Concentration of orally administered antimicrobial agent in burn scar tissue, granulation tissue, normal skin and serum

Burns ◽  
1993 ◽  
Vol 19 (6) ◽  
pp. 529-530 ◽  
Author(s):  
Y. Sawada ◽  
T. Ohkubo ◽  
M. Kudo ◽  
K. Sugawara
Keyword(s):  
Antimicrobial Agent ◽  
Granulation Tissue ◽  
Normal Skin ◽  
Scar Tissue ◽  
Burn Scar

scholarly journals COMPARATIVE STUDY FOR USING OF SUB MUCOSA OF SMALL INTESTINE IN HEALING OF CLEAN AND INFECTED AVULSION WOUNDS

2009 ◽  
Vol 33 (1) ◽  
pp. 90-97
Author(s):  
N. H. AL-FALAHI
Keyword(s):  
Small Intestine ◽  
Granulation Tissue ◽  
Group Treatment ◽  
Normal Skin ◽  
Scar Tissue ◽  
Control Group ◽  
Wound Site ◽  
The Third ◽  
Macroscopic Finding ◽  
Thigh Region

This study was done on 29 mature rabbits to observe the effect of sub mucosa of small intestine of sheep inthe healing of avulsion wound in rabbits, animals divided to three equal groups:First group: The avulsion wound in the thigh region was left without treatment, just covering with bandage andconsidered as a control group.Second group: Treatment of clean avulsion wound in the thigh region was done by covering it with sub mucosaof small intestine which previously prepared.Third group: Treatment of infected avulsion wound in the thigh region was done by covering it with sub mucosaof small intestine which previously prepared.The results of this study show that the sub mucosas of small intestine have the ability to enhance healing of thewound with little formation of scar tissue.The macroscopic finding show the faster in approximation of wound edges in groups two and three in the secondweek and with little formation of granulation and the wound site be similar to normal skin in the third week ascompared with control group in which the healing occur by formation of scar tissue observed in the third weekand continue to the forth week, while The histopathological finding show faster in organization of granulationtissue in the second week in groups two and three and the tissue appeared similar to normal skin in the third week,while in control group show increase in formation of granulation tissue which continue until the third week

scholarly journals Assessment of Hydroxyproline Levels in Non-Ischemic Diabetic Foot Ulcers During Recovery. A Prospective Case-Control Study

2015 ◽  
Vol 22 (4) ◽  
pp. 361-366
Author(s):  
Seyed Mansour Alamshah ◽  
Aliasghar Hemmati ◽  
Zahra Nazari
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Normal Skin ◽  
Repair Process ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Control Groups ◽  
Mean Values ◽  
The Mean ◽  
Medical University

Abstract Background and aims: Proline hydroxylation is essential for collagen synthesis in wound healing. Therefore, hydroxyproline quantification may be a suitable marker of wound healing in diabetic tissue. Material and method: This is a prospective casecontrol clinical study including 90 referral patients from our clinics in Golestan hospital affiliated to Jundishapour Medical University, Ahwaz-Iran, during a period of 18 months. Three groups were recruited: intervening diabetics with non-ischemic foot ulcers, diabetics without foot ulcers (normal diabetics) and non-diabetics without foot ulcers (normal non-diabetics) as control groups (n=30 per group). 500 mg of granulation tissue from ulcers after treatment and 500 mg of normal skin from both control groups were taken for the measurement of hydroxyproline levels. Results: 13 (43.3%) males and 17 (56.7%) females in trial group were analysed. There was no significant differences in age, gender, and BMI between groups. Mean hydroxyproline concentration in wound granulation tissue (140.44 μg/g) was statistically different from the mean concentration in the skin content of normal diabetics (173.22 g/g,) and the skin content of nondiabetics (178.83 μg/g) (p=0.001). There were no statistically significant differences between the mean values of normal diabetics and non-diabetics (p=0.63). Conclusion: Our results showed the presence of a lower quantity of hydroxyproline in diabetic patients with foot ulcers compared to control groups. This raises the issue of its effectiveness in delaying the repair process in diabetics. Therefore, compensating for tissue hydroxyproline deficit can be a clue in improving diabetic tissue repair.

scholarly journals Method for the prevention of inflammatory processes in the bone part of the external auditory canal accompanied by the growth of connective tissue

2020 ◽  
Vol 19 (4) ◽  
pp. 21-26
Author(s):  
I. A. Anikin ◽  
◽  
S. A. Eremin ◽  
A. E. Shinkareva ◽  
◽  
...  
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Granulation Tissue ◽  
Satisfactory Result ◽  
External Auditory Canal ◽  
Inflammatory Process ◽  
Local Therapy ◽  
Scar Tissue ◽  
Inflammatory Processes ◽  
Bone Section

Otosurgery plays an important role in the rehabilitation of patients with hearing loss. Any operation can be accompanied by a long inflammatory process with excessive development of connective tissue, forming atresia or stenosis of the external auditory canal. Formed scars in the external auditory canal reduce the effectiveness of treatment and can lead to reoperation. In the treatment of scars, the use of injections of a suspension of prolonged steroids directly into the developing connective tissue is effective. We have developed a method of injecting drugs into the scar tissue of the bone section of the external auditory canal, which allows the use of such therapy in patients after otosurgery. 12 people were treated with the proposed technique. All patients had an inflammatory process in the external auditory canal with undesirable growth of connective tissue. Previous local therapy did not bring a satisfactory result. Patients received injections of a suspension of steroids into developing scar tissue. The treatment period was 1-8 weeks, for which 1 to 4 sessions of injections were performed. As a result of treatment according to the developed method, in all cases a cessation of the pathological inflammatory process was observed. Timely therapy made it possible to completely eliminate the excess granulation tissue (100%), to stop the growth of the scar, or even to cause a significant decrease (33%). The developed method allows to use of a small dose of a substance (0,1–0,5 ml) for injection to achieve the desired therapeutic effect.

scholarly journals A rare development of basal cell carcinoma on trichoepithelioma in a chemical burn scar tissue

Medicine ◽  
2018 ◽  
Vol 97 (38) ◽  
pp. e12252 ◽  
Author(s):  
Seong Hwan Kim ◽  
Dong Wan Kim ◽  
Jae Ha Hwang ◽  
Kwang Seog Kim ◽  
Sam Yong Lee
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Scar Tissue ◽  
Chemical Burn ◽  
Burn Scar

Polymeric Nanofibre Scaffold for the Delivery of a Transforming Growth Factor β1 Inhibitor

2017 ◽  
Vol 70 (3) ◽  
pp. 280 ◽  
Author(s):  
Vipul Agarwal ◽  
Fiona M. Wood ◽  
Mark Fear ◽  
K. Swaminathan Iyer
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Normal Skin ◽  
Scar Tissue ◽  
Transforming Growth Factor Β1 ◽  
Collagen I ◽  
Elevated Concentration ◽  
Skin Wound Healing

Skin scarring is a highly prevalent and inevitable outcome of adult mammalian wound healing. Scar tissue is both pathologically and aesthetically inferior to the normal skin owing to elevated concentration of highly orientated collagen I architecture in the innate repaired tissue. With highly invasive surgery being the main treatment modality, there is a great need for alternative strategies to mitigate the problem of scar formation. Tissue engineering approaches using polymeric scaffolds have shown tremendous promise in various disease models including skin wound healing; however, the problem of skin scarring has been greatly overlooked. Herein, we developed an electrospun poly(glycidyl methacrylate) (ES-PGMA) scaffold incorporating a small-molecule antiscarring agent, PXS64. PXS64, a lipophilic neutral analogue of mannose-6-phosphate, has been shown to inhibit the activation of transforming growth factor β1 (TGFβ1). TGFβ1 is a primary protein cytokine regulating the expression of collagen I during wound healing and therefore governs the formation of scar tissue. The nanofibres were tested for biocompatibility as a tissue engineering scaffold and for their efficacy to inhibit TGFβ1 activation in human dermal skin fibroblasts.

scholarly journals Second Generation Self-Inflating Tissue Expanders: A Two-Year Experience

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Jamal Omran Al Madani
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Normal Skin ◽  
Tissue Expansion ◽  
Clinic Visit ◽  
Plastic Shell ◽  
Burn Scar ◽  
Tissue Expanders ◽  
Great Reliability ◽  
Attractive Option

Background. Tissue expansion is a well-established surgical technique that produces an additional amount of normal skin to cover a defect. This technique is appealing because the skin quality and color are from the patient’s own. The widely used injectable expanders are of great reliability but carry the disadvantage of being painful during injection and most of the time require multiple clinic visits. So the idea of self-inflation became attractive and hydrogel expanders were developed and became widely known for being painless during clinic visit and decrease number of visits. The first generation expanders were modified by adding an enclosing plastic shell to decrease the unopposed expansion that occurred in the first generation expanders, which lead to pressure necrosis of the skin flaps. This made it an attractive option for tissue expansion in children and some adult patients. Patients, Materials, and Methods. Charts of 17 patients were retrospectively reviewed, all of them had second generation self-inflating expanders implanted over a 2-year period for one of two purposes, the treatment of giant nevi or burn scars. Results. Fifteen patients were females and 2 were males. The indication was large burn scar in 14 cases (14/17), in which 47/55 expanders were implanted, and giant nevus in 3/17 cases in which 8/55 expanders were implanted. Extrusion of the expander occurred in 8/55 expanders (14.5%), which occurred in 6/14 patients. The highest percentage of extrusion occurred in the neck in which two out of three expanders extruded; otherwise this complication does not seem to be related to the indication, gender, nor age of the patients. It seems to be that it is technical in nature. The patients did not have to get any injections to fill the tissue expanders, which made the expansion process less painful and more convenient. Conclusion. This seems to be currently the largest published review in which second generation expanders were used. Those expanders seem to offer a desirable advantage of being painless for children, also they do not require repeated visits to the surgeon’s clinic, which is of great value for patients living in the periphery.

scholarly journals Schwann cells contribute to keloid formation

2021 ◽  
Author(s):  
Martin Direder ◽  
Tamara Weiss ◽  
Dragan Copic ◽  
Vera Vorstandlechner ◽  
Maria Laggner ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Normal Skin ◽  
Scar Tissue ◽  
Functional Impairments ◽  
Novel Treatment ◽  
M2 Polarization ◽  
Keloid Formation ◽  
Hypertrophic Scar Tissue ◽  
Schwann Cell Differentiation ◽  
Abundant Population

Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the presence of an abundant population of Schwann cells that persisted in the hypertrophic scar tissue after wound healing. In contrast to normal skin, keloidal Schwann cells possess a repair-like phenotype and high cellular plasticity. Our data support the hypothesis that keloidal Schwann cells contribute to the formation of the extracellular matrix and are able to affect M2 polarization of macrophages. Indeed, we show that macrophages in keloids predominantly display a M2 polarization and produce factors that inhibit Schwann cell differentiation. Our data suggest a contribution of this cross-talk to the continuous expansion of keloids, and that targeting Schwann cells might represent an interesting novel treatment option for keloids.

scholarly journals The effect of human adipose-derived multipotent mesenchymal stromal cells in the fibrin gel on the healing of full-thickness skin excision wounds in mice

2017 ◽  
Vol 5 (1) ◽  
pp. 14-22 ◽  
Author(s):  
O. Tykhvynskaya ◽  
O. Rogulska ◽  
N. Volkova ◽  
E. Revenko ◽  
S. Mazur ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Granulation Tissue ◽  
Stromal Cells ◽  
Healing Process ◽  
Complete Recovery ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Scar Tissue ◽  
Human Blood Plasma ◽  
Full Thickness ◽  
Fibrin Gel

Prospects for the widespread use of multipotent mesenchymal stromal cells (MSCs) in regenerative medicine determine the relevance of studying their abilities to affect the reparative process in experimental systems in vivo.Materials and methods. The effect of human adipose-derived MSCs on the healing rate and completeness of damaged skin site reconstitution was examined using full-thickness excision wound model in mice. The reparative activity of MSCs was revealed in planimetric and histological studies. Human blood plasma-derived fibrin gel was used as a scaffold for MSCs delivery.Results and conclusions. Compared to the spontaneous healing process, application of fibrin gel on the excisional skin wounds promotes earlier maturation of granulation tissue and further formation of loose scar tissue with skin derivates. MSCs in the fibrin gel contribute to the improve of wound epithelialization, the decrease of the inflammatory response, faster maturation of the granulation tissue, including marks of angiogenesis, as well as promotes complete recovery of the dermal and epidermal layers of the damaged site of skin.

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