Mathematical models of the relationship between HDL-Cholesterol and Serum Triglyceride: an empirical evaluation

The relationship between plasma HDL-cholesterol subfractions (HDL2 and HDL3), measured using a differential precipitation method, and serum triglycerides, was studied in 402 healthy Caucasion males attending a health screening centre in London. Mean values for HDL2 and HDL3 were 0·42± 0·24 mmol/L and 0·81±0·15 mmol/L respectively. HDL2 was found to show a stronger negative correlation with serum triglyceride and a stronger positive correlation with total HDL than HDL3. HDL2 also showed a stronger correlation with age than either total HDL or HDL3. Mean levels of HDL2 were 20% higher in subjects over 55 years of age compared with those who were less than 55 years of age. Reference values of HDL2 and HDL3 are presented for different age ranges.

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Subclinical Hypothyroidism and Indices for Metabolic Syndrome in Japanese Women: One-Year Follow-Up Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-1353 ◽

2013 ◽

Vol 98 (8) ◽

pp. 3280-3287 ◽

Cited By ~ 18

Author(s):

Yasuyo Nakajima ◽

Masanobu Yamada ◽

Masako Akuzawa ◽

Sumiyasu Ishii ◽

Yasuhiro Masamura ◽

...

Keyword(s):

Metabolic Syndrome ◽

Odds Ratio ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Free T4 ◽

The Relationship

Context: Subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) increase with age; however, their relationship remains unclear. Objective: Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year. Design: Cross-sectional and longitudinal follow-up studies of cases were collected from Takasaki Hidaka Hospital between 2003 and 2007. Participants: Overall, 11 498 participants of health checkups were analyzed. The mean age was 48 ± 9 years. Main Outcome Measures: The relationship between SCH and indices of MetS were examined. Results: Serum free T4 levels were lower in women than men in most of the age groups, and the prevalence of SCH, 6.3% in women vs 3.4% in men, increased with age, reaching 14.6% in 70-year-old women. Multivariate logistic-regression analyses revealed that waist circumference and the serum triglyceride and low-density lipoprotein-cholesterol levels were significantly higher in subjects with SCH than without among women. Reflecting these findings, the adjusted odds ratio of MetS in patients with SCH was higher than in the euthyroid subjects in women with an odds ratio of 2.7 (95% confidence interval 1.1–5.6; P = .017) but not in men. Furthermore, progression from euthyroid into SCH resulted in a significant increase in the serum triglyceride levels but not low-density lipoprotein-cholesterol in women. Conclusion: Japanese women exhibited a high prevalence of SCH associated with low free T4 levels. There was a strong association between SCH and several indices of metabolic syndrome in women. SCH may affect serum triglyceride levels and be a risk factor for metabolic syndrome.

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The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects

Endocrine Journal ◽

10.1507/endocrj.k07e-039 ◽

2008 ◽

Vol 55 (1) ◽

pp. 205-212 ◽

Cited By ~ 18

Author(s):

Ayumi TOKUNAGA ◽

Atsuko MIURA ◽

Yukiyoshi OKAUCHI ◽

Katsumori SEGAWA ◽

Atsunori FUKUHARA ◽

...

Keyword(s):

Serum Triglyceride ◽

Hdl Cholesterol ◽

Cholesterol Levels ◽

Japanese Subjects

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Mathematical Alternatives to Standard Probability that Provide Selectable Degrees of Precision

10.1093/oxfordhb/9780199607617.013.11 ◽

2017 ◽

Author(s):

Terrence Fine

Keyword(s):

Mathematical Modeling ◽

Mathematical Models ◽

Theory Of Measurement ◽

Belief Functions ◽

Standard Practice ◽

Mathematical Probability ◽

Comparative Probability ◽

The Relationship ◽

Standard Probability

This chapter challenges the nearly universal reliance upon standard mathematical probability for mathematical modeling of chance and uncertain phenomena, and offers four alternatives. In standard practice, precise assignments are made inappropriately, even to the occurrences of events that may be unobservable in principle. Four familiar examples of chance or uncertain phenomena are discussed, about which this is true. The theory of measurement provides an understanding of the relationship between the accuracy of information and the precision with which the phenomenon under examination should be modeled mathematically. The model of modal or classificatory probability offers the least precision. Comparative probability, plausibility/belief functions and upper/lower probabilities are carefully considered. The selectable precision of these alternative mathematical models of chance and uncertainty makes for an improved range of levels of accuracy in modeling the empirical domain phenomena of chance, uncertainty, and indeterminacy. Knowledge of such models encourages further thought in this direction.

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Analysis of Stress and Strain to Determine the Pressure Changes in Tight-Fitting Garment

Autex Research Journal ◽

10.2478/aut-2019-0006 ◽

2020 ◽

Vol 20 (1) ◽

pp. 49-55

Author(s):

Nareerut Jariyapunya ◽

Blažena Musilová

Keyword(s):

Mechanical Properties ◽

Mathematical Models ◽

Initial Phase ◽

Circumferential Stress ◽

The Body ◽

Stress And Strain ◽

Laplace’S Law ◽

Pressure Changes ◽

The Relationship ◽

Laplace's Law

AbstractBased on the mechanical properties of stretch fabrics and Laplace’s law, the mathematical models have been developed enabling one to determine the values of the relationship between the fabric strain and the circumferential stress depending on pressure and diameter of the body. The results obtained refer to the values of the parameters assessed for the initial phase of their exploitation, which allow us to preliminarily predict the values of these parameters.

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Fermentation improved gene modulatory effects of soy milk to lower serum triglyceride and elevate HDL‐cholesterol in SD rats on high cholesterol diets.

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.lb244 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Yunhye Kim ◽

Seung‐Min Lee ◽

Hyejung Choi ◽

Jina Choi ◽

Yue Yi ◽

...

Keyword(s):

Serum Triglyceride ◽

Hdl Cholesterol ◽

Soy Milk ◽

High Cholesterol ◽

Lower Serum ◽

Sd Rats

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PATTERNS OF CHANGES IN FLUORESCENCE OF NADH AND FAD COENZYMES AND THEIR RELATIONSHIP IN SKELETAL MUSCLE IN EARLY POST-MORTEM PERIOD (EXPERIMENTAL STUDY)

Russian Journal of Forensic Medicine ◽

10.19048/fm318 ◽

2020 ◽

Author(s):

Anastasia S. Babkina

Keyword(s):

Skeletal Muscle ◽

Mathematical Models ◽

Fluorescence Intensity ◽

Statistical Significance ◽

Linear Regression Analysis ◽

Post Mortem ◽

Redox Ratio ◽

Measuring Device ◽

Nadh Fluorescence ◽

The Relationship

Abstract. The paper presents changes and mathematical models of autofluorescence of reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) and their redox ratio (RR) in the rat skeletal muscle during the first 24 hours after death. Aim. To establish a pattern of change in the fluorescence intensity of NADH and FAD coenzymes, as well as their relationship in the skeletal muscle during the first 24 hours after death using mathematical modeling. Material and methods. The experiment was performed on Sprague Dawley rats. The fluorescence intensity of FAD and NADH coenzymes in skeletal muscle was measured in situ in living rats under general anesthesia, 5 minutes after euthanasia, and at intervals of 1.5-3 h during the 24-hour postmortem period. To estimate the fluorescence intensity of NADH and FAD coenzymes and to calculate the RR, the Lasma MC-3 fluorescence measuring device with special software was used. The obtained data were analyzed by non-linear regression analysis. The summary, accuracy estimation and significance of the regression equation coefficients were assessed using SigmaPlot 10.0 software. The significance of the regression model was tested using the Fisher F-criterion. Results. During the first 3 hours of the postmortem period, an increase in the mean values of RR and NADH fluorescence was detected, starting from 4.5 and till 24 hours post-mortem their gradual decrease was observed. The relationship between NADH, RR and time after death is characterized by the Weibull equation. The statistical significance of NADH and RR models, based on the obtained equations was considered high. Conclusion. The analysis of the obtained data allowed to create mathematical models describing the relationship between RR and NADH fluorescence intensity and time after death, which confirms non-randomness and regularity of the discovered patterns.time of death; NADH; FAD; auto-fluorescence; redox ratio; early post-mortem changes

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ANALISIS HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN (HDL) PADA PASIEN DIABETES MELLITUS TIPE 2 DI RSUP SANGLAH

Meditory : The Journal of Medical Laboratory ◽

10.33992/m.v4i2.38 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Nyoman Jirna

Keyword(s):

Blood Sugar ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Fasting Blood Sugar ◽

Cholesterol Levels ◽

Sugar Levels ◽

Dm Type 2 ◽

The Relationship

Abstract Diabetes mellitus (DM) is a group of metabolic diseases with characteristic hyperglycemia that happen by abnormal secretions of insulin, insulin action, or both. The condition of insulin resistance in DM type 2 cause abnormal lipid metabolism that indicated by increase or decrease levels of lipid fraction in plasma, include increase levels of Very Low Density Lipoprotein (VLDL) or triglycerides, decrease levels of High Density Lipoprotein (HDL), and formed small dense Low Density Lipoprotein (LDL). The purpose of this study is to determine the relationship between the fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2. The method use an analytical study with cross sectional design. Sampling examined as many as 35 samples by purposive sampling. The relationship between fasting blood sugar levels with HDL cholesterol levels is analyzed by Pearson Product Moment Correlation test. Based on the result concluded that there is a relationship between fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2 in RSUP Sanglah with significant value sig=0,030 (sig

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Abstract 391: Sterol Efflux Function and Protein Composition of HDL Associates With Recovery From Stroke

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.37.suppl_1.391 ◽

2017 ◽

Vol 37 (suppl_1) ◽

Author(s):

Deanna Plubell ◽

Alexandra Fenton ◽

Clark Wayne ◽

Neil A Zakai ◽

Joseph F Quinn ◽

...

Keyword(s):

Stroke Risk ◽

Protein Composition ◽

Hdl Cholesterol ◽

Time Dependent ◽

Stroke Recovery ◽

Control Group ◽

Post Stroke ◽

Dependent Protein ◽

Meta Analyses ◽

The Relationship

Background: Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke are discordant and question the value of HDL-C as a marker for stroke risk prediction. Other properties of HDL-C such as cholesterol efflux capacity (CEC) and proteome, are less studied. Methods: We investigated the changes in HDL CEC and proteome to determine if they are associated with improved stroke recovery. Plasma from age- and lipid profile-matched healthy controls (N = 35) and stroke patients were collected at 24 (early, N = 35) and 96 hour (late, N = 20) post stroke, and analyzed with three independent assays to measure macrophage-mediated, ABCA1 and ABCG1-specific sterol efflux, and HDL proteome. Stroke recovery was assessed at 3 months using the Modified Rankin Scores (MRS) and the NIH Stroke Scale (NIHSS). Results: Both macrophage- and ABCG1-mediated CEC were reduced by 50% ( P <0.0001) and 20% ( P <0.038) in early and late post stroke samples, respectively, compared to the control group. Patients who had comparable or increased CEC between the two-time points exhibited lower NIHSS and MRS indicating better recovery. Proteomic analysis of HDL indicated a distinct time-dependent remodeling post stroke. Coagulation complement cascade proteins (FGB, FGA, A2M, C3) significantly increased (FDR>0.01) early and returned to control levels later, inflammation proteins (SAA1, SAA2, PON1, C4B) increased early and continued to increase. Interestingly, platelet adhesion proteins (DSG1, JUP, ITGB1, ITGA2, TUBB, DNAH3, PF4) were abundantly present in only later samples. Conclusion: 1) patients who maintain or improve HDL CEC post stroke exhibit better recovery scores, 2) post stroke HDL proteome remodeling is dynamic with distinct time-dependent protein signatures that may associate with stroke recovery.

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Pulmonary Vascular Lipid Deposition After Administration of Intravenous Fat to Infants

PEDIATRICS ◽

10.1542/peds.79.1.99 ◽

1987 ◽

Vol 79 (1) ◽

pp. 99-102

Author(s):

Robert J. Shulman ◽

Claire Langston ◽

Richard J. Schanler

Keyword(s):

Risk Factor ◽

Lipid Emulsion ◽

Clinical Course ◽

Serum Triglyceride ◽

Peak Serum ◽

Lipid Deposition ◽

Fat Emulsion ◽

Intravenous Fat Emulsion ◽

Intravenous Lipid Emulsion ◽

The Relationship

The incidence of pulmonary vascular lipid deposits in infants who did or did not receive intravenous lipid emulsion was determined through a review of the pulmonary histopathology and clinical course of 39 neonates who died during a two-year period. The relationship between pulmonary vascular lipid deposits and the duration and amount of administered intravenous fat emulsion was assessed. In addition, the effect of monitored serum triglyceride levels on the development of pulmonary vascular lipid deposits was evaluated. The incidence of pulmonary vascular lipid deposits was greater in the group that received intravenous fat emulsion (P < .02). Both the amount (grams per kilogram per day) and duration (days) of intravenous fat emulsion infusion were correlated positively with severity (P < .05) in infants who had pulmonary vascular lipid deposits. No relationship was seen between peak serum triglyceride levels, the frequency of elevated triglycerides, and pulmonary vascular lipid deposits. Although administered fat emulsion was a risk factor for the development of pulmonary vascular deposits, two of 13 infants who had not received intravenous fat emulsion had such deposits.

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