scholarly journals Correction to: AAV9-Mediated Cardiac CNTF Overexpression Exacerbated Adverse Cardiac Remodeling in Streptozotocin-Induced Type 1 Diabetic Models

2021 ◽  
Author(s):  
Peng Zhong ◽  
Jianye Peng ◽  
Tao Liu ◽  
Hua-sheng Ding
Keyword(s):  
Cardiac Remodeling

scholarly journals A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kang Sun ◽  
Yi-yuan Li ◽  
Jin Jin
Keyword(s):  
Nk Cells ◽  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
Cardiac Tissue ◽  
Early Stage ◽  
Cardiac Injury ◽  
Inflammatory Cells ◽  
Treg Cells ◽  
Scar Formation

AbstractThe response of immune cells in cardiac injury is divided into three continuous phases: inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation phases directly influence the tissue repair. In cardiac homeostasis, cardiac tissue resident macrophages (cTMs) phagocytose bacteria and apoptotic cells. Meanwhile, NK cells prevent the maturation and transport of inflammatory cells. After cardiac injury, cTMs phagocytose the dead cardiomyocytes (CMs), regulate the proliferation and angiogenesis of cardiac progenitor cells. NK cells prevent the cardiac fibrosis, and promote vascularization and angiogenesis. Type 1 macrophages trigger the cardioprotective responses and promote tissue fibrosis in the early stage. Reversely, type 2 macrophages promote cardiac remodeling and angiogenesis in the late stage. Circulating macrophages and neutrophils firstly lead to chronic inflammation by secreting proinflammatory cytokines, and then release anti-inflammatory cytokines and growth factors, which regulate cardiac remodeling. In this process, dendritic cells (DCs) mediate the regulation of monocyte and macrophage recruitment. Recruited eosinophils and Mast cells (MCs) release some mediators which contribute to coronary vasoconstriction, leukocyte recruitment, formation of new blood vessels, scar formation. In adaptive immunity, effector T cells, especially Th17 cells, lead to the pathogenesis of cardiac fibrosis, including the distal fibrosis and scar formation. CMs protectors, Treg cells, inhibit reduce the inflammatory response, then directly trigger the regeneration of local progenitor cell via IL-10. B cells reduce myocardial injury by preserving cardiac function during the resolution of inflammation.

scholarly journals Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats

2017 ◽  
Vol 35 (2) ◽  
pp. e12246 ◽  
Author(s):  
Jinghong Luo ◽  
Xuanlan Chen ◽  
Chufan Luo ◽  
Guihua Lu ◽  
Longyun Peng ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Cardiac Remodeling ◽  
Ischemic Heart ◽  
Ischemic Heart Failure

scholarly journals The Implications of Hyperoxia, Type 1 Diabetes and Sex on Cardiovascular Physiology in Mice

2021 ◽  
Author(s):  
Katarina Bojkovic ◽  
Jennifer Rodgers ◽  
Riddhi Vichare ◽  
Asmita Nandi ◽  
Hussein Mansour ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Type I Diabetes ◽  
Comorbid Condition ◽  
Diabetic Patients ◽  
Type I ◽  
Wild Type ◽  
Cardiac Pathophysiology ◽  
Provision Of Care ◽  
Akita Mice

Abstract Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.

P2485Cardiac abnormalities and vascular damage in young adults with type 1 diabetes mellitus: incidence and associations with kidney dysfunction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
D Medvedev ◽  
K Mahamat ◽  
N Soseliya ◽  
V Efimova ◽  
A Safarova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Cardiac Remodeling ◽  
Systolic Dysfunction ◽  
Global Longitudinal Strain ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Applanation Tonometry ◽  
Cross Sectional

Abstract Background In contrast to type 2 diabetes mellitus (DM), cardiac and vascular abnormalities in type 1 DM (T1DM) are not well investigated. We aimed to evaluate occurrence of cardiac remodeling, arterial stiffness and blood pressure (BP) phenotypes in T1DM patients. Methods The cross-sectional study consecutively included T1DM patients 18–44 y.o. without known CVD, in whom 24-hour monitoring of peripheral and central BP (ABPM) with BPLab Vasotens, applanation tonometry and conventional and speckle tracking echo were performed. BP phenotypes were determined according to current guidelines, PWV and CBP - according to individual reference values. Presence of systolic dysfunction was defined as global longitudinal strain (GLS) <20%, left ventricular hypertrophy (LVH) as LV myocardial mass index (LVMI) >95/>115 g/m2 for women/men, LV remodeling (LVR) as RWT ≥0.43. P<0.05 was considered significant. Results A total of 125 patients with T1DM (mean age 29,2±7,6 years, 60% male, median duration of DM 6,9 [2; 11] years, HbA1c 9.9 [6; 12] %, mean BMI 23±3 kg/m2, smoking 39%, median GFR 100 [86; 117] ml/min/1.73 m2, GFR <60 ml/min/1.73 m2 – in 8.8%, median albuminuria 19 [8; 24] mg/g (moderate and high albuminuria in 14.6% and 2.2%) were investigated. According to office BP and ABPM hypertension (HTN) was diagnosed in 28% patients (true and masked in 4.8 and 23.2%, respectively) and true normotension in 72%. Isolated nocturnal HTN was observed in 14.4%. Majority of the patients were dippers (51.2%), non-dippers and night-peakers profiles were registered in and 43.2% and 5.6%, respectively. Central SBP and PWV elevation were observed in 17.6% and 57.6% (PWV >10 m/s - only in 2.4%). Cardiac abnormalities were revealed in 72.4% of patients: GLS<20%, LVH, LVR and diastolic dysfunction (DD) in 71.2, 12, 39.2 and 16.8% patients, respectively. Isolated GLS <20% was detected in 30%, combination of GLS<20% with LVH (or LVR) and DD in 47.2%. Patients with vs without HTN were characterized by higher PWV (7.8±1.5 vs 6.9±1.2, p<0.001), LVMI (89.9 [75; 96] vs 71.5 [64; 77] p<0.001), incidence of DD (29.6 vs 12.2%, p=0.03), LVH (28 vs 6%, p=0.002), trend towards higher rate of central SBP increase (32.7% vs 17.4%, p=0.08), lower incidence of LVR (26 vs 44%, p=0.002) and similar GLS (p=0.16). Groups with vs without nocturnal HTN did not differ by PWV, central SBP, GLS and LVMI. PWV increase was associated only with higher LVMI (88.2 [69; 95] vs 77.6 [68; 83], p=0.042). Correlations (p<0.05) with albuminuria were observed for GLS (r=−0.26), DD (r=0.22) and non-dipping state (r=−0.34). GFR correlated (p<0.05) with GLS (r=−0.32) and PWV (r=−0.32). Conclusion Incidence of prognostically unfavourable phenotypes of HTN, cardiac remodeling and arterial stiffness (even in patients without HTN) were relatively high in T1DM population. GLS and non-dipping state correlated with albuminuria, GLS and PWV with GFR

scholarly journals Angiotensin II Type 1 Receptor Blockade Prevents Cardiac Remodeling in Bradykinin B 2 Receptor Knockout Mice

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 391-396 ◽  
Author(s):  
Paolo Madeddu ◽  
Costanza Emanueli ◽  
Roberta Maestri ◽  
Maria Bonaria Salis ◽  
Alessandra Minasi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Knockout Mice ◽  
Cardiac Remodeling ◽  
Receptor Blockade

scholarly journals Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice

2002 ◽  
Vol 22 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Lan Wu ◽  
Masaru Iwai ◽  
Hironori Nakagami ◽  
Rui Chen ◽  
Jun Suzuki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Cardiac Remodeling ◽  
Receptor Blockade

scholarly journals Role of glucagon-like peptide-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts

2011 ◽  
Vol 30 (1) ◽  
pp. 34-44 ◽  
Author(s):  
G. Barakat ◽  
N. Nuwayri-Salti ◽  
L. Kadi ◽  
K. Bitar ◽  
W. Al-Jaroud ◽  
...  
Keyword(s):  
Cardiac Remodeling ◽  
Diabetic Rat ◽  
Early Prevention ◽  
Rat Hearts ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Klinsmann Carolo dos Santos ◽  
Sarah Santiloni Cury ◽  
Ana Paula Costa Rodrigues Ferraz ◽  
José Eduardo Corrente ◽  
Bianca Mariani Gonçalves ◽  
...  
Keyword(s):  
Body Weight ◽  
Pancreatic Islet ◽  
Cardiac Remodeling ◽  
Leaf Extract ◽  
Cardiac Tissue ◽  
Diabetic Rats ◽  
Cardiac Tissues ◽  
Smallanthus Sonchifolius ◽  
And Oxidative Stress

Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg−1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue. The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.

Abstract 315: Coenzyme Q 10 Protects Against Diabetes-Induced Diastolic Dysfunction and Adverse Cardiac Remodeling in a Mouse Model of Type 1 Diabetes

2012 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
Karina Huynh ◽  
Helen Kiriazis ◽  
Xiao-Jun Du ◽  
Jane E Love ◽  
Karin Jandeleit-Dahm ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diastolic Dysfunction ◽  
Olive Oil ◽  
Diabetic Cardiomyopathy ◽  
Cardiac Remodeling ◽  
Coenzyme Q ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Diabetic Mice

Diastolic dysfunction is often the earliest manifestation of diabetic cardiomyopathy, usually accompanied by adverse cardiac remodeling and increased oxidative stress. We tested the hypothesis that administration of Coenzyme Q 10 (CoQ) attenuates type 1 diabetes-induced left ventricular (LV) dysfunction and remodeling. Further, we aimed to compare the efficacy of CoQ to the ACEI, ramipril. Male 6-week old mice received either streptozotocin (STZ, 55mg/kg/day for 5 days) to induce diabetes, or citrate buffer. After 4 weeks, mice were treated with either CoQ dissolved in olive oil (10mg/kg/day), olive oil alone, ramipril (3mg/kg/day) or left untreated for 8 weeks (n=11-14/group). Diabetic mice had increased blood glucose levels compared with non-diabetic controls. Superoxide (O 2 - ) production was enhanced in untreated diabetic mice, and attenuated with CoQ treatment. Diastolic function was impaired in diabetic mice, on Doppler echocardiography (E/A ratio, deceleration time DT) and catheterization (LV end diastolic pressure EDP and LV-dP/dt). Administration of CoQ ameliorated diastolic dysfunction on E/A ratio, DT and LVEDP in diabetic mice, with a similar trend on LV-dP/dt. Although DT and LVEDP were improved with ramipril treatment, E/A ratio was not. Diabetic mice also exhibited cardiomyocyte hypertrophy (H&E staining), cardiac fibrosis (Sirius red staining) and increased apoptosis. Both CoQ and ramipril reduced these markers of adverse LV remodeling. In conclusion, these data suggest that both CoQ and ramipril can attenuate diabetic cardiomyopathy. Addition of CoQ to standard care may offer improved treatment of diastolic dysfunction in diabetic patients.

scholarly journals New Angiotensin II Type 1 Receptor Blocker, Azilsartan, Attenuates Cardiac Remodeling after Myocardial Infarction

2013 ◽  
Vol 36 (8) ◽  
pp. 1326-1331 ◽  
Author(s):  
Yuichi Nakamura ◽  
Satoshi Suzuki ◽  
Shu-ichi Saitoh ◽  
Yasuchika Takeishi
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Ii ◽  
Cardiac Remodeling ◽  
Receptor Blocker
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