Practice of wastewater irrigation and its impacts on human health and environment: a state of the art

Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.

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Brain organoids and insights on human evolution

F1000Research ◽

10.12688/f1000research.18495.1 ◽

2019 ◽

Vol 8 ◽

pp. 760 ◽

Cited By ~ 4

Author(s):

Alysson R. Muotri

Keyword(s):

Stem Cells ◽

Human Brain ◽

Human Health ◽

Human Evolution ◽

Pluripotent Stem Cells ◽

Disease Modeling ◽

State Of The Art ◽

Future Perspectives ◽

Promising Technique ◽

Current State

Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions. Although the applications for disease modeling in a dish have become routine, the use of these brain organoids as evolutionary tools is only now getting momentum. Here, we will review the current state of the art on the use of brain organoids from different species and the molecular and cellular insights generated from these studies. Besides, we will discuss how this model might be beneficial for human health and the limitations and future perspectives of this technology.

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Emerging investigator series: towards a framework for establishing the impacts of pharmaceuticals in wastewater irrigation systems on agro-ecosystems and human health

Environmental Science Processes & Impacts ◽

10.1039/c9em00020h ◽

2019 ◽

Vol 21 (4) ◽

pp. 605-622 ◽

Cited By ~ 9

Author(s):

Laura J. Carter ◽

Benny Chefetz ◽

Ziad Abdeen ◽

Alistair B. A. Boxall

Keyword(s):

Human Health ◽

Water Scarcity ◽

Wastewater Irrigation ◽

Agricultural Irrigation ◽

Agricultural Water ◽

Reclaimed Wastewater ◽

Irrigation Systems ◽

Water Demands ◽

Attractive Option

Use of reclaimed wastewater for agricultural irrigation is seen as an attractive option to meet agricultural water demands of a growing number of countries suffering from water scarcity.

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Interactions Between Food and Gut Microbiota: Impact on Human Health

Annual Review of Food Science and Technology ◽

10.1146/annurev-food-032818-121303 ◽

2019 ◽

Vol 10 (1) ◽

pp. 389-408 ◽

Cited By ~ 9

Author(s):

Yanbei Wu ◽

Jiawei Wan ◽

Uyory Choe ◽

Quynhchi Pham ◽

Norberta W. Schoene ◽

...

Keyword(s):

Gut Microbiota ◽

Health Outcomes ◽

Human Health ◽

State Of The Art ◽

Current Knowledge ◽

The Other ◽

Bioactive Components ◽

Food Components ◽

The Relationship

Understanding the relationship between food and the gut microbiota, their interactions, and how each modulates the other is critical for successful promotion of human health. This review seeks to summarize ( a) the current knowledge on the effects of food and food components on gut microbiota and ( b) the association between gut microbiota, consumption of food, and food bioactive components and the resulting beneficial health outcomes. Our goal is to provide state-of-the-art information on food and gut microbiota interactions and to stimulate discussions and research approaches that will move the field forward.

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