Molecular insight into IgE-mediated reactions to sesame (Sesamum indicum L.) seed proteins

Food allergy is an IgE-mediated abnormal response to otherwise harmless food proteins, affecting between 5% and 10% of the world preschool children population and 1% to 5% adults. Several physical, chemical, and biotechnological approaches have been used to reduce the allergenicity of food allergens. Fermentation processes that contribute to technological and desirable changes in taste, flavor, digestibility, and texture of food products constitute one of these approaches. Lactic acid bacteria (LAB), used as starter cultures in dairy products, are a subject of increasing interest in fermentation of plant proteins. However, the studies designed to assess the impact of LAB on reduction of allergenicity of seed proteins are at an early stage. This review presents the current knowledge on food fermentation, with a focus on seed proteins that are increasingly used as ingredients, and its impacts on food potential allergenicity.

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IgE-Mediated Cross-Reactivity among Leguminous Seed Proteins in Peanut Allergic Children

Plant Foods for Human Nutrition ◽

10.1007/s11130-010-0199-8 ◽

2010 ◽

Vol 65 (4) ◽

pp. 396-402 ◽

Cited By ~ 17

Author(s):

Cinzia Ballabio ◽

Chiara Magni ◽

Patrizia Restani ◽

Maria Mottini ◽

Alessandro Fiocchi ◽

...

Keyword(s):

Seed Proteins ◽

Cross Reactivity ◽

Leguminous Seed ◽

Ige Mediated

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Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice

Journal of Immunology Research ◽

10.1155/2014/474217 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 11

Author(s):

Yuki Nakamura ◽

Kayoko Ishimaru ◽

Yu Tahara ◽

Shigenobu Shibata ◽

Atsuhito Nakao

Keyword(s):

Circadian Clock ◽

Suprachiasmatic Nucleus ◽

Anaphylactic Reaction ◽

Cell Types ◽

Time Of Day ◽

Industrialized Countries ◽

Important Regulator ◽

Ige Mediated ◽

Central Clock ◽

Insight Into

Anaphylaxis is a severe systemic allergic reaction which is rapid in onset and potentially fatal, caused by excessive release of mediators including histamine and cytokines/chemokines from mast cells and basophils upon allergen/IgE stimulation. Increased prevalence of anaphylaxis in industrialized countries requires urgent needs for better understanding of anaphylaxis. However, the pathophysiology of the disease is not fully understood. Here we report that the circadian clock may be an important regulator of anaphylaxis. In mammals, the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus synchronizes and entrains peripheral circadian clock present in virtually all cell types via neural and endocrine pathways, thereby driving the daily rhythms in behavior and physiology. We found that mechanical disruption of the SCN resulted in the absence of a time of day-dependent variation in passive systemic anaphylactic (PSA) reaction in mice, associated with loss of daily variations in serum histamine, MCP-1 (CCL2), and IL-6 levels. These results suggest that the central SCN clock controls the time of day-dependent variation in IgE-mediated systemic anaphylactic reaction, which may provide a novel insight into the pathophysiology of anaphylaxis.

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Investigation of Angiostensin‐converting enzyme inhibitory potential and allergenicity of Sesamum indicum Linn seed proteins by an in silico approach (LB541)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.lb541 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Oluwakemi Rotimi ◽

Olugbenga Oluwagbemi ◽

Wisdom Iyanda‐Joel ◽

Elizabeth Omotosho ◽

Marion Adebiyi ◽

...

Keyword(s):

In Silico ◽

Seed Proteins ◽

Sesamum Indicum ◽

Converting Enzyme ◽

Inhibitory Potential

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Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

10.1101/2020.07.14.203539 ◽

2020 ◽

Author(s):

Chinh Tran-To Su ◽

Wai-Heng Lua ◽

Jun-Jie Poh ◽

Wei-Li Ling ◽

Joshua Yi Yeo ◽

...

Keyword(s):

Specific Ige ◽

Type I ◽

Type Iv ◽

Mechanistic Insight ◽

Ige Mediated ◽

Underlying Mechanisms ◽

Type I Hypersensitivity ◽

Insight Into ◽

Shed Light ◽

Selection Of

SUMMARYNickel (Ni) allergy has been reported in contact dermatitis Type IV (Ni-specific T cells mediated) and asthmatic Type I (IgE-mediated) hypersensitivities. Associations between the two hypersensitivities have been found in some patients, but the underlying mechanisms remain enigmatic. Using Her2-specific IgEs as models, we found additional binding to Ni-NTA without observable changes in binding to Her2 and that glutamine, together with the canonical Ni2+-binding histidine, could form Ni2+ binding signatures. This mechanism may underlie Type I hypersensitivity in the selection of anti-Ni2+ IgEs. This mechanism may also underlie Type IV hypersensitivity and the interaction of immunoglobulin proteins with other heavy metal ions. Our findings shed light to how Ni hypersensitivities can occur and how they can be avoided in therapeutics design, or even incorporated for biotechnological purification purposes.

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Widely targeted metabolome profiling of different colored sesame (Sesamum indicum L.) seeds provides new insight into their antioxidant activities

Food Research International ◽

10.1016/j.foodres.2021.110850 ◽

2022 ◽

Vol 151 ◽

pp. 110850

Author(s):

Senouwa Segla Koffi Dossou ◽

Fangtao Xu ◽

Jun You ◽

Rong Zhou ◽

Donghua Li ◽

...

Keyword(s):

Antioxidant Activities ◽

Sesamum Indicum ◽

Metabolome Profiling ◽

Insight Into

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Germ-free mice exhibit mast cells with impaired functionality and gut homing and do not develop food allergy

10.1101/394213 ◽

2018 ◽

Author(s):

Martin Schwarzer ◽

Petra Hermanova ◽

Dagmar Srutkova ◽

Jaroslav Golias ◽

Tomas Hudcovic ◽

...

Keyword(s):

Food Allergy ◽

Mast Cells ◽

Specific Ige ◽

Edema Formation ◽

Germ Free ◽

Mechanistic Insight ◽

Mucosal Mast Cells ◽

Ige Mediated ◽

Low Levels ◽

Insight Into

ABSTRACTBackgroundMucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory.ObjectiveWe tested the hypothesis that commensal bacteria are essential for MC migration to the gut and their maturation impacting the susceptibility to FA.MethodsThe development and severity of FA symptoms was studied in sensitized germ-free (GF), conventional (CV) and mice mono-colonized with L. plantarum WCFS1 or co-housed with CV mice. MC were phenotypically and functionally characterized.ResultsSystemic sensitization and oral challenge of GF mice with ovalbumin led to increased levels of specific IgE in serum compared to CV mice. Remarkably, despite the high levels of sensitization, GF mice did not develop diarrhea or anaphylactic hypothermia, common symptoms of FA. In the gut, GF mice expressed low levels of the MC tissue-homing markers CXCL1 and CXCL2 and harbored fewer MC which exhibited lower levels of MC protease-1 after challenge. Additionally, MC in GF mice were less mature as confirmed by flow-cytometry and reduced edema formation after injection of degranulation-provoking compound 48/80. Co-housing of GF mice with CV mice fully restored their susceptibility to develop FA. However, this did not occur when GF mice were mono-colonized with L. plantarum.ConclusionOur results demonstrate that microbiota-induced maturation and gut-homing of MC is a critical step for the development of symptoms of experimental FA. This new mechanistic insight into microbiota-MC-FA axis can be exploited in the prevention and treatment of FA in humans.

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Calibration problems in hydrogen luminosities

Symposium - International Astronomical Union ◽

10.1017/s0074180900053626 ◽

1966 ◽

Vol 24 ◽

pp. 322-330

Author(s):

A. Beer

Keyword(s):

Galactic Structure ◽

B Stars ◽

Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

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