Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension

Over the last decades, there has been a substantial increase in the prevalence of mental health disorders, including an increased prevalence of depression, anxiety, cognitive, and sleep disorders. Diet and its bioactive components have been recognized among the modifiable risk factors, possibly influencing their pathogenesis. This review aimed to summarize molecular mechanisms underlying the putative beneficial effects toward brain health of different dietary factors, such as micro- and macronutrient intake and habits, such as feeding time and circadian rhythm. The role of hormonal homeostasis in the context of glucose metabolism and adiponectin regulation and its impact on systemic and neuro-inflammation has also been considered and deepened. In addition, the effect of individual bioactive molecules exerting antioxidant activities and acting as anti-inflammatory agents, such as omega-3 fatty acids and polyphenols, considered beneficial for the central nervous system via modulation of adult neurogenesis, synaptic and neuronal plasticity, and microglia activation has been summarized. An overview of the regulation of the gut–brain axis and its effect on the modulation of systemic inflammation and oxidative stress has been provided. Finally, the impact of bioactive molecules on inflammation and oxidative stress and its association with brain health has been summarized.

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The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3 /Caspase‐1 signaling pathway and oxidative stress in Wistar rats

Environmental Toxicology ◽

10.1002/tox.23095 ◽

2021 ◽

Author(s):

Jialiu Wei ◽

Xifeng Wang ◽

Qian Liu ◽

Na Zhou ◽

Shuxiang Zhu ◽

...

Keyword(s):

Oxidative Stress ◽

Signaling Pathway ◽

Wistar Rats ◽

Caspase 1 ◽

The Impact ◽

And Oxidative Stress

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Mercury Exposure and Endothelial Dysfunction

International Journal of Toxicology ◽

10.1177/1091581815589766 ◽

2015 ◽

Vol 34 (4) ◽

pp. 300-307 ◽

Cited By ~ 13

Author(s):

Swati Omanwar ◽

M. Fahim

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Endothelial Dysfunction ◽

Vascular Endothelium ◽

Circulatory System ◽

Vital Role ◽

Mercury Exposure ◽

And Function ◽

The Impact ◽

And Oxidative Stress

Vascular endothelium plays a vital role in the organization and function of the blood vessel and maintains homeostasis of the circulatory system and normal arterial function. Functional disruption of the endothelium is recognized as the beginning event that triggers the development of consequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. There is a growing data associating mercury exposure with endothelial dysfunction and higher risk of CVD. This review explores and evaluates the impact of mercury exposure on CVD and endothelial function, highlighting the interplay of nitric oxide and oxidative stress.

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A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats

British Journal Of Nutrition ◽

10.1017/s0007114516004608 ◽

2017 ◽

Vol 117 (2) ◽

pp. 218-229 ◽

Cited By ~ 18

Author(s):

K. Gil-Cardoso ◽

I. Ginés ◽

M. Pinent ◽

A. Ardévol ◽

X. Terra ◽

...

Keyword(s):

Oxidative Stress ◽

Intestinal Inflammation ◽

Cafeteria Diet ◽

Zucker Rats ◽

Standard Diet ◽

Metabolic Alterations ◽

Genetic Obesity ◽

Obesogenic Diet ◽

The Impact ◽

And Oxidative Stress

AbstractThe gastrointestinal alterations associated with the consumption of an obesogenic diet, such as inflammation, permeability impairment and oxidative stress, have been poorly explored in both diet-induced obesity (DIO) and genetic obesity. The aim of the present study was to examine the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. For this purpose, female Wistar rats (n 48) were administered a standard or a cafeteria diet (CAF diet) for 12, 14·5 or 17 weeks and were compared with fa/fa Zucker rats fed a standard diet for 10 weeks. Morphometric variables, plasma biochemical parameters, myeloperoxidase (MPO) activity and reactive oxygen species (ROS) levels in the ileum were assessed, as well as the expressions of proinflammatory genes (TNF-α and inducible nitric oxide synthase (iNOS)) and intestinal permeability genes (zonula occludens-1, claudin-1 and occludin). Both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. Interestingly, the 17-week CAF group and the fa/fa rats exhibited alterations in the expressions of permeability genes. Relevantly, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.

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Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets

10.20944/preprints202111.0346.v1 ◽

2021 ◽

Author(s):

Carmela Balistreri ◽

Calogera Pisano ◽

Giovanni Ruvolo

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Genetic Variants ◽

Complex Disease ◽

Ascending Aorta ◽

Oxygen Species ◽

Aorta Aneurysm ◽

Independent Risk Factors ◽

The Impact ◽

And Oxidative Stress

Ascending aorta aneurysm (AsAA) is a complex disease, currently defined an inflammatory disease. In the sporadic form, AsAA has, indeed, a complex physiopathology with a strong inflammatory basis, significantly modulated by genetic variants in innate/inflammatory genes, acting as independent risk factors and as largely evidenced in our recent studies performed during the last 10 years. Based on these premises, here, we want to revise the impact of reactive oxygen species (ROS) and oxidative stress on AsAA pathophysiology and consequently on the onset and progression of sporadic AsAA. This might consent to add other important pieces in the intricate puzzle of the pathophysiology of this disease with the translational aim to identify biomarkers and targets to apply in the complex management of AsAA, by facilitating the AsAA diagnosis currently based only on imaging evaluations, and the treatment exclusively founded on surgery approaches.

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The impact of various antihypertensive medications on vascular aging

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2021-27-2-133-145 ◽

2021 ◽

Vol 27 (2) ◽

pp. 133-145

Author(s):

E. N. Dudinskaya ◽

L. V. Matchekhina ◽

K. A. Eruslanova ◽

O. A. Dogotar ◽

L. P. Ryltseva ◽

...

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Pulse Wave ◽

Antihypertensive Drugs ◽

Augmentation Index ◽

Vascular Aging ◽

Antihypertensive Medications ◽

The Impact ◽

Stress Patterns ◽

And Oxidative Stress

The review summarizes the data of past two decades on the effect of hypertension on vascular aging and considers the effect of chronic inflammation and oxidative stress patterns on the remodeling of cardiovascular system. Clinical studies on the effect of various classes of antihypertensive drugs on age-associated parameters of vascular aging are discussed. These include endothelial dysfunction and arterial assessed by endothelium-dependent vasodilation, pulse wave velocity, augmentation index, cardiovascular index, thickness of the intima-media complex, and so on.

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The impact of insulin-like growth factor-1, growth hormone, and oxidative stress in the experimental model of juvenile and adult hypothyroid retinal degeneration

Ibnosina Journal of Medicine and Biomedical Sciences ◽

10.4103/1947-489x.210888 ◽

2011 ◽

Vol 3 (5) ◽

pp. 150

Author(s):

OmymaG Ahmed ◽

Amal Taha ◽

FatenY Mahmoud

Keyword(s):

Oxidative Stress ◽

Growth Hormone ◽

Growth Factor ◽

Retinal Degeneration ◽

Experimental Model ◽

Insulin Like Growth Factor ◽

The Impact ◽

And Oxidative Stress

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Perfluorooctanesulfonic Acid and Perfluorohexanesulfonic Acid Alter the Blood Lipidome and the Hepatic Proteome in a Murine Model of Diet-Induced Obesity

Toxicological Sciences ◽

10.1093/toxsci/kfaa148 ◽

2020 ◽

Vol 178 (2) ◽

pp. 311-324

Author(s):

Marisa Pfohl ◽

Lishann Ingram ◽

Emily Marques ◽

Adam Auclair ◽

Benjamin Barlock ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Metabolism ◽

Expression Profiles ◽

Environmental Toxicants ◽

High Fat ◽

High Carbohydrate ◽

Lipid Species ◽

Perfluorooctanesulfonic Acid ◽

The Impact ◽

And Oxidative Stress

Abstract Perfluoroalkyl substances (PFAS) represent a family of environmental toxicants that have infiltrated the living world. This study explores diet-PFAS interactions and the impact of perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic (PFHxS) on the hepatic proteome and blood lipidomic profiles. Male C57BL/6J mice were fed with either a low-fat diet (10.5% kcal from fat) or a high fat (58% kcal from fat) high carbohydrate (42 g/l) diet with or without PFOS or PFHxS in feed (0.0003% wt/wt) for 29 weeks. Lipidomic, proteomic, and gene expression profiles were determined to explore lipid outcomes and hepatic mechanistic pathways. With administration of a high-fat high-carbohydrate diet, PFOS and PFHxS increased hepatic expression of targets involved in lipid metabolism and oxidative stress. In the blood, PFOS and PFHxS altered serum phosphatidylcholines, phosphatidylethanolamines, plasmogens, sphingomyelins, and triglycerides. Furthermore, oxidized lipid species were enriched in the blood lipidome of PFOS and PFHxS treated mice. These data support the hypothesis that PFOS and PFHxS increase the risk of metabolic and inflammatory disease induced by diet, possibly by inducing dysregulated lipid metabolism and oxidative stress.

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