Parallel Causation in Oncogenic and Anthropogenic Degradation and Extinction

Abstract We propose that the onset and progressive destructive action of cancer within an individual bears a profound and striking similarity to the onset and progressive human-engendered destruction of global ecosystems and the extinction of entire species. Cancer in the human body and our human role in planetary, especially biotic, degradation are uncannily similar systems. For starters, they are the only two known complex systems where a discrete component changes its normal ecological role and function—turning on and potentially killing its host, and in so doing, itself. Both are “hostile takeovers.” Clearly, humans are integral to both systems. With cancer we are the host and victims of the rogue behavior of what starts out as a normal, healthy, and functionally important part of our bodies. With the biodiversity crisis, we are the part of the system that has changed, expanded, and proven so destructive to the system in which we live. We argue that given that these threats to our bodies and Earth are both essentially ecological diseases, understanding the critical role of ecological interdependencies for avoiding both cancer’s and humankind’s destruction of their respective homes should hopefully promote better stewardship of both by the only animal capable of recognizing the problems—us.

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Identifikasi Peran dan Strategi Pelabuhan Bebas Sabang

Jurnal Rekayasa Hijau ◽

10.26760/jrh.v4i3.167-178 ◽

2020 ◽

Vol 4 (3) ◽

pp. 167-178

Author(s):

Zurayna Sari

Keyword(s):

Economic Development ◽

Descriptive Analysis ◽

Regional Growth ◽

Maintenance Strategy ◽

Regional Economic ◽

Growth Center ◽

Free Port ◽

And Function ◽

Role And Function

ABSTRAKPelabuhan berperan sebagai fasilitas penunjang pusat pertumbuhan regional dalam proses pembangunan ekonomi wilayah. Pelabuhan Bebas Sabang diarahkan sebagai pusat pertumbuhan ekonomi regional dan diharapkan dapat meningkatkan perekonomian Kawasan Sabang. Permasalahan yang dihadapi Pelabuhan Bebas Sabang adalah belum optimalnya peran dan fungsi Pelabuhan Bebas Sabang dalam menunjang perekonomian wilayah. Penelitian ini bertujuan untuk mengetahui peran Pelabuhan Bebas Sabang dalam mendorong perkembangan perekonomian Kawasan Sabang. Lingkup materi yang dibahas mencakup peran-peran Pelabuhan Bebas Sabang, menentukan potensi dan masalah serta upaya-upaya peningkatan peran Pelabuhan Bebas Sabang. Metode analisis yang dilakukan adalah analisis deskriptif dengan pendekatan analisis data kualitatif dan kuantitatif. Alat analisis yang digunakan adalah analisis SWOT IFAS-EFAS. Hasil analisis menunjukkan dalam kurun waktu 4 (empat) tahun terakhir dari tahun 2010-2013, Pelabuhan Bebas Sabang belum optimal dalam menjalankan perannya, sehingga membutuhkan strategi pengembangan dengan pendekatan Agressive Maintenance Strategy (strategi perbaikan agresif), yaitu strategi konsolidasi internal dengan memperbaiki faktor-faktor kelemahan untuk memaksimalkan pemanfaatan peluang.Kata kunci: Pengelolaan, SWOT IFAS-EFAS, WilayahABSTRACTPort was supporting facility of regional growth center in the process of regional economic development. Sabang free port was directed as the center of regional economic growth and expected to raise the economy of sabang. Problems faced by sabang free port was yet optimal role and function in supporting the economy of the region. This study aimed to determine the role of sabang free port in supporting the economic development of sabang. The covered material scope included roles of sabang free port, determining the potentials and problems and efforts of increasing the role of sabang free port. The method of analysis was descriptive analysis with qualitative and quantitative approach. The analytical tool used was the swot ifas-efas analysis. The analysis results showed in the period of 4 (four) years from 2010 until 2013, sabang free port was not optimal in carrying out its role yet, so it requires development strategies with agressive maintenance strategy approach, which is internal consolidation strategy by improving vulnerability factors to maximize the utilization of opportunities.Keywords:, Management, Regional, SWOT IFAS-EFAS

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Faculty Opinions recommendation of Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1162955.623591 ◽

2009 ◽

Author(s):

Teresa Compton

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Replication ◽

Critical Role ◽

Cyclophilin A ◽

Structure And Function ◽

Replication Complex ◽

Isomerase Activity ◽

And Function

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Beyond Bias

The Oxford Handbook of Ethics of AI ◽

10.1093/oxfordhb/9780190067397.013.47 ◽

2020 ◽

pp. 736-753

Author(s):

Chelsea Barabas

Keyword(s):

Best Practices ◽

Criminal Law ◽

Criminal Justice Reform ◽

Trade Offs ◽

System P ◽

Accuracy Measures ◽

Criminal Legal System ◽

And Function ◽

Role And Function

This chapter discusses contemporary debates regarding the use of artificial intelligence as a vehicle for criminal justice reform. It closely examines two general approaches to what has been widely branded as “algorithmic fairness” in criminal law: the development of formal fairness criteria and accuracy measures that illustrate the trade-offs of different algorithmic interventions; and the development of “best practices” and managerialist standards for maintaining a baseline of accuracy, transparency, and validity in these systems. Attempts to render AI-branded tools more accurate by addressing narrow notions of bias miss the deeper methodological and epistemological issues regarding the fairness of these tools. The key question is whether predictive tools reflect and reinforce punitive practices that drive disparate outcomes, and how data regimes interact with the penal ideology to naturalize these practices. The chapter then calls for a radically different understanding of the role and function of the carceral state, as a starting place for re-imagining the role of “AI” as a transformative force in the criminal legal system.

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Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

International Journal of Molecular Sciences ◽

10.3390/ijms22179317 ◽

2021 ◽

Vol 22 (17) ◽

pp. 9317

Author(s):

Konstantinos Zifkos ◽

Christophe Dubois ◽

Katrin Schäfer

Keyword(s):

Experimental Evidence ◽

Extracellular Vesicles ◽

Thrombus Formation ◽

Experimental Studies ◽

Cell Types ◽

Heterogenous Group ◽

Clearance Mechanism ◽

And Function ◽

Role And Function

Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles, including exosomes, microvesicles and apoptotic bodies, which are released into the extracellular environment in response to proinflammatory or proapoptotic stimuli. From earlier studies suggesting that EV shedding constitutes a cellular clearance mechanism, it has become evident that EV formation, secretion and uptake represent important mechanisms of intercellular communication and exchange of a wide variety of molecules, with relevance in both physiological and pathological situations. The putative role of EVs in hemostasis and thrombosis is supported by clinical and experimental studies unraveling how these cell-derived structures affect clot formation (and resolution). From those studies, it has become clear that the prothrombotic effects of EVs are not restricted to the exposure of tissue factor (TF) and phosphatidylserines (PS), but also involve multiplication of procoagulant surfaces, cross-linking of different cellular players at the site of injury and transfer of activation signals to other cell types. Here, we summarize the existing and novel clinical and experimental evidence on the role and function of EVs during arterial and venous thrombus formation and how they may be used as biomarkers as well as therapeutic vectors.

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Optimizing the Clerics (Religious Scholars) Role in Actualizing Good Governance Concept

International Journal on Advanced Science Education and Religion ◽

10.33648/ijoaser.v1i1.3 ◽

2018 ◽

Vol 1 (1) ◽

pp. 23-30

Author(s):

M Muhammadong ◽

St Habibah ◽

Dalilul Falihin ◽

Muhammad Adnan Hudain

Keyword(s):

Development Process ◽

Good Governance ◽

Development Programs ◽

City Development ◽

Strategic Decisions ◽

The Government ◽

And Function ◽

Role And Function ◽

Descriptive Method

The purpose of this research is to describe the role of the clerics to actualize good governance concept in the development of Makassar City. Therefore, clerics are not merely issuing “fatwas” (religious advises) for the sake of society, but also, clerics can also play a role in development process. The method applied in this research is a descriptive method. While the approach applied is a qualitative method because the issues that are studied are phenomenological. The results show that the role of clerics is optimal in actualizing good governance concept in Makassar City development process. The role and function of the clerics can be represented as a community counselor in line with the government's role as servant and protector of society. Moreover, the policy taken by the government has been supported by all the clerics in actualizing development programs for the mutual good of the societies. In making strategic decisions, clerics sometimes contribute and suggestions to the government to improve social support of that decision

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A Review on Role of Macro and Micro Banking Environment on Non-Performing Assets Management

Behavioral Finance and Decision-Making Models - Advances in Finance, Accounting, and Economics ◽

10.4018/978-1-5225-7399-9.ch016 ◽

2019 ◽

pp. 281-294

Author(s):

Biswajit Prasad Chhatoi ◽

Sharada Prasad Sahoo

Keyword(s):

Critical Role ◽

Banking System ◽

Financial Assets ◽

Policy Changes ◽

Public And Private ◽

Private Banks ◽

Specific Factors ◽

And Function ◽

Asset Creation

In a self-resilient economy, banking system assumes importance in imparting momentum to economic growth and prosperity through mobilization of financial assets. Performance of banks, irrespective of their nature and function, is germane to their asset creation and maintenance capacity. In a neo-liberal regime, radical policy changes have crept into loan mechanism, thereby subjecting the banks to efficiently recover the loans, which is a vital asset for any banking firm. In this context, the authors through intensive review of literature identified micro and macro banking factors responsible for productive NPA management. The macro banking factors refer to the economic environment whereas the micro banking factors refer to the bank and branch-specific factors. The authors identified the critical role of organizational structure, involvement of employees, and organizational efficiency in driving prudent NPA management. The authors have found that the efficiency in managing NPAs differ in public and private banks, which is attributed to involvement of employees.

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Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells

Cell Death and Differentiation ◽

10.1038/s41418-020-0546-8 ◽

2020 ◽

Vol 27 (10) ◽

pp. 2843-2855

Author(s):

Zhi Liu ◽

Haohao Zhang ◽

Yiming Hu ◽

Dandan Liu ◽

Lingling Li ◽

...

Keyword(s):

Epithelial Cells ◽

Critical Role ◽

Histone H3 ◽

Thymic Epithelial Cells ◽

Medullary Thymic Epithelial Cells ◽

And Function

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The role of the cerebellum in creativity and expert stone knapping

Adaptive Behavior ◽

10.1177/1059712320966462 ◽

2020 ◽

pp. 105971232096646

Author(s):

Frederick L Coolidge

Keyword(s):

Critical Role ◽

Brain Regions ◽

Stone Tool ◽

Fine Motor ◽

Engagement Theory ◽

Motor Movements ◽

And Function ◽

The Mind ◽

Stone Knapping

The purpose of this article is to review the evolution and function of the cerebellum, particularly in regard to its role in creativity and expert stone knapping. First, the article reviews the history of the cerebellum, its evolution and phylogenetics, and its concerted evolution with various brain regions. It also notes the critical role of the cerebellum and the cerebro-cerebellar network in its traditionally recognized control of gross and fine motor movements and in its exaptation for basic and higher level cognitive processes, particularly in regard to increasingly more sophisticated stone knapping. Also, reviewed are various theories, advanced over the past three decades, of how the cerebellum tweaks and refines thoughts, images, and ideas just as it refines and smooths motor movements. Baddeley’s working memory model is also prominently featured, as are the works of Ito, Vandervert, and others on the cerebellum’s role in novel problem-solving, insight, and creativity. Finally, this article reviews two “Cognitive Rubicons” in stone tool knapping, Theory of Mind and stone knapping, and Malafouris’ Material Engagement Theory. The article concludes with a novel hypothesis that the automaticity provided by the cerebellum derived from extensive practice in stone knapping may have freed Baddeley’s central executive from its attentional demands and allows the mind to “wander and wonder.”

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