Ameliorative effect of synthetic γ-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress

2016 ◽  
Vol 23 (23) ◽  
pp. 23930-23935 ◽  
Author(s):  
Naila Chand ◽  
Sher Muhammad ◽  
Rifat Ullah Khan ◽  
Ibrahim Abdullah Alhidary ◽  
Zia ur Rehman
Keyword(s):  
Immune Response ◽  
Heat Stress ◽  
Antioxidant Status ◽  
Aminobutyric Acid ◽  
Performance Traits ◽  
Ameliorative Effect ◽  
Cyclic Heat

Performance traits and immune response of broiler chicks treated with zinc and ascorbic acid supplementation during cyclic heat stress

2014 ◽  
Vol 58 (10) ◽  
pp. 2153-2157 ◽  
Author(s):  
Naila Chand ◽  
Shabana Naz ◽  
Ajab Khan ◽  
Sarzamin Khan ◽  
Rifat Ullah Khan
Keyword(s):  
Immune Response ◽  
Ascorbic Acid ◽  
Heat Stress ◽  
Broiler Chicks ◽  
Acid Supplementation ◽  
Performance Traits ◽  
Cyclic Heat ◽  
Ascorbic Acid Supplementation

scholarly journals Effect of a synbiotic supplement on cecal microbial ecology, antioxidant status, and immune response of broiler chickens reared under heat stress

2019 ◽  
Vol 98 (10) ◽  
pp. 4408-4415 ◽  
Author(s):  
A.A. Mohammed ◽  
S Jiang ◽  
J.A. Jacobs ◽  
H.W. Cheng
Keyword(s):  
Immune Response ◽  
Heat Stress ◽  
Microbial Ecology ◽  
Broiler Chickens ◽  
Antioxidant Status

Feeding rumen-protected gamma-aminobutyric acid enhances the immune response and antioxidant status of heat-stressed lactating dairy cows

2016 ◽  
Vol 60 ◽  
pp. 103-108 ◽  
Author(s):  
Jianbo Cheng ◽  
Nan Zheng ◽  
Xianzhi Sun ◽  
Songli Li ◽  
Jiaqi Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Dairy Cows ◽  
Antioxidant Status ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Lactating Dairy Cows

scholarly journals Effects of In Ovo Feeding of γ-Aminobutyric Acid on Growth Performances, Plasma Metabolites, and Antioxidant Status in Broilers Exposed to Cyclic Heat Stress

2021 ◽  
Vol 13 (19) ◽  
pp. 11032
Author(s):  
Chris-Major Ncho ◽  
Akshat Goel ◽  
Chae-Mi Jeong ◽  
Vaishali Gupta ◽  
Yang-Ho Choi
Keyword(s):  
Heat Stress ◽  
Fatty Acid Synthase ◽  
Aminobutyric Acid ◽  
Daily Weight Gain ◽  
Plasma Metabolites ◽  
Mrna Levels ◽  
In Ovo ◽  
Positive Effects ◽  
Cyclic Heat ◽  
In Ovo Feeding

γ-aminobutyric acid (GABA) is an amino acid used for mitigating the detrimental effects of heat stress in broilers. In addition, a growing body of literature suggests that the in ovo feeding of various nutrients can enhance the post-hatch thermotolerance of broilers. Therefore, we hypothesized that the supplementation of GABA during incubation might have positive effects in heat-stressed broilers. Chicks hatched from eggs were divided into three groups described as follows: chicks hatched from eggs incubated at normal temperature and then raised under thermoneutral temperature (CON); chicks hatched from eggs incubated at normal temperature but raised under cyclic heat stress (HS) (CON+HS); and chicks hatched from eggs injected with 60 mg of GABA dissolved in 0.6 mL of distilled water but raised under cyclic HS (G10+HS). The HS was applied between 28 and 31 days of age with ambient temperatures raised from 22 ± 1 °C to 33 ± 1 °C for 6 h daily. Compared to the CON group, average daily weight gain was significantly lower in the CON+HS but not in the G10+HS group. Feed intake was significantly decreased in both the CON+HS and G10+HS groups. Compared to the CON group, plasma corticosterone levels were significantly increased in the CON+HS group, but not the G10+HS group. Hepatic mRNA levels of the acetyl-CoA carboxylase gene (ACC) were significantly reduced in the G10+HS group compared to the CON group. In addition, positive Pearson correlation coefficients were found in mRNA levels between fatty acid synthase (FAS) and nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1) (r = 0.55, p < 0.05), NOX1 and NOX4 (r = 0.65, p < 0.01), and catalase (CAT) and superoxide dismutase (SOD) (r = 0.62, p < 0.05). Taken together, the results suggest that this study can serve as a basis for future work focusing on the in ovo feeding of GABA as a technique to combat heat stress in broilers.

scholarly journals Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2279
Author(s):  
Wen-Chao Liu ◽  
Yan-Ru Zhu ◽  
Zhi-Hui Zhao ◽  
Ping Jiang ◽  
Fu-Quan Yin
Keyword(s):  
Immune Response ◽  
Heat Stress ◽  
Antioxidant Capacity ◽  
Mrna Expression ◽  
Tight Junctions ◽  
Heme Oxygenase 1 ◽  
Glutathione S Transferase ◽  
Expression Levels ◽  
Ameliorative Effect ◽  
Relative Mrna Expression

To evaluate the ameliorative effect of algae-derived polysaccharide (ADP) supplementation on duodenal injury caused by heat stress (HS) in broilers, a total of 144 male yellow-feathered broilers (56-day-old) were randomly allocated into three groups: The TN group (thermoneutral zone, broilers were raised at 23.6 ± 1.8 °C); HS group (heat stress, broilers were exposed to 33.2 ± 1.5 °C 10 h/day, 8:00 a.m.–18:00 p.m., the temperature in the remaining period was consistent with the TN group); HSA group (heat-stressed broilers were fed with ADP supplemented diet at 1000 mg/kg). There were six replications in each treatment, and eight broilers in each replication. The feeding trial lasted four weeks. The results showed that dietary ADP supplementation tended to increase the villus height (p = 0.077) and villus width (p = 0.062), and decrease the apoptosis rate (p = 0.081) in the duodenum of broilers under HS. Furthermore, dietary ADP increased the relative mRNA and protein (based on immunofluorescence) expression levels of occludin and zonula occludens-1 (ZO-1) in the duodenum of broilers under HS (p < 0.05). In addition, dietary ADP enhanced the total antioxidation capacity (T-AOC) and activity of glutathione-S transferase (GST), while reducing the malondialdehyde (MDA) concentration of the duodenum in broilers under HS (p < 0.05). Moreover, dietary ADP supplementation upregulated the duodenal nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), glutathione peroxidase 1 (GPx1) and glutathione S-transferase theta 1 (GSTT1) mRNA expression levels in heat-stressed broilers (p < 0.05). Furthermore, compared with the HS group, broilers fed with an ADP supplemented diet had a higher relative mRNA expression of inhibitor kappa B alpha (IκBα) (p < 0.05) and a lower relative mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the duodenum (p < 0.05). In summary, dietary ADP supplementation had an ameliorative effect on HS-induced impairment of tight junctions, antioxidant capacity and the immune response of the duodenum in broilers. These beneficial effects might be related to the modulation of Nrf2 and NF-κB signaling pathways.

Effects of dietary glutamine and gamma-aminobutyric acid on meat colour, pH, composition, and water-holding characteristic in broilers under cyclic heat stress

2012 ◽  
Vol 53 (4) ◽  
pp. 471-481 ◽  
Author(s):  
S.F. Dai ◽  
F. Gao ◽  
X.L. Xu ◽  
W.H. Zhang ◽  
S.X. Song ◽  
...  
Keyword(s):  
Heat Stress ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Cyclic Heat ◽  
Meat Colour ◽  
Water Holding

scholarly journals Ameliorative Effect of Zinc and Multistrain Probiotic on Muscle and Bone Characteristics in Broiler Reared under Cyclic Heat Stress

2019 ◽  
Vol 51 (3) ◽  
Author(s):  
Muqader Shah ◽  
Hafsa Zaneb ◽  
Saima Masood ◽  
Rifat Ullah Khan ◽  
Salahud Din ◽  
...  
Keyword(s):  
Heat Stress ◽  
Ameliorative Effect ◽  
Cyclic Heat
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