A novel electrochemical biosensor for lung cancer-related gene detection based on copper ferrite-enhanced photoinitiated chain-growth amplification

2021 ◽  
pp. 338843
Author(s):  
Qianrui Liu ◽  
Huifang Xie ◽  
Jingliang Liu ◽  
Jinming Kong ◽  
Xueji Zhang
Keyword(s):  
Lung Cancer ◽  
Electrochemical Biosensor ◽  
Chain Growth ◽  
Copper Ferrite ◽  
Related Gene ◽  
Gene Detection ◽  
Cancer Related Gene

scholarly journals Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Jun Lu ◽  
Xiaoli Zhang ◽  
Tingting Shen ◽  
Chao Ma ◽  
Jun Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Regulation Of Transcription ◽  
Peptidase Activity ◽  
Gene Ontology Analysis ◽  
Apoptosis Induction ◽  
Related Gene ◽  
Cancer Related Gene ◽  
Intracellular Signal ◽  
Profiling Analysis

Traditional Chinese medicine Jinfukang (JFK) has been clinically used for treating lung cancer. To examine whether epigenetic modifications are involved in its anticancer activity, we performed a global profiling analysis of H3K4Me3, an epigenomic marker associated with active gene expression, in JFK-treated lung cancer cells. We identified 11,670 genes with significantly altered status of H3K4Me3 modification following JFK treatment (P<0.05). Gene Ontology analysis indicates that these genes are involved in tumor-related pathways, including pathway in cancer, basal cell carcinoma, apoptosis, induction of programmed cell death, regulation of transcription (DNA-templated), intracellular signal transduction, and regulation of peptidase activity. In particular, we found that the levels of H3K4Me3 at the promoters ofSUSD2, CCND2, BCL2A1,andTMEM158are significantly altered in A549, NCI-H1975, NCI-H1650, and NCI-H2228 cells, when treated with JFK. Collectively, these findings provide the first evidence that the anticancer activity of JFK involves modulation of histone modification at many cancer-related gene loci.

Genome-Wide Analysis of mRNA Expression Profiling Identified Lung Cancer-Related Gene in Xuanwei, China

2018 ◽  
Vol 64 (09/2018) ◽  
Author(s):  
Chunyan Wu ◽  
Guibo Song ◽  
Guosheng Xiong ◽  
Lingjiao Lu ◽  
Xin Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mrna Expression ◽  
Expression Profiling ◽  
Related Gene ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Cancer Related Gene ◽  
Mrna Expression Profiling

Detection EGFR exon 19 status of lung cancer patients by DNA electrochemical biosensor

2016 ◽  
Vol 80 ◽  
pp. 411-417 ◽  
Author(s):  
Xiong-Wei Xu ◽  
Xiu-Hua Weng ◽  
Chang-Lian Wang ◽  
Wei-Wei Lin ◽  
Ai-Lin Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Electrochemical Biosensor ◽  
Dna Electrochemical Biosensor ◽  
Lung Cancer Patients ◽  
Exon 19

Twin target self-amplification-based DNA machine for highly sensitive detection of cancer-related gene

2018 ◽  
Vol 1011 ◽  
pp. 86-93 ◽  
Author(s):  
Huo Xu ◽  
Yifan Jiang ◽  
Dengyou Liu ◽  
Kai Liu ◽  
Yafeng Zhang ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
Related Gene ◽  
Highly Sensitive ◽  
Cancer Related Gene ◽  
Dna Machine ◽  
Highly Sensitive Detection
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