The verification of the reliability of a triglyceride–glucose index and its availability as an advanced tool

Metabolomics ◽  
2021 ◽  
Vol 17 (11) ◽  
Author(s):  
Sarang Jeong ◽  
Jong Ho Lee
Keyword(s):  
Triglyceride Glucose Index ◽  
Advanced Tool

Elevated triglyceride–glucose index predicts risk of incident ischaemic stroke: The Rural Chinese Cohort Study

2021 ◽  
pp. 101246
Author(s):  
Yang Zhao ◽  
Haohang Sun ◽  
Weidong Zhang ◽  
Yuanlin Xi ◽  
Xuezhong Shi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Ischaemic Stroke ◽  
Triglyceride Glucose Index ◽  
Chinese Cohort

Relationship of triglyceride–glucose index with chronic limb-threatening ischemia in lower extremity peripheral artery disease

Vascular ◽  
2021 ◽  
pp. 170853812110183
Author(s):  
Arda Aybars Pala ◽  
Yusuf Salim Urcun
Keyword(s):  
Lower Extremity ◽  
High Density Lipoprotein ◽  
Peripheral Artery Disease ◽  
Density Lipoprotein ◽  
Peripheral Artery ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Group 2 ◽  
Artery Disease ◽  
Group 1

Objectives Triglyceride-glucose index (TyG index), which is defined as the simple and novel marker of insulin resistance, is becoming increasingly important as a promising predictive marker for atherosclerotic diseases. Chronic limb-threatening ischemia is defined as the most advanced stage of the lower extremity peripheral artery disease, whose main cause is atherosclerosis and is associated in this respect with amputation, impaired quality of life, and mortality. The main purpose of the present study was to investigate the relation between the calculated TyG index values and chronic limb-threatening ischemia development. Methods A total of 296 patients who were diagnosed with lower extremity peripheral artery disease in our outpatient clinic between October 2018 and October 2020 were included in this study retrospectively. Two groups were formed by clinically staging the patients according to Rutherford Classification. Patients who did not develop chronic limb-threatening ischemia were classified as “Group 1” ( n = 224) and those who developed were classified as “Group 2” ( n = 72). Results The mean TyG index values that were calculated in Group 2 were significantly higher than in Group 1 (9.27 ± 0.31 vs. 9.00 ± 0.34, p < 0.001). In the multivariate logistic regression analysis conducted to determine the predictors of chronic limb-threatening ischemia development, C-reactive protein (OR [Odds Ratio]: 1.220, 95% CI [confidence interval]: 1.092–1.363, p < 0.001), high-density lipoprotein cholesterol (OR: 0.775, 95% CI: 0.715–0.839, p < 0.001) and TyG index (OR: 5.796, 95% CI: 2.050–16.382, p = 0.001) were identified as independent predictors. Receiver operating characteristic analysis revealed that the cut-off value of TyG index was 9.13 (area under the curve: 0.721, p < 0.001) with 70.8% sensitivity and 65.2% specificity. The TyG index was significantly correlated with Rutherford category, high-density lipoprotein cholesterol and mean platelet volume. Conclusions Chronic limb-threatening ischemia development may be predicted with the TyG index value, which is calculated easily from routine biochemical parameters, in patients diagnosed with lower extremity peripheral artery disease.

scholarly journals FACTORS IMPACTING THE COMMERCIAL POTENTIAL OF TECHNOLOGIES: EXPERT APPROACH

2017 ◽  
Vol 23 (2) ◽  
pp. 410-427 ◽  
Author(s):  
Vaida ZEMLICKIENĖ ◽  
Alminas MAČIULIS ◽  
Manuela TVARONAVIČIENĖ
Keyword(s):  
Decision Making ◽  
Technology Development ◽  
Mathematical Statistics ◽  
Development Model ◽  
Commercial Potential ◽  
Early Stages ◽  
Expert Opinions ◽  
Decision Making Processes ◽  
Recommended Guidelines ◽  
Advanced Tool

In order to ensure the harmonious activity of the institutions engaged in R&D and to reduce the uncertainty of the commercialization of technologies, an advanced tool for verifying decisions on technology development at early stages of commercialization, i.e. an instrument for assessing the commercial potential of technology, is needed. The article is aimed at defining the importance of factors in the commercial potential of technologies with the help of expert research. To achieve the goal, the following tasks have been approached: (1) on the basis of the created system for factors in the commercial potential of technologies, to conduct expert research aimed at collecting information on the importance of factors in technologies; (2) to apply the methods of mathematical statistics in order to determine the compatibility level of expert opinions and the significance of factors. The system of factors in the commercial potential of technologies and the identified significance of factors can be used as recommended guidelines for technology developers, investors and potential owners in the decision-making processes of commercialization, investment or purchase of technology as well as at the next stage of research on the development model for assessing the commercial potential of technologies.

scholarly journals Influence of uric acid on the correlation between waist circumference and triglyceride glucose index: an analysis from CHARLS

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jia Zheng ◽  
Min Jiang ◽  
Yanxia Xie
Keyword(s):  
Uric Acid ◽  
Waist Circumference ◽  
Mediation Effects ◽  
Panel Model ◽  
Triglyceride Glucose Index ◽  
Study Population ◽  
Relationship Of ◽  
The Relationship ◽  
Longitudinal Relationships

Abstract Background Waist circumference (WC) and uric acid (UA) are significantly related. Still, their temporal sequence and how the sequence works on future risk of triglyceride glucose (TyG) are unknown, especially in the Chinese population. Methods Cross-lagged panel model was used to analyze the reciprocal, longitudinal relationships among a set of interrelated variables. The mediation model was constructed to test the effect of the relationship between WC and UA on TyG. Results A total of 5727 subjects were enrolled in our study population, of which 53.5% were women, and the mean age was 59.0 (standard deviation, 8.62) years. After adjusting for traditional confounding factors, the results showed that a higher level of baseline WC was significantly associated with a higher level of follow-up UA (β = 0.003, P = 0.031) and follow-up TyG (β = 0.003, P < 0.001);. Simultaneously, there was no statistical association between the level of baseline UA and the level of follow-up WC (β = − 0.009, P = 0.951). The mediation effects of UA on WC-TyG were estimated to be 18.1% in adults, and 36.2% in women. Conclusions The current study demonstrated that higher baseline level of WC probably preceded UA’ level in general population. In addition, UA mediated the relationship of WC to TyG, especially in females. And the possible mechanism would require further clarification.

scholarly journals SinusCor: an advanced tool for heart rate variability analysis

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Rhenan Bartels ◽  
Leonardo Neumamm ◽  
Tiago Peçanha ◽  
Alysson Roncally Silva Carvalho
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Heart Rate Variability Analysis ◽  
Variability Analysis ◽  
Advanced Tool

scholarly journals Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea

2021 ◽  
Vol 10 (9) ◽  
pp. 1932
Author(s):  
Andras Bikov ◽  
Stefan M. Frent ◽  
Martina Meszaros ◽  
Laszlo Kunos ◽  
Alexander G. Mathioudakis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Obese Patients ◽  
Triglyceride Glucose Index ◽  
Cigarette Pack ◽  
Obstructive Sleep ◽  
And Control

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.

scholarly journals Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

2020 ◽  
Author(s):  
Minghui Li ◽  
Aihua Zhan ◽  
Xiao Huang ◽  
Lihua Hu ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave ◽  
Fasting Glucose ◽  
Independent Predictor ◽  
Positive Association ◽  
Regression Analyses ◽  
Registry Study ◽  
Hypertensive Patients ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).Conclusion: TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.

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