Facile synthesis of reduced graphene oxide using Acalypha indica and Raphanus sativus extracts and their in vitro cytotoxicity activity against human breast (MCF-7) and lung (A549) cancer cell lines

3 Biotech ◽  
2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Parthipan Punniyakotti ◽  
Rajasekar Aruliah ◽  
Subramania Angaiah
Keyword(s):  
Graphene Oxide ◽  
Raphanus Sativus ◽  
In Vitro Cytotoxicity ◽  
Human Breast ◽  
Facile Synthesis ◽  
Cytotoxicity Activity ◽  
Reduced Graphene ◽  
Acalypha Indica ◽  
Mcf 7

scholarly journals In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Hueh Zan Chong ◽  
Asmah Rahmat ◽  
Swee Keong Yeap ◽  
Abdah Md Akim ◽  
Noorjahan Banu Alitheen ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
In Vitro Cytotoxicity ◽  
Breast Adenocarcinoma ◽  
Human Breast ◽  
Human Breast Adenocarcinoma ◽  
Strobilanthes Crispus ◽  
Mcf 7

scholarly journals Screening for cytotoxic activity of Habenaria longicorniculata J graham tubers- an in-vitro study

2020 ◽  
Vol 9 (5) ◽  
pp. 367-370
Author(s):  
BN Satish ◽  
◽  
Mallya Suma V ◽  
Vishwanatha ◽  
◽  
...  
Keyword(s):  
Cell Lines ◽  
In Vitro Study ◽  
In Vitro Cytotoxicity ◽  
Liver Carcinoma ◽  
Human Breast ◽  
Hela Cell Lines ◽  
Tuber Extract ◽  
Human Cervix ◽  
Mcf 7

About: Habenaria longicorniculata J. Graham are tuberous orchid, the tubers utilized by flok healers in cancer managemnet, as a rejuvenator. A study has been planned to evaluate In-vitro cytotoxicity of tuber extract against selected cell lines. Materials and Methods: H. longicorniculata J.Graham identified, uprooted during their flowering time. Tuber extract of this plant used for its In-vitro cytotoxicity against selected cell lines of Human Breast cancer (MCF 7), Human Liver carcinoma (HepG2), and Human cervix adenocarcinoma (HeLa) cells as per standard protocol. Results: Tuber Extract exhibited a CTC50 value of >1000 on MCF 7, HepG2 and HeLa cell lines. The results from the MTT assay indicate that 72hr extract incubation with the combined extracts is toxic to the cells and the level of damage is concentration dependent.

scholarly journals In vitro Cytotoxicity Activity of Chrysin, Morin and Resveratrol Against MCF-7 Breast Cancer Cell Lines

2016 ◽  
Vol 13 (3) ◽  
pp. 1633-1637 ◽  
Author(s):  
Arlene Thomas ◽  
Niraja Ranadive ◽  
Harisha Nayak ◽  
Sneha Surendran ◽  
Madhavan Nampoothiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
In Vitro Cytotoxicity ◽  
Breast Cancer Cell Lines ◽  
Cytotoxicity Activity ◽  
Mcf 7

Silk sericin induced fabrication of reduced graphene oxide and its in-vitro cytotoxicity, photothermal evaluation

2018 ◽  
Vol 186 ◽  
pp. 189-196 ◽  
Author(s):  
Sireesh Babu Maddinedi ◽  
Jegatheeswaran Sonamuthu ◽  
Serap SuzuK Yildiz ◽  
Guobin Han ◽  
Yurong Cai ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
In Vitro Cytotoxicity ◽  
Silk Sericin ◽  
Reduced Graphene

scholarly journals POTENTIAL ANTICANCER ACTIVITY IN-VITRO FROM EXTRACT OF Turbinaria decurrens Bory

2020 ◽  
Vol 24 (1) ◽  
pp. 22-24
Author(s):  
Fitriyanti Jumaetri Sami
Keyword(s):  
Ethyl Acetate ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Causes Of Death ◽  
Human Breast ◽  
Cytotoxicity Activity ◽  
Mtt Method ◽  
Diphenyltetrazolium Bromide ◽  
Mcf 7

Cancer is one of the biggest causes of death in the world, not least in Indonesia. Brown algae (T. decurrens Bory) is one of the marine organisms that can be used as a source of natural medicinal ingredients. The purpose of this study was to examine the potential cytotoxicity of extracts of n-hexane, ethyl acetate, and methanol from T. decurrens Bory against MCF-7 human breast cancer cells and H460 lung cancer cells. Samples were extracted using multilevel maceration methods using n-hexane, ethyl acetate, and methanol. Cytotoxicity activity was carried out by the MTT method (3- (4,5-dimethylthiazolyl-2) -2,5-diphenyltetrazolium bromide). The results showed that all extracts of T. decurrens Bory were potential as anticancer. Ethyl acetate extract can inhibit cancer cells at a concentration of 10 µg / mL with more than 50% cytotoxicity compared to other extracts, both against MCF-7 and H460 cells.

scholarly journals Myrtus comunis and Eucalyptus camaldulensis cytotoxicity on breast cancer cells

2012 ◽  
pp. 65-73 ◽  
Author(s):  
Jelena Hrubik ◽  
Sonja Kaisarevic ◽  
Branka Glisic ◽  
Emilija Jovin ◽  
Neda Mimica-Dukic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Eucalyptus Camaldulensis ◽  
In Vitro Cytotoxicity ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Significant Difference ◽  
Ic50 Values ◽  
Eucalyptus Camaldulensis Dehnh ◽  
Mcf 7

In vitro cytotoxicity of methanol, ethyl acetate, n-buthanol, and water extracts of Myrtus communis L. and Eucalyptus camaldulensis Dehnh. was examined against two human breast cancer cell lines (MCF 7 and MDA-MB-231) using MTT and SRB assays. The results showed significant cytotoxic potential of examined extracts, with IC50 values ranging from 7 to 138 ?g/ml for M. communis and 3-250 ?g/ml for E. camaldulensis. The two plants generally expressed similar activity, and no significant difference in cell line?s sensitivity towards extracts was observed. The results indicate to M. communis and E. camaldulensis as candidates for thorough chemical analyses for identification of active compounds, and eventually for attention in the process of discovery of new natural products in the control of cancer.

scholarly journals Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2416 ◽  
Author(s):  
Abd Amr ◽  
Mohamed Abo-Ghalia ◽  
Gaber Moustafa ◽  
Mohamed Al-Omar ◽  
Eman Nossier ◽  
...  
Keyword(s):  
Cell Lines ◽  
Inhibitory Activity ◽  
Active Sites ◽  
Kinase Inhibitors ◽  
Docking Studies ◽  
In Vitro Cytotoxicity ◽  
Binding Modes ◽  
Cytotoxicity Activity ◽  
Mcf 7

A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material. Structures of the newly synthesized compounds were established by IR, 1H and 13C-NMR, and MS spectral data and elemental analysis. The in-vitro cytotoxicity activity was investigated for all compounds against MCF-7 and HepG-2 cell lines and the majority of the compounds showed potent anticancer activity against the tested cell lines in comparison with the reference drugs. Out of the macrocyclic pyrido-pentapeptide based compounds, 5c showed encouraging inhibitory activity on MCF-7 and HepG-2 cell lines with IC50 values 9.41 ± 1.25 and 7.53 ± 1.33 μM, respectively. Interestingly, 5c also demonstrated multitarget profile and excellent inhibitory activity towards VEGFR-2, CDK-2 and PDGFRβ kinases. Furthermore, molecular modeling studies of the compound 5c revealed its possible binding modes into the active sites of those kinases.

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