scholarly journals Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates

2015 ◽  
Vol 213 (6) ◽  
pp. 830.e1-830.e19 ◽  
Author(s):  
Kristina M. Adams Waldorf ◽  
Natasha Singh ◽  
Aarthi R. Mohan ◽  
Roger C. Young ◽  
Lisa Ngo ◽  
...  
2021 ◽  
Vol 3 (1) ◽  
pp. 18-24
Author(s):  
Nilda Yulita Siregar ◽  
Cici Fitrayanti Kias ◽  
Nurfatimah Nurfatimah ◽  
Fransisca Noya ◽  
Lisda Widianti Longgupa ◽  
...  

Introduction: Fear and anxiety during pregnancy and childbirth can cause problems such as preterm labor and low birth weight. Purpose: The purpose of this study was to determine the level of anxiety of third-trimester pregnant women in dealing with labor. Methods: This type of research is a descriptive study and analyzed with frequency distribution. The population was all pregnant women in the third trimester who were in the working area of ​​the Mapane Community Health Center with a total of 37 people. The sampling technique used total sampling. The results showed that only 8.1% of pregnant women experienced mild anxiety, while 91.9% did not experience anxiety. pregnant women who experience mild anxiety are 20% in the risk age group, 20% with diploma education, 11.5% in mothers who do not work, 60% in primigravidas, and 15.8% in mothers who do not get support from their husbands. Anxiety occurs mostly in primigravida because it is the first experience of pregnancy. It suggested for village midwives providing information about pregnancy and childbirth, especially for primigravida mothers, and involving their husbands in posyandu activities for pregnant women.


Author(s):  
Fatin Shallal Farhan ◽  
Ban Hadi Hameed ◽  
Muna Abdulghani Zghair

Objective: The effectiveness of progesterone in the prevention of threatened preterm labor has been established for many years, but the preferable route, dose, and duration of treatment are until now under the evaluation of researches. The aim of this study was to determine the effect of rectal progesterone on Doppler indices of the uterine arteries in pregnant women with threatened preterm delivery.Methods: A prospective case–control study was conducted at the obstetric ward and the Outpatients Department of Al-Yarmouk Teaching Hospital in Baghdad for the period of 1 year from April 1, 2017, to April 1, 2018. 100 women were enrolled in the study, 50 of them were pregnant women with a diagnosis of preterm labor assigned as a study group and the other 50 were apparently healthy pregnant women of the same gestational age assigned as a control group. Doppler study of uterine arteries was done to all participants, and the results were compared for both groups. The patients with preterm labor received nifedipine tocolysis initially until contractions subsided and Doppler study had been repeated for those women after 1 week of rectal progesterone therapy.Results: The study group had a significantly higher resistance index (RI) than the control group (0.58 vs. 0.52) as p<0.05, in spite of the pulsatility index (PI) being higher for the study group compared to the control group (0.78 vs. 0.77) but this difference was not statistically significant. The RI before the therapy (0.58) was significantly higher than the index after therapy (0.52), and the PI was again significantly higher before therapy (0.78) than after therapy (0.71) as p<0.05. During the follow-up period, 3 (6.5%), 4 (8.7), and 39 (84.8%) patients delivered within 1 week, after 1 week, and at term, respectively.Conclusion: Rectal progesterone can arrest threatened preterm labor, and this effect is possible in part explained by its action on uterine arteries.


2021 ◽  
Vol 4 (1) ◽  
pp. 56-63
Author(s):  
Triyoga Pramadana ◽  
◽  
Anita Rachmawati ◽  
Dini Pusianawati

Objective: This study aimed to determine differences in cervical length changes between administration of nifedipine and isoxsuprine. Method: Subjects of the study were pregnant women who meet the inclusion criteria (n=16). Treatments were given for 48 hours. Parameters measured was the cervical length before and after the administration of nifedipine and isoxsuprine. This study was conducted in Dr. Hasan Sadikin General Hospital from January until April 2020. Result: Less shortening of the cervical length after administration of tocolytic isoxsuprin for 48 hours compared with tocolytic nifedipine and statistically significant with p value of 0.0001 (p<0.05) using Paired T tests. Conclusion: Isoxsuprin is more effective to prevent shortening of the cervical length compared to nifedipine in cases of threatened preterm labor. Key word: Nifedipine, Isoxsuprine, cervical length, threatened preterm labor


2021 ◽  
Vol 2 ◽  
Author(s):  
Roopali Rajput ◽  
Jitender Sharma

The risk of viral infection during pregnancy is well-documented; however, the intervention modalities that in practice enable maternal-fetal protection are restricted by limited understanding. This becomes all the more challenging during pandemics. During many different epidemic and pandemic viral outbreaks, worse outcomes (fetal abnormalities, mortality, preterm labor, etc.) seem to affect pregnant women than what has been evident when compared to non-pregnant women. The condition of pregnancy, which is widely understood as “immunosuppressed,” needs to be re-understood in terms of the way the immune system works during such a state. The immune system gets transformed to accommodate and facilitate fetal growth. The interference of such supportive conversion by viral infection and the risk of co-infection lead to adverse fetal outcomes. Hence, it is crucial to understand the risk and impact of potent viral infections likely to be encountered during pregnancy. In the present article, we review the effects imposed by previously established and recently emerging/re-emerging viral infections on maternal and fetal health. Such understanding is important in devising strategies for better preparedness and knowing the treatment options available to mitigate the relevant adverse outcomes.


2019 ◽  
Vol 64 (2) ◽  
pp. 89-93 ◽  
Author(s):  
A. . Smirnova ◽  
N. . Borzova ◽  
N. . Sotnikova ◽  
A. . Malyshkina ◽  
E. . Bojko

Perinatal lesions of the Central nervous system (CNS) in newborns occupy a leading place in the structure of perinatal morbidity and subsequent disability of children. To identify the features of the content of sRAGE in pregnant women with threatening preterm labor (UPR) in the period of 22-27 weeks, who subsequently gave birth to children with perinatal CNS lesion. Serum of venous blood of pregnant women with UPR at the term of 22-27 weeks was determined by ELISA once the content of sRAGE. If the value of sRAGE in pregnant women is 659.5 PG/ml or less, perinatal hypoxic lesions of the Central nervous system in newborns are predicted with an accuracy of 75.8% (sensitivity of 82.6%, specificity of 66.7%).


2011 ◽  
Vol 204 (1) ◽  
pp. S83
Author(s):  
Xin Wang ◽  
Erik Rytting ◽  
Tatiana Nanovskaya ◽  
Svetlana Patrikeeva ◽  
Shannon Clark ◽  
...  
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document