Risk factors and epidemiology of Acinetobacter baumannii infections in a university hospital in Northern Italy: A case-control study

2016 ◽  
Vol 44 (12) ◽  
pp. 1600-1605 ◽  
Author(s):  
I. Ardoino ◽  
F. Zangirolami ◽  
D. Iemmi ◽  
M. Lanzoni ◽  
M. Cargnelutti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acinetobacter Baumannii ◽  
Case Control Study ◽  
Case Control ◽  
Northern Italy ◽  
University Hospital ◽  
Control Study

Association between Neuroleptics and Venous Thromboembolism: A Case-Control Study.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 2601-2601
Author(s):  
Karine Lacut ◽  
Gregoire Le Gal ◽  
Emmanuel Oger ◽  
Dominique Mottier
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Antipsychotic Drugs ◽  
Case Control Study ◽  
Case Control ◽  
University Hospital ◽  
Number Of Patients ◽  
Increased Risk ◽  
Significant Difference ◽  
Control Study

Abstract Background: Preliminary reports suggest that use of antipsychotic drugs is associated with an increased risk of venous thromboembolism (VTE), but others did not confirm these results. Objective: To evaluate the relationship between antipsychotic drugs and VTE. Design: Case-control study (EDITH) designed to investigate genetic and environmental risk factors of VTE. Setting: Brest University Hospital. Participants: 857 patients consecutively hospitalized for a documented venous thromboembolic event were included between May 2000 and May 2004. Controls were matched on age, sex and the main risk factors of venous thromboembolism (cancer, surgery, pregnancy…). Results: The mean age of patients was 67.7 year. No significant difference was found between cases and controls concerning the main characteristics, except for smocking and body mass index. Among cases, 89 (10.4%) were current users of neuroleptics compared to 35 (4.8%) among controls. Current use of neuroleptics was associated with a significant increased risk of venous thromboembolism (OR = 2.32, 95% CI: 1.55–3.48). Excluding neuroleptics used for non psychiatric disorders, and after adjustment on the main confounding factors, this association remained significant (OR = 3.48, 95% CI: 2.00–6.04). No difference was found between the different chemical categories of neuroleptics, but the number of patients in some groups had limited statistical power to demonstrate significant differences. Biological mechanisms of action have been proposed to explain this relation. Analyses are ongoing for anti-phospholipid antibodies and homocysteine. Conclusion: In this case-control study of hospitalized patients, neuroleptics use was associated with a significant increased risk of venous thromboembolism. These results are concordant with previous reports. Nevertheless, further investigations are needed to explain wich mechanisms may be involved in such association and before use of neuroleptics can be definitely considered as risk factor for venous thromboembolism.

Occupational Risk Factors for Renal Cell Cancer: A Case-Control Study in Northern Italy

2002 ◽  
Vol 44 (11) ◽  
pp. 1028-1036 ◽  
Author(s):  
Stefano Mattioli ◽  
Davide Truffelli ◽  
Alberto Baldasseroni ◽  
Alessandro Risi ◽  
Bruno Marchesini ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Case Control Study ◽  
Cell Cancer ◽  
Case Control ◽  
Northern Italy ◽  
Occupational Risk ◽  
Occupational Risk Factors ◽  
Control Study

scholarly journals Identification of risk factors for death from tetanus in Pernambuco, Brazil: a case-control study

2000 ◽  
Vol 42 (6) ◽  
pp. 333-339 ◽  
Author(s):  
Demócrito B. MIRANDA-FILHO ◽  
Ricardo A.A. XIMENES ◽  
Silvya N. BERNARDINO ◽  
Abelardo G. ESCARIÃO
Keyword(s):  
Risk Factors ◽  
Medical Records ◽  
Case Control Study ◽  
Artificial Ventilation ◽  
Case Control ◽  
The State ◽  
University Hospital ◽  
State University ◽  
Neck Stiffness ◽  
Control Study

A case-control study was conducted to identify risk factors for death from tetanus in the State of Pernambuco, Brazil. Information was obtained from medical records of 152 cases and 152 controls, admitted to the tetanus unit in the State University Hospital, in Recife, from 1990 to 1995. Variables were grouped in three different sets. Crude and adjusted odds ratios, p-values and 95% confidence intervals were estimated. Variables selected in the multivariate analysis in each set were controlled for the effect of those selected in the others. All factors related to the disease progression - incubation period, time elapsed between the occurrence of the first tetanus symptom and admission, and period of onset - showed a statistically significant association with death from tetanus. Similarly, signs and/or symptoms occurring on admission or in the following 24 hours (second set): reflex spasms, neck stiffness, respiratory signs/symptoms and respiratory failure requiring artificial ventilation (third set) were associated with death from tetanus even when adjusted for the effect of the others.

scholarly journals Risk Factors for rectal colonization with carbapenem-resistant Acinetobacter baumannii in hospital: a matched case-control study

2021 ◽  
Author(s):  
marianna meschiari ◽  
Shaniko Kaleci ◽  
Gabriella Orlando ◽  
Silvia Selmi ◽  
Antonella Santoro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Acinetobacter Baumannii ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Carbapenem Resistant ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background During the last decade carbapenem-resistant Acinetobacter baumannii (CRAB) became hyper-endemic in hospitals due to difficult to control spreading. Our aim is to identify risk factors for nosocomial rectal CRAB colonization in an endemic hospital. Methods A retrospective matched case-control study (ratio 1:2) with a prospective inclusion of cases and concurrent selection of controls was conducted from January 2017 to December 2018 in a tertiary-care hospital. Universal active surveillance for CRAB was implemented. Univariate and multivariate logistic regression was carried out using a stepwise selection method to compare prognostic factors between cases and controls. A sub-analysis was carried out according to the type of department. Results Forty-five cases with nosocomial rectal CRAB colonization and 90 controls were included. One hundred and two (75%) patients were hospitalized in medical departments. At multivariable analysis significant risk factors associated with CRAB colonization were: use of permanent devices (OR: 10.15, 95%CI: 2.27–45.39; P = 0.002), mechanical ventilation (OR: 40.01, 95%CI: 4.05–395.1; P = 0.002), urinary catheters (OR: 4.9, 95%CI:1.52–16.19; P = 0.008), McCabe score (OR: 5.45, 95%CI: 1.87–15.89; P = 0.002), length of stay (OR: 1.03, 95%CI: 1.01–1.05; P = 0.002), carbapenem use (OR: 5.39, 95%CI: 1.14–25.44; P = 0.033). The sub-analysis showed that patients admitted to different departments had different risk factors. In geriatric department a fatal disease and a longer hospital stay represented significant risk factors both in univariate and multivariate analysis, while in internal medicine department the use of permanent devices, current antibiotic therapy and antibiotic polytherapy represented significant risk factors for CRAB at the univariate analysis, also confirmed in multivariate analysis. Conclusions Our data suggest that active surveillance for rectal CRAB colonization should be addressed to patients with an unfavourable prognosis, longer hospitalizations and carriers of multiple devices. To counter CRAB spreading in endemic settings, clinicians must limit the use of carbapenems, and reinforce interventions aimed at proper use of devices.

scholarly journals Risk factors for cancer of the tongue and the mouth. A case-control study from northern Italy

Cancer ◽  
1992 ◽  
Vol 70 (9) ◽  
pp. 2227-2233 ◽  
Author(s):  
Silvia Franceschi ◽  
Salvatore Barra ◽  
Carlo La Vecchia ◽  
Ettore Bidoli ◽  
Eva Negri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Northern Italy ◽  
Control Study

scholarly journals Risk Factors for Acquisition of Imipenem-Resistant Acinetobacter baumannii: a Case-Control Study

2004 ◽  
Vol 48 (3) ◽  
pp. 1070-1070
Author(s):  
Sang-Oh Lee ◽  
Nam Joong Kim ◽  
Sang-Ho Choi ◽  
Tae Hyong Kim ◽  
Jin-Won Chung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acinetobacter Baumannii ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Risk Factors for Healthcare-Associated Extensively Drug-Resistant Acinetobacter baumannii Infections: A Case-Control Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85973 ◽  
Author(s):  
Ming-Chin Chan ◽  
Sheng-Kang Chiu ◽  
Po-Ren Hsueh ◽  
Ning-Chi Wang ◽  
Chih-Chien Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acinetobacter Baumannii ◽  
Case Control Study ◽  
Case Control ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Healthcare Associated ◽  
Control Study

scholarly journals Risk factors for nosocomial rectal colonization with carbapenem-resistant Acinetobacter baumannii in hospital: a matched case–control study

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Marianna Meschiari ◽  
Shaniko Kaleci ◽  
Gabriella Orlando ◽  
Silvia Selmi ◽  
Antonella Santoro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Acinetobacter Baumannii ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Carbapenem Resistant ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background During the last decade carbapenem-resistant Acinetobacter baumannii (CRAB) became hyper-endemic in hospitals due to difficult to control spreading. Our aim is to identify risk factors for nosocomial rectal CRAB colonization in an endemic hospital. Methods A retrospective matched case–control study (ratio 1:2) with a prospective inclusion of cases and concurrent selection of controls was conducted from January 2017 to December 2018 in a tertiary-care hospital. Universal active surveillance for CRAB was implemented. Univariate and multivariate logistic regression was carried out using a stepwise selection method to compare prognostic factors between cases and controls. A sub-analysis was carried out according to the type of department. Results Forty-five cases with nosocomial rectal CRAB colonization and 90 controls were included. One hundred and two (75%) patients were hospitalized in medical departments. At multivariable analysis significant risk factors associated with CRAB colonization were: use of permanent devices (OR 10.15, 95% CI 2.27–45.39; P = 0.002), mechanical ventilation (OR 40.01, 95% CI 4.05–395.1; P = 0.002), urinary catheters (OR 4.9, 95% CI 1.52–16.19; P = 0.008), McCabe score (OR 5.45, 95% CI 1.87–15.89; P = 0.002), length of stay (OR 1.03, 95% CI 1.01–1.05; P = 0.002), carbapenem use (OR 5.39, 95% CI 1.14–25.44; P = 0.033). The sub-analysis showed that patients admitted to different departments had different risk factors. In geriatric department a fatal disease and a longer hospital stay represented significant risk factors both in univariate and multivariate analysis, while in internal medicine department the use of permanent devices, current antibiotic therapy and antibiotic polytherapy represented significant risk factors for CRAB at the univariate analysis, also confirmed in multivariate analysis. Conclusions Our data suggest that active surveillance for rectal CRAB colonization should be addressed to patients with an unfavourable prognosis, longer hospitalizations and carriers of multiple devices. To counter CRAB spreading in endemic settings, clinicians must limit the use of carbapenems, and reinforce interventions aimed at proper use of devices.

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