Omega-3 Fatty Acids and Their Impact on Prostate Cancer Risk

2016 ◽  
Vol 5 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Mandi M. Hopkins ◽  
Kathryn E. Meier
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Do Omega-3 Dietary Fatty Acids Lower Prostate Cancer Risk? A Review of the Literature

2007 ◽  
Vol 1 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Martin C. Schumacher ◽  
Brett Laven ◽  
Alicja Wolk ◽  
Charles B. Brendler ◽  
Peter Ekman
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Dietary Fatty Acids ◽  
Omega 3 ◽  
Review Of The Literature

scholarly journals A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1647
Author(s):  
Karin Yurko-Mauro ◽  
Mary Van Elswyk ◽  
Lynn Teo
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Polyunsaturated Fatty Acids ◽  
Scoping Review ◽  
Genetic Variants ◽  
Prostate Cancer Risk ◽  
Lymphocytic Leukemia ◽  
Omega 3 ◽  
Long Chain

This scoping review examines the interaction of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and genetic variants of various types of cancers. A comprehensive search was performed to identify controlled and observational studies conducted through August 2017. Eighteen unique studies were included: breast cancer (n = 2), gastric cancer (n = 1), exocrine pancreatic cancer (n = 1), chronic lymphocytic leukemia (n = 1), prostate cancer (n = 7) and colorectal cancer (n = 6). An additional 13 studies that focused on fish intake or at-risk populations were summarized to increase readers’ understanding of the topic based on this review, DHA and EPA interact with certain genetic variants to decrease breast, colorectal and prostate cancer risk, although data was limited and identified polymorphisms were heterogeneous. The evidence to date demonstrates that omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) may decrease cancer risk by affecting genetic variants of inflammatory pathways, oxidative stress and tumor apoptosis. Collectively, data supports the notion that once a genetic variant is identified, the benefits of a targeted, personalized therapeutic regimen that includes DHA and/or EPA should be considered.

scholarly journals Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1616 ◽  
Author(s):  
Hanane Moussa ◽  
Molière Nguile-Makao ◽  
Karine Robitaille ◽  
Marie-Hélène Guertin ◽  
Janie Allaire ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Active Surveillance ◽  
Experimental Studies ◽  
Low Risk ◽  
Prostate Tissue ◽  
High Grade ◽  
Protective Effects ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08–0.79; p-trend = 0.03) was associated with lower odds of high-grade PCa. Similar results were observed for LCω3 dietary intake (OR 0.30; 95% CI 0.11-0.83; p-trend = 0.02) but no association for RBC. LCω3-EPA levels in the target prostate tissue are inversely associated with high-grade PCa in men with low-risk PCa, supporting that prostate tissue FA, but not RBC FA, is a reliable biomarker of PCa risk.

scholarly journals Omega-3 Fatty Acids and Other FFA4 Agonists Inhibit Growth Factor Signaling in Human Prostate Cancer Cells

2014 ◽  
Vol 352 (2) ◽  
pp. 380-394 ◽  
Author(s):  
Ze Liu ◽  
Mandi M. Hopkins ◽  
Zhihong Zhang ◽  
Chrystal B. Quisenberry ◽  
Louise C. Fix ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Prostate ◽  
Growth Factor Signaling ◽  
Human Prostate Cancer ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Prostate Cancer Cells
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