Abstract 391: Sterol Efflux Function and Protein Composition of HDL Associates With Recovery From Stroke

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Deanna Plubell ◽  
Alexandra Fenton ◽  
Clark Wayne ◽  
Neil A Zakai ◽  
Joseph F Quinn ◽  
...  
Keyword(s):  
Stroke Risk ◽  
Protein Composition ◽  
Hdl Cholesterol ◽  
Time Dependent ◽  
Stroke Recovery ◽  
Control Group ◽  
Post Stroke ◽  
Dependent Protein ◽  
Meta Analyses ◽  
The Relationship

Background: Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke are discordant and question the value of HDL-C as a marker for stroke risk prediction. Other properties of HDL-C such as cholesterol efflux capacity (CEC) and proteome, are less studied. Methods: We investigated the changes in HDL CEC and proteome to determine if they are associated with improved stroke recovery. Plasma from age- and lipid profile-matched healthy controls (N = 35) and stroke patients were collected at 24 (early, N = 35) and 96 hour (late, N = 20) post stroke, and analyzed with three independent assays to measure macrophage-mediated, ABCA1 and ABCG1-specific sterol efflux, and HDL proteome. Stroke recovery was assessed at 3 months using the Modified Rankin Scores (MRS) and the NIH Stroke Scale (NIHSS). Results: Both macrophage- and ABCG1-mediated CEC were reduced by 50% ( P <0.0001) and 20% ( P <0.038) in early and late post stroke samples, respectively, compared to the control group. Patients who had comparable or increased CEC between the two-time points exhibited lower NIHSS and MRS indicating better recovery. Proteomic analysis of HDL indicated a distinct time-dependent remodeling post stroke. Coagulation complement cascade proteins (FGB, FGA, A2M, C3) significantly increased (FDR>0.01) early and returned to control levels later, inflammation proteins (SAA1, SAA2, PON1, C4B) increased early and continued to increase. Interestingly, platelet adhesion proteins (DSG1, JUP, ITGB1, ITGA2, TUBB, DNAH3, PF4) were abundantly present in only later samples. Conclusion: 1) patients who maintain or improve HDL CEC post stroke exhibit better recovery scores, 2) post stroke HDL proteome remodeling is dynamic with distinct time-dependent protein signatures that may associate with stroke recovery.

scholarly journals Paradoks Konsumsi Kopi Terhadap Risiko Kejadian Stroke: Sebuah Kajian Sistematis

2021 ◽  
Vol 3 (1) ◽  
pp. 51-60
Author(s):  
Andi Muh. Aunul Khaliq Gunawan ◽  
Indah Nurul Khairunnisa ◽  
Muthia Kintan Fais
Keyword(s):  
Systematic Review ◽  
Cardiovascular Events ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Increased Risk ◽  
The World ◽  
Meta Analyses ◽  
Relationship Of ◽  
The Relationship

Background: Coffee is one of the drinks most often consumed throughout the world and is the second most popular beverage in the world after water. At present, the effect of coffee consumption on the human body is increasingly being studied, especially on the cardiovascular system. Many studies say that coffee consumption can prevent stroke, either directly or indirectly against stroke risk factors by a variety of mechanisms caused by the compounds contained in coffee. However, to date various prospective studies looking at the relationship between coffee consumption and stroke risk are still inconsistent. Objectives: To determine the relationship of coffee consumption with the risk of stroke. Methods: We searched on MEDLINE and PubMed, using the keywords “coffee” or “caffeine” and "stroke or cardiovascular events" which follows the flow and search rules of the Reporting Item Options for Systematic Review and Meta Analysis (PRISMA) to find studies with cohort design in the last 10 years starting in 2009-2019. Discussion: Among 226 citations identified in this systematic review, only 10 studies met the inclusion criteria. Four studies provided evidence that coffee consumption habits were not associated with an increased risk of stroke, while 6 other studies explaining that more coffee consumption has protective benefits against the risk of stroke. Conclusion: Coffee consumption shows a preventive effect on stroke risk. Keywords: caffeine, coffee, relative risk, stroke risk   Latar Belakang: Kopi merupakan salah satu minuman yang paling sering dikonsumsi di seluruh dunia dan menjadi minuman populer kedua di dunia setelah air. Saat ini, pengaruh konsumsi kopi untuk tubuh manusia semakin banyak diteliti, khususnya terhadap sistem kardiovaskular. Banyak penelitian mengatakan bahwa konsumsi kopi dapat mencegah timbulnya penyakit stroke, baik secara langsung atau tidak langsung terhadap faktor risiko stroke dengan beragam mekanisme yang ditimbulkan oleh senyawa yang terkandung dalam kopi. Namun, hingga saat ini beragam studi prospektif yang mengamati hubungan antara konsumsi kopi dan risiko stroke masih belum konsisten. Tujuan: Untuk mengetahui hubungan konsumsi kopi dengan risiko terjadinya stroke. Metode: Pencarian dilakukan pada MEDLINE dan PubMed dengan menggunakan kata kunci “coffee or caffeine” and “stroke or cardiovascular events”. yang mengikuti alur dan kaidah pencarian Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) untuk mencari studi dengan desain cohort dalam rentang waktu 10 tahun terakhir mulai tahun 2009-2019. Pembahasan: Dari 226 sitasi yang teridentifikasi pada systematic review, hanya 10 studi yang sesuai dengan kriteria inklusi. Empat penelitian memberikan bukti bahwa kebiasaan mengonsumsi kopi tidak dikaitkan dengan peningkatan risiko stroke, sedangkan 6 penelitian lainnya, menjelaskan bahwa konsumsi kopi yang lebih banyak memiliki manfaat perlindungan terhadap risiko kejadian stroke. Kesimpulan: Konsumsi kopi menunjukkan efek pencegahan terhadap risiko stroke. Kata Kunci: kafein, kopi, risiko relatif, risiko stroke

Effects of Acupuncture at Taixi Acupoint (KI3) on Kidney Proteome

2011 ◽  
Vol 39 (04) ◽  
pp. 687-692 ◽  
Author(s):  
Chun-Ri Li ◽  
Ze-Dong Cheng ◽  
Zhi-Xing Zhang ◽  
Andre Kim ◽  
Jong-Myung Ha ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Protein Composition ◽  
Quinone Reductase ◽  
Acupuncture Group ◽  
Control Group ◽  
Two Dimensional Gel Electrophoresis ◽  
Flight Mass Spectrometry ◽  
Male Wistar Rats ◽  
Electrophilic Stress ◽  
The Relationship

This research explored and identified the protein composition of rat kidneys after acupuncture at the Taixi acupoint (KI3). Twelve adult male Wistar rats were randomly divided into a control group (n = 6) and an acupuncture group (n = 6). Rats in the acupuncture group received electroacupuncture on the bilateral KI3 for seven days. The kidneys were perfused with ice-cold saline and all kidney proteins were isolated. After protein sample preparation, two-dimensional gel electrophoresis (2-DE) was performed. The interesting spots were analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). There were nine protein spots with three-fold up-regulation in the kidney after the acupuncture. NAD-dependent isocitrate dehydrogenase and quinone reductase, the proteins involved in energy metabolism, the reduction of endogenous quinones, chemoprotection, and electrophilic stress, were identified. The data indicated that acupuncture at the KI3 of the kidney meridian of the foot shaoyin was able to increase NAD-dependent isocitrate dehydrogenase and quinone reductase expression in the kidney, and supported the relationship between the kidney and KI3.

scholarly journals APOA5 gene polymorphism assessment and association with hypertriglyceridemia in the military force of the State of Goiás

2021 ◽  
Vol 10 (7) ◽  
pp. e8410716229
Author(s):  
Raphael dos Reis Frazao Silva ◽  
Tiago Lemos de Nascimento ◽  
Antonio Marcio Teodoro Cordeiro Silva ◽  
Sergio Henrique Nascente Costa ◽  
Frank Sousa Castro ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Lipid Profile ◽  
Real Time ◽  
Hdl Cholesterol ◽  
The State ◽  
Control Group ◽  
Military Force ◽  
Cholesterol Levels ◽  
The Military ◽  
The Relationship

According to the World Health Organization (WHO), dyslipidemias are determinant for the onset of cardiovascular diseases and represent more than 30% of global deaths. Changes in serum lipid levels are a direct consequence of dyslipidemia.   This study aimed to verify the relationship between genetic polymorphism APOA5  and dyslipidemia. This is a case-control study with 199 officers of the military force of the state of Goiás in which the relationship between lipid profile and genetic polymorphism rs964184 was evaluated. Real-time Polymerase Chain Reaction (real-time PCR) was used to identify genetic polymorphism rs964184. Of the participants analyzed, 93% were male and 7% female, the lipid profile showed that 115 participants had dyslipidemia (group of cases) and 84 were within the reference range (control group). The genetic polymorphism rs964184 of the case group showed that 64.3% (74/115) of the participants had genotype CC, 33.0% (38/115) had cg genotype and 2.6% (3/115) had GG genotype. In the control group, 69.0% (58/84) had genotype CC, 27.4% (23/84) had cg genotype, 3.6% (3/84) had GG genotype. In conclusion, the G alllea is related to high levels of triglycerides (≥ 150 mg/dL) and the C allea is related to normal HDL cholesterol levels (≥ 40 mg/dL). Therefore, homozygous (GG) or heterozygous (CG) individuals are more inclined to have high triglycerides and low HDL cholesterol levels, which are associated with an increased risk of developing cardiovascular disease.

scholarly journals MINDFULNESS DENGAN PERILAKU PERAN SAKIT PADA PASIEN PASCA STROKE

2020 ◽  
Vol 2 (2) ◽  
pp. 88-94
Author(s):  
Andi Dian Diarfah ◽  
Andi Weri Sompa
Keyword(s):  
Data Analysis ◽  
Family Support ◽  
Stroke Recovery ◽  
Sick Role ◽  
Stroke Patients ◽  
Common Cause ◽  
Role Behavior ◽  
Post Stroke ◽  
Process Scale ◽  
The Relationship

Stroke is a common cause of disability and has a large impact on an individual's life. Stroke recovery is very individual and requires a long process. Family support is not enough to give effect to the recovery of post-stroke sufferers, the mindfulness of post-stroke sufferers themselves to recover is also needed. The purpose was determined the relationship between mindfulness with sick role behavior in post-stroke patients with. The subjects were 110 people with characteristics aged 30-65 years. The instruments of this study were the Applied Mindfulness Process Scale (AMPS) and Barcylas Sick Role Process Inventory (BSRPI). The technique of Mediated Multiple Regression was the data analysis. The results showed there was a correlation between mindfulness and sick role behavior  (β = 0.51, p 0.05).

scholarly journals Meta-analysis of 5-hydroxytryptamine transporter gene promoter region polymorphism and post-stroke depression

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092594
Author(s):  
Yukai Wang ◽  
HongYu Liu ◽  
Yan Jiang ◽  
Xinxiu Shi ◽  
Yankun Shao ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Subgroup Analysis ◽  
Promoter Region ◽  
Gene Promoter ◽  
Control Group ◽  
Transporter Gene ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
The Relationship ◽  
Gene Promoter Region

Objective To investigate the relationship between 5-hydroxytryptamine transporter gene promoter region ( 5-HTTLPR) gene polymorphism and post-stroke depression (PSD). Methods We searched the CNKI, China Science and Technology Journal, China WanFang, PubMed, Embase, and Web of Science databases for studies of the relationship between 5-HTTLPR polymorphism and PSD. Data were evaluated using Stata software. Results The L allele was significantly related to the S allele (OR = 0.57, 95% confidence interval (CI) 0.49–0.65). The dominant genotype LL + LS was related to SS (OR = 0.48, 95%CI 0.39–0.59), the recessive genotype LL was related to LS + SS (OR = 0.39, 95%CI: 0.30–0.51), the homozygous genotype LL was related to SS (OR = 0.24, 95%CI 0.18–0.33), and the heterozygous genotype LS was related to SS (OR = 0.55, 95 CI 0.44–0.68). All the differences were significant. Ethnicity subgroup analysis showed significant differences among the five genotypes in both Asians and Caucasians. Hardy–Weinberg equilibrium (HWE) subgroup analysis showed that, after removal of a non-HWE-conforming control group, all five genotypes were significant and genotypes LL, LS + LL, and LS and L allele had beneficial effects on recovery from PSD. Conclusion 5-HTTLPR gene polymorphism is strongly associated with PSD, and the LL, LS + LL, and LS genotypes and L allele may protect against this condition.

scholarly journals The Impact of Voluntary Exercise on Stroke Recovery

2021 ◽  
Vol 15 ◽  
Author(s):  
Klara J. Lohkamp ◽  
Amanda J. Kiliaan ◽  
Justin Shenk ◽  
Vivienne Verweij ◽  
Maximilian Wiesmann
Keyword(s):  
Functional Connectivity ◽  
Voluntary Exercise ◽  
Stroke Recovery ◽  
Control Group ◽  
Therapeutic Effects ◽  
Stroke Treatment ◽  
Post Stroke ◽  
Post Surgery ◽  
Running Wheels ◽  
The Impact

Stroke treatment is limited to time-critical thrombectomy and rehabilitation by physiotherapy. Studies report beneficial effects of exercise; however, a knowledge gap exists regarding underlying mechanisms that benefit recovery of brain networks and cognition. This study aims to unravel therapeutic effects of voluntary exercise in stroke-induced mice to develop better personalized treatments. Male C57Bl6/JOlaHsd mice were subjected to transient middle cerebral artery occlusion. After surgery, the animals were divided in a voluntary exercise group with access to running wheels (RW), and a control group without running wheels (NRW). During 6 days post-stroke, activity/walking patterns were measured 24/7 in digital ventilated cages. Day 7 post-surgery, animals underwent MRI scanning (11.7T) to investigate functional connectivity (rsfMRI) and white matter (WM) integrity (DTI). Additionally, postmortem polarized light imaging (PLI) was performed to quantify WM fiber density and orientation. After MRI the animals were sacrificed and neuroinflammation and cerebral vascularisation studied. Voluntary exercise promoted myelin density recovery corresponding to higher fractional anisotropy. The deteriorating impact of stroke on WM dispersion was detected only in NRW mice. Moreover, rsfMRI revealed increased functional connectivity, cerebral blood flow and vascular quality leading to improved motor skills in the RW group. Furthermore, voluntary exercise showed immunomodulatory properties post-stroke. This study not only helped determining the therapeutic value of voluntary exercise, but also provided understanding of pathological mechanisms involved in stroke.

Problems of post-hospital rehabilitation of patients suffering from post-stroke depression

2020 ◽  
pp. 31-37
Author(s):  
M. A. Privalova ◽  
L. A. Karasaeva ◽  
G. A. Alekseev ◽  
A. A. Okhotnikova
Keyword(s):  
Cerebrovascular Accident ◽  
Recovery Period ◽  
Main Group ◽  
Stroke Recovery ◽  
Control Group ◽  
Antidepressant Medications ◽  
Post Stroke ◽  
Acute Cerebrovascular Accident ◽  
Post Stroke Depression ◽  
Hospital Rehabilitation

The article covers the issues of organization of rehabilitation at the post-hospital stage for patients who have suffered an acute cerebrovascular accident. According to statistics, almost half of patients who have suffered an acute cerebrovascular accident have a risk of a repeated stroke in the next five years of life against the background of manifestations of post-stroke depression. It is established that in these cases, one of the causes of repeated cerebrovascular accidents is the failure of patients to take prescribed antidepressant medications. The article analyzes two groups of patients who were observed in dynamics up to 6–12 months after the rehabilitation treatment in the Department of Neurology of the hospital. The main group included the patients with diagnosed post-stroke depression. The control group included patients without signs of clinically apparent depression. As a result of a retrospective study, it was found that 85,7 % of patients in the main group who had a repeated stroke did not adhere to the regime for taking antidepressant medications. Among the patients who continue to take antidepressants, there have not been repeated cases of cerebral circulatory disorders. Therefore, timely detection and correction of post-stroke depression in the early stroke recovery period and maintaining the principle of continuity at the post-hospital stage of rehabilitation contributes not only to the recovery of neurological deficit, but also reduces the risk of developing repeated disorders of cerebral circulation.

scholarly journals Quantitative Evaluation of Task-Induced Neurological Outcome after Stroke

2021 ◽  
Vol 11 (7) ◽  
pp. 900
Author(s):  
Iqram Hussain ◽  
Se-Jin Park
Keyword(s):  
Ischemic Stroke ◽  
Neurological Outcome ◽  
Healthy Adults ◽  
Stroke Recovery ◽  
Control Group ◽  
Stroke Patients ◽  
Stroke Treatment ◽  
Post Stroke ◽  
Continuous Eeg ◽  
Stroke Group

Electroencephalography (EEG) can access ischemic stroke-derived cortical impairment and is believed to be a prospective predictive method for acute stroke prognostics, neurological outcome, and post-stroke rehabilitation management. This study aims to quantify EEG features to understand task-induced neurological declines due to stroke and evaluate the biomarkers to distinguish the ischemic stroke group and the healthy adult group. We investigated forty-eight stroke patients (average age 72.2 years, 62% male) admitted to the rehabilitation center and seventy-five healthy adults (average age 77 years, 31% male) with no history of known neurological diseases. EEG was recorded through frontal, central, temporal, and occipital cortical electrodes (Fz, C1, C2, T7, T8, Oz) using wireless EEG devices and a newly developed data acquisition platform within three months after the appearance of symptoms of ischemic stroke (clinically confirmed). Continuous EEG data were recorded during the consecutive resting, motor (walking and working activities), and cognitive reading tasks. The statistical results showed that alpha, theta, and delta activities are biomarkers classifying the stroke patients and the healthy adults in the motor and cognitive states. DAR and DTR of the stroke group differed significantly from those of the healthy control group during the resting, motor, and cognitive tasks. Using the machine-learning approach, the C5.0 model showed 78% accuracy for the resting state, 89% accuracy in the functional motor walking condition, 84% accuracy in the working condition, and 85% accuracy in the cognitive reading state for classification the stroke group and the control group. This study is expected to be helpful for post-stroke treatment and post-stroke recovery.

Adolescents’ self-mutilation - Relationship with dependent behaviour

2003 ◽  
Vol 62 (4) ◽  
pp. 241-249 ◽  
Author(s):  
M. Bolognini ◽  
B. Plancherel ◽  
J. Laget ◽  
P. Stéphan ◽  
O. Halfon
Keyword(s):  
Suicide Attempts ◽  
Clinical Sample ◽  
Control Sample ◽  
Clinical Population ◽  
Control Group ◽  
Clinical Group ◽  
Self Mutilation ◽  
Self Harm ◽  
Partial Overlap ◽  
The Relationship

The aim of this study, which was carried out in the French-speacking part of Switzerland, was to examine the relationship between suicide attempts and self-mutilation by adolescents and young adults. The population, aged 14-25 years (N = 308), included a clinical sample of dependent subjects (drug abuse and eating disorders) compared to a control sample. On the basis of the Mini Neuropsychiatric Interview ( Sheehan et al., 1998 ), DSM-IV criteria were used for the inclusion of the clinical population. The results concerning the occurrence of suicide attempts as well as on self-mutilation confirm most of the hypotheses postulated: suicidal attempts and self-mutilation were more common in the clinical group compared to the control group, and there was a correlation between suicide attempts and self-mutilation. However, there was only a partial overlap, attesting that suicide and self-harm might correspond to two different types of behaviour.

A Meta-Analysis of Interviews and Cognitive Ability

2013 ◽  
Vol 12 (4) ◽  
pp. 157-169 ◽  
Author(s):  
Philip L. Roth ◽  
Allen I. Huffcutt
Keyword(s):  
Cognitive Ability ◽  
Meta Analysis ◽  
Incremental Validity ◽  
Employment Interviews ◽  
Moderator Analysis ◽  
The Future ◽  
Research Questions ◽  
Meta Analyses ◽  
The Relationship

The topic of what interviews measure has received a great deal of attention over the years. One line of research has investigated the relationship between interviews and the construct of cognitive ability. A previous meta-analysis reported an overall corrected correlation of .40 ( Huffcutt, Roth, & McDaniel, 1996 ). A more recent meta-analysis reported a noticeably lower corrected correlation of .27 ( Berry, Sackett, & Landers, 2007 ). After reviewing both meta-analyses, it appears that the two studies posed different research questions. Further, there were a number of coding judgments in Berry et al. that merit review, and there was no moderator analysis for educational versus employment interviews. As a result, we reanalyzed the work by Berry et al. and found a corrected correlation of .42 for employment interviews (.15 higher than Berry et al., a 56% increase). Further, educational interviews were associated with a corrected correlation of .21, supporting their influence as a moderator. We suggest a better estimate of the correlation between employment interviews and cognitive ability is .42, and this takes us “back to the future” in that the better overall estimate of the employment interviews – cognitive ability relationship is roughly .40. This difference has implications for what is being measured by interviews and their incremental validity.

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