Neuropeptide profile changes in sensory neurones after partial prepyloric resection in pigs

2016 ◽  
Vol 206 ◽  
pp. 48-56 ◽  
Author(s):  
L. Rytel ◽  
J. Całka
Author(s):  
Furkaan Majied Hamied ◽  
Deyaa Neama Kadhim ◽  
Sohaib A Mahmood

In order to facilitate the corneal stromal ablation in photorefractive keratectomy the epithelium is removed so corneal repair associated with changes in epithelium and stroma. To study the corneal epithelial thickness and pachymetry profile changes after photorefractive keratec­tomy (PRK) for myopia. Retrospective analysis of the postoperative corneal epithelial thickness and pachymetry profile changes in 22 eyes of 12 patients treated with PRK for myopia or myopic astigmatism. Corneal and epithelial thickness maps within the central 6 mm were obtained by anterior segment spectral-domain optical coherence tomography (SD-OCT) preop­eratively and at 3 months postoperatively. Correlations between pachymetry,epithelial thickness changes and the amount of correction,were analyzed.Compared to preoperative values,the central 2 mm and the paracentral 2 to 5 mm zone epithelium was 1 ± 2.85 and 1 ± 3.11 μm thicker,respec­tively,at 3 months postoperatively (P <.05). The spheri­cal equivalent (SE) changed from-2.80 ± 2.028 diop­ters (D) preoperatively to -0.40 ± 0.42 D at 3 months postoperatively. Females show greater postoperative epithelial thickening, 2.6 ± 3.77 μm,than males,0.34 ± 1.98 μm. There was a trend toward greater epithelial thickening with a larger amount of programmed SE correction, and thinner preoperative epithelium. No correlation between epithelial thickness change and postoperative change in refraction was detected.Negative correlation between between age, refractive error,with the pre and post-operative pachymetry. In general female pachymetry reading is higher than it in male.The corneal epithelial thickness in­creased after PRK up to 3 months postoperatively. It was affected by the amount of myopia treated, gender, and preoperative epithelial thickness. The refractive outcomes did not affected by the postoperative epithelial thickening. Negative correlation between between age, refractive error, with the pre and post-operative pachymetry. In general female pachymetry reading is higher than it in male.


Energies ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1478
Author(s):  
Radoslaw Wrobel ◽  
Gustaw Sierzputowski ◽  
Zbigniew Sroka ◽  
Radostin Dimitrov

Alternative fuels appeared soon after the first internal combustion engines were designed. The history of alternative fuels is basically as long as the history of the automotive industry. Initially, fuels whose physicochemical properties allowed for a change in parameters of the combustion process in order to achieve greater efficiency and reliability were searched for. Nowadays, there are significantly more variables; in addition to the above mentioned parameters, alternative fuels are being sought that will ensure environmental protection during vehicle operation and improve the ergonomics of use. This article outlines the results of the authors’ own comparative tests of vibrations of a vibroacoustic character. Based on a popular engine model, the vibration–acoustic responses of a system powered by two types of fuel, namely, diesel and biodiesel (B10), are compared. The research consists of comparing vibrations in both time and frequency domains. In the case of the time domain, the evaluation was performed with vibrations as a function of engine torque and speed. In the case of frequency analysis, the focus was on changes in the frequency response for the tested fuels. The research shows that the profile of vibroacoustic vibrations changes in the case of biodiesel power supply in relation to standard fuel. The vibration profile changes significantly as a function of speed and only slightly in relation to the engine load. The results presented in this article show different vibroacoustic responses of an engine powered by diesel and biodiesel; the change is minor for lower speeds but significant (other harmonics are dominant) for higher speeds (changes in the dominant harmonic magnitude of up to 10% at a crankshaft speed of 3000 rpm).


Author(s):  
Sabrina Di Masi ◽  
Giuseppe E. De Benedetto ◽  
Cosimino Malitesta ◽  
Maria Saponari ◽  
Cinzia Citti ◽  
...  

AbstractOlive quick decline syndrome (OQDS) is a disorder associated with bacterial infections caused by Xylella fastidiosa subsp. pauca ST53 in olive trees. Metabolic profile changes occurring in infected olive trees are still poorly investigated, but have the potential to unravel reliable biomarkers to be exploited for early diagnosis of infections. In this study, an untargeted metabolomic method using high-performance liquid chromatography coupled to quadrupole-time-of-flight high-resolution mass spectrometry (HPLC-ESI-Q-TOF-MS) was used to detect differences in samples (leaves) from healthy (Ctrl) and infected (Xf) olive trees. Both unsupervised and supervised data analysis clearly differentiated the groups. Different metabolites have been identified as potential specific biomarkers, and their characterization strongly suggests that metabolism of flavonoids and long-chain fatty acids is perturbed in Xf samples. In particular, a decrease in the defence capabilities of the host after Xf infection is proposed because of a significant dysregulation of some metabolites belonging to flavonoid family. Moreover, oleic acid is confirmed as a putative diffusible signal factor (DSF). This study provides new insights into the host-pathogen interactions and confirms LC-HRMS-based metabolomics as a powerful approach for disease-associated biomarkers discovery in plants. Graphical abstract


Author(s):  
Varun Gupta ◽  
Pradeep Tandon ◽  
Dipti Shastri ◽  
Vinay K. Chugh
Keyword(s):  

2021 ◽  
Vol 9 (2) ◽  
pp. 354
Author(s):  
Nuria Crua Asensio ◽  
Javier Macho Rendón ◽  
Marc Torrent Burgas

The rise in the number of antibiotic-resistant bacteria has become a serious threat to health, making it important to identify, characterize and optimize new molecules to help us to overcome the infections they cause. It is well known that Acinetobacter baumannii has a significant capacity to evade the actions of antibacterial drugs, leading to its emergence as one of the bacteria responsible for hospital and community-acquired infections. Nonetheless, how this pathogen infects and survives inside the host cell is unclear. In this study, we analyze the time-resolved transcriptional profile changes observed in human epithelial HeLa cells after infection by A. baumannii, demonstrating how it survives in host cells and starts to replicate 4 h post infection. These findings were achieved by sequencing RNA to obtain a set of Differentially Expressed Genes (DEGs) to understand how bacteria alter the host cells’ environment for their own benefit. We also determine common features observed in this set of genes and identify the protein–protein networks that reveal highly-interacted proteins. The combination of these findings paves the way for the discovery of new antimicrobial candidates for the treatment of multidrug-resistant bacteria.


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