Actually, many discussions on the potential risks of silver nanoparticles (AgNPs) have
been reported; however, unfortunately, very few considered the great differences between the nature
of silver and sources of their syntheses. All data suggested that the effects on toxicity of AgNPs are
related to the combination of the specific properties of AgNPs. In this context, this review presents
and discusses the recent progress in the nanotoxicity of AgNPs, obtained by different biogenic synthetic
protocols, in comparison with chemical synthetic methods, driving to the formation of
nanoparticles with diverse structures, and size distributions. Biogenic syntheses of AgNPs using
several biological sources and other chemical agents are presented and discussed. Toxicity in different
animals is also presented and discussed. By considering the actual state of the art, it can be assumed
that oral, intravenous and inhalation doses of AgNPs from 0.1 to 2 mg/Kg in mice and rats are
considered a safe administration. In terms of ecotoxicity, it is more concerning since many of the in
vivo assays showed a very low lethal dose, i.e., 50% (LD50). Therefore, we have to be very careful
with the AgNPs residues in the environment.