaffolds may be used to manufacture composite scaffolds characterized by high biocompatibility, mechanical efficiency and load-bearing capabilities that render these biomaterials suitable for regenerative medicine applications. Usually, bioceramics have been used to repair hard tissues, such as bone and dental defects. More recently, in the field of soft tissue engineering, this form of scaffold has also shown promising applications. Indeed, soft tissues are continuously exposed to damages, such as burns or mechanical traumas, tumors and degenerative pathology, and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. It is known that scaffolds can affect the ability to bind, proliferate and differentiate cells similar to those of autologous tissues. Therefore, it is important to investigate the interaction between bioceramics and somatic/stem cells derived from soft tissues in order to promote tissue healing. Biomimetic scaffolds are frequently employed as drug-delivery system using several therapeutic molecules to increase their biological performance, leading to ultimate products with innovative functionalities. This review provides an overview of essential requirements for soft tissue engineering biomaterials. Data on recent progresses of porous bioceramics and composites for tissue repair are also presented.

scholarly journals Gingiva-Derived Mesenchymal Stem Cells: Potential Application in Tissue Engineering and Regenerative Medicine - A Comprehensive Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Dane Kim ◽  
Alisa E. Lee ◽  
Qilin Xu ◽  
Qunzhou Zhang ◽  
Anh D. Le
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Crest ◽  
Potential Application ◽  
Bioactive Molecules ◽  
Therapeutic Effects ◽  
Regenerative Therapy ◽  
Neural Crest Origin ◽  
Anti Inflammatory

A unique subpopulation of mesenchymal stem cells (MSCs) has been isolated and characterized from human gingival tissues (GMSCs). Similar to MSCs derived from other sources of tissues, e.g. bone marrow, adipose or umbilical cord, GMSCs also possess multipotent differentiation capacities and potent immunomodulatory effects on both innate and adaptive immune cells through the secretion of various types of bioactive factors with immunosuppressive and anti-inflammatory functions. Uniquely, GMSCs are highly proliferative and have the propensity to differentiate into neural cell lineages due to the neural crest-origin. These properties have endowed GMSCs with potent regenerative and therapeutic potentials in various preclinical models of human disorders, particularly, some inflammatory and autoimmune diseases, skin diseases, oral and maxillofacial disorders, and peripheral nerve injuries. All types of cells release extracellular vesicles (EVs), including exosomes, that play critical roles in cell-cell communication through their cargos containing a variety of bioactive molecules, such as proteins, nucleic acids, and lipids. Like EVs released by other sources of MSCs, GMSC-derived EVs have been shown to possess similar biological functions and therapeutic effects on several preclinical diseases models as GMSCs, thus representing a promising cell-free platform for regenerative therapy. Taken together, due to the easily accessibility and less morbidity of harvesting gingival tissues as well as the potent immunomodulatory and anti-inflammatory functions, GMSCs represent a unique source of MSCs of a neural crest-origin for potential application in tissue engineering and regenerative therapy.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021 ◽  
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

Mapping the elemental and crystalline phase distribution in Cu2+ doped 45S5 bioactive glass upon crystallization

CrystEngComm ◽  
2021 ◽  
Author(s):  
Qaisar Nawaz ◽  
Araceli de Pablos Martin ◽  
Lutz Berthold ◽  
Juliana Martins de Souza e Silva ◽  
Katrin Hurle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Crystalline Phase ◽  
Phase Distribution ◽  
Metallic Ions ◽  
Bioactive Glasses ◽  
Stimulation Of

Bioactive glasses (BGs) incorporating metallic ions to impart antibacterial activity and stimulation of osteogenesis and angiogenesis are promising candidates for bone tissue engineering. Silicate BGs of the 45S5 composition (45...

scholarly journals A glimpse of biodegradable polymers and their biomedical applications

e-Polymers ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 385-410 ◽  
Author(s):  
Tejas V. Shah ◽  
Dilip V. Vasava
Keyword(s):  
Tissue Engineering ◽  
Physical Properties ◽  
Biodegradable Polymers ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Recent Literature ◽  
Drug Carrier ◽  
Physiochemical Properties ◽  
The Past ◽  
Stimuli Response

AbstractOver the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

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