Graphene Oxide for Drug Delivery and Cancer Therapy

2019 ◽  
pp. 447-488
Author(s):  
Romina Muñoz ◽  
Dinesh Pratap Singh ◽  
Rajesh Kumar ◽  
Atsunori Matsuda
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

Amphiphilic prodrug-decorated graphene oxide as a multi-functional drug delivery system for efficient cancer therapy

2018 ◽  
Vol 89 ◽  
pp. 15-24 ◽  
Author(s):  
Chunzhi Huang ◽  
Jilian Wu ◽  
Wei Jiang ◽  
Ruiling Liu ◽  
Zhonghao Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System

Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy

2018 ◽  
Vol 6 (26) ◽  
pp. 4360-4367 ◽  
Author(s):  
Wenjing Jiang ◽  
Fan Mo ◽  
Yaohui Lin ◽  
Xusheng Wang ◽  
LiangJun Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Reduced Graphene Oxide ◽  
Tumor Targeting ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Reduced Graphene ◽  
Controllable Release

A tumor targeting dual stimuli responsive controllable release drug delivery nanoplatform was fabricated for chemo-photothermal synergetic cancer therapy based on DNA-conjugated reduced graphene oxide.

Supramolecular Nanomedicine Derived from Cucurbit[7]uril-Conjugated Nano-Graphene Oxide for Multi-modality Cancer Therapy

2021 ◽  
Author(s):  
Yuan-Fu Ding ◽  
Cheryl Kwong ◽  
Shengke Li ◽  
Yating Pan ◽  
Jianwen Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Surface Functionalization ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Π Stacking ◽  
Nano Graphene

Nano-graphene oxide (NGO) has attracted increasing attentions as advanced drug delivery systems. However, the current surface functionalization and drug-loading of NGO either relies on π−π stacking that is limited to...

scholarly journals Graphene Oxide-Based Stimuli-Responsive Platforms for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2797
Author(s):  
Tejal V. Patil ◽  
Dinesh K. Patel ◽  
Sayan Deb Dutta ◽  
Keya Ganguly ◽  
Ki-Taek Lim
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Electric Fields ◽  
High Surface ◽  
High Surface Area ◽  
Stimuli Responsive ◽  
Internal Factors ◽  
Responsive Materials

Graphene is a two-dimensional sp2 hybridized carbon material that has attracted tremendous attention for its stimuli-responsive applications, owing to its high surface area and excellent electrical, optical, thermal, and mechanical properties. The physicochemical properties of graphene can be tuned by surface functionalization. The biomedical field pays special attention to stimuli-responsive materials due to their responsive abilities under different conditions. Stimuli-responsive materials exhibit great potential in changing their behavior upon exposure to external or internal factors, such as pH, light, electric field, magnetic field, and temperature. Graphene-based materials, particularly graphene oxide (GO), have been widely used in stimuli-responsive applications due to their superior biocompatibility compared to other forms of graphene. GO has been commonly utilized in tissue engineering, bioimaging, biosensing, cancer therapy, and drug delivery. GO-based stimuli-responsive platforms for wound healing applications have not yet been fully explored. This review describes the effects of different stimuli-responsive factors, such as pH, light, temperature, and magnetic and electric fields on GO-based materials and their applications. The wound healing applications of GO-based materials is extensively discussed with cancer therapy and drug delivery.

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

Chitosan-Based Hydrogel Nanoparticles for Cancer Therapy

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Azadi A. ◽  
Khazaei M. ◽  
Ashrafi H.
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Recent Decade ◽  
Reticuloendothelial System ◽  
Malignant Neoplasms ◽  
Mortality And Morbidity ◽  
Hydrogel Nanoparticles ◽  
Tissue Invasion ◽  
Causes Of Mortality ◽  
Nanoparticulate Systems

Cancer, an uncontrollable growth of cells, is among the leading causes of mortality and morbidity throughout the world. Malignant neoplasms are difficult to treat diseases because of their single in kind characteristics such as tissue invasion, metastasis, evading reticuloendothelial system (RES) and so forth. In recent decade polymeric nanoparticulate systems has gained special attention in drug delivery and targeting among all biocompatible nanoforms. Among these systems, chitosan-based hydrogel nanoparticles have been wildly utilized for drug delivery purposes. The usage of chitosan nanogels in cancer therapy significantly improved in recent years. The various cancers were the target of chitosan nanogels. Also, modification of other delivery systems with chitosan were much reported. The aim of this study is the review and update of the recent studies on chitosan nanogels applications in cancer therapy by focus on cancer based classification.

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

2017 ◽  
Vol 10 (4) ◽  
pp. 3768-3771
Author(s):  
Soumitra Satapathi ◽  
Rutusmita Mishra ◽  
Manisha Chatterjee ◽  
Partha Roy ◽  
Somesh Mohapatra
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Cell ◽  
High Surface ◽  
High Surface Area ◽  
Cancer Cell Line ◽  
Xrd Analysis ◽  
Graphene Derivatives ◽  
Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

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