scholarly journals Role of bariatric surgery in obese women with endometrial cancer risk

2016 ◽  
Vol 214 (1) ◽  
pp. 138-139
Author(s):  
Anawin Sanguankeo ◽  
Sikarin Upala
Keyword(s):  
Bariatric Surgery ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Obese Women ◽  
Endometrial Cancer Risk

scholarly journals Allium vegetables intake and endometrial cancer risk

2009 ◽  
Vol 12 (9) ◽  
pp. 1576-1579 ◽  
Author(s):  
Carlotta Galeone ◽  
Claudio Pelucchi ◽  
Luigino Dal Maso ◽  
Eva Negri ◽  
Maurizio Montella ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Wide Spectrum ◽  
Protective Role ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Allium Vegetables ◽  
Control Study

AbstractObjectiveThe potential role of allium vegetables on endometrial cancer risk has been scarcely investigated and the results of previous Chinese studies are not easily applicable to Western populations. Therefore, we evaluated the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case–control study.SettingWe analysed data from a multi-centre case–control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions. Information was collected by trained interviewers using a validated and reproducible FFQ. Multivariate odds ratios and 95 % confidence intervals were obtained after allowance for recognized confounding factors.ResultsCompared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0·94 (95 % CI 0·72, 1·21) for <2 portions/week and 0·40 (95 % CI 0·22, 0·72) for ≥2 portions/week, with a significant inverse trend in risk (P = 0·01). The OR for an increment of one portion (i.e. 80 g) of onions per week was 0·81 (95 % CI 0·70, 0·95). For garlic, the OR for successive categories of intake were 0·89 (95 % CI 0·68, 1·15) for intermediate use and 0·62 (95 % CI 0·42, 0·92) for high use, with a significant inverse trend in risk (P = 0·02).ConclusionsOur study found a moderate protective role of allium vegetables on the risk of endometrial cancer.

Disparities in the ameliorative effects of bariatric surgery on endometrial cancer risk biomarkers.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e13038-e13038
Author(s):  
Faina Linkov ◽  
Sharon Goughnour ◽  
Robert P. Edwards ◽  
Anna Lokshin ◽  
Ramesh Ramanathan ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
Risk Biomarkers

scholarly journals Glycaemic index, glycaemic load and risk of endometrial cancer: a prospective cohort study

2005 ◽  
Vol 8 (7) ◽  
pp. 912-919 ◽  
Author(s):  
Stephanie AN Silvera ◽  
Thomas E Rohan ◽  
Meera Jain ◽  
Paul D Terry ◽  
Geoffrey R Howe ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Hormone Replacement ◽  
Premenopausal Women ◽  
Glycaemic Index ◽  
Obese Women ◽  
Endometrial Cancer Risk ◽  
Glycaemic Load

AbstractObjectiveHigh-glycaemic-load diets may increase endometrial cancer risk by increasing circulating insulin levels and, as a consequence, circulating oestrogen levels. Given the paucity of epidemiological data regarding the relationship between dietary glycaemic index and glycaemic load and endometrial cancer risk, we sought to examine these associations using data from a prospective cohort study.Design, setting and subjectsWe examined the association between dietary glycaemic load and endometrial cancer risk in a cohort of 49 613 Canadian women aged between 40 and 59 years at baseline who completed self-administered food-frequency questionnaires between 1982 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000.ResultsDuring a mean of 16.4 years of follow-up, we observed 426 incident cases of endometrial cancer. Hazard ratios for the highest versus the lowest quartile level of overall glycaemic index and glycaemic load were 1.47 (95% confidence interval (CI) = 0.90–2.41; P for trend = 0.14) and 1.36 (95% CI = 1.01–1.84; P for trend = 0.21), respectively. No association was observed between total carbohydrate or total sugar consumption and endometrial cancer risk. Among obese women (body mass index > 30 kg m−2) the hazard ratio for the highest versus the lowest quartile level of glycaemic load was 1.88 (95% CI = 1.08–3.29; P for trend = 0.54) and there was a 55% increased risk for the highest versus the lowest quartile level of glycaemic load among premenopausal women. There was also evidence to support a positive association between glycaemic load and endometrial cancer risk among postmenopausal women who had used hormone replacement therapy.ConclusionsOur data suggest that diets with high glycaemic index or high glycaemic load may be associated with endometrial cancer risk overall, and particularly among obese women, premenopausal women and postmenopausal women who use hormone replacement therapy.

scholarly journals Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment

2016 ◽  
Vol 34 (35) ◽  
pp. 4225-4230 ◽  
Author(s):  
Michaela A. Onstad ◽  
Rosemarie E. Schmandt ◽  
Karen H. Lu
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Molecular Mechanisms ◽  
Risk Prevention ◽  
Endometrial Cancer Risk ◽  
Obesity Epidemic ◽  
Incidence And Mortality ◽  
Cancer Types ◽  
The Impact

In sharp contrast to many other cancer types, the incidence and mortality of endometrial cancer continue to grow. This unfortunate trend is, in no small part, a result of the worldwide obesity epidemic. More than half of endometrial cancers are currently attributable to obesity, which is recognized as an independent risk factor for this disease. In this review, we identify the molecular mechanisms by which obesity and adipose tissue contribute to the pathogenesis of endometrial cancer. We further discuss the impact of obesity on the clinical management of the disease and examine the development of rational behavioral and pharmaceutical interventions aimed at reducing endometrial cancer risk, improving cancer outcomes, and preserving fertility in an increasingly younger population of patients with endometrial cancer.

scholarly journals The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk

2018 ◽  
Vol 144 (3) ◽  
pp. 641-650 ◽  
Author(s):  
Michelle L. MacKintosh ◽  
Abigail E. Derbyshire ◽  
Rhona J. McVey ◽  
James Bolton ◽  
Mahshid Nickkho‐Amiry ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
The Impact ◽  
Tissue Biomarkers

scholarly journals Assessing the Role of Selenium in Endometrial Cancer Risk: A Mendelian Randomization Study

2019 ◽  
Vol 9 ◽  
Author(s):  
Pik Fang Kho ◽  
Dylan M. Glubb ◽  
Deborah J. Thompson ◽  
Amanda B. Spurdle ◽  
Tracy A. O'Mara
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Mendelian Randomization ◽  
Endometrial Cancer Risk

scholarly journals Intentional weight loss, weight cycling, and endometrial cancer risk: a systematic review and meta-analysis

2019 ◽  
Vol 29 (9) ◽  
pp. 1361-1371 ◽  
Author(s):  
Xiaochen Zhang ◽  
Jennifer Rhoades ◽  
Bette J Caan ◽  
David E Cohn ◽  
Ritu Salani ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Weight Cycling ◽  
Healthy Weight ◽  
Intentional Weight Loss ◽  
Endometrial Cancer Risk

PurposeWeight cycling, defined as intentional weight loss followed by unintentional weight regain, may attenuate the benefit of intentional weight loss on endometrial cancer risk. We summarized the literature on intentional weight loss, weight cycling after intentional weight loss, bariatric surgery, and endometrial cancer risk.MethodsA systematic search was conducted using MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases published between January 2000 and November 2018. We followed Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) guidelines. We qualitatively summarized studies related to intentional weight loss and weight cycling due to the inconsistent definition, and quantitatively summarized studies when bariatric surgery was the mechanism of intentional weight loss.ResultsA total of 127 full-text articles were reviewed, and 13 were included (bariatric surgery n=7, self-reported intentional weight loss n=2, self-reported weight cycling n=4). Qualitative synthesis suggested that, compared with stable weight, self-reported intentional weight loss was associated with lower endometrial cancer risk (RR range 0.61–0.96), whereas self-reported weight cycling was associated with higher endometrial cancer risk (OR range 1.07–2.33). The meta-analysis yielded a 59% lower risk of endometrial cancer following bariatric surgery (OR 0.41, 95% CI 0.22 to 0.74).ConclusionsOur findings support the notion that intentional weight loss and maintenance of a stable, healthy weight can lower endometrial cancer risk. Strategies to improve awareness and maintenance of weight loss among women with obesity are needed to reduce endometrial cancer risk.

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