scholarly journals Clinical and Economic Impact of Previous Bariatric Surgery on Liver Transplantation: a Nationwide, Population-Based Retrospective Study

2021 ◽  
Author(s):  
Antonio Iannelli ◽  
Julie Bulsei ◽  
Tarek Debs ◽  
Albert Tran ◽  
Andrea Lazzati ◽  
...  

Abstract Purpose The present study aims to determine the impact of previous bariatric surgery (BS) on the length of hospital stay; the incidence of mortality, re-transplantation, and re-hospitalization after LT; and the related economic costs, through the analysis of the French National Health Insurance Information System. Materials and Methods All patients aged > 18 years who underwent LT in France in the period from 2010 to 2019 were included. Thirty-nine patients with a history of BS (study group) were compared with 1798 obese patients without previous BS (control group). Results At the time of LT, patients with a history of BS were significantly younger than those of the control group and had lower Charlson comorbidity index. Female sex was significantly more represented in the study group. No significant differences were detected between the two groups regarding the postoperative mortality rate after LT (10.3% in the study group versus 8.0% in the control group), long-term mortality (0.038 versus 0.029 person-year of follow-up, respectively), re-transplantation (adjusted hazard ratio (HR) = 2.15, p = 0.2437), re-hospitalization (adjusted analysis, IRR = 0.93, p = 0.7517), and costs of LT hospitalization (73,515 € in the study group versus 65,878 € in the control group). After 1:2 propensity score matching, the duration of the LT hospital stay was significantly longer in the study group (58.3 versus 33.4 days, p = 0.0172). Conclusion No significant differences were detected between patients with previous BS versus obese patients without history of BS undergoing LT concerning the rates of mortality, re-LT, re-hospitalization after LT, and costs of hospitalization and re-hospitalizations. Graphical abstract

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Lei Wang ◽  
Minzhou Zhang ◽  
Liheng Guo ◽  
Jianyong Qi ◽  
Haiming Luo ◽  
...  

Objective. To determine the impact of an integrative medicine clinical pathways (CPs) on the length of in-hospital stay and on outcomes for patients with acute myocardial infarction (AMI).Methods. A multicenter nonrandomized controlled trial enrolling 197 consecutive patients with AMI at eight urban TCM hospitals was conducted between 1 January 2010 and 31 October 2010. These patients were enrolled in the interventional group after the CPs had been implemented. The control group included 405 patients with AMI from eight hospitals; these patients were treated between 1 January 2008 and 31 December 2009, before the CPs were implemented. Outcome measures were the length of hospital stay costs of medical care, and major cardiovascular events (MACEs) during hospitalization.Results. Compared with the control group, the patients in intervention group had a shorter length of hospital stay (9.2±4.2days versus12.7±8.6days,P<0.05), and reduced healthcare costs in hospital (46365.7±18266.9versus52866.0±35404.4,P<0.05). There were statistically significant differences in MACE between the two groups during the hospitalization period (2.5% versus 6.9%,P=0.03).Conclusion. These data suggest that the development and implementation of the clinical pathways based in Integrative Medicine could further improve quality of care and outcome for patients with AMI.


2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Juliette C. Slieker ◽  
Steve Aellen ◽  
Philippe Eggimann ◽  
Valentine Guarnero ◽  
Markus Schäfer ◽  
...  

Background. Serum procalcitonin (PCT) is a useful biomarker to tailor the duration of antibiotics in respiratory infections. The objective of this study was to determine whether PCT levels could tailor postoperative antibiotic therapy in patients operated for peritonitis. Method. Patients with peritonitis were randomized postoperatively. The control group received antibiotics for a defined duration according to institutional guidelines. In the study group, antibiotics were stopped based on serum PCT levels. Patients were stratified into three categories: (1) gastrointestinal perforation, (2) perforated appendicitis, and (3) postoperative complication. Primary outcome was duration of antibiotics. Results. We included 162 patients: 83 and 79 patients in the control group and study group, respectively. In the subgroup of patients with peritonitis due to gastrointestinal perforation, we found 7 days of antibiotics in the PCT group versus 10 days in the control group (p value 0.065). There was no difference in infectious complications, mortality, median length of hospital stay, and necessity to restart antibiotics. Conclusion. No significant differences were found in duration of antibiotics when applying PCT guidance. However, in the subgroup of primary perforation of the gastrointestinal tract, there was a difference in duration of antibiotics in favor of the PCT group without obtaining significance, as the study was not powered for subgroup analysis. Further studies including only this subgroup should be performed.


2019 ◽  
Author(s):  
Pengfei Li ◽  
Dean Chou ◽  
Yuqiang Wang ◽  
Limin Wang ◽  
Ganggang Zhang ◽  
...  

Abstract Background Currently, conventional placement of natural pressure drainage after single-level anterior cervical discectomy with fusion and plating (ACDF) is used clinically to prevent complications such as symptomatic epidural hematoma and incision infection. Nevertheless, a literature review reported that there is no uniform standard for whether to place drainage after single-level ACDF surgery, and comparative studies on this subject are rare.Methods A prospective study of 100 patients who underwent single-level ACDF from January 2017 to June 2018 and met the selection criteria were randomly divided into the control group (45 patients with drainage after surgery) and the study group (48 patients without drainage after surgery). The same types of preoperative preparation, surgical technique and postoperative management were used in the two groups. The perioperative indicators, postoperative clinical efficacy and complications were compared between the two groups.Results The preoperative and postoperative Japanese Orthopaedic Association (JOA) scores, Visual Analogue Scale (VAS) scores and Neck Dysfunction Index (NDI) scores in the two groups were significantly different (P < 0.05). The length of hospital stay in the study group was significantly shorter than that in the control group (P < 0.05). There were no significant differences in postoperative fever, surgical site infection, symptomatic epidural hematoma, rate of incision healing, or complications between the two groups (P>0.05).Conclusions The safety and clinical outcome of patients with drainage after single-level ACDF were consistent with those of nondrainage patients. Additionally, nondrainage after single-level ACDF resulted in a decreased length of hospital stay and lessened the associated expenses.


2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1431.2-1432
Author(s):  
O. Hamdi ◽  
M. Sellami ◽  
M. Yasmine ◽  
A. Fazaa ◽  
S. Miladi ◽  
...  

Background:Rheumatic diseases such as rheumatoid arthritis (RA) and spondyloarthritis (SA) may occur among women of childbearing age. Adverse events during pregnancy including disease flare, preterm delivery, and neonatal or fetal death have been reported.Objectives:Our aim was to assess the impact of rheumatic diseases on the course of pregnancy.Methods:We conducted a cross-sectional study involving patients with RA (2010 ACR/EULAR criteria) and SA (2009 ASAS criteria) (study group) as well as healthy controls (control group) matched by age and gender. All women included had at least one pregnancy. Data were collected through telephonic interviews. We used the Student t test to compare the study group and the control group.Results:We enrolled 57 patients (30 RA and 27 SA) and 57 controls. The mean age in the study and the control groups were respectively 43.2 ± 8.2 years [26-48] and 37.5 ± 6 years. The mean chronic inflammatory rheumatisms duration was 13.81 ± 6.2 years. A history of primary sterility was found in 3 patients (1 RA and 2 SA) and none in the control group. The mean age during the first pregnancy was significantly higher in the study group (28 ± 6.2 years versus 24 ± 7 years in the control group) (p=0.01). Eight patients (5 RA and 3 SA) had a history of spontaneous miscarriage. A terminated pregnancy was noted in 3 patients (1 RA and 2 SA). Complications during pregnancy in the study group were gestational diabetes (0.3%), premature delivery (0.3), premature rupture of membranes (0.3%), abortion threat (0.3%) and pre-eclampsia (6%). Pregnancy was more associated with complications in the study group (p=0.05). Cesarean section was more used in the study group (28 patients versus 9 in the control group; p= 0.00). The main indications of cesarean section in the study group were macrosomia (11 patients), scar uterus (6 patients), sacroiliitis (4 SA patients), twin pregnancy (2 patients), and undetermined reasons (6 patients). Fetal presentation in the study group was the seat presentation (3%), top presentation (4%), face (2%), and forehead presentation (0.3%) with no significant difference with the control group. Complications of childbirth in the study group were hemorrhage of delivery (10.3%), cord widening (6.6%), perinatal asphyxia (4.9%), and dystocia (1.9%). However, no statistically significant differences were found between the two groups in the prevalence of complications of childbirth. During pregnancy, 5 patients were on salazopyrine, 2 on corticosteroids and, 1 on non-steroidal anti-inflammatories.Conclusion:Our study showed that pregnancies with rheumatic diseases were at increased risk of having maternal complications and adverse neonatal outcomes.Disclosure of Interests:None declared


Circulation ◽  
2001 ◽  
Vol 104 (suppl_1) ◽  
Author(s):  
Giovanni Battista Luciani ◽  
Tiziano Menon ◽  
Barbara Vecchi ◽  
Stefano Auriemma ◽  
Alessandro Mazzucco

Background Extracorporeal circulation contributes to morbidity after open-heart surgery by causing a systemic inflammatory reaction. Modified ultrafiltration is a technique able to remove the fluid overload and inflammatory mediators associated with use of cardiopulmonary bypass. It has been shown to reduce morbidity after cardiac operations in children, but the impact on adult cardiac procedures is unknown. Methods and Results Five hundred seventy-three consecutive adult patients were prospectively randomized to either ultrafiltration after cardiopulmonary bypass (treatment) or to no ultrafiltration (control). Parsonnet score was used to assess the severity of the patients’ clinical conditions. Analysis was done with Student’s t test or Mann-Whitney U test for continuous variables and Fisher’s exact test or Pearson’s χ 2 for discrete variables. Hospital mortality was 2.5% (7 of 284) in the treatment group versus 3.8% (11 of 289) in the control group ( P =0.357). Hospital morbidity was lower in treated patients (66 of 284 [23.2%] versus 117 of 289 [40.5%], P =0.0001). Cardiac morbidity was similar (26 of 284 [9.1%] versus 35 of 289 [12.1%], P =0.251), whereas significantly lower rates of respiratory (20 of 284 [7.0%] versus 36 of 289 [12.5%], P =0.029), neurological (5 of 284 [1.8%] versus 14 of 289 [4.8%], P =0.039), and gastrointestinal (0 of 284 versus 4 of 289 [1.4%], P =0.044) complications were found in treated patients. Transfusion requirements were also lower in treated patients (1.66±2.6 versus 2.25±3.8 U/patient, P =0.039). Duration of intensive care (39.9±49.2 versus 46.3±72.8 hours, P =0.218) and hospital stay (7.6±3.5 versus 7.9±4.4 days, P =0.372) were comparable. Conclusions Modified ultrafiltration after cardiopulmonary bypass is associated with a lower prevalence of early morbidity and lower blood transfusion requirements. The impact on length of hospital stay needs further analysis. Routine application of modified ultrafiltration after adult cardiac operations is warranted.


2020 ◽  
Vol 2 (4) ◽  
pp. First
Author(s):  
Francesco Giovanardi ◽  
Francesco Falbo ◽  
Chiara Celano ◽  
Michele Casella ◽  
Marco Palisi

Background: Establish protocols to enhance the surgical management (ERAS) can improve outcomes, shortening hospital stay and save resources. Several studies have carried out for colorectal surgery, while a lack of evidence for gastrectomy remains.This study aims to evaluate the impact of ERAS strategies in a large series of patients underwent gastric cancer surgery. Methods: This is a propensity score-matched case-control study, comparing an ERAS group with a control group. Data were recorded through a tailored and protected web-based system. Primary outcomes: hospital stay, complications rate. Among the secondary outcomes, there are: POD of mobilization, POD of starting liquid diet and soft solid diet. Results: Patients in the ERAS and control groups were 1:1 matched by the closest propensity score on the logit scale and with a Caliber = 0.2. The successful matching resulted in a total sample of 440 patients. The two groups showed no differences in all baseline patients characteristics, type of surgery (P=0.31) and stage of the disease (P=0.61). A benefit in favor of the ERAS management was found in the length of hospital stay (P=0.0004) and complications rate (P=0.001). Conclusion: An ERAS program can safely be established in referral centers for gastric cancer, enabling to significantly improve the main clinical outcomes.


Kidney360 ◽  
2020 ◽  
pp. 10.34067/KID.0004832020
Author(s):  
Flavia Carvalho Silveira ◽  
William P. Martin ◽  
Gabrielle Maranga ◽  
Carel W. le Roux ◽  
Christine J. Ren-Fielding

Background: 20% of patients with chronic kidney disease (CKD) in the United States have a body-mass index (BMI) ≥35 kg/m2. Bariatric surgery reduces progression of CKD to end-stage kidney disease (ESKD), but the risk of perioperative complications remains a concern. Methods: 24-month data spanning 2017-2018 were obtained from the Metabolic and Bariatric Surgery Quality Improvement Program (MBSAQIP) database and analyzed. Surgical complications were assessed based on the length of hospital stay, mortality, reoperation, readmission, surgical site infection (SSI), and worsening of kidney function during the first 30 days after surgery. Results: The 277,948 patients who had primary bariatric procedures were 44±11.9 (mean±SD) years old, 79.6% female, and 71.2% Caucasian. Mean BMI was 45.7±7.6 kg/m2. Compared with patients with an eGFR ≥90 mL/min/BSA, those with stage 5 CKD/ESKD were 1.91 times more likely to be readmitted within 30 days of a bariatric procedure (95% CI, 1.37-2.67; p<0.001). Similarly, length of hospital stay beyond 2 days was 2.05-fold (95% CI, 1.64-2.56; p<0.001) higher and risk of deep incisional surgical site infection was 6.92-fold (95% CI, 1.62-29.52; p=0.009) higher for those with stage 5 CKD/ESKD. Risk of early postoperative mortality increased with declining preoperative eGFR, such that patients with CKD stage 3b were 3.27 (95% CI, 1.82-5.89; p<0.001) times more likely to die compared with those with normal kidney function. However, absolute mortality rates remained relatively low at 0.53% in those with CKD stage 3b. Furthermore, absolute mortality rates were less than 0.5% in those with CKD stages 4 and 5, and these advanced CKD stages were not independently associated with an increased risk of early postoperative mortality. Conclusion: Increased severity of kidney disease was associated with increased complications after bariatric surgery. However, even for the population with advanced CKD, the absolute rates of postoperative complications were low. The mounting evidence for bariatric surgery as a renoprotective intervention in people with and without established kidney disease suggests that bariatric surgery should be considered a safe and effective option for patients with CKD.


2018 ◽  
Vol 74 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Haonan Guan ◽  
Sanwei Chen ◽  
Qiang Huang

Background: The effect of enteral immunonutrition (EIN) in patients undergoing pancreaticoduodenectomy (PD) is still doubtful. This meta-analysis aimed to assess the impact of EIN on postoperative clinical outcomes for patients undergoing PD. Methods: A literature search was carried out to identify all of the randomized controlled trials (RCTs) concerning the use of EIN for PD. Data collection ended on April 1, 2018. Pooled risk ratios (RRs) and the mean difference (MD) with a 95% CI were calculated using fixed effects or random effects models. The analyses were performed with RevMan 5.3.5. Results: Four RCTs with a total of 299 patients were included. Immunonutrition reduced the incidence of postoperative infectious complications (RR 0.58, 95% CI 0.37–0.92; p = 0.02) and shortened the length of hospital stay (MD –1.79, 95% CI –3.40 to 0.18; p = 0.03). Conversely, there were no significant differences in the incidence of overall postoperative complications (RR 0.81, 95% CI 0.62–1.05; p = 0.11), non-infectious complications (RR 0.94, 95% CI 0.69–1.28; p = 0.70) and postoperative mortality (RR 2.43, 95% CI 0.37–16.10; p = 0.36). Conclusions: EIN reduced postoperative infectious complications and shortened the length of the hospital stay; immunonutrition should be encouraged in patients undergoing PD.


2017 ◽  
Vol 41 (1) ◽  
pp. 9-14
Author(s):  
Samiha Amin ◽  
ARM Luthful Kabir

Background: Recurrent wheeze in infancy is a common clinical problem and one of the most important causes of health facility visits in Bangladesh. Recurrent wheeze is an important manifestation of bronchiolitis, pneumonia and asthma.Objectives: The study was conducted to identify the risk factors associated with recurrent wheeze in infancy.Methods: This case control study was conducted at Dhaka Shishu Hospital and Dhaka Medical College Hospital (DMCH) during August 2008- June 2009 including 50 infants (1- 12 months of age) with recurrent (3 or more) wheeze or wheeze persisting for more than one month during first year of life as study group and 50 children (12 months to 24 months of age) who had no wheeze during first year of life as control groupResults: The study group comprised of 34 (68.0%) male and 16(32.0%) female infants and control group included 31(62.0%) male and 19 (38.0 %) female children. The mean age of study group was 9 months and that of the control group was 18 months. The median age of first attack of wheeze was 4 months. Twenty one (42.0%) infants in study group and 29 (58.0%) in control group were exclusively breastfed. On the other hand, 29 (58.0%) studied cases and 21(42.0%) controls were mixed fed (formula, cow’s milk, suji along with breast milk).The study children who were exclusively breastfed had lesser incidence of recurrent wheeze than those who were mixed fed but the difference was not significant (P> 0.05). There was past history of bronchiolitis in 45 (90.0%) cases of study group in comparison to only 3 (6.0%) cases of control group (p <0.05). Past history of pneumonia was present in 15 (30.0%) cases of study group compared to only 3 (6.0%) cases of control group (P <0.05). There was history of mother’s asthma among 14 (28.0%) infants of study group versus only 1 (2.0%) mother of control group (P <0.05). There was history of father’s asthma in 8 (16.0%) cases of study group in comparison to none of control group (P<0.05). In this study we observed that 11 (22.0%) infants of study group had sibs suffering from wheeze compared to only 3 (6.0%) children of control group (<0.05). Sixteen (32.0%) infants of study group versus only 6 (12.0%) children of control group had atopic dermatitis and 33 (66.0%) cases of study group had suffered from allergic rhinitis whereas only 10 (20.0%) children had allergic rhinitis in control group (P<0.05). Atopic dermatitis and allergic rhinitis among study children were significantly associated with recurrent wheeze during infancy. Twenty (40.0%) study cases had exposure to tobacco smoke compared to 22 (44.0%) cases of control group. Exposure to tobacco smoke was not found to be associated with recurrent wheeze (P >0.05)Conclusion: The risk factors of recurrent wheeze in infancy identified in this study were past history of bronchiolitis , past history of pneumonia, asthma in parents (father and mother), wheeze in other sibs and atopic condition in children (atopic dermatitis, allergic rhinitis). Exclusively breastfed children had lesser incidence of recurrent wheeze than those who were mixed fed but the difference was not significant and exposure to tobacco smoke was not associated with recurrent wheeze in infancy in the present study.Bangladesh J Child Health 2017; VOL 41 (1) :9-14


Author(s):  
Adriana Maria Fuzer Grael TINÓS ◽  
Gerson Aparecido FORATORI-JUNIOR ◽  
Wagner MARCENES ◽  
Felipe Borges CAMARGO ◽  
Francisco Carlos GROPPO ◽  
...  

ABSTRACT Background: Obesity and bariatric surgery may be related with mental and oral disorders. Aim: To evaluate the impact of bariatric surgery on anxiety, initial dental caries lesion and gingival bleeding in obese patients. Methods: Eighty-nine patients were divided in two groups: Control Group (CG) - obese patients and Experimental Group (EG) - patients submitted to bariatric surgery. EG was analyzed before and 12 months after bariatric surgery; for the CG, was respected an interval of 12 months between the evaluations. International Caries Detection and Assessment System, Gingival Bleeding Index and Trace-State Anxiety Inventory were used. Medical profile, anthropometrics data, sociodemographic and behavioral variables were considered. Results: There were no statistically significant differences between groups in evaluation times regarding to initial dental caries lesion and anxiety. However, the number of teeth with initial dental caries lesion (p=0.0033) and gingival bleeding (p<0.0001) increased significantly after bariatric surgery in EG. Conclusion: These results reinforce the need for multi-professional team follow-up, including dental care, for both obese and bariatric patients.


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