Management Strategies for Locoregional Recurrence in Early-Stage Gastric Cancer: Retrospective Analysis and Comprehensive Literature Review

2010 ◽  
Vol 43 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Ahmed Salem ◽  
Sameh Hashem ◽  
Layth Y. I. Mula-Hussain ◽  
Issa Mohammed ◽  
Ala’a Nour ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Literature Review ◽  
Retrospective Analysis ◽  
Locoregional Recurrence ◽  
Early Stage ◽  
Management Strategies ◽  
Comprehensive Literature Review

scholarly journals Methods for conducting international Delphi surveys to optimise global participation in core outcome set development: a case study in gastric cancer informed by a comprehensive literature review

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Bilal Alkhaffaf ◽  
Jane M. Blazeby ◽  
Aleksandra Metryka ◽  
Anne-Marie Glenny ◽  
Ademola Adeyeye ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Literature Review ◽  
Healthcare Professionals ◽  
Vascular Malformations ◽  
Methodological Approach ◽  
Core Outcome Set ◽  
Core Outcome ◽  
Comprehensive Literature Review ◽  
International Participation

Abstract Background Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. It is common for these surveys to be conducted in a single language potentially excluding those not fluent in that tongue. The aim of this study is to summarise current approaches for optimising international participation in Delphi studies and make recommendations for future practice. Methods A comprehensive literature review of current approaches to translating Delphi surveys for COS development was undertaken. A standardised methodology adapted from international guidance derived from 12 major sets of translation guidelines in the field of outcome reporting was developed. As a case study, this was applied to a COS project for surgical trials in gastric cancer to translate a Delphi survey into 7 target languages from regions active in gastric cancer research. Results Three hundred thirty-two abstracts were screened and four studies addressing COS development in rheumatoid and osteoarthritis, vascular malformations and polypharmacy were eligible for inclusion. There was wide variation in methodological approaches to translation, including the number of forward translations, the inclusion of back translation, the employment of cognitive debriefing and how discrepancies and disagreements were handled. Important considerations were identified during the development of the gastric cancer survey including establishing translation groups, timelines, understanding financial implications, strategies to maximise recruitment and regulatory approvals. The methodological approach to translating the Delphi surveys was easily reproducible by local collaborators and resulted in an additional 637 participants to the 315 recruited to complete the source language survey. Ninety-nine per cent of patients and 97% of healthcare professionals from non-English-speaking regions used translated surveys. Conclusion Consideration of the issues described will improve planning by other COS developers and can be used to widen international participation from both patients and healthcare professionals.

A retrospective analysis of epidemiology and treatment patterns for gastric cancer at a tertiary health care center in India

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4086-4086
Author(s):  
R. Digumarti ◽  
S. J. Rajappa ◽  
S. Uppalapati ◽  
A. Surath
Keyword(s):  
Gastric Cancer ◽  
Retrospective Analysis ◽  
Palliative Chemotherapy ◽  
Early Stage ◽  
Care Center ◽  
Tertiary Care ◽  
Locally Advanced ◽  
Treatment Patterns ◽  
The Body ◽  
Early Stage Disease

4086 Background: Gastric cancer is the second most common gastrointestinal cancer in our hospital based cancer registry. This retrospective analysis aims at studying the epidemiology and treatment patterns for gastric cancer at our hospital, which is a tertiary care cancer center for the state of Andhra Pradesh in south India. Methods: A retrospective analysis of the case records of 125 consecutive patients with gastric cancer who presented to our department between Jan 2004 and Dec 2005 were analysed. Data regarding epidemiology, stages at diagnosis and treatment plans were collected. Patients with early gastric cancer received 5FU based chemoradiation or chemotherapy only. Palliative chemotherapy included 5FU/cisplatin based regimens. Results: A total of 125 patients were analysed. The median age was 61years (range 18–82 years). 71% were males and 29% females. Being a tertiary care center, 92% were referred with a confirmed diagnosis on endoscopic biopsy. 30% were smokers, 11% consumed alcohol, 40% had both habits while 29% had neither. The most common part of the stomach involved was the antro-pyloric region (44%) followed by the body (30%), GE junction/cardia (20%) while 6% had diffuse involvement including linitis plastica. At diagnosis, 35% were early stage, 56% metastatic and 8% locally advanced tumors. 90% patients who had surgery for early stage disease had T2,3 tumors. One third had inadequate nodal staging.70% of patients who had curative resections underwent adjuvant chemoradiation and 30% had chemotherapy only. Of all patients with metastatic disease, 65% palliative chemotherapy while 45% opted for best supportive care. Conclusions: The distribution of tumors within the stomach is similar to Japanese data, which may reflect the common etiological factors like high salt diet. The fact that one third of patients had inadequate nodal dissection stresses the relevance of adjuvant chamoradiotherapy protocols. The high incidence of smoking as a contributory factor in the etiology reflects the need for aggressive anti tobacco legislation. The study reiterates the need for inexpensive and novel therapies for palliation of symptoms in patients with advanced disease and widens the scope for collaborative clinical trials. No significant financial relationships to disclose.

scholarly journals 3D Tree Reconstruction in Support of Urban Microclimate Simulation: A Comprehensive Literature Review

Buildings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 417
Author(s):  
Han Xu ◽  
Cynthia Changxin Wang ◽  
Xuesong Shen ◽  
Sisi Zlatanova
Keyword(s):  
Literature Review ◽  
Urban Areas ◽  
Early Stage ◽  
Urban Trees ◽  
Information Modeling ◽  
Tree Reconstruction ◽  
Urban Microclimate ◽  
Rapid Urbanization ◽  
Comprehensive Literature Review ◽  
Depth Analysis

The negative climate change induced by rapid urbanization has become a global environmental issue. Numerous studies have been devoted to microclimate regulation functions performed by urban vegetation. Digital city information modeling provides a powerful tool for various simulations and data analytics for the sustainable development of urban areas. However, the method reconstructing urban trees is still in its early stage compared to the relatively mature building modeling. Most prior studies on tree reconstruction focused on retrieving geometric features, while other factors related to urban microclimate simulation were rarely addressed. This paper presents a comprehensive literature review and in-depth analysis covering two distinct research directions in relation to urban microclimate simulation. The first one is set on the identification of key factors related to trees’ impact on urban microclimate. The second one is dedicated to approaches for three-dimensional (3D) tree reconstruction. Based on the findings, the paper identifies information including trees’ geometric, physiological characteristics and relation to the surroundings required for 3D tree reconstruction in the context of urban microclimate simulation, and further assesses the potential of the 3D tree reconstruction approaches to accommodate these pieces of information. An appropriate 3D tree reconstruction approach, which allows for the supply of the required information for urban microclimate simulation, is recommended.

scholarly journals Methods for conducting international Delphi surveys to optimise global participation in Core Outcome Set development: a case study in gastric cancer informed by a comprehensive literature review.

2021 ◽  
Author(s):  
Bilal Alkhaffaf ◽  
Jane M Blazeby ◽  
Aleksandra Metryka ◽  
Anne-Marie Glenny ◽  
Ademola Adeyeye ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Literature Review ◽  
Healthcare Professionals ◽  
Vascular Malformations ◽  
Methodological Approach ◽  
Core Outcome Set ◽  
Core Outcome ◽  
Comprehensive Literature Review ◽  
International Participation

Abstract BackgroundCore outcome sets (COS) should be relevant to key stakeholders, and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. It is common for these surveys to be conducted in a single language potentially excluding those not fluent in that tongue. The aim of this study is to summarise current approaches for optimising international participation in Delphi studies and make recommendations for future practice.MethodsA comprehensive literature review of current approaches to translating Delphi surveys for COS development was undertaken. A standardised methodology adapted from international guidance derived from 12 major sets of translation guidelines in the field of outcomes reporting was developed. As a case study this was applied to a COS project for surgical trials in gastric cancer to translate a Delphi survey into 7 target languages from regions active in gastric cancer research.Results332 abstracts were screened and four studies addressing COS development in rheumatoid and osteo-arthritis, vascular malformations and polypharmacy were eligible for inclusion. There was wide variation in methodological approaches to translation, including the number of forward translations, the inclusion of back translation, the employment of cognitive debriefing and how discrepancies and disagreements were handled. Important considerations were identified during the development of the gastric cancer survey including establishing translation groups, timelines, understanding financial implications, strategies to maximise recruitment and regulatory approvals. The methodological approach to translating the Delphi surveys were easily reproducible by local collaborators and resulted in an additional 637 participants to the 315 recruited to complete the source language survey. 99% of patients and 97% of healthcare professionals from non-English speaking regions used translated surveys.ConclusionConsideration of the issues described will improve planning by other COS developers and can be used to widen international participation from both patients and healthcare professionals.

Pneumomediastinum: A Rare Presentation of Inflicted Injuries in Infants

2020 ◽  
Author(s):  
Adam Lee ◽  
Adam Bajinting ◽  
Abby Lunneen ◽  
Colleen M. Fitzpatrick ◽  
Gustavo A. Villalona
Keyword(s):  
Literature Review ◽  
Retrospective Review ◽  
Review Of The Literature ◽  
Rare Presentation ◽  
Spontaneous Pneumomediastinum ◽  
Nonaccidental Trauma ◽  
Comprehensive Literature Review ◽  
Healthy Infants ◽  
History Of

AbstractReports of incidental pneumomediastinum in infants secondary to inflicted trauma are limited. A retrospective review of infants with pneumomediastinum and history of inflicted trauma was performed. A comprehensive literature review was performed. Three infants presented with pneumomediastinum associated with inflicted trauma. Mean age was 4.6 weeks. All patients underwent diagnostic studies, as well as a standardized evaluation for nonaccidental trauma. All patients with pneumomediastinum were resolved at follow-up. Review of the literature identified other cases with similar presentations with related oropharyngeal injuries. Spontaneous pneumomediastinum in previously healthy infants may be associated with inflicted injuries. Clinicians should be aware of the possibility of an oropharyngeal perforation related to this presentation.

Conceptualización del desempeño exportador: análisis de los avances en la literatura de los negocios internacionales

Oikos ◽  
2016 ◽  
Vol 19 (40) ◽  
pp. 137
Author(s):  
Roberto Horta
Keyword(s):  
Performance Analysis ◽  
Literature Review ◽  
International Business ◽  
Export Performance ◽  
Comprehensive Literature Review

RESUMENEl objetivo de este artículo es el de analizar el concepto “desempeño exportador”, concepto muy usado en la literatura relacionada con los negocios internacionales, a los efectos de aportar a su conceptualización y medición. Para ello, se efectúa una amplia revisión de la literatura y se analizan los avances realizados por los investigadores a los efectos de aportar a las dimensiones y formas de medir este concepto. Se concluye que se trata de un concepto en el cual siguen existiendo diversos enfoques, aunque existen avances importantes en la forma de operacionalizar el desempeño exportador.Palabras clave: conceptualización, desempeño exportador, negocios internacionales.Conceptualization of export performance: analysis of developments in the literature of international business ABSTRACTThe aim of this paper is to analyze the concept of "export performance" concept very use in the literature of international business, in order to contribute to its conceptualization and measurement. For this, a comprehensive literature review is performed and the progress made by researchers to contribute to the dimensions and ways of measuring this concept is discussed. Concluded that it is a concept which still exist several approaches, although there are significant advances in how to operationalize export performance.Keywords: conceptualization, export performance, international business.Conceptualização do desempenho exportador: a análise dos avanços na literatura dos negócios internacionais RESUMO O objetivo deste artigo é analisar o conceito de "desempenho exportador", conceito utilizado amplamente na literatura sobre negócios internacionais, aos efeitos de contribuir para a conceituação e medição. Para fazer isso, se faz uma extensa revisão da literatura e analisam-se os avanços realizados pelos pesquisadores aos efeitos de contribuir nas dimensões e formas de medir este conceito. Conclui-se que se trata de um conceito no qual continuam existindo diversas abordagens, apesar dos avanços significativos na forma de operacionalizar o desempenho exportador.Palavras-chave: conceituação, desempenho exportador, negócios internacionais.

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