scholarly journals A Comprehensive Review of COVID-19 Virology, Vaccines, Variants, and Therapeutics

2021 ◽  
Author(s):  
Lauren Forchette ◽  
William Sebastian ◽  
Tuoen Liu
Keyword(s):  
Health Care Professionals ◽  
New Technologies ◽  
Review Paper ◽  
Current Management ◽  
Management Guidelines ◽  
The Past ◽  
Immunological Mechanisms ◽  
Mutant Strains ◽  
Crucial Information ◽  
Important Variant

SummarySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and 3.8 million deaths worldwide. Throughout the past year, multiple vaccines have already been developed and used, while some others are in the process of being developed. However, the emergence of new mutant strains of SARS-CoV-2 that have demonstrated immune-evading characteristics and an increase in infective capabilities leads to potential ineffectiveness of the vaccines against these variants. The purpose of this review article is to highlight the current understanding of the immunological mechanisms of the virus and vaccines, as well as to investigate some key variants and mutations of the virus driving the current pandemic and their impacts on current management guidelines. We also discussed new technologies being developed for the prevention, treatment, and detection of SARS-CoV-2. In this paper, we thoroughly reviewed and provided crucial information on SARS-CoV-2 virology, vaccines and drugs being used and developed for its prevention and treatment, as well as important variant strains. Our review paper will be beneficial to health care professionals and researchers so they can have a better understanding of the basic sciences, prevention, and clinical treatment of COVID-19 during the pandemic. This paper consists of the most updated information that has been available as of June 21, 2021.

scholarly journals Recent advances in understanding and managing mitral valve disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1686 ◽  
Author(s):  
Wendy Tsang
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Mitral Valve Disease ◽  
New Technologies ◽  
Mitral Valve Surgery ◽  
Valve Surgery ◽  
Valve Disease ◽  
Management Guidelines ◽  
The Past ◽  
Bioprosthetic Valves

Interest in the mitral valve has increased over the past few years with the development of new technologies that allow intervention in patients previously deemed too ill for treatment. This increased attention has resulted in a significant increase in publications on the mitral valve, the majority of which focus on mitral regurgitation and mitral valve surgery/intervention. The focus of this review is on publications in the past few years that offer additional insights into our understanding and management of mitral valve disease and specifically mitral regurgitation. It will discuss mitral valve anatomy, epidemiology of mitral valve disease, changes in the 2017 management guidelines, management of mitral bioprosthetic valves, transcatheter mitral valve procedures and the repair of rheumatic valves.

scholarly journals Therapeutic Advances in Oncology

2021 ◽  
Vol 22 (4) ◽  
pp. 2008
Author(s):  
Jinsha Liu ◽  
Priyanka Pandya ◽  
Sepideh Afshar
Keyword(s):  
Small Molecules ◽  
New Technologies ◽  
Treatment Options ◽  
Current Treatment ◽  
Bispecific Antibodies ◽  
Gene Therapies ◽  
Therapeutic Modalities ◽  
The Past ◽  
Drug Conjugates ◽  
Novel Targets

Around 77 new oncology drugs were approved by the FDA in the past five years; however, most cancers remain untreated. Small molecules and antibodies are dominant therapeutic modalities in oncology. Antibody-drug conjugates, bispecific antibodies, peptides, cell, and gene-therapies are emerging to address the unmet patient need. Advancement in the discovery and development platforms, identification of novel targets, and emergence of new technologies have greatly expanded the treatment options for patients. Here, we provide an overview of various therapeutic modalities and the current treatment options in oncology, and an in-depth discussion of the therapeutics in the preclinical stage for the treatment of breast cancer, lung cancer, and multiple myeloma.

The Future of the Planetary Trust in a Kaleidoscopic World

2021 ◽  
pp. 1-8
Author(s):  
Edith Brown Weiss
Keyword(s):  
Artificial Intelligence ◽  
Natural Resource ◽  
Human Activities ◽  
New Technologies ◽  
Future Generations ◽  
Nuclear War ◽  
Human Environment ◽  
The Past ◽  
Resource Degradation ◽  
Shared Goal

Today, it is evident that we are part of a planetary trust. Conserving our planet represents a public good, global as well as local. The threats to future generations resulting from human activities make applying the normative framework of a planetary trust even more urgent than in the past decades. Initially, the planetary trust focused primarily on threats to the natural system of our human environment such as pollution and natural resource degradation, and on threats to cultural heritage. Now, we face a higher threat of nuclear war, cyber wars, and threats from gene drivers that can cause inheritable changes to genes, potential threats from other new technologies such as artificial intelligence, and possible pandemics. In this context, it is proposed that in the kaleidoscopic world, we must engage all the actors to cooperate with the shared goal of caring for and maintaining planet Earth in trust for present and future generations.

Experiences of Knowledge Transfer on Industrial Heritage Using Games, Storytelling, and New Technologies

2021 ◽  
Vol 14 (2) ◽  
pp. 1-26
Author(s):  
Gonzalo Andrés López ◽  
David Checa Cruz
Keyword(s):  
New Technologies ◽  
Daily Life ◽  
3D Modelling ◽  
Historical Evolution ◽  
Educational Tool ◽  
Economic Activities ◽  
Industrial Heritage ◽  
Urban Economic ◽  
The Past ◽  
A Value

The industry has a relevant spatial and socioeconomic importance in most of the Spanish cities and nowadays is one of the main urban economic activities. However, in many situations, and despite recent advances in the past two decades, industrial heritage is a value that is still not sufficiently widespread in society. The factories, their activity, and their historical evolution are often disconnected and isolated from the daily life of the cities, being quite an unknown aspect for most of the citizens. This contribution presents the result of various experiences of knowledge transmission on the heritage value of industry, through the use of games and storytelling technique as an educational tool and the combination of different technologies (3D modelling, videomapping, virtual reality) as useful tools to spread the explanation of this phenomenon.

scholarly journals Healthcare Applications of Artificial Intelligence and Analytics: A Review and Proposed Framework

2020 ◽  
Vol 10 (18) ◽  
pp. 6553
Author(s):  
Sabrina Azzi ◽  
Stéphane Gagnon ◽  
Alex Ramirez ◽  
Gregory Richards
Keyword(s):  
Artificial Intelligence ◽  
Chronic Care ◽  
Review Paper ◽  
Research Community ◽  
Patient Needs ◽  
Care Needs ◽  
Healthcare Applications ◽  
Medical Specialties ◽  
The Past ◽  
Promising Application

Healthcare is considered as one of the most promising application areas for artificial intelligence and analytics (AIA) just after the emergence of the latter. AI combined to analytics technologies is increasingly changing medical practice and healthcare in an impressive way using efficient algorithms from various branches of information technology (IT). Indeed, numerous works are published every year in several universities and innovation centers worldwide, but there are concerns about progress in their effective success. There are growing examples of AIA being implemented in healthcare with promising results. This review paper summarizes the past 5 years of healthcare applications of AIA, across different techniques and medical specialties, and discusses the current issues and challenges, related to this revolutionary technology. A total of 24,782 articles were identified. The aim of this paper is to provide the research community with the necessary background to push this field even further and propose a framework that will help integrate diverse AIA technologies around patient needs in various healthcare contexts, especially for chronic care patients, who present the most complex comorbidities and care needs.

New technologies and new policies: the ICRC's evolving approach to working with separated families

2012 ◽  
Vol 94 (888) ◽  
pp. 1455-1479 ◽  
Author(s):  
Olivier Dubois ◽  
Katharine Marshall ◽  
Siobhan Sparkes McNamara
Keyword(s):  
New Technologies ◽  
Rapid Rise ◽  
Changing Environment ◽  
Humanitarian Action ◽  
The Past ◽  
New Policies ◽  
Humanitarian Work ◽  
Insight Into

AbstractThe field of humanitarian action is far from static, and the ICRC has worked over the years to evolve and respond to changing needs and changing circumstances. The past several decades have seen a proliferation of humanitarian actors, protracted, complex conflicts, and the rapid rise of new technologies that have significantly impacted how humanitarian work is done. The ICRC has been continually challenged to adapt in this changing environment, and its core work of supporting separated families – through restoration of family links and through support to the families of the missing – provides insight into ways that it has met this challenge and areas in which it may still seek to improve.

scholarly journals Innovation Pathways in the NHS: An Introductory Review

2021 ◽  
Author(s):  
Anmol Arora ◽  
Andrew Wright ◽  
Mark Cheng ◽  
Zahra Khwaja ◽  
Matthew Seah
Keyword(s):  
Health Care ◽  
National Health ◽  
Health Care Professionals ◽  
New Technologies ◽  
Care Delivery ◽  
Cost Effective ◽  
Care Models ◽  
Set Up ◽  
The Uk ◽  
Introductory Review

AbstractHealthcare as an industry is recognised as one of the most innovative. Despite heavy regulation, there is substantial scope for new technologies and care models to not only boost patient outcomes but to do so at reduced cost to healthcare systems and consumers. Promoting innovation within national health systems such as the National Health Service (NHS) in the United Kingdom (UK) has been set as a key target for health care professionals and policy makers. However, while the UK has a world-class biomedical research industry, several reports in the last twenty years have highlighted the difficulties faced by the NHS in encouraging and adopting innovations, with the journey from idea to implementation of health technology often taking years and being very expensive, with a high failure rate. This has led to the establishment of several innovation pathways within and around the NHS, to encourage the invention, development and implementation of cost-effective technologies that improve health care delivery. These pathways span local, regional and national health infrastructure. They operate at different stages of the innovation pipeline, with their scope and work defined by location, technology area or industry sector, based on the specific problem identified when they were set up. In this introductory review, we outline each of the major innovation pathways operating at local, regional and national levels across the NHS, including their history, governance, operating procedures and areas of expertise. The extent to which innovation pathways address current challenges faced by innovators is discussed, as well as areas for improvement and future study.

BIG DATA PROCESSING IN THE DIGITALIZATION OF ENTERPRISE ACTIVITIES

2021 ◽  
Vol 75 (3) ◽  
pp. 76-82
Author(s):  
G.T. Balakayeva ◽  
◽  
D.K. Darkenbayev ◽  
M. Turdaliyev ◽  
◽  
...  
Keyword(s):  
Social Networks ◽  
Growth Rate ◽  
Big Data ◽  
Data Processing ◽  
New Technologies ◽  
Large Data ◽  
Modern Society ◽  
Information Flows ◽  
Professional Activities ◽  
The Past

The growth rate of these enterprises has increased significantly in the last decade. Research has shown that over the past two decades, the amount of data has increased approximately tenfold every two years - this exceeded Moore's Law, which doubles the power of processors. About thirty thousand gigabytes of data are accumulated every second, and their processing requires an increase in the efficiency of data processing. Uploading videos, photos and letters from users on social networks leads to the accumulation of a large amount of data, including unstructured ones. This leads to the need for enterprises to work with big data of different formats, which must be prepared in a certain way for further work in order to obtain the results of modeling and calculations. In connection with the above, the research carried out in the article on processing and storing large data of an enterprise, developing a model and algorithms, as well as using new technologies is relevant. Undoubtedly, every year the information flows of enterprises will increase and in this regard, it is important to solve the issues of storing and processing large amounts of data. The relevance of the article is due to the growing digitalization, the increasing transition to professional activities online in many areas of modern society. The article provides a detailed analysis and research of these new technologies.

scholarly journals International Market Entry Strategies: Relational, Digital, and Hybrid Approaches

2018 ◽  
Vol 26 (1) ◽  
pp. 30-60 ◽  
Author(s):  
George F. Watson ◽  
Scott Weaven ◽  
Helen Perkins ◽  
Deepak Sardana ◽  
Robert W. Palmatier
Keyword(s):  
Market Entry ◽  
New Technologies ◽  
International Market ◽  
Business Environment ◽  
Internet Technology ◽  
Global Business ◽  
The Past ◽  
Hybrid Approaches ◽  
Entry Strategies ◽  
Relational Strategies

The adoption of digital communications, facilitated by Internet technology, has been among the most significant international business developments of the past 25 years. This article investigates the effect of these new technologies and the changing global business environment to understand how relational approaches to international market entry (IME) are changing in light of macro developments. Despite substantial resources in business practice dedicated to combining relational strategies in digital settings, this analysis of extant literature reveals that fewer than 3% of peer-reviewed research articles in the international marketing domain examine digital contexts. To address this gap, the authors assess 25 years of literature to provide (1) a description of the evolution of IME research; (2) a review and synthesis of pertinent literature that adopts relational, digital, and hybrid approaches to IME; (3) a taxonomy of IME strategies; and (4) directions for further research.

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