An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer’s Disease in Triple-Transgenic Middle-Aged Mice

2022 ◽  
Author(s):  
Zhijun He ◽  
Lin Zheng ◽  
Xu Zhao ◽  
Xiaoqian Li ◽  
Hua Xue ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Middle Aged ◽  
Adequate Supply ◽  
Aged Mice

Primacy and Recency Effects in Memory: Longitudinal Findings for a Middle-Aged Sample at Risk for Alzheimer's Disease

2011 ◽  
Author(s):  
Asenath Larue ◽  
Bruce Hermann ◽  
Erin Jonaitis ◽  
Rebecca Koscik ◽  
Mark A. Sager
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
At Risk ◽  
Aged Sample ◽  
Middle Aged ◽  
Recency Effects

Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer’s Disease Mice

2020 ◽  
Vol 17 (1) ◽  
pp. 93-103 ◽  
Author(s):  
Jing Ma ◽  
Yuan Gao ◽  
Wei Tang ◽  
Wei Huang ◽  
Yong Tang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dendritic Spines ◽  
Dendritic Spine ◽  
Early Stage ◽  
Learning Ability ◽  
Middle Aged ◽  
Protein Levels ◽  
Spine Pathology ◽  
The Impact

Background: Studies have suggested that cognitive impairment in Alzheimer’s disease (AD) is associated with dendritic spine loss, especially in the hippocampus. Fluoxetine (FLX) has been shown to improve cognition in the early stage of AD and to be associated with diminishing synapse degeneration in the hippocampus. However, little is known about whether FLX affects the pathogenesis of AD in the middle-tolate stage and whether its effects are correlated with the amelioration of hippocampal dendritic dysfunction. Previously, it has been observed that FLX improves the spatial learning ability of middleaged APP/PS1 mice. Objective: In the present study, we further characterized the impact of FLX on dendritic spines in the hippocampus of middle-aged APP/PS1 mice. Results: It has been found that the numbers of dendritic spines in dentate gyrus (DG), CA1 and CA2/3 of hippocampus were significantly increased by FLX. Meanwhile, FLX effectively attenuated hyperphosphorylation of tau at Ser396 and elevated protein levels of postsynaptic density 95 (PSD-95) and synapsin-1 (SYN-1) in the hippocampus. Conclusion: These results indicated that the enhanced learning ability observed in FLX-treated middle-aged APP/PS1 mice might be associated with remarkable mitigation of hippocampal dendritic spine pathology by FLX and suggested that FLX might be explored as a new strategy for therapy of AD in the middle-to-late stage.

Long‐term adiposity is associated with poorer cognitive performance in middle‐aged adults at high risk of Alzheimer’s disease

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Rebecca West ◽  
Ramit Ravona‐Springer ◽  
Inbal Sharvit‐Ginon ◽  
Sapir Golan ◽  
Anthony Heymann ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Risk ◽  
Cognitive Performance ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals P4-573: PROXIMITY TO PARENTAL ONSET AND APOE ε4 INDEPENDENTLY CONTRIBUTE TO AMYLOID BURDEN IN MIDDLE-AGED ADULTS WITH A FAMILY HISTORY OF SPORADIC ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1539-P1539
Author(s):  
Eider M. Arenaza-Urquijo ◽  
Gemma Salvadó ◽  
Carolina Minguillón ◽  
Marta Crous-Bou ◽  
Gonzalo Sánchez-Benavides ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Amyloid Burden ◽  
Middle Aged ◽  
Sporadic Alzheimer’S Disease ◽  
Apoe Ε4 ◽  
History Of ◽  
Middle Aged Adults

IC-P-018: VERBAL FLUENCY MEASURES ARE ASSOCIATED WITH ALZHEIMER'S DISEASE BIOMARKERS IN CLINICALLY UNIMPAIRED LATE MIDDLE-AGED ADULTS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

2006 ◽  
Vol 14 (7S_Part_1) ◽  
pp. P23-P24 ◽  
Author(s):  
Kimberly D. Mueller ◽  
Samantha L. Allison ◽  
Rebecca L. Koscik ◽  
Erin Jonaitis ◽  
Brad T. Christian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Verbal Fluency ◽  
Middle Aged ◽  
Disease Biomarkers ◽  
Middle Aged Adults

scholarly journals Weight loss predicts Alzheimer’s disease biomarker positivity in cognitively unimpaired middle‐aged adults

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Oriol Grau‐Rivera ◽  
Irene Navalpotro ◽  
Gonzalo Sánchez‐Benavides ◽  
Marc Suárez‐Calvet ◽  
Marta Milà‐Alomà ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Weight Loss ◽  
Middle Aged ◽  
Disease Biomarker ◽  
Middle Aged Adults

scholarly journals Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients

2019 ◽  
Vol 112 ◽  
pp. 23-29 ◽  
Author(s):  
Carolina Abulafia ◽  
Leticia Fiorentini ◽  
David A. Loewenstein ◽  
Rosie Curiel-Cid ◽  
Gustavo Sevlever ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Executive Functioning ◽  
Late Onset ◽  
Middle Aged ◽  
Cognitively Normal

scholarly journals Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

BMC Medicine ◽  
2006 ◽  
Vol 4 (1) ◽  
Author(s):  
Mehul A Trivedi ◽  
Taylor W Schmitz ◽  
Michele L Ries ◽  
Britta M Torgerson ◽  
Mark A Sager ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Episodic Encoding

P1-438: NEUROPSYCHIATRIC BURDEN IS RELATED TO INCREASED AMYLOID BUT NOT TAU DEPOSITION IN LATE-MIDDLE- AGED COGNITIVELY NORMAL INDIVIDUALS WITH A FAMILY HISTORY OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P478-P479
Author(s):  
Alexa Pichet Binette ◽  
Etienne Vachon-Presseau ◽  
Julie Gonneaud ◽  
Natalie L. Marchant ◽  
Pierre Bellec ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family History ◽  
Middle Aged ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
History Of
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