Genetics, adaptation to environmental changes and archaic admixture in the pathogenesis of diabetes mellitus in Indigenous Australians

2019 ◽  
Vol 20 (3) ◽  
pp. 321-332
Author(s):  
Malgorzata Monika Brzozowska ◽  
Essi Havula ◽  
Richard Benjamin Allen ◽  
Murray P. Cox
Keyword(s):  
Diabetes Mellitus ◽  
Environmental Changes ◽  
Indigenous Australians ◽  
Archaic Admixture

Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions

2020 ◽  
Vol 19 (2) ◽  
pp. 176-192
Author(s):  
Samantha Bedell ◽  
Janine Hutson ◽  
Barbra de Vrijer ◽  
Genevieve Eastabrook
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Obesity ◽  
Environmental Changes ◽  
Current Knowledge ◽  
Therapeutic Interventions ◽  
Placental Development ◽  
Exchange Site ◽  
And Function

: Obesity and gestational diabetes mellitus (GDM) are becoming more common among pregnant women worldwide and are individually associated with a number of placenta-mediated obstetric complications, including preeclampsia, macrosomia, intrauterine growth restriction and stillbirth. The placenta serves several functions throughout pregnancy and is the main exchange site for the transfer of nutrients and gas from mother to fetus. In pregnancies complicated by maternal obesity or GDM, the placenta is exposed to environmental changes, such as increased inflammation and oxidative stress, dyslipidemia, and altered hormone levels. These changes can affect placental development and function and lead to abnormal fetal growth and development as well as metabolic and cardiovascular abnormalities in the offspring. This review aims to summarize current knowledge on the effects of obesity and GDM on placental development and function. Understanding these processes is key in developing therapeutic interventions with the goal of mitigating these effects and preventing future cardiovascular and metabolic pathology in subsequent generations.

scholarly journals Prevention of diabetes mellitus: past, present, and future

2009 ◽  
Vol 55 (2) ◽  
pp. 3-9
Author(s):  
E V Titovich
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Environmental Changes ◽  
Early Age ◽  
Annual Increase ◽  
Definite Effect ◽  
The World ◽  
Genetic Level ◽  
Prevention Of Diabetes

The incidence of type 1 diabetes mellitus (T1DM) is increasing in many countries of the world, the average annual increase in the frequency of the disease in European children is 3.4% at the age of 0-14 and 6.3% at the age of 0-5. The increase in the incidence of type 1 diabetes at an early age has a definite effect on the whole society as a whole, increasing the burden both on the patients themselves and their families, in particular, leading to an earlier development of complications. Since these changes in the development of diabetes have occurred too quickly to be due to changes at the genetic level, they are most likely a consequence of environmental changes.

scholarly journals The pharmacokinetics of metformin and concentrations of haemoglobin A1Cand lactate in Indigenous and non-Indigenous Australians with type 2 diabetes mellitus

2015 ◽  
Vol 79 (4) ◽  
pp. 617-623 ◽  
Author(s):  
Janna K. Duong ◽  
Shaun S. Kumar ◽  
Timothy J. Furlong ◽  
Carl M. Kirkpatrick ◽  
Garry G. Graham ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Indigenous Australians

scholarly journals Practical Application of Dermatoglyphics in Disease Identification

2017 ◽  
Vol 03 ◽  
pp. 129
Author(s):  
Yuliana   ◽  
Keyword(s):  
Breast Cancer ◽  
Diabetes Mellitus ◽  
Down Syndrome ◽  
Bronchial Asthma ◽  
Environmental Changes ◽  
Postnatal Life ◽  
Practical Application ◽  
Intrauterine Environment ◽  
Genetic Studies ◽  
Disease Identification

Dermatoglyphics (fingerprint) indicates epidermal ridge patterns of sole, palm, fingers, and toes. It is unique for each person, because it is determined by interaction of genes and intrauterine environment. Once dermatoglyphic patterns are formed, it is not affected by age, development, and environmental changes in postnatal life. Therefore, they exhibit positive values in predicting various genetically influenced disorders. Dermatoglyphics plays an important role in medicolegal, anthropology, and genetic studies. Diabetes mellitus, hypertension, Down syndrome, bronchial asthma, schizophrenia, and breast cancer are some of the diseases that can be screened by dermatoglyphic identification.

scholarly journals The Role of Archaic Human Genes in the Current Epidemic of Diabetes Mellitus in Indigenous Australians

2018 ◽  
Author(s):  
Malgorzata Brzozowska ◽  
Richard Allen
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Selection ◽  
Modern Human ◽  
Indigenous Australians ◽  
Genetic Studies ◽  
Obesity And Diabetes ◽  
Human Genes ◽  
Ancient Gene

Indigenous Australians have been particularly affected by type 2 diabetes mellitus due to their genetic susceptibility and a range of environmental risk factors. Recent genetic studies link predisposition to some diseases, including diabetes, to archaic humans, such as Neanderthals and Denisovans, suggesting persistence of ancient alleles in the genomes of modern humans. In this review we discuss the evolutionary role of the negative genetic selection associated with an adopted Western lifestyle as well as DNA variants influencing predisposition to obesity and diabetes in the Australian Indigenous population. We review the contribution of the ancient gene/pathways to the modern human phenotypes including the Neanderthal haplotype-tagging SNPs in NTRK2 gene, which may continue to play a role in obesity in Indigenous Australians.

scholarly journals Clinico-etiological profile and outcome of hyponatremia in hospitalised adult patients

2015 ◽  
Vol 1 (7) ◽  
pp. 293 ◽  
Author(s):  
Parijat P. Baji ◽  
Suresh S. Borkar
Keyword(s):  
Diabetes Mellitus ◽  
Serum Sodium ◽  
Environmental Changes ◽  
The Elderly ◽  
Sodium Concentration ◽  
Electrolyte Balance ◽  
Electrolyte Abnormality ◽  
Chi Square ◽  
Exact Test ◽  
Hospitalised Patients

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong><span lang="EN-US"> Hyponatremia is a common electrolyte abnormality in hospitalised patients. Incidence varies from 1% to 40%. It is common in the elderly, mainly owing to impaired water and electrolyte balance in response to diet, drugs and environmental changes. This study is to evaluate clinical features, aetiologies and outcome in patients with hyponatremia (Sr. Na &lt;120 mmol/L at the time of admission).</span></p><p class="abstract"><strong><span lang="EN-US">Methods: </span></strong>An observational study was conducted in 76 patients admitted in Kamalnayan Bajaj Hospital, Aurangabad from August 2013 to August 2014. All patients having their serum sodium concentration less than 120 mmol/L were included in the study. History, examination and relevant details were taken. Outcome was noted. Student’s t-test, chi square test and Fisher’s exact test were applied for statistical analysis.</p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong><span lang="EN-US"> In the present study, mean age of the patients was 59.4% years. 43% patients were euvolemic, 38% hypervolemic and 19% hypovolemic. Nausea (54%) was most common gastrointestinal while drowsiness (42%) was the most common neurological symptom. Etiology of hyponatremia was multifactorial in 76% cases. Use of diuretics (53%) was the most common etiological factor. SIADH was suspected in nine patients. Mortality was 21%. Most common comorbid conditions were hypertension (51%) and diabetes mellitus (42%).</span></p><p class="abstract"><strong><span lang="EN-US">Conclusions: </span></strong>Hyponatremia is a common electrolyte abnormality in hospitalised patients. There is an increasing tendency for it to occur with increasing age, hypertension, diabetes mellitus and use of drugs (diuretics). Nausea, vomiting and drowsiness are the commonest symptoms. Mortality is high, though not directly related to serum sodium levels. Hyponatremia acts as a poor prognostic marker of primary disease.</p>

Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus

1998 ◽  
Vol 39 (5) ◽  
pp. 663-668 ◽  
Author(s):  
Harry N. Bawden ◽  
Aidan Stokes ◽  
Carol S. Camfield ◽  
Peter R. Camfield ◽  
Sonia Salisbury
Keyword(s):  
Diabetes Mellitus ◽  
Peer Relationship ◽  
Tourette’S Disorder ◽  
Relationship Problems ◽  
Tourette's Disorder

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Linking transcription, RNA polymerase II elongation and alternative splicing

2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Rna Polymerase Ii ◽  
Environmental Changes ◽  
Transcription Elongation ◽  
Single Gene ◽  
Regulation Of Gene Expression ◽  
Regulation Of Transcription ◽  
Stepping Stones ◽  
Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

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