A comparison of self-reported puberty using the Pubertal Development Scale and the Sexual Maturation Scale in a school-based epidemiologic survey

2006 ◽  
Vol 29 (5) ◽  
pp. 709-720 ◽  
Author(s):  
Lyndal Bond ◽  
Jackie Clements ◽  
Nadine Bertalli ◽  
Tracy Evans-Whipp ◽  
Barbara J. McMorris ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Pubertal Development ◽  
Epidemiologic Survey ◽  
School Based

scholarly journals The Role of Fetal, Infant, and Childhood Nutrition in the Timing of Sexual Maturation

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 419
Author(s):  
Valeria Calcaterra ◽  
Hellas Cena ◽  
Corrado Regalbuto ◽  
Federica Vinci ◽  
Debora Porri ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Pubertal Development ◽  
Endocrine System ◽  
Metabolic Adaptation ◽  
Fetal Life ◽  
Critical Periods ◽  
Important Indicator ◽  
Prenatal Growth ◽  
Adaptation Response ◽  
Healthy Growth

Puberty is a crucial developmental stage in the life span, necessary to achieve reproductive and somatic maturity. Timing of puberty is modulated by and responds to central neurotransmitters, hormones, and environmental factors leading to hypothalamic-pituitary-gonadal axis maturation. The connection between hormones and nutrition during critical periods of growth, like fetal life or infancy, is fundamental for metabolic adaptation response and pubertal development control and prediction. Since birth weight is an important indicator of growth estimation during fetal life, restricted prenatal growth, such as intrauterine growth restriction (IUGR) and small for gestational age (SGA), may impact endocrine system, affecting pubertal development. Successively, lactation along with early life optimal nutrition during infancy and childhood may be important in order to set up timing of sexual maturation and provide successful reproduction at a later time. Sexual maturation and healthy growth are also influenced by nutrition requirements and diet composition. Early nutritional surveillance and monitoring of pubertal development is recommended in all children, particularly in those at risk, such as the ones born SGA and/or IUGR, as well as in the case of sudden weight gain during infancy. Adequate macro and micronutrient intake is essential for healthy growth and sexual maturity.

Body phenotypes and sexual maturation in Brazilian and US adolescents: evidence for a change in body mass index Category

2020 ◽  
pp. 1-26
Author(s):  
Jéssica Cumpian Silva ◽  
Ana Elisa Madalena Rinaldi ◽  
Francisco de Assis Guedes Vasconcelos ◽  
Maria Alice Altenburg Assis ◽  
Camila Medeiros Mazzeti ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Body Mass ◽  
Phase Angle ◽  
Sexual Maturation ◽  
Biochemical Parameters ◽  
Pubertal Development ◽  
The United States ◽  
Pubic Hair ◽  
Cholesterol Ratio

ABSTRACT Objective: Our study aimed to describe body phenotypes (BP) estimated by multivariate analysis and their association with body mass. Design: Body phenotypes were defined based on demographic variables, anthropometric data (body mass, height, skinfolds and circumferences), body composition (phase angle measured by bioelectrical impedance analysis), biochemical parameters (triglycerides, glucose, total cholesterol ratio/Low Density Lipoproteins (LDL), haemoglobin and sexual maturation (pubic hair and breasts or gonads). Analysis of variance (ANOVA) was performed to verify the differences between skin colour and the stages of pubertal development, body phenotypes, body composition, anthropometric, and biochemical variables. Setting: Cities of São Paulo-SP, Piracicaba-SP and Florianópolis-SC from Brazil and the United States. Participants: 9269 adolescents aged between 10 to 15 years old. Results: The composition of BP was similar in all surveys, which are: BP1 was composed by skinfolds, body mass and circumferences variables; BP2 by pubic hair, breast in girls or gonad in boys, height and age; BP3 by cholesterol, triglycerides and glucose; and BP4 by phase angle, haemoglobin and glucose (negative loading). There was a strong correlation (r = 0.9, p <0.001) between BP1 and body mass index. Conclusion: We highlighted independence observed between biochemical parameters, anthropometry, body composition and sexual maturation. BP may support the calculation of scores for diagnosis of obesity based on anthropometric variables and overcome ambiguity in the isolated use of body mass index.

scholarly journals MiR-505-3p is a Repressor of the Puberty Onset in Female Mice miR-505-3p and the puberty onset

2018 ◽  
Author(s):  
Yuxun Zhou ◽  
Li Tong ◽  
Maochun Wang ◽  
Xueying Chang ◽  
Sijia Wang ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Positional Cloning ◽  
Target Gene ◽  
Pubertal Development ◽  
Ectopic Expression ◽  
Reproductive Capacity ◽  
Vaginal Opening ◽  
Female Mice ◽  
Puberty Onset ◽  
The Impact

AbstractPuberty onset is a complex trait regulated by multiple genetic and environmental factors. In this study, we narrowed a puberty related QTL down to a 1.7 Mb region on chromosome X in female mice and inferred miR-505-3p as the functional gene.We conducted ectopic expression of miR-505-3p in the hypothalamus of prepubertal female mice through lentivirus-mediated orthotopic injection. The impact of miR-505-3p on female puberty was evaluated by the measurement of pubertal events and histological analysis. The results showed that female mice with overexpression of miR-505-3p in the hypothalamus manifested later puberty onset timing both in vaginal opening and ovary maturation, followed by weaker fertility lying in the longer interval time between mating and delivery, higher abortion rate and smaller litter size. We also constructed miR-505-3p knockout mice by CRISPR/Cas9 technology. MiR-505-3p knockout female mice showed earlier vaginal opening timing, higher serum gonadotrophin and higher expression of puberty-related gene, as well as its target gene Srsf1 in the hypothalamus than their wild type littermates.Srsf1 was proved to be the target gene of miR-505-3p that played the major role in this process. The results of RIP-seq (RNA Immunoprecipitation-sequencing) showed that SF2, the protein product of Srsf1 gene, mainly bound to ribosome protein (RP) mRNAs in GT1-7 cells. The collective evidence implied that miR-505-3p/SRSF1/RP could play a role in the sexual maturation regulation of mammals.Author summaryThe puberty onset in mammals is a vital biological process that signals the acquisition of reproductive capacity. The initiation of puberty is triggered by the activation of hypothalamic pulsatile GnRH surge. The dysregulation of pubertal development shows relevance to later health risks of type 2 diabetes, cardiovascular disease, breast cancer and other health disorders. Recent progress indicates that a lot of genes play a role in the excitatory or inhibitory regulation of GnRH release. However, the detailed pathway of pubertal timing remains unclear. Our previous studies isolated an X-linked QTL that was associated with the timing of puberty in mice. In this study, we proved that miR-505-3p was a female puberty onset regulator based on data from positional cloning, ectopic expression and knockout mouse models. We also assigned Srsf1 as the functional target gene of miR-505-3p underlying this process. The results of RIP-seq showed that SF2, the protein of Srsf1 gene, preferential bound to ribosome protein (RP) mRNAs in GT1-7 cells. We propose that miR-505-3p/SF2/RP could play a role in the sexual maturation regulation of mammals.

scholarly journals Neurokinin B Is Critical for Normal Timing of Sexual Maturation but Dispensable for Adult Reproductive Function in Female Mice

Endocrinology ◽  
2015 ◽  
Vol 156 (4) ◽  
pp. 1386-1397 ◽  
Author(s):  
Cadence True ◽  
Sayeda Nasrin Alam ◽  
Kimberly Cox ◽  
Yee-Ming Chan ◽  
Stephanie B. Seminara
Keyword(s):  
Sexual Maturation ◽  
Pubertal Development ◽  
Critical Role ◽  
Reproductive Function ◽  
Wild Type ◽  
Neurokinin B ◽  
Gene Encoding ◽  
Estrous Cycles ◽  
Pubertal Delay ◽  
Deficient Mice

Abstract Humans carrying mutations in neurokinin B (NKB) or the NKB receptor fail to undergo puberty due to decreased secretion of GnRH. Despite this pubertal delay, many of these patients go on to achieve activation of their hypothalamic-pituitary-gonadal axis in adulthood, a phenomenon termed reversal, indicating that NKB signaling may play a more critical role for the timing of pubertal development than adult reproductive function. NKB receptor-deficient mice are hypogonadotropic but have no defects in the timing of sexual maturation. The current study has performed the first phenotypic evaluation of mice bearing mutations in Tac2, the gene encoding the NKB ligand, to determine whether they have impaired sexual development similar to their human counterparts. Male Tac2−/− mice showed no difference in the timing of sexual maturation or fertility compared with wild-type littermates and were fertile. In contrast, Tac2−/− females had profound delays in sexual maturation, with time to vaginal opening and first estrus occurring significantly later than controls, and initial abnormalities in estrous cycles. However, cycling recovered in adulthood and Tac2−/− females were fertile, although they produced fewer pups per litter. Thus, female Tac2−/− mice parallel humans harboring NKB pathway mutations, with delayed sexual maturation and activation of the reproductive cascade later in life. Moreover, direct comparison of NKB ligand and receptor-deficient females confirmed that only NKB ligand-deficient animals have delayed sexual maturation, suggesting that in the absence of the NKB receptor, NKB may regulate the timing of sexual maturation through other tachykinin receptors.

Insulin-like growth factor binding protein-3 in normal pubertal girls

1992 ◽  
Vol 126 (5) ◽  
pp. 381-386 ◽  
Author(s):  
Darrell M Wilson ◽  
Mark A Stene ◽  
Joel D Killen ◽  
Lawrence D Hammer ◽  
Iris F Litt ◽  
...  
Keyword(s):  
Pubertal Development ◽  
Red Cell ◽  
Pubertal Stage ◽  
Health Curriculum ◽  
School Based ◽  
Igf I ◽  
Pubertal Stages ◽  
Nutrition Intake ◽  
The Mean ◽  
Igfbp 3

IGFBP-3 concentrations rise in the second decade of life. To test the hypothesis that the stage of pubertal development, independent of chronological age, was associated with these increases we measured serum IGFBP-3 concentrations by radioimmunoassay in 324 sixth and seventh grade girls (12.3±0.7 years) at the beginning of a multisite school-based health curriculum. The mean (±sd) serum IGFBP-3 among the 242 girls with complete data was 4.0±0.7mg/l. Pubertal stage was significantly associated with IGFBP-3 (p<0.0001, ANOVA). Mean concentrations rose from 3.5±0.7 mg/l among those with the earliest pubertal stages to 4.2±0.7mg/l among the mature girls. IGF-I and IGFBP-3 concentrations were significantly correlated (Spearman's r=0.43, p<0.0001). After controlling for the association between pubertal development and IGFBP-3 concentrations, only the waist/hip ratio, among the various measures of body composition, was significantly associated with IGFBP-3 concentration (Spearman's r= −0.23, p=0.0002). Likewise, none of the measures of nutrition: intake of total calories, protein, fat and carbohydrate; serum iron; red cell mean corpuscular volume; or cholesterol; were significantly associated with IGFBP-3 concentrations. There was, however, a small, but significant association between IGFBP-3 concentrations and both serum transferrin and blood hemoglobin concentrations. Pubertal stage has a significant impact on IGFBP-3 concentrations and those attempting to utilize IGFBP-3 concentrations during adolescence should be cognizant of the subject's pubertal stage.

scholarly journals Sexual maturation in girls: association with physical activity and sedentary behaviour

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
V Desnouck ◽  
C Pedroni ◽  
M Dujeu ◽  
N Moreau ◽  
T Lebacq ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Sexual Maturation ◽  
Pubertal Development ◽  
Negative Consequences ◽  
Cross Sectional ◽  
School Aged Children ◽  
French Speaking ◽  
Relationship Of ◽  
The Relationship

Abstract Introduction During adolescence, physical activity tends to decline, especially among girls. Adolescent inactivity is due in part to biological factors, among which pubertal development may play a role. Our aim was to study in girls, the relationship of sexual maturation based on menarche with physical activity and sedentary behaviour. Methods Analyses were based on a two-stage random sample of 3,911 10-15-year-old girls included in the 2018 cross-sectional Health Behaviour in School-aged Children survey carried out in French-speaking schools. Menarche, sufficient levels of physical activity (PA) (global PA: at least 60 min. of moderate- to vigorous-intensity PA daily, and vigorous PA: at least 3 times/week), sedentary week time based on all-screen use duration (SWT; categories based on tertiles), and sociodemographic characteristics were self-reported. Multilevel multiple binary (for PA) and multinomial (for SWT) logistic regressions were performed, stratified by age group (≤12.5 years vs. &gt;12.5 years). Results Twenty percent of girls aged ≤ 12.5 years and 85.0% of girls aged &gt; 12.5 years have had their first period. Within the group aged ≤12.5, post-menarcheal girls were more likely to spend long SWT (≥8h/day) than pre-menarcheal girls (vs. short SWT (&lt;4h/day): aRRR= 1.74 [1.27-2.37]; NS for moderate SWT (4-7h/day)). Within those aged &gt;12.5, post-menarcheal girls were less likely to engage in sufficient vigorous PA (aOR=0.76 [0.59-0.98]) than pre-menarcheal girls. Moreover, they were more likely to spend moderate (aRRR=1.70 [1.19-2.42]) and long SWT (aRRR=2.74 [1.94-3.88]) than pre-menarcheal girls of same ages. Additional adjustments for age modified the strength of associations. Conclusions Our results suggest that during adolescence, the physiological changes induced by sexual maturation may contribute to the decline in physical activity (in &gt; 12.5 years), and in the increase in sedentary behaviour in girls. Potential confounding by age will be explored further. Key messages Development of strategies aimed at improving physical activity among adolescent girls should take into account, among other aspects, pubertal development. Specific interventions, targeting pubescent girls, should also be developed to reduce screen time in order to prevent its potential negative consequences.

Premature sexual maturation

2011 ◽  
pp. 1127-1136
Author(s):  
Jean-Claude Carel ◽  
Juliane Léger
Keyword(s):  
Sexual Maturation ◽  
Pubertal Development ◽  
Central Precocious Puberty ◽  
Controversial Issues ◽  
Factors Affecting ◽  
Appropriate Treatment ◽  
Paediatric Endocrinology ◽  
The World ◽  
Definition Of ◽  
Long Acting

Premature sexual maturation is a frequent cause for referral in paediatric endocrinology. Although clinical evaluation will suffice to reassure the patient and family in a majority of cases, premature sexual maturation can reveal severe conditions and need a thorough evaluation to identify its cause and potential for progression, in order to propose an appropriate treatment (1). Although the use of long-acting GnRH agonists has revolutionized the treatment of central precocious puberty, questions remain regarding their optimal use (2). One of the main ongoing controversial issues in the area is the definition of normal pubertal development and there is a need for longitudinal assessments of normally developing children in the various areas of the world and of a better understanding of the factors affecting normal pubertal development to improve the recognition and proper management of premature sexual maturation.

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