scholarly journals A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1647
Author(s):  
Karin Yurko-Mauro ◽  
Mary Van Elswyk ◽  
Lynn Teo
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Polyunsaturated Fatty Acids ◽  
Scoping Review ◽  
Genetic Variants ◽  
Prostate Cancer Risk ◽  
Lymphocytic Leukemia ◽  
Omega 3 ◽  
Long Chain

This scoping review examines the interaction of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and genetic variants of various types of cancers. A comprehensive search was performed to identify controlled and observational studies conducted through August 2017. Eighteen unique studies were included: breast cancer (n = 2), gastric cancer (n = 1), exocrine pancreatic cancer (n = 1), chronic lymphocytic leukemia (n = 1), prostate cancer (n = 7) and colorectal cancer (n = 6). An additional 13 studies that focused on fish intake or at-risk populations were summarized to increase readers’ understanding of the topic based on this review, DHA and EPA interact with certain genetic variants to decrease breast, colorectal and prostate cancer risk, although data was limited and identified polymorphisms were heterogeneous. The evidence to date demonstrates that omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) may decrease cancer risk by affecting genetic variants of inflammatory pathways, oxidative stress and tumor apoptosis. Collectively, data supports the notion that once a genetic variant is identified, the benefits of a targeted, personalized therapeutic regimen that includes DHA and/or EPA should be considered.

scholarly journals The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

2013 ◽  
Vol 7 (5-6) ◽  
pp. 333 ◽  
Author(s):  
Michael Chua ◽  
M.C.D. Sio ◽  
M.C. Sorongon ◽  
M.L. Morales Jr.
Keyword(s):  
Prostate Cancer ◽  
Serum Level ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Serum Levels ◽  
High Serum ◽  
High Grade ◽  
Omega 3 ◽  
High Blood Level ◽  
Long Chain

Objective: Our objective was to systematically analyze the evidence for an association between serum level long chain omega-3 polyunsaturated fatty acid (n-3 PUFA) and prostate cancer risk from human epidemiological studies.Study Procedures: We searched biomedical literature databases up to November 2011 and included epidemiological studies with description of long chain n-3 PUFA and incidence of prostate cancer in humans. Critical appraisal was done by two independent reviewers. Data were pooled using the general variance-based method with random-effects model; effect estimates were expressed as risk ratio with 95% confidence interval (CI). Heterogeneity was assessed by Chi2 and quantified by I2, publication bias was also determined.Results: In total, 12 studies were included. Significant negative association was noted between high serum level of n-3 PUFA docosapentaenoicacid (DPA) and total prostate cancer risk (RR:0.756;95% CI 0.599, 0.955; p = 0.019). Likewise, a positive association between high blood level of fish oil contents, eicosapentaenoicacid (EPA) and docosahexaenoic acid (DHA), and high-grade prostate tumour incidence (RR:1.381; 95% CI 1.050, 1.817; p = 0.021) was noted; however, this finding was evident only after adjustment was done on interstudy variability through the removal of a lower quality study from the pool.Conclusions: High serum levels of long chain n-3 PUFA DPA is associated with reduced total prostate cancer risk. While high blood level of EPA and DHA is possibly associated with increased high-grade prostate tumour risk.

Omega-3-Fettsäuren bei Krebserkrankungen

2021 ◽  
Vol 53 (04) ◽  
pp. 186-188
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Treatment ◽  
Scoping Review ◽  
Clinical Evidence ◽  
Omega 3 ◽  
Long Chain

Newell M et al. N-3 long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acid, and the role of supplementation during cancer treatment: A scoping review of current clinical evidence. Cancers (Basel) 2021; 13: 1206. doi: 10.3390/cancers13061206

Do Omega-3 Dietary Fatty Acids Lower Prostate Cancer Risk? A Review of the Literature

2007 ◽  
Vol 1 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Martin C. Schumacher ◽  
Brett Laven ◽  
Alicja Wolk ◽  
Charles B. Brendler ◽  
Peter Ekman
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Dietary Fatty Acids ◽  
Omega 3 ◽  
Review Of The Literature

scholarly journals Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LCω-3PUFA) and Prostate Cancer

2015 ◽  
Vol 67 (4) ◽  
pp. 543-554 ◽  
Author(s):  
Dominik D. Alexander ◽  
Julie K. Bassett ◽  
Douglas L. Weed ◽  
Erin Cernkovich Barrett ◽  
Heather Watson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Meta Analysis ◽  
Omega 3 ◽  
Long Chain

scholarly journals Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium

2016 ◽  
Vol 115 (5) ◽  
pp. 624-631 ◽  
Author(s):  
Nikhil K Khankari ◽  
◽  
Harvey J Murff ◽  
Chenjie Zeng ◽  
Wanqing Wen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Polyunsaturated Fatty Acids ◽  
Prostate Cancer Risk ◽  
Mendelian Randomisation
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