scholarly journals Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes

2021 ◽  
Author(s):  
Pooyan Makvandi ◽  
Milad Ashrafizadeh ◽  
Matineh Ghomi ◽  
Masoud Najafi ◽  
Hamid Heydari Sheikh Hossein ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Hyaluronic Acid ◽  
Body Temperature ◽  
The Body ◽  
E Coli ◽  
Human Body Temperature ◽  
Thermosensitive Hydrogels ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Immense Potential

AbstractInjectable materials have shown great potential in tissue engineering applications. However, bacterial infection is one of the main challenges in using these materials in the field of regenerative medicine. In this study, biogenically synthesized silver nanoparticle-decorated multi-walled carbon nanotubes (Ag/MWCNTs) were deployed for adorning biogenic-derived AgNPs which were subsequently used in the preparation of thermosensitive hydrogels based on hyaluronic acid encompassing these green-synthesized NPs. The antibacterial capacity of AgNPs decorated on MWCNTs synthesized through Camellia sinensis extract in an organic solvent-free medium displayed a superior activity by inhibiting the growth of Gram-negative (E. coli and Klebsiella) and Gram-positive (S. aureus and E. faecalis). The injectable hydrogel nanocomposites demonstrated good mechanical properties, as well. The thermosensitive hyaluronic acid-based hydrogels also exhibited Tgel below the body temperature, indicating the transition from liquid-like behavior to elastic gel-like behavior. Such a promising injectable nanocomposite could be applied as liquid, pomade, or ointment to enter wound cavities or bone defects and subsequently its transition in situ to gel form at human body temperature bodes well for their immense potential application in the biomedical sector.

Defect-induced vibrational response of multi-walled carbon nanotubes using resonance Raman spectroscopy

2005 ◽  
Vol 20 (12) ◽  
pp. 3368-3373 ◽  
Author(s):  
S.A. Curran ◽  
J.A. Talla ◽  
D. Zhang ◽  
D.L. Carroll
Keyword(s):  
Carbon Nanotubes ◽  
Raman Spectroscopy ◽  
Acid Treatment ◽  
Defect Formation ◽  
Double Resonance ◽  
Resonance Raman ◽  
The Body ◽  
Structural Defects ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

We systematically introduced defects onto the body of multi-walled carbon nanotubes through an acid treatment, and the evolution of these defects was examined by Raman spectroscopy using different excitation wavelengths. The D and D′ modes are most prominent and responsive to defect formation caused by acid treatment and exhibit dispersive behavior upon changing the excitation wavelengths as expected from the double resonance Raman (DRR) mechanism. Several weaker Raman resonances including D″ and L1 (L2) + D′ modes were also observed at the lower excitation wavelengths (633 and 785 nm). In addition, specific structural defects including the typical pentagon-heptagon structure (Stone–Wales defects) were identified by Raman spectroscopy. In a closer analysis we also observed Haeckelite structures, specifically Ag mode response in R5,7 and O5,6,7.

scholarly journals Polyanilino-Carbon Nanotubes Derivatised Cytochrome P450 2E1 Nanobiosensor for the Determination of Pyrazinamide Anti-Tuberculosis Drugs

Nano Hybrids ◽  
2014 ◽  
Vol 6 ◽  
pp. 59-73 ◽  
Author(s):  
Unathi Sidwaba ◽  
Rachel F. Ajayi ◽  
Usisipho Feleni ◽  
Samantha Douman ◽  
Priscilla Gloria Lorraine Baker ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Cytochrome P450 ◽  
The Body ◽  
Tb Treatment ◽  
Biosensor System ◽  
Electrochemically Deposited ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Dynamic Linear Range

Pyrazinamine (PZA) is one of the most commonly prescribed anti-tuberculosis (anti-TB) drug due to its ability to significantly shorten the TB treatment period. However, excess PZA in the body causes hepatotoxicity and liver damage. This, therefore, calls for new methods for ensuring reliable dosing of the drug, which will differ from person to person due to interindividual differences in drug metabolism. A novel biosensor system for monitoring the metabolism of PZA was prepared with nanocomposite of multi-walled carbon nanotubes (MWCNTs), polyaniline (PANI) and cytochrome P450 3A4 (CYP3A4) electrochemically deposited on a glassy carbon electrode (GCE). The nanocomposite biosensor system exhibited enhanced electroactivity that is attributable to the catalytic effect of the incorporated MWCNTs. The biosensor had a sensitivity of 7.80 μA/μg mL-1 PZA and a dynamic linear range of 4.92 160 ng/mL PZA.

scholarly journals The structure of multi-walled carbon nanotubes as a factor affecting the life of E. Coli

2020 ◽  
Vol 1611 ◽  
pp. 012009 ◽  
Author(s):  
A P Popov ◽  
A I Dimitrieva ◽  
A V Kovalenko ◽  
D S Yumanov ◽  
A V Stepanov ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
E Coli ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

scholarly journals Вплив вуглецевих наночастинок на гепатотоксичність тетрахлорметану

2018 ◽  
Author(s):  
N. Ya. Letniak ◽  
M. M. Korda
Keyword(s):  
Carbon Nanotubes ◽  
Alkaline Phosphatase ◽  
Thermal Properties ◽  
Carbon Nanoparticles ◽  
Soft Tissues ◽  
The Body ◽  
Male Rats ◽  
Multi Walled Carbon Nanotubes ◽  
A Cell ◽  
Walled Carbon Nanotubes

Introduction. Carbon nanoparticles have unique mechanical, electrical and thermal properties and are widely used in scientific research, industry and medicine. They are a promising nanomaterial for medical use due to their really high biocompatibility with blood, bones, cartilages and soft tissues. The capability of nanotubes to transport medicines and chemicals inside a cell predicts the possibility of the increase of classical substances toxicity in case of their intake into the body together with nanotubes.The aim of the study – to determine how nanoparticles affect the hepatotoxic properties of  tetrachloromethane.Research Methods. The experiments were performed on outbred male rats, which were administered intraperitoneally with 0.5 ml of suspension of single-walled, multi-walled or multi-walled functionalized by COOH nanotubes (60 mg/kg) separately or together with tetrachlormethane (2 ml/kg). The animals were taken out of the experiment in 3, 6 and 48 hours after the administration of the nanotubes and tetrachlormethane. Alanine and aspartate transaminases, alkaline phosphatase activities, as well as total protein and urea contents were measured in rat blood plasma.Results and Discussion. It has been shown that only multi-walled carbon nanotubes changed significantly  the studied parameters. The administration of tetrachloromethane to rats caused significant changes of all indices.Maximal changes of all parameters were registered in the group of animals that were coadministered with carbon nanotubes and tetrachloromethane. In this case, activities of transaminases and alkaline phosphatase in blood significantly changed compared to the similar indicators in the group of animals, which were administered with the chemical toxicant only.Conclusion. Carbon nanotubes enhance the negative hepatotoxic effects of tetrachlormethane.

Single- and multi-walled carbon nanotubes for solar cell applications

2018 ◽  
Vol 32 (21) ◽  
pp. 1830007
Author(s):  
Madina Obaidullah ◽  
Volkan Esat ◽  
Cumali Sabah
Keyword(s):  
Carbon Nanotubes ◽  
Tin Oxide ◽  
Indium Tin Oxide ◽  
Organic Polymer ◽  
Dye Sensitized ◽  
Transparent Conducting ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Immense Potential ◽  
Different Parts

Emerging nanotechnologies have revealed carbon nanotubes (CNTs) as one of the best materials with immense potential. Considering the outstanding physical, mechanical, electrochemical, thermal, and optoelectronic properties of CNTs, extensive studies have been reported assessing their applications in several disciplines. This paper presents a broad review of the studies in the literature that address the contribution of CNTs in terms of their applications as different parts of solar cells such as photoelectrode, photoconductor, top and back electrode, replacement of indium tin oxide (ITO) as transparent conducting electrode (TCE) in a variety of photovoltaics such as silicon, organic, polymer and dye-sensitized with their subsequent efficiencies.

scholarly journals Effect of multi-walled carbon nanotubes on Escherichia coli biofilm formation

2021 ◽  
pp. 87-92
Author(s):  
Yu. G. Maksimova ◽  
◽  
Ya. E. Bykova ◽  
◽  
Keyword(s):  
Escherichia Coli ◽  
Carbon Nanotubes ◽  
Biofilm Formation ◽  
Culture Medium ◽  
Nano Materials ◽  
E Coli ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Different Sources ◽  
Degree Of Purification

The effect of purified and unpurified multi-walled carbon nanotubes on the biofilm formation of Esche-richia coli strains isolated from different sources has been studied. It has been shown that carbon nano-materials in the culture medium do not inhibit biofilm formation, but on days 1–3 of growth lead to the formation of more massive biofilms of some strains. Significantly more intense destruction of mature bio-films of E. coli K12, E. coli K12 TG1 (pXen7) and one natural strain in the presence of carbon nanotubes in the medium was noted. No clear dependence of biofilm formation and destruction of formed biofilms on the degree of purification of nanotubes was found.

scholarly journals NANOTUBS INCREASE TETRACHLOROMETHANE INDUCED OXIDATIVE STRESS

2017 ◽  
Author(s):  
N. Ya. Letniak ◽  
I. P. Kuzmak ◽  
M. M. Korda
Keyword(s):  
Oxidative Stress ◽  
Carbon Nanotubes ◽  
Chemical Properties ◽  
Thiobarbituric Acid ◽  
The Body ◽  
Male Rats ◽  
Total Antioxidant ◽  
Multi Walled Carbon Nanotubes ◽  
Physical And Chemical ◽  
Walled Carbon Nanotubes

Background. The unique physical and chemical properties of carbon nanotubes determine wide-ranging prospects for their use in biology and medicine. The capability of nanotubes to transport medicines and chemicals inside a cell makes the possibility of classical toxicants toxicity increase in case of their intake to the body with nanotubes, an urgent issue.Objective. The aim of the research was to study the effect of carbon nanotubes on the capability of the chemical toxicant tetrachloromethane (TCM) to induce oxidative stress in serum and liver of rats.Methods. The experiments were performed on outbred male rats, which were administered intraperitoneally with 0.5 ml of suspension of single-walled, multi-walled or multi-walled functionalized COOH nanotubes (60 mg/kg) only or together with TCM (2 ml/kg). The animals were taken out of the experiment in 3, 6 and 48 hours after the administration of the nanotubes and TCM. The activity of catalase, superoxide dismutase, the content of thiobarbituric acid reactive substances (TARS), reduced glutathione, ceruloplasmin and total antioxidant activity of serum were determined in serum and liver.Results. It was established that under the influence of multi-walled carbon nanotubes the studied parameters changed significantly. The administration of tetrachloromethane to rats caused significant changes in all indicators. Maximal changes in the rates were recorded in the group of animals that were administered with carbon nanotubes and tetrachloromethane togeather. In this case, a number of the studied parameters of blood and liver significantly changed compare to the similar indicators of the group of animals, which were administered with the chemical toxicant only.Conclusions. Carbon nanotubes increase the capability of the chemical toxicant tetrachloride to cause oxidative stress in liver and serum.

Sign in / Sign up

Export Citation Format

Share Document