Polymorphisms of the vitamin D receptor and their effect on bone mass density in patients with normocalcemic hyperparathyroidism

Endocrine ◽  
2015 ◽  
Vol 50 (3) ◽  
pp. 816-818 ◽  
Author(s):  
Jose Luis Perez Castrillón ◽  
Gonzalo Díaz-Soto ◽  
Olatz Izaola Jauregui ◽  
Enrique Romero ◽  
Daniel de Luis Román
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Vitamin D Receptor ◽  
Mass Density ◽  
Bone Mass Density ◽  
Normocalcemic Hyperparathyroidism

scholarly journals Long-Term Effects of Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Body Composition and Bone Mass Density

Obesity Facts ◽  
2020 ◽  
pp. 1-10
Author(s):  
Julian Bühler ◽  
Silvan Rast ◽  
Christoph Beglinger ◽  
Ralph Peterli ◽  
Thomas Peters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Body Composition ◽  
Sleeve Gastrectomy ◽  
Bone Mass ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Mass Density ◽  
Bone Mass Density

<b><i>Background:</i></b> Currently, the two most common bariatric procedures are laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). Long-term data comparing the two interventions in terms of their effect on body composition and bone mass density (BMD) are scarce. <b><i>Objective:</i></b> The aim of this study was to assess body composition and BMD at least 5 years after LSG and LRYGB. <b><i>Setting:</i></b> Department of Endocrinology and Nutrition, St. Claraspital Basel and St. Clara Research Ltd., Basel, Switzerland. <b><i>Methods:</i></b>Bariatric patients at least 5 years after surgery (LSG or LRYGB) were recruited, and body composition and BMD were measured by means of dual-energy X-ray absorptiometry. Data from body composition before surgery were included in the analysis. Blood samples were taken for determination of plasma calcium, parathyroid hormone, vitamin D<sub>3</sub>, alkaline phosphatase, and C-terminal telopeptide, and the individual risk for osteoporotic fracture assessed by the Fracture Risk Assessment Tool score was calculated. After surgery, all patients received multivitamins, vitamin D<sub>3</sub>, and zinc. In addition, LRYGB patients were prescribed calcium. <b><i>Results:</i></b> A total of 142 patients were included, 72 LSG and 70 LRYGB, before surgery: median body mass index 43.1, median age 45.5 years, 62.7% females. Follow-up after a median of 6.7 years. For LRYGB, the percentage total weight loss at follow-up was 26.3% and for LSG 24.1% (<i>p</i> = 0.243). LRYGB led to a slightly lower fat percentage in body composition. At follow-up, 45% of both groups had a T score at the femoral neck below –1, indicating osteopenia. No clinically relevant difference in BMD was found between the groups. <b><i>Conclusions:</i></b>At 6.7 years after surgery, no difference in body composition and BMD between LRYGB and LSG was found. Deficiencies and bone loss remain an issue after both interventions and should be monitored.

scholarly journals The Effects of Vitamin D Supplementation on Serum Levels of 25 (OH) D, Serum Calcium, and Bone Density in Adolescent: A Literature Review

2021 ◽  
Vol 5 (2) ◽  
pp. 180
Author(s):  
Nurnashriana Jufri ◽  
Nurmaladewi Nurmaladewi ◽  
Fifi Nirmala
Keyword(s):  
Vitamin D ◽  
Bone Density ◽  
Literature Review ◽  
Bone Mass ◽  
Serum Calcium ◽  
Biochemical Parameters ◽  
Linear Growth ◽  
Mass Density ◽  
Vitamin D Supplementation ◽  
Bone Mass Density

Latar Belakang: Stunting dan penurunan densitas tulang merupakan salah satu masalah gizi yang umum diderita oleh remaja. Hal ini terjadi akibat kurangnya asupan zat gizi yang adekuat terutama vitamin D yang berfungsi untuk pertumbuhan tulang dan mineralisasi jaringan. Jumlah yang terbatas dari makanan dan faktor pigmentasi kulit menjadi penyebab terjadinya defisiensi vitamin D sehingga dibutuhkan upaya suplementasi untuk memenuhi kebutuhan tersebut.Tujuan: Untuk menganalisis efek suplementasi vitamin D terhadap pertumbuhan linier remaja.Metode: Penelusuran artikel pada tinjauan pustaka ini dilakukan menggunakan mesin pencarian melalui Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, dan WILEY. Artikel memuat teks penuh, berbahasa inggris dan tahun terbit mulai dari 2010 hingga 2020. Kata kunci pencarian yang dimasukkan adalah vitamin D supplementation, adolescent or teenagers, linear growth, dan Bone Mass Density (BMD).Hasil: Hasil skrining menemukan 12 artikel yang memenuhi kriteria inklusi dan diklasifikasikan berdasarkan luaran penelitian yaitu kadar serum 25(OH)D merupakan parameter biokimia yang merupakan luaran yang terdapat pada 10 artikel penelitian. Parameter biokimia serum kalsium sebanyak 6 artikel, densitas tulang sebanyak 8 artikel, dan tinggi badan 2 artikel.Kesimpulan: Suplementasi vitamin D yang diberikan pada remaja yang sehat maupun tidak sehat terbukti meningkatkan kadar serum 25(OH)D.Kata kunci: Suplementasi vitamin D, serum 25(OH)D, densitas massa tulang, pertumbuhan linier remaja. ABSTRACT Background: Stunting and decreased bone density are some of the common nutritional problems that remain by adolescents. This occurs due to lack of adequate nutrition, especially vitamin D which functions for bone growth and tissue mineralization. A limited amount of food and skin pigmentation factors cause vitamin D deficiency so supplementation efforts are needed to meet those needs.Objective: To analyze the effect of vitamin D supplementation on the linear growth of adolescents.Method: Searching for articles in this literature review was done using a search engine through Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, and WILEY. The article contains the full text, English language, and year of publication from 2010 to 2020. The search keywords entered are vitamin D supplementation, adolescent or teenagers, linear growth, and Bone Mass Density (BMD).Results: The screening results found 12 articles that met the inclusion criteria and were classified based on research outcomes, namely serum 25 (OH) D levels were biochemical parameters which were the results contained in 10 research articles. Biochemical parameters of serum calcium were 6 articles, bone density were 8 articles, and height were 2 articles.Conclusion: Vitamin D supplementation given to healthy and unhealthy adolescents has been shown to increase serum 25 (OH) D levels.Keywords: Vitamin D supplementation, serum 25 (OH) D, bone mass density, adolescent linear growth. 

scholarly journals Association of vitamin D deficiency and bone mass with liver and heart iron overload in transfusion dependent thalassemia

2020 ◽  
Vol 7 (7) ◽  
pp. 1544
Author(s):  
Anjali Verma ◽  
Alok Khanna ◽  
Babita Jangra ◽  
Sanjiv Nanda ◽  
Surender Verma
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Iron Overload ◽  
Vitamin D Deficiency ◽  
Mass Density ◽  
Iron Concentration ◽  
Bone Mass Density ◽  
Liver Iron ◽  
Vitamin D Levels ◽  
Liver Iron Overload

Background: Transfusion dependent thalassemia patients are reported to have Vitamin D insufficiency/deficiency in many countries. Vitamin D hydroxylation occurs in the liver; whether liver iron overload interferes with this step has not been addressed till date. This study helps to establish an association between liver iron concentration (LIC) and heart iron concentration (MIC) with vitamin D levels and Bone Mass Density in these patients.Methods: A cross sectional study was done by including transfusion dependent Thalassemia patients (TM) if they had an assessment of Liver and cardiac iron done by T2*MRI and bone mineral density by DEXA. Clinical data regarding age, gender, type of iron chelation therapy and laboratory data of S. ferritin and Vitamin D was collected. Data was assessed using appropriate statistical methods.Results: Among 40 TM patients were taken and mean age was 17.6 years. Vitamin D deficiency was identified in 26(65%). 20 out of them had an LIC>7mg/g DW and 6 had MIC>1.65mg/g DW. There was a significant association between LIC>7mg/g and vitamin D level<20 ng/ml and a significant inverse correlation between LIC and vitamin D, suggesting that liver iron overload may indeed affect vitamin D metabolism. Osteopenia was present in 32.5% and osteoporosis was present in 27.5 % of all TM patients. Reduced Bone Mass Density was also found to be linked with iron over load.Conclusions: Regular monitoring of vitamin D levels and supplementation is required in patients with severe liver and heart iron load. More studies are needed to confirm these results.

scholarly journals MON-337 Peripheral Neurological Complications in Pregnancy- Is Idiopathic Transient Osteoporosis of Pregnancy Concerning?

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Asma Khaled Aljaberi ◽  
Miklos Szolics
Keyword(s):  
Vitamin D ◽  
Bone Mass ◽  
Mass Density ◽  
Healthy Woman ◽  
Neurological Complications ◽  
Hip Pain ◽  
Bone Mass Density ◽  
Transient Osteoporosis ◽  
Dxa Scan ◽  
Hip Mri

Abstract Idiopathic transient osteoporosis of pregnancy (ITOP) is a rare and under-reported condition that has affected healthy pregnancies. ITOP usually presents in the final trimester of a normal pregnancy. Radiographic studies detect drastic loss of bone mass, elevated rates of turnover in the bone, and edema in the affected portion. We present a 26-year-old previously healthy woman, who was admitted at 39 weeks of gestation with severe left hip pain and inability to walk for one month.The pain was constant, progressive, involving left lower limb, and associated with numbness and weakness. Neurological exam revealed diminished power in the left hip (motor power was 2/5), and inability to stand and walk due to pain in the left hip. She was unable to stand by herself. Investigations revealed anemia, low vitamin B12, low vitamin D and magnesium. Bilateral hip MRI showed increased T2WI signal in the left femoral head consistent with idiopathic transient osteoporosis of the left hip (ITOP). DXA scan showed bone mass density (BMD) below expected for age.The patient had induced vaginal labor without complication. The left hip pain improved after delivery. She was treated conservatively with Calcium, Magnesium and vitamin D. The patient symptoms completely resolved in 3 months post-delivery. DXA scan and Hip MRI at 1 year interval showed normal BMD and complete resolution of previous bone marrow edema and changes seen in MRI hip. This case report serves to highlight the effect of pregnancy on bone mass during third trimester which may result in transient osteoporosis of pregnancy leading to weakness and gait disturbance. Clinical symptoms can be misdiagnosed as a peripheral neurological complications instead of bone metabolism changes of pregnancy.

scholarly journals Factors Associated With Changes In Bone-Mass Density In Post Menopause Female Patients With Osteopenia

2021 ◽  
Vol 2 (2) ◽  
pp. 177-186
Author(s):  
Bagus Suryana ◽  
◽  
Muhammad Febriliant ◽  
Rulli Rosandi ◽  
Sukarlin Sukarlin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Vitamin D ◽  
Bone Mass ◽  
Significant Relationship ◽  
Mass Density ◽  
Bone Mass Density ◽  
Factors Associated ◽  
Vitamin D Levels ◽  
Postmenopausal Osteopenia

Background: Many factors can cause changes in bone mass density (BMD) in women with postmenopausal osteopenia. Aim: Determine factors associated with changes in BMD in postmenopausal women with osteopenia with the most influential risk factors within 1 year. Methods: Survey was conducted on 38 patients who were included in the inclusion criteria with a cross-sectional study analysis and had BMD data for the last 2 years, body mass index, and conducted interviews for physical activity, age of menopause, and duration of menopause. Blood samples were also taken to check total calcium levels, vitamin D levels and estrogen levels. Finally, patients are followed for up to 1 week for daily nutrition records. The relationship between these factors and changes in BMD was analyzed using Pearson's or Spearman's test. The analysis result was considered significant if p<0.05. Results: There was no significant relationship between body mass index, menopause duration, physical activity, dietary calcium, serum calcium levels and serum estradiol levels on changes in BMD with p value > 0.05. However, there was a significant relationship between menopause onset and changes in ward mass density (r = 0,321, p = 0,04) and lumbal 1 (r = 0,333, p = 0,04), serum vitamin D levels and changes in great trochanter mass density (r = 0,336, p = 0,036), physical activity score and changes in ward mass density (r = -0,522, p < 0,01). Conclusion: menopause onset, vitamin D and physical activity are significantly associated with changes in BMD in female patients with postmenopausal osteopenia.

scholarly journals Asupan kalsium, vitamin D, kafein, merokok, indeks massa tubuh dan hubungannya dengan kejadian osteoporosis pada pria di Kecamatan Duren Sawit, Jakarta Timur

2009 ◽  
Vol 6 (2) ◽  
pp. 53
Author(s):  
Eka Susanti ◽  
I Dewa Putu Pramantara ◽  
Retno Pangastuti
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Bone Mass ◽  
Body Mass ◽  
Significant Relationship ◽  
Mass Density ◽  
Bone Mass Density ◽  
Caffeine Consumption ◽  
Vitamin D Intake ◽  
The Relationship

Background: Osteoporosis can cause public health problem because both man and woman have high risk factor for osteoporosis. This is related to high morbidity and mortality of man. The increase of elderly population intensifies the frequency of the prevalence of osteoporosis, which limits activities of the patients.Objective: To identify the relationship between calcium, vitamin D, and caffeine intake, smoking, and mass body index with osteoporosis among elderly men.Method: This study was analytical observational which used cross sectional design. Subject of the study were men of 55– 65 years old purposively chosen. The study was carried out at Sub district of Duren Sawit, Jakarta Timur.Result: There was no significant relationship between calcium intake and bone mass density (p > 0.05). There was no significant relationship between vitamin D intake and bone mass density (p > 0.05), smoking and bone mass density (p > 0.05), and caffeine consumption and bone mass density (p > 0.05). There was a significant relationship between body mass index and osteoporosis (p < 0.05).Conclusion: The relationship between calcium and vitamin D intake, smoking, caffeine consumption, and osteoporosis was insignificant. The relationship between body mass index and osteoporosis was significant.

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