Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones

Background: Striae gravidarum, a clinical condition commonly seen in pregnant women, produces serious cosmetic problems and may lead to psychological problems. Aim: The present study investigated whether there was any relation between the presence of striae in primigravid pregnant women and blood vitamin C levels, and factors thought to contribute to the formation of striae such as family history, weight gained during pregnancy, smoking status, abdominal and thigh circumference, and age. Methods: Overall, 69 primigravid women attending routine antenatal follow-up and, using prophylactic iron and vitamin preparations, underwent investigation. All were pregnant 36 or more weeks. Scoring was based on striae examination and whether striae were present. The relation between the presence of striae, vitamin C blood levels, and other factors was investigated. Results and Conclusions: Multiple logistic regression analysis showed a significant relation between the presence of striae and blood vitamin C levels (p = 0.046) and between the presence of striae and family history (p = 0.023). No significant relation was found between the presence of striae and age, weight gained during pregnancy, abdominal and thigh circumference, or smoking status. It was concluded that further, more comprehensive studies on the issue are required.

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Hodgkin Disease and Pregnancy - A Case Report

Macedonian Medical Review ◽

10.2478/mmr-2014-0021 ◽

2014 ◽

Vol 68 (2) ◽

pp. 104-106

Author(s):

Aleksandra Pivkova Veljanovska ◽

Sonja Genadieva Stavrik ◽

Zlate Stojanoski ◽

Lazar Cadievski ◽

Adela Stefanija ◽

...

Keyword(s):

Case Report ◽

Pregnant Women ◽

Hodgkin Disease ◽

Morbidity And Mortality ◽

Chemotherapy Treatment ◽

Related Factors ◽

Hematological Disorder

Abstract The article presents a case with diagnosed Hodgkin disease (HD) during pregnancy. The aim of this case study was to present diagnostic possibilities in determining HD stage during pregnancy and therapeutic dilemmas. The incidence of HD during pregnancy is 3.2% of all cases with this malignant hematological disorder. The treatment of this disease during pregnancy depends on disease-related factors, pregnancy-related factors, as well as possible implications for fetal morbidity and mortality. The need of analysis of the nature of the disease during pregnancy indicates examination of a larger series of pregnant women with HD and the drawn conclusions affect the decision whether chemotherapy treatment should start immediately or it should be postponed for after delivery.

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Exploring COVID-19 Related Factors Influencing Antenatal Care Services Uptake: A Qualitative Study among Women in a Rural Community in Southwest Ethiopia

Journal of Primary Care & Community Health ◽

10.1177/2150132721996892 ◽

2021 ◽

Vol 12 ◽

pp. 215013272199689

Author(s):

Shewangizaw Hailemariam ◽

Wubetu Agegnehu ◽

Misganaw Derese

Keyword(s):

Health Care ◽

Maternal Health ◽

Qualitative Study ◽

Antenatal Care ◽

Pregnant Women ◽

Health Facility ◽

Care Service ◽

Maternal Health Service ◽

Related Factors ◽

Factors Influencing

Introduction: Evidences suggest a significant decline in maternal health service uptake following the coronavirus disease 2019 (COVID-19) pandemic in Ethiopia. However, COVID-19 related factors impacting the service uptake are not sufficiently addressed. Hence, the current study was intended to explore COVID-19 related factors influencing antenatal care service uptake in rural Ethiopia. Methods: A community-based qualitative study was conducted from September 25/2020 to November 25/2020 among selected pregnant women residing in rural districts of Bench-Sheko Zone, and healthcare providers working in the local health care facilities. Six focus group discussions and 9 in-depth interviews were made between pregnant women, and health care providers, respectively. Data was collected by health education and behavioral science professionals who also have experience in qualitative data collection procedure. Data were transcribed, translated, and analyzed thematically using Open Code 4.0 software. Result: The study revealed several COVID-19 related factors influencing the uptake of antenatal care service during the pandemic. Health facility related barriers, perceived poor quality of care during the pandemic, government measures against COVID-19, anxiety related to the pandemic, and risk minimization were the identified factors possibly influencing the current antenatal care service uptake among women in rural Bench-Sheko Zone. Conclusion: COVID-19 preventive measures, and health facility related factors and individual factors were responsible for the current decline in antenatal care service uptake. Preserving essential health care service is critical to prevent avoidable losses of maternal and child lives during the pandemic period. Hence, programs and strategies designed to maintain maternal health services particularly, antenatal care service have better take the above determinants into consideration.

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Health anxiety and related factors among pregnant women during the COVID-19 pandemic: a cross-sectional study from Iran

BMC Psychiatry ◽

10.1186/s12888-021-03092-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Najmieh Saadati ◽

Poorandokht Afshari ◽

Hatam Boostani ◽

Maryam Beheshtinasab ◽

Parvin Abedi ◽

...

Keyword(s):

Pregnant Women ◽

Health Care Providers ◽

Health Anxiety ◽

Cross Sectional Study ◽

Care Providers ◽

Sectional Study ◽

Third Trimester ◽

Related Factors ◽

Cross Sectional ◽

The Third

Abstract Background The COVID-19 pandemic has affected many countries around the world and Iran was no exception. The aim of this study was to evaluate health anxiety of Iranian pregnant women during the COVID-19 pandemic. Methods In this cross-sectional study, 300 pregnant women in different trimesters (n = 100 in each trimester) were recruited. A demographic questionnaire and the Health Anxiety Questionnaire were used to collect data. Scores of < 27, 27–34 and more than 35 were defined as low, moderate and high health anxiety, respectively. Due to nationwide restrictions, data were collected through social media groups. Chi-square tests, ANOVA and multiple linear regression were used to analyze the data. Results Mean (SD) total anxiety scores were 22.3 ± 9.5, 24.6 ± 9.3 and 25.4 ± 10.6 in the first, second and third trimesters of pregnancy, respectively. 9, 13 and 21% of women had severe anxiety in the first, second and third trimesters of pregnancy, respectively. Women in the third trimester had significantly higher health anxiety scores than those in the first trimester (p = 0.045). Conclusion At the time of the COVID-19 pandemic, women in the second and third trimesters of pregnancy were more worried about consequences of disease, but total health anxiety scores were significantly higher among women in the third trimester of pregnancy. Health care providers should pay more attention to the mental health of pregnant women in times of crises such as the COVID-19 pandemic.

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Urinary concentrations of phthalate metabolites in pregnant women living near Chapala Lake, Jalisco, Mexico

Archives of Environmental & Occupational Health ◽

10.1080/19338244.2020.1861423 ◽

2020 ◽

pp. 1-5

Author(s):

Ariana Rodríguez Arreola ◽

A. Aaron Peregrina-Lucano

Keyword(s):

Pregnant Women ◽

Phthalate Metabolites

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Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

10.20944/preprints201909.0252.v1 ◽

2019 ◽

Author(s):

Khalid Najm Nadheer ◽

Zohreh Zahraei ◽

Hussein Al-Hakeim

Keyword(s):

Pregnant Women ◽

Serum Copper ◽

Control Group ◽

Vascular Endothelial ◽

Related Factors ◽

Soluble Endoglin ◽

Iraqi Women ◽

Endothelial Integrity ◽

And Control ◽

Endothelial Growth Factor

Preeclampsia (PE) is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction and the impairment of placenta vascular endothelial integrity. This study aimed to investigate the effect of serum copper (Cu) level on some angiogenesis-related factors including vascular endothelial growth factor-A (VEGF-A), soluble Fms-like tyrosine kinase-1 (sVEGF-R1), soluble endoglin (sEng) and cerruloplasmin (Cp) in Iraqi women with preeclampsia (PE) and control pregnant women. Therefore, 60 women with PE in addition to 30 healthy pregnant women were enrolled in the study. Serum concentration of sEng, VEGF-A, sVEGF-R1, and Cu in PE group significantly increased (p<0.05) in the PE group compared with that in the control group. Increased production of antiangiogenic factors, soluble VEGF-A and sEng contribute to the pathophysiology of PE, indicating the involvement of these parameters in the angiogenic balance in patients with PE. Tests for between-subject effects showed that the circulating angiogenesis factors and Cu were significantly associated with the presence of PE. Serum Cu level was significantly correlated with VEGF- A and VEGF-R1 levels but not with sEng. Multiple regression analysis revealed that only Cp and BP can significantly predict the complications in women with PE. In conclusion, serum Cu has a role in the angiogenesis in women with PE and may be a new drug target in the prevention or treatment of PE.

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Recruitment of low-income pregnant women into a dietary and dental care intervention: lessons from a feasibility trial

10.21203/rs.2.10813/v2 ◽

2020 ◽

Author(s):

Amanda Rodrigues Amorim Adegboye ◽

Paula G Cocate ◽

Camila Benaim ◽

Maria Claudia da Veiga Carvalho ◽

Michael M Schlüssel ◽

...

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Low Income ◽

Quantitative Data ◽

Health Centre ◽

Feasibility Trial ◽

Random Allocation ◽

Eligibility Criteria ◽

Related Factors ◽

Phone Calls

Abstract Background: There are difficulties in carrying out research in low-income urban communities, but the methodological challenges and suggestions on how to deal with them are often undocumented. The aim of this study is to describe the challenges of recruiting and enrolling low-income pregnant women with periodontitis to a clinical trial on vitamin D/calcium milk fortification and periodontal therapy (PT) and describe the patient-, study protocol- and setting-related factors related to women’s ineligibility and refusal to participate in the study. Methods: A mixed-method sequential exploratory design was applied. Qualitative and quantitative data on recruitment to a 2x2 factorial feasibility clinical trial were used. 18 women attending the health centre in a low-income area in Duque de Caxias (Rio de Janeiro, Brazil) took part in focus group discussions and data were thematically analysed. Quantitative data were analysed using appropriate descriptive statistics, including absolute and relative frequencies. Results: Of all referrals (767), 548 (78.5%) did not meet the initial eligibility criteria. The main reason for exclusion (58%) was advanced gestational age (>20 weeks) at first prenatal appointment. In the periodontal examination (dental screen), the main reason for exclusion was the presence of extensive caries (64 out of 127 exclusions). Non-participation of those eligible after the periodontal examination was approximately 24% (22 out 92 eligible women) and predominantly associated with patient-related barriers (e.g. transportation barriers, family obligations, unresponsive to phone calls, and disconnected telephones). The study recruited 70 women with periodontitis in 53 weeks and did not reach the benchmark of 120 women in 36 weeks (58.3% of the original target). Recruitment was severely hindered by health centre closures due to general strikes. The recruitment yields were 9.1% (70/767) of all women contacted at first prenatal visit and 76.1% (70/92) of those screened eligible and enrolled in the trial. Women did not report concerns regarding random allocation and considered fortified milk as a healthy and safe food for pregnant women. Some women reported that financial constraints (e.g. transportation cost) could hinder participation in the study. Conclusion: Engagement between the research team and health centre staff (e.g. nurses) facilitated referral and recruitment, yet some pregnant women failed to participate in the study largely due to significant patient-related socio-demographic barriers and setting-related factors. Our data illustrate the complexity of overcoming recruitment and enrolment challenges for clinical trials in resource-limited settings.

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Maternal Urinary Phthalate Metabolites are Associated with Lipidomic Profiles Among Pregnant Women in Puerto Rico

ISEE Conference Abstracts ◽

10.1289/isee.2020.virtual.p-1070 ◽

2020 ◽

Vol 2020 (1) ◽

Author(s):

P. Ashrap ◽

D.J. Watkins ◽

B. Mukherjee ◽

Z. Rosario ◽

C. M. ◽

...

Keyword(s):

Puerto Rico ◽

Pregnant Women ◽

Phthalate Metabolites

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The identification of pregnant women with renal colic who may need surgical intervention

10.21203/rs.3.rs-228233/v1 ◽

2021 ◽

Author(s):

He Maomao ◽

Ming Lei ◽

Lin Xiaoting ◽

Xiaolan Xu ◽

Zhihui He

Keyword(s):

Pregnant Women ◽

Renal Colic ◽

Surgical Intervention ◽

Clinical Laboratory ◽

Ureteral Stone ◽

Univariate Analysis ◽

White Blood Cells ◽

Stone Size ◽

Related Factors ◽

In Pregnancy

Abstract Objectives: To analyze clinical data and stone-related factors to identify predictive factors for surgical intervention in pregnant women with renal colic. Methods: We conducted a retrospective review of 212 pregnant women presenting with renal colic between 1st January 2009 and 31st December 2019. Patients were grouped according to surgical intervention and a range of demographic, clinical, laboratory, and ultrasound data were obtained. Univariate and multivariate analyses identified a range of predictive variables for surgical intervention. In addition, we used receiver operating characteristic (ROC) curve analysis to evaluate the predictive power of our model and created a nomogram for clinical application. Results: Of the 212 patients presenting with acute renal colic in pregnancy, 100 patients (47.2%) underwent surgical intervention and 112 patients (52.8%) were treated conservatively. Univariate analysis identified significant differences between the two groups with regards to fever, the duration of pain, white blood cells (WBCs), C-reactive protein (CRP), ureteral stone size, hydronephrosis, and stone location. Multivariate analysis further identified a number of independent predictors for surgical intervention, including fever, a duration of pain ≥4 days, a ureteral stone size ≥ 8 mm, and moderate or severe hydronephrosis.Conclusions: We identified several independent predictors for surgical intervention for renal colic in pregnancy. Fever, a duration of pain ≥4 days, a ureteral stone size ≥8 mm, and moderate/severe hydronephrosis, play significant roles in predicting surgical intervention. Our nomogram can help to calculate the probability of surgical intervention in a simple and efficient manner. Prospective studies are now required to validate our model.

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Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

10.21203/rs.2.9191/v1 ◽

2019 ◽

Author(s):

Fangfang Hu ◽

Huixin Yang ◽

Lixin Sun ◽

Jingjing Luo ◽

Siwen Zhang ◽

...

Keyword(s):

Pregnant Women ◽

Maternity Hospital ◽

Age Group ◽

Pregnancy Induced Hypertension ◽

Child Transmission ◽

Related Factors ◽

Induced Hypertension ◽

Maternal Syphilis ◽

Mother To Child ◽

In Pregnancy

Abstract Background. It is of great public health significance to monitor the global meiosis mother-to-child transmission plan proposed by WHO and monitor the prevalence of maternal syphilis and the factors affecting mother-to-child transmission. Methods. We collected 271 medical records of prenatally diagnosed (from 87286 pregnant women) of syphilis among pregnant women a maternity hospital in Jilin Province China from 2013 to 2017. The chi-square test and Logistic multiple regression analysis were used to describe the clinical characteristics of pregnant women with syphilis and the related factors of adverse pregnancy outcome. Results. The average prevalence of maternal syphilis is 0.31% (95%[CI]: 0.27%-0.35%). The mean age of 271 pregnant women with syphilis is 27.62±5.4 years old. The maternal syphilis prevalence of absence of paid occupation is 73.8%; rural population accounts for 43.6%. Maternal women with a history of abortion accounted for 43.1%, of which 53.1% had abortion ≥2; The average rate of treatment in pregnancy is 25.5% (95%[CI]: 25.4%-25.6%). The prevalence rate of APOs are 43.9% (95%[CI]: 38.1%-49.9%), declined in five years (P<0.05). APOs was significantly higher in women at 30–34 age group than that in 0-24 age group (OR= 2.916, 95%CI: 1.298-6.549) and higher in Un-treatment in pregnancy than that in receive treatment (OR=2.469, 95%CI:1.225-4.975). PROM occurrence (OR=2.702, 95%CI:1.219-5.988); CRP elevation (≥10 mg/L) and RPR high titer (≥1:8) are related to the occurrence of APOs. Abortion, prematurity and low birth weight are associated with no treatment during pregnancy (P<0.05). Comparison of 42 cases of pregnancy-induced hypertension and non-pregnancy-induced hypertension, Dysmenorrhea (OR= 3.654, 95%CI:1.812-7.369) and elevated urine protein (OR= 2.259, 95%CI:1.161-4.394) are the influencing factors of maternal syphilis complicated with pregnancy-induced hypertension. Conclusions. The prevalence of maternal syphilis in northern China is lower than that of 10 years ago, but the decline is still lower than that in the economically developed regions of the south. The rate of non-treatment of syphilis during pregnancy is high, and should be alert to the rebound of maternal syphilis.

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