Unveiling the future reservoir of anti-cancer molecule—Combretastatin A4 from callus and cell aggregate suspension culture of flame creeper (Combretum microphyllum): growth, exudation and elicitation studies

2020 ◽  
Vol 143 (3) ◽  
pp. 681-691
Author(s):  
Harshita Pandey ◽  
Pallavi Pandey ◽  
Sailendra Singh ◽  
Arvind Singh Negi ◽  
Suchitra Banerjee
Keyword(s):  
Suspension Culture ◽  
Cell Aggregate ◽  
Anti Cancer ◽  
Combretastatin A4 ◽  
The Future ◽  
Elicitation Studies

scholarly journals The Ambivalent Function of YAP in Apoptosis and Cancer

2018 ◽  
Vol 19 (12) ◽  
pp. 3770 ◽  
Author(s):  
Xianbin Zhang ◽  
Ahmed Abdelrahman ◽  
Brigitte Vollmar ◽  
Dietmar Zechner
Keyword(s):  
Clinical Trials ◽  
Signaling Pathway ◽  
Clinical Relevance ◽  
Protein A ◽  
Vital Role ◽  
Cancer Drugs ◽  
Good Target ◽  
Anti Cancer ◽  
The Future

Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials.

scholarly journals Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

2018 ◽  
Vol 19 (10) ◽  
pp. 3270 ◽  
Author(s):  
Yasuyoshi Miyata ◽  
Hideki Sakai
Keyword(s):  
Molecular Mechanisms ◽  
Royal Jelly ◽  
Biological Activities ◽  
Treatment Strategies ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Glandular Secretion ◽  
Anti Cancer ◽  
The Future ◽  
Queen Honeybee

Royal jelly (RJ) is a glandular secretion produced by worker honeybees and is a special food for the queen honeybee. It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities. Consequently, RJ is used as cosmetic and dietary supplement throughout the world. In addition, in vitro studies and animal experiments have demonstrated that RJ inhibits cell proliferation and stimulates apoptosis in various types of malignant cells and affects the production of various chemokines, anti-oxidants and growth factors and the expression of cancer-related molecules in patients with malignancies, especially in patients treated with anti-cancer agents. Therefore, RJ is thought to exert anti-cancer effects on tumor growth and exhibit protective functions against drug-induced toxicities. RJ has also been demonstrated to be useful for suppression of adverse events, the maintenance of the quality of life during treatment and the improvement of prognosis in animal models and patients with malignancies. To understand the mechanisms of the beneficial effects of RJ, knowledge of the changes induced at the molecular level by RJ with respect to cell survival, inflammation, oxidative stress and other cancer-related factors is essential. In addition, the effects of combination therapies of RJ and other anti-cancer agents or natural compounds are important to determine the future direction of RJ-based treatment strategies. Therefore, in this review, we have covered the following five issues: (1) the anti-cancer effects of RJ and its main component, 10-hydroxy-2-decenoic acid; (2) the protective effects of RJ against anti-cancer agent-induced toxicities; (3) the molecular mechanisms of such beneficial effects of RJ; (4) the safety and toxicity of RJ; and (5) the future directions of RJ-based treatment strategies, with a discussion on the limitations of the study of the biological activities of RJ.

scholarly journals Repurposed anti-cancer drugs: the future for anti-infective therapy?

2020 ◽  
Vol 18 (7) ◽  
pp. 609-612 ◽  
Author(s):  
Héctor Quezada ◽  
Mariano Martínez-Vázquez ◽  
Esaú López-Jácome ◽  
Bertha González-Pedrajo ◽  
Ángel Andrade ◽  
...  
Keyword(s):  
Cancer Drugs ◽  
Anti Cancer ◽  
The Future

scholarly journals The peptide vaccine of the future

2020 ◽  
pp. mcp.R120.002309
Author(s):  
Annika Nelde ◽  
Hans Georg Rammensee ◽  
Juliane Sarah Walz
Keyword(s):  
Immune Responses ◽  
Target Selection ◽  
Peptide Vaccine ◽  
Predictive Biomarkers ◽  
Peptide Vaccines ◽  
Peptide Vaccination ◽  
Anti Cancer ◽  
The Future ◽  
Clinical Responses ◽  
Review Current

The approach of peptide-based anti-cancer vaccination has proven the ability to induce cancer-specific immune responses in multiple studies for various cancer entities. However, clinical responses remain so far limited to single patients and broad clinical applicability was not achieved. Therefore, further efforts are required to improve peptide vaccination in order to integrate this low side effect therapy into the clinical routine of cancer therapy. To design clinically effective peptide vaccines in the future, different issues have to be addressed and optimized comprising antigen target selection as well as choice of optimal adjuvants and vaccination schedules. Furthermore, the combination of peptide-based vaccines with other immuno- and molecular targeted therapies as well as the development of predictive biomarkers could further improve efficacy. In this review, current approaches in the development of peptide-based vaccines and critical implications for optimal vaccine design are discussed.

Research Development and Optimization Modifications of Anti-cancer peptides

2020 ◽  
Vol 20 ◽  
Author(s):  
Zhi-Gang Sun ◽  
Liang-Hui Zhao ◽  
Stacy Mary Yeh ◽  
Zhi-Na Li ◽  
Xin Ming
Keyword(s):  
Clinical Application ◽  
Structural Modification ◽  
Biological Tissues ◽  
Research Development ◽  
Anti Cancer ◽  
The Future ◽  
Cancer Inhibition

: Anti-cancer peptides play an important role in the area of cancer inhibition. A variety of anti-cancer peptides have emerged through the extraction and structural modification of peptides from biological tissues. This review provides the research background of anti-cancer peptides, the introduction on the mechanism of anti-cancer peptides in inhibition of cancers, the discovery and development of anti-cancer peptides, and the optimization modifications of anti-cancer peptides in the clinical application. In conclusion, anti-cancer peptides will play a greater role in the future oncologic clinic.

scholarly journals Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 1535-1543 ◽  
Author(s):  
Narsimha Reddy Penthala ◽  
Leena Madhukuri ◽  
Shraddha Thakkar ◽  
Nikhil Reddy Madadi ◽  
Gauri Lamture ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Tumor Cell ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Solid Tumor ◽  
Tumor Cell Lines ◽  
Anti Cancer ◽  
Combretastatin A4 ◽  
Nanomolar Range

Novel, stable combretastatin-A4 heterocyclic (2H)-1,2,3-triazole analogues displayed potent cytotoxic activity against both hematological and solid tumor cell lines with GI50 values in the low nanomolar range.

scholarly journals Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3361 ◽  
Author(s):  
Teresa Glomb ◽  
Karolina Szymankiewicz ◽  
Piotr Świątek
Keyword(s):  
Biological Activity ◽  
Growth Factors ◽  
Cell Lines ◽  
Cancer Drugs ◽  
Inhibition Of Growth ◽  
Anti Cancer ◽  
The Future ◽  
Derivatives Of ◽  
Cancer Activity

Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.

Cell aggregate suspension culture for large-scale production of biomolecules

In Vitro ◽  
1980 ◽  
Vol 16 (6) ◽  
pp. 486-490 ◽  
Author(s):  
W. R. Tolbert ◽  
M. M. Hitt ◽  
J. Feder
Keyword(s):  
Suspension Culture ◽  
Large Scale ◽  
Scale Production ◽  
Cell Aggregate ◽  
Large Scale Production
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