3D-Printed Modified-Release Tablets: A Review of the Recent Advances

The broad spectrum of applications of three-dimensional printing (3D printing, 3DP) has attracted the attention of researchers working in diverse fields. In pharmaceutics, the main idea behind 3D printing products is to design and develop delivery systems that are suited to an individual’s needs. In this way, the size, appearance, shape, and rate of delivery of a wide array of medicines could be easily adjusted. The aim of this chapter is to provide a compilation of the 3D printing techniques, used for the fabrication of oral drug delivery systems, and review the relevant scientific developments in particular those with modified-release characteristics.

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Utility of Three-Dimensional Printing for Preoperative Assessment of Children with Extra-Cranial Solid Tumors: A Systematic Review

Pediatric Reports ◽

10.3390/pediatric14010006 ◽

2022 ◽

Vol 14 (1) ◽

pp. 32-39

Author(s):

Sachit Anand ◽

Nellai Krishnan ◽

Prabudh Goel ◽

Anjan Kumar Dhua ◽

Vishesh Jain ◽

...

Keyword(s):

Systematic Review ◽

3D Printing ◽

Solid Tumors ◽

Surgical Planning ◽

Three Dimensional ◽

Current Evidence ◽

Printing Technology ◽

Three Dimensional Printing ◽

3D Printed ◽

Dimensional Printing

Background: In cases with solid tumors, preoperative radiological investigations provide valuable information on the anatomy of the tumor and the adjoining structures, thus helping in operative planning. However, due to a two-dimensional view in these investigations, a detailed spatial relationship is difficult to decipher. In contrast, three-dimensional (3D) printing technology provides a precise topographic view to perform safe surgical resections of these tumors. This systematic review aimed to summarize and analyze current evidence on the utility of 3D printing in pediatric extra-cranial solid tumors. Methods: The present study was registered on PROSPERO—international prospective register of systematic reviews (registration number: CRD42020206022). PubMed, Embase, SCOPUS, and Google Scholar databases were explored with appropriate search criteria to select the relevant studies. Data were extracted to study the bibliographic information of each article, the number of patients in each study, age of the patient(s), type of tumor, organ of involvement, application of 3D printing (surgical planning, training, and/or parental education). The details of 3D printing, such as type of imaging used, software details, printing technique, printing material, and cost were also synthesized. Results: Eight studies were finally included in the systematic review. Three-dimensional printing technology was used in thirty children with Wilms tumor (n = 13), neuroblastoma (n = 7), hepatic tumors (n = 8), retroperitoneal tumor (n = 1), and synovial sarcoma (n = 1). Among the included studies, the technology was utilized for preoperative surgical planning (five studies), improved understanding of the surgical anatomy of solid organs (two studies), and improving the parental understanding of the tumor and its management (one study). Computed tomography and magnetic resonance imaging were either performed alone or in combination for radiological evaluation in these children. Different types of printers and printing materials were used in the included studies. The cost of the 3D printed models and time involved (range 10 h to 4–5 days) were reported by two studies each. Conclusions: 3D printed models can be of great assistance to pediatric surgeons in understanding the spatial relationships of tumors with the adjacent anatomic structures. They also facilitate the understanding of families, improving doctor–patient communication.

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Development of Smartphone-Controlled Hand and Arm Exoskeleton for Persons with Disability

Open Engineering ◽

10.1515/eng-2021-0016 ◽

2020 ◽

Vol 11 (1) ◽

pp. 161-170

Author(s):

J-R. R. Diego ◽

Dan William C. Martinez ◽

Gerald S. Robles ◽

John Ryan C. Dizon

Keyword(s):

3D Printing ◽

Low Cost ◽

Three Dimensional ◽

Prosthetic Device ◽

Three Dimensional Printing ◽

Plastic Materials ◽

3D Printed ◽

Available Technology ◽

Electronic Parts ◽

Dimensional Printing

AbstractThis study addresses the need for assistive technology of people who lost control of their upper limbs as well as people who are undergoing rehabilitation. Loss of upper limb control causes lack of functionality and social acceptability especially for many people in developing countries with fewer available technology. The study develops a modern but low-cost prosthetic device that can be controlled by users using a smartphone and can be rapidly manufactured using three-dimensional printing (3D printing) of plastic materials. The development of the prosthetic device includes designing the mechanical and electronic parts, programming the Arduino board and Android application for control, simulation and analysis of 3D printed parts most subjected to stress, and 3D printing the parts under different settings. The device was tested in terms of time spent and capacity of lifting varying loads when not worn and when worn by users. The device can effectively lift 500 grams of load in one second for a person weighing between 50 to 60 kilograms.

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3D Reconstruction Role in Surgical Treatment of Sinonasal Tumours

Revista de Chimie ◽

10.37358/rc.18.6.6345 ◽

2018 ◽

Vol 69 (6) ◽

pp. 1455-1457

Author(s):

Dragos Octavian Palade ◽

Bogdan Mihail Cobzeanu ◽

Petronela Zaharia ◽

Marius Dabija

Keyword(s):

3D Printing ◽

Three Dimensional ◽

Patient Specific ◽

Three Dimensional Printing ◽

Great Progress ◽

3D Printed ◽

Medical Modeling ◽

Dimensional Printing ◽

Tissue Defects

Three-dimensional printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. Nowadays, 3D printing is very well integrated in the surgical practice and research. Also, the field of head and neck reconstructive surgery is constantly evolving because of the three-dimensional printing, a technology which can be widely used in a variety of situations such as reconstruction of tissue defects, surgical planning, medical modeling and prosthesis. By using 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients and will also provide a rapid production of personalized patient-specific devices. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otorhinolaryngology.

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Systematic review of three-dimensional printing for simulation training of interventional radiology trainees

3D Printing in Medicine ◽

10.1186/s41205-021-00102-y ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Chase Tenewitz ◽

Rebecca T. Le ◽

Mauricio Hernandez ◽

Saif Baig ◽

Travis E. Meyer

Keyword(s):

Interventional Radiology ◽

3D Printing ◽

Simulation Training ◽

Three Dimensional ◽

Simulation Models ◽

Cochrane Library ◽

Three Dimensional Printing ◽

3D Printed ◽

Key Terms ◽

Dimensional Printing

Abstract Rationale and objectives Three-dimensional (3D) printing has been utilized as a means of producing high-quality simulation models for trainees in procedure-intensive or surgical subspecialties. However, less is known about its role for trainee education within interventional radiology (IR). Thus, the purpose of this review was to assess the state of current literature regarding the use of 3D printed simulation models in IR procedural simulation experiences. Materials and methods A literature query was conducted through April 2020 for articles discussing three-dimensional printing for simulations in PubMed, Embase, CINAHL, Web of Science, and the Cochrane library databases using key terms relating to 3D printing, radiology, simulation, training, and interventional radiology. Results We identified a scarcity of published sources, 4 total articles, that appraised the use of three-dimensional printing for simulation training in IR. While trainee feedback is generally supportive of the use of three-dimensional printing within the field, current applications utilizing 3D printed models are heterogeneous, reflecting a lack of best practices standards in the realm of medical education. Conclusions Presently available literature endorses the use of three-dimensional printing within interventional radiology as a teaching tool. Literature documenting the benefits of 3D printed models for IR simulation has the potential to expand within the field, as it offers a straightforward, sustainable, and reproducible means for hands-on training that ought to be standardized.

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Three-dimensional-printing for microfluidics or the other way around?

International Journal of Bioprinting ◽

10.18063/ijb.v5i2.192 ◽

2019 ◽

Vol 5 (2) ◽

Cited By ~ 1

Author(s):

Yi Zhang

Keyword(s):

3D Printing ◽

Social Impact ◽

Three Dimensional ◽

The Other ◽

Complex Structures ◽

Three Dimensional Printing ◽

Strong Focus ◽

3D Printed ◽

Near Net Shape ◽

Dimensional Printing

As microfluidic devices are designed to tackle more intricate tasks, the architecture of microfluidic devicesbecomes more complex, and more sophisticated fabrication techniques are in demand. Therefore, it is sensible to fabricatemicrofluidic devices by three-dimensional (3D)-printing, which is well-recognized for its unique ability to monolithicallyfabricate complex structures using a near-net-shape additive manufacturing process. Many 3D-printed microfluidic platformshave been demonstrated but can 3D-printed microfluidics meet the demanding requirements in today’s context, and hasmicrofluidics truly benefited from 3D-printing? In contrast to 3D-printed microfluidics, some go the other way around andexploit microfluidics for 3D-printing. Many innovative printing strategies have been made possible with microfluidicsenabled3D-printing, although the limitations are also largely evident. In this perspective article, we take a look at the currentdevelopment in 3D-printed microfluidics and microfluidics-enabled 3D printing with a strong focus on the limitations of thetwo technologies. More importantly, we attempt to identify the innovations required to overcome these limitations and todevelop new high-value applications that would make a scientific and social impact in the future.

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Cotton-containing printing wires based on the two-dimensional braiding method for three-dimensional printing of clothing

Textile Research Journal ◽

10.1177/00405175211059208 ◽

2021 ◽

pp. 004051752110592

Author(s):

Meng-jie Wu ◽

Chao Zhi ◽

Li Tu ◽

Yong-zhen Wang ◽

Yang Dai ◽

...

Keyword(s):

3D Printing ◽

Thermoplastic Polyurethane ◽

Three Dimensional ◽

Acrylonitrile Butadiene Styrene ◽

Two Dimensional ◽

Three Dimensional Printing ◽

Textile Materials ◽

Fused Deposition ◽

3D Printed ◽

Dimensional Printing

There is a large somatosensory gap between the three-dimensional (3D) printing of clothing and traditional garments due to the limitations (e.g., air permeability and skin-friendliness) of the printing materials. For this reason, the application of traditional textile materials in 3D printing has become a hot topic in the field of 3D printed clothing. Based on the above, this work prepared four kinds of cotton-containing composite solutions and then impregnated thermoplastic polyurethane core yarns in these solutions to obtain four types of 3D printed cotton-containing composite core yarns (3Dp-C-CYs). Afterward, based on the two-dimensional (2D) braiding method, four kinds of cotton-containing 3D printing wires used for fused deposition molding technology were prepared by wrapping low-melting polyester filaments around the different 3Dp-C-CYs. After comparing the printing performance of the four cotton-containing 3D printing wires, the wire containing cotton powders had the best comprehensive performance and was selected to print the cotton-containing 3D printed fabrics. The results showed that the cotton-containing 3D printed fabric has good flatness and contains a large number of cotton powders; in addition, compared with the traditional polylactic acid and acrylonitrile butadiene styrene copolymer 3D printed fabrics, the 3D printed fabric made up of cotton-containing 3D printing wire can provide a closer wearing experience to that of cotton fabric. The 3D printing wire produced by the 2D braiding method offers a new idea for applying traditional textile materials in 3D printing, showing great application potentials in the field of 3D printing of clothing.

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Mitigating Scattering Effects in Light-Based Three-Dimensional Printing Using Machine Learning

Journal of Manufacturing Science and Engineering ◽

10.1115/1.4046986 ◽

2020 ◽

Vol 142 (8) ◽

Cited By ~ 1

Author(s):

Shangting You ◽

Jiaao Guan ◽

Jeffrey Alido ◽

Henry H. Hwang ◽

Ronald Yu ◽

...

Keyword(s):

Machine Learning ◽

3D Printing ◽

Light Exposure ◽

Three Dimensional ◽

Exposure Dose ◽

Printing Process ◽

Three Dimensional Printing ◽

Scattering Effects ◽

3D Printed ◽

Dimensional Printing

Abstract When using light-based three-dimensional (3D) printing methods to fabricate functional micro-devices, unwanted light scattering during the printing process is a significant challenge to achieve high-resolution fabrication. We report the use of a deep neural network (NN)-based machine learning (ML) technique to mitigate the scattering effect, where our NN was employed to study the highly sophisticated relationship between the input digital masks and their corresponding output 3D printed structures. Furthermore, the NN was used to model an inverse 3D printing process, where it took desired printed structures as inputs and subsequently generated grayscale digital masks that optimized the light exposure dose according to the desired structures’ local features. Verification results showed that using NN-generated digital masks yielded significant improvements in printing fidelity when compared with using masks identical to the desired structures.

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Accuracy and Internal Fit of 3D printed Occlusal Splint, according to the printing position

Clinical and Laboratorial Research in Dentistry ◽

10.11606/issn.2357-8041.clrd.2018.148012 ◽

2018 ◽

Cited By ~ 1

Author(s):

Mayra Torres Vasques ◽

Dalva Cruz Laganá

Keyword(s):

3D Printing ◽

Three Dimensional ◽

Digital Technologies ◽

3D Printer ◽

Occlusal Splint ◽

Three Dimensional Printing ◽

Dimensional Measurement ◽

3D Printed ◽

Internal Fit ◽

Dimensional Printing

Understanding the importance of 3D printing strategies is a key to obtain predictable, optimized and consistent dental appliances using digital technologies. This study aims to present the influence of printing orientation on the intraoral fit of full arch coverage splints. Splints were designed for two patients using the CAD software and printed in a SLA 3D printer with different orientations (0, 30, and 90 degrees), and the internal fit was checked on patients’ mouth. Differences between the fit of the splints were verified, with the worst results for 90º oriented splints, although more detailed studies are recommended by the authors. DESCRIPTORS | Three-Dimensional Printing; Accuracy; Dimensional Measurement; Occlusal Splint; Print Orientation.

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Comparison of Activation Methods for 3D-Printed Electrodes for Microbial Electrochemical Technologies

Applied Sciences ◽

10.3390/app12010275 ◽

2021 ◽

Vol 12 (1) ◽

pp. 275

Author(s):

Raúl M. Alonso ◽

Isabel San Martín ◽

Antonio Morán ◽

Adrián Escapa

Keyword(s):

3D Printing ◽

Electrochemical Performance ◽

Three Dimensional ◽

Three Dimensional Printing ◽

Activation Procedure ◽

Current Activation ◽

3D Printed ◽

Current Densities ◽

New Generation ◽

Dimensional Printing

Three-dimensional printing could provide flexibility in the design of a new generation of electrodes to be used in microbial electrochemical technologies (MET). In this work, we demonstrate the feasibility of using polylactic acid (PLA)/graphene—a common 3D-printing material—to build custom bioelectrodes. We also show that a suitable activation procedure is crucial to achieve an acceptable electrochemical performance (plain PLA/graphene bioanodes produce negligible amounts of current). Activation with acetone and dimethylformamide resulted in current densities similar to those typically observed in bioanodes built with more conventional materials (about 5A m−2). In addition, the electrodes thus activated favored the proliferation of electroactive bacteria.

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Current State of Three-Dimensional Printing for Simulation Training of Interventional Radiology Trainees

10.21203/rs.3.rs-108379/v1 ◽

2020 ◽

Author(s):

Chase Tenewitz ◽

Rebecca Le ◽

Mauricio Hernandez ◽

Saif Baig ◽

Travis Meyer

Keyword(s):

Interventional Radiology ◽

3D Printing ◽

Best Practices ◽

Three Dimensional ◽

Three Dimensional Printing ◽

Search Terms ◽

Current State ◽

Hands On ◽

3D Printed ◽

Dimensional Printing

Abstract Objectives: The purpose of this review was to assess the use of three-dimensional (3D) printing in interventional radiology (IR) simulation experiences.Materials and Methods: A literature query was conducted in April 2020 for articles discussing 3D printing for simulations in numerous library databases using various search terms.Results: While trainee feedback is generally supportive of 3D printing within the field of IR, current applications utilizing 3D printed models are heterogeneous, reflecting a lack of best practices standards in the realm of medical education.Conclusions: Presently available literature endorses the use of 3D printing within IR. 3D printing has the potential to expand within the field, as it offers a straightforward, sustainable, and reproducible means for hands-on training that ought to be standardized.

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