scholarly journals Evaluation of CA-125 as an Indicator of Imaging During Follow-up of Carcinoma Ovary: Original Research

2020 ◽  
Vol 70 (4) ◽  
pp. 289-294
Author(s):  
Pesona Grace Lucksom ◽  
Sonia Mathai ◽  
Jaydip Bhaumik ◽  
Anik Ghosh
Keyword(s):  
Ca 125 ◽  
Original Research ◽  
Carcinoma Ovary

Is there a role for CA-125 in monitoring patients with early endometrial cancer?

1991 ◽  
Vol 1 (4) ◽  
pp. 169-172
Author(s):  
M. Prefontaine ◽  
G. J. O'Connell ◽  
E. Ryan ◽  
K. J. Murphy
Keyword(s):  
Endometrial Cancer ◽  
Positive Predictive Value ◽  
Endometrial Carcinoma ◽  
Predictive Value ◽  
Clinical Status ◽  
Statistical Correlation ◽  
Ca 125 ◽  
Recurrent Malignancy ◽  
Low Prevalence

Elevated CA-125 levels have been reported in some women with endometrial carcinoma. Current follow-up policy for these patients does not involve the use of tumor markers. CA-125 measurements were performed in 28 patients with a diagnosis of endometrial cancer, 14 clinically free of disease and 14 with known disease. Based on the sensitivity (0.64) and specificity (0.93) observed we constructed a model to estimate the predictive value of the assay as a marker in the follow-up of patients who have completed treatment. This model would involve a CA-125 assay every six months for five years in 100 patients with stage I and II disease. Despite the high statistical correlation between the clinical status of the patient and the CA-125 value observed in our study, the positive predictive value would be approximately 24% in such a follow-up protocol where a low prevalence of recurrent malignancy is expected.

ESGO Statement on the Role of CA‐125 Measurement in Follow-Up of Epithelial Ovarian Cancer

2012 ◽  
Vol 22 (1) ◽  
pp. 175-175 ◽  
Author(s):  
Nicoletta Colombo ◽  
Gerald Gitsch ◽  
Nicolas Reed ◽  
Frederic Amant ◽  
David Cibula ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Ca 125

Successful Careers and Cognitive Style: A Follow-up Study of Childhood Family Discontinuity

1991 ◽  
Vol 69 (3_suppl) ◽  
pp. 1071-1074
Author(s):  
Virginia Z. Gordon
Keyword(s):  
Problem Solving ◽  
Cognitive Style ◽  
Career Path ◽  
Cognitive Styles ◽  
Original Research ◽  
Original Sample ◽  
Follow Up Study ◽  
Successful Career ◽  
Problem Solving Style

It was predicted that those participants who experienced discontinuity (death, divorce, and separations) from their parent(s) in childhood and who had successful careers in adulthood would manifest more innovative than adaptive cognitive styles on the Kirton Adaption-Innovation Inventory. The original research showed 61% of the sample members ( n = 41) experienced family discontinuity. Ninety percent ( n = 37) of the previous participants responded and showed 59% family discontinuity. Fifty-four percent in the follow-up study chose an alternative career path (counterstriving), the same percentage as in the original sample. When both family discontinuity and counterstriving were present, statistically significant innovation scores occurred. Family discontinuity in childhood and a successful career in adulthood are likely to be associated with high striving-motivation and an innovative (paradigm-breaking) problem-solving style.

scholarly journals Serum CA 125 is of clinical value in the staging and follow-up of patients with non-hodgkin's lymphoma

Cancer ◽  
1998 ◽  
Vol 82 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Mario Lazzarino ◽  
Ester Orlandi ◽  
Catherine Klersy ◽  
Cesare Astori ◽  
Ercole Brusamolino ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Ca 125 ◽  
Clinical Value ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Fifth Alon Dembo Memorial Workshop: Case 3

2010 ◽  
Vol 20 (Suppl 2) ◽  
pp. S24-S26 ◽  
Author(s):  
Peter E. Schwartz
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cancer Patient ◽  
Recurrent Ovarian Cancer ◽  
Ca 125 ◽  
Advanced Stage ◽  
Recurrent Cancer ◽  
Treatment Regimens ◽  
Platinum Sensitive ◽  
Very High

Background:OVO5/EORTC 55855, a study punitively refuting the value of CA-125 in the follow-up of ovarian cancer patients, has many deficiencies, including a heterogeneous ovarian cancer patient population, no control of initial treatment regimens, and no control of subsequent surgery or chemotherapeutic management for recurrence. Recent studies suggest a role for prompt surgery in selected cases of recurrent ovarian cancer with CA-125 elevations, a role for tamoxifen in managing rising CA-125 levels in patients without evidence of disease and the use of platinum doublets for treating recurrent platinum-sensitive disease, none of which were incorporated into OVo5/EORTC 55955.Case:A patient with advanced stage ovarian cancer presenting with a CA-125 level of 2000 U/mL, who is initially treated with surgery followed by chemotherapy and has a normal CT scan and normal CA-125 at completion of her initial chemotherapy.Conclusion:This patient remains at a very high risk for recurrence. I would continue to monitor this patient with serial CA-125 levels to identify recurrent cancer and consider initiating treatment before it is clinically obvious.

scholarly journals Borderline Ovarian Tumors: Fifteen Years’ Experience at a Scottish Tertiary Cancer Center

2018 ◽  
Vol 28 (9) ◽  
pp. 1683-1691 ◽  
Author(s):  
James May ◽  
Karolina Skorupskaite ◽  
Mario Congiu ◽  
Nidal Ghaoui ◽  
Graeme A. Walker ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Surgical Management ◽  
Early Stage ◽  
Ovarian Tumors ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Borderline Ovarian Tumors ◽  
Gynecology And Obstetrics ◽  
Preoperative Serum

ObjectivesSince the recognition of borderline ovarian tumors (BOTs) in the 1970s, the management of this subset of epithelial ovarian tumors has presented a challenge to clinicians. The majority present at an early stage, but their diagnosis is often only made following surgery, hence the heterogeneity of surgical management. Borderline ovarian tumors are morphologically diverse, and their behavior is subsequently also heterogeneous. We aimed to assess recurrence rates and the rate of malignant transformation in patients diagnosed with BOT. Secondary objectives included a review of current management and assessment of tumor markers, stage, cyst dimensions, and the presence of micropapillary features as prognostic indicators of recurrence.MethodsThis retrospective cohort study included all patients treated with BOT between 2000 and 2015 in the southeast region of Scotland. Clinical, surgicopathological, and follow-up data were collated. Data were analyzed with reference to recurrence and malignant transformation.ResultsTwo hundred seventy-five patients underwent treatment for BOT in the study period. Surgical management was highly variable. A diagnosis of recurrent/persistent BOT or ovarian malignancy following initial treatment of BOT was rare, with only 12 (4%) of 275 cases. There were 7 cases (3%) of ovarian malignancy. Advanced International Federation of Gynecology and Obstetrics stage was the most prominent prognostic factor. Elevated preoperative serum CA-125 and the presence of micropapillary features correlated with advanced stage at presentation. With a lack of clear guidance, follow-up was highly variable with a median of 43 months (0–136 months).ConclusionsTo our knowledge, this study is the largest BOT cohort in the United Kingdom. Recurrent disease is rare in optimally staged, completely resected, early-stage BOT, without high-risk features. Caution is needed in women electing not to undergo completion staging after diagnosis and in those opting for a fertility-preserving approach. Thorough informed consent and clear plans for surveillance and follow-up are needed with consideration of delayed completion surgery as appropriate.

scholarly journals A Study of the Energy Efficiency Management in Green Standard for Energy and Environmental Design (G-SEED)-Certified Apartments in South Korea

2018 ◽  
Vol 10 (10) ◽  
pp. 3402 ◽  
Author(s):  
Hyemi Kim ◽  
Wonjun Park
Keyword(s):  
Energy Efficiency ◽  
South Korea ◽  
Management System ◽  
Environmental Design ◽  
Information Management System ◽  
Management Systems ◽  
Original Research ◽  
Seed Certification ◽  
The Government

With an increase in the number of Green Standard for Energy and Environmental Design (G-SEED)-certified apartments in South Korea, people are receiving incentives from the government to purchase them. Since 2013, many benefits for G-SEED-certified buildings have been offered, such as tax reductions and deregulation of building codes/guidelines. As beneficial incentives are granted to G-SEED-certified buildings, follow-up management of the buildings is also necessary. However, to date, there are no appropriate follow-up management systems or legal regulations for G-SEED-certified buildings. Buildings that are certified by G-SEED in Korean housing buildings account for 6.25% of Korea’s total area. In addition, G-SEED certification has been obtained for more than 20% of the total completed housing area (2014–2017). Therefore, the energy efficiency-management of G-SEED certified buildings is also very important economically for reducing greenhouse gas emissions. In this study, domestic and foreign energy efficiency follow-up management systems were analyzed, and the amount of energy that is used by apartment houses with incentives was investigated. We have identified problems with the G-SEED system by analyzing evaluation methods, evaluation items, and points of G-SEED certification in related research studies. We also compared the energy consumption of an apartment building with G-SEED certification with that of adjacent complexes, thereby applying original research methods. The results show that energy use in G-SEED-certified buildings was not efficient. Accordingly, the study confirms that continuous management after G-SEED certification by establishing a follow-up management system is needed. In this study, domestic and foreign follow-up management systems were compared, problems with the apartment housing information management system run by the government were examined, and improvement measures were suggested.

scholarly journals Abdominal pain: a survey of clinically important outcomes for future research

CJEM ◽  
2010 ◽  
Vol 12 (06) ◽  
pp. 485-490 ◽  
Author(s):  
Angela M. Mills ◽  
Anthony J. Dean ◽  
Judd E. Hollander ◽  
Esther H. Chen
Keyword(s):  
Abdominal Pain ◽  
Acute Abdominal Pain ◽  
Future Research ◽  
Original Research ◽  
Emergency Physicians ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Clinically Significant

ABSTRACT Objective: We aimed to use the consensus opinion of a group of expert emergency physicians to derive a set of emergency diagnoses for acute abdominal pain that might be used as clinically significant outcomes for future research. Methods: We conducted a cross-sectional survey of a convenience sample of emergency physicians with expertise in abdominal pain. These experts were authors of textbook chapters, peer-reviewed original research with a focus on abdominal pain or widely published clinical guidelines. Respondents were asked to categorize 50 possible diagnoses of acute abdominal pain into 1 of 3 categories: 1) unacceptable not to diagnose on the first emergency department (ED) visit; 2) although optimal to diagnose on first visit, failure to diagnose would not be expected to have serious adverse consequences provided the patient had follow-up within the next 2–7 days; 3) if not diagnosed during the first visit, unlikely to cause long-term risk to the patient provided the patient had follow-up within the next 1–2 months. Standard descriptive statistical analysis was used to summarize survey data. Results: Thirty emergency physicians completed the survey. Of 50 total diagnoses, 16 were categorized as “unacceptable not to diagnose in the ED” with greater than 85% agreement, and 12 were categorized as “acceptable not to diagnose in the ED” with greater than 85% agreement. Conclusion: Our study identifies a set of abdominal pain conditions considered by expert emergency physicians to be clinically important to diagnose during the initial ED visit. These diseases may be used as “clinically significant” outcomes for future research on abdominal pain.

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