Effects of alginate oligosaccharide on the growth performance, antioxidant capacity and intestinal digestion-absorption function in weaned pigs

2017 ◽  
Vol 234 ◽  
pp. 118-127 ◽  
Author(s):  
Jin Wan ◽  
Jiao Zhang ◽  
Daiwen Chen ◽  
Bing Yu ◽  
Jun He
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Weaned Pigs ◽  
Absorption Function ◽  
Intestinal Digestion ◽  
Alginate Oligosaccharide

scholarly journals Effects of probiotic BaSC06 on intestinal digestion and absorption function, antioxidant capacity and macrophage polarization and microbiota composition in fattening pigs

2020 ◽  
Author(s):  
Xuefang Cao ◽  
Li Tang ◽  
Zihan Zeng ◽  
Baikui Wang ◽  
Yuanhao Zhou ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Intestinal Microbiota ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Microbiota Composition ◽  
Absorption Function ◽  
M2 Polarization ◽  
Intestinal Digestion ◽  
Fattening Pigs

Abstract Background: The previous study in our team found that supplementation of probiotic Bacillus amyloliquefaciens SC06 (BaSC06) as an alternative to antibiotics (Kitasamycin) can effectively reduce the diarrhea rate and promote the growth performance of weaned piglets. We speculate that BaSC06 may become a better substitute for antibiotics for fattening pigs. Hence, the objective of the present study is to evaluate the effects of BaSC06 substitute antibiotics on growth performance, digestive functions, antioxidant capacity, macrophage polarization and intestinal microbiota of fattening pigs. Methods: A total of 117 fattening pigs with similar weight and genetic basis were selected and divided into three groups: Anti group, fed with basal diet supplemented with 40 g/t Kitasamycin; Anti + Ba group, fed with 1 × 108 CFU/kg BaSC06 and 20 g/t Kitasamycin; Ba group, fed with 1 × 108 CFU/kg BaSC06 replaced Kitasamycin. Each treatment had three replications of 13 pigs per pen. Results: It indicated that BaSC06 replacement significantly improved ADFI and ADG in fattening pigs. It also improved intestinal digestion and absorption function with the increased activities of intestinal digestive enzymes and higher expression of glucose transporters SGLT1 and small peptide transporters PEPT1, maintained intestinal integrity significantly. Besides, supplementation with BaSC06 enhanced intestinal and body antioxidant capacity by activating Nrf2/ Keap1 antioxidant signaling pathway. In addition, BaSC06 as a substitute could alleviate intestinal inflammation by inhibiting the production of pro-inflammatory cytokines and chemokine and simultaneously increase the expression of M1 and M2 macrophage marker proteins in the intestinal mucosa. The transcription factor STAT3 regulated M2 polarization, which maintained immune homeostasis and reduced inflammation. What’s more, BaSC06 could improve the composition of the microbiota as well by increasing the proportion of Firmicutes, and reducing the proportion of Bacteroidetes and Proteobacteria. Conclusions: Taken together, our findings indicated that diet supplementation with BaSC06 instead of antibiotics increased the growth performance of piglets by improving the digestion and absorption of nutrients, intestinal microbiota composition and mucosal structure, antioxidative capacity and immune functions (including increasing M1and M2 polarization of macrophage).

scholarly journals New insights into the role of chitosan oligosaccharide in enhancing growth performance, antioxidant capacity, immunity and intestinal development of weaned pigs

RSC Advances ◽  
2017 ◽  
Vol 7 (16) ◽  
pp. 9669-9679 ◽  
Author(s):  
Jin Wan ◽  
Fei Jiang ◽  
Qingsong Xu ◽  
Daiwen Chen ◽  
Bing Yu ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Chitosan Oligosaccharide ◽  
Intestinal Development ◽  
Weaned Pigs ◽  
Growth Stimulant

Chitosan oligosaccharide (COS), an oligomer ofd-glucosamine, is a vital growth stimulant in the pig industry.

Effects of tea tree oil supplementation on growth performance, antioxidant capacity, immune status and microbial community in weaned pigs

2021 ◽  
Vol 75 (2) ◽  
pp. 121-136
Author(s):  
Gang Zhang ◽  
Jinbiao Zhao ◽  
Wenxuan Dong ◽  
Xiaoming Song ◽  
Jianjun Zang ◽  
...  
Keyword(s):  
Microbial Community ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Immune Status ◽  
Tea Tree Oil ◽  
Weaned Pigs ◽  
Tea Tree

scholarly journals Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs

2021 ◽  
Vol 8 ◽  
Author(s):  
Lixue Wang ◽  
Ying Zhang ◽  
Ling Liu ◽  
Fei Huang ◽  
Bing Dong
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Conversion Rate ◽  
Nutrient Digestibility ◽  
Intestinal Morphology ◽  
Tea Tree Oil ◽  
Feed Conversion ◽  
Weaned Pigs ◽  
Tea Tree ◽  
Feed Conversion Rate

Tea tree oil (TTO) exerts key roles in improving growth performance of pigs. However, knowledge is limited regarding comparative effects of Encp TTO and Un-encp TTO supplementation on growth performance of pigs. A study determined the effects of TTO or its capsulation on growth performance, antioxidant capacity, and intestinal microbiome of weaned pigs. A total of 144 healthy pigs (8.5 ± 0.24 kg) were subjected to four treatments for a 28-d trial with six replicates per treatment and six pigs per pen: negative control, NC; positive control, PC (antibiotic supplemented); Un-encp TTO (supplemented with unencapsulated TTO); Encp TTO (supplemented with encapsulated TTO). NC, TTO, and PC treatments were compared with regard to improved average daily gain (ADG), average daily feed intake (ADFI), feed conversion rate, nutrient digestibility, and intestinal morphology (p < 0.05) and decreased diarrhea rate. TTO- and PC-treated pigs had higher levels of serum superoxide dismutase, glutathione peroxidase, and immunoglobulin G; lower levels of liver aspartate aminotransferase and alanine aminotransferase; and improved concentrations of interleukin 10 (IL-10), tumor necrosis factor α, and IL-1β (p < 0.05). TTO- and PC-treated pigs had higher abundance of beneficial bacterial species Subdoligranulum and lower abundance of diarrhea associated species Escherichia–Shigella in cecal and colonic digesta (p < 0.05). Encapsulation of TTO preserved more activities of TTO than its unencapsulated counterpart by showing higher ADG, ADFI, and feed conversion rate during day 1 (d1) to d14 (p < 0.05) and tended to lower diarrhea rate (p = 0.083) and improve villous height/crypt depth (VH/CD) ratio (p = 0.089) in jejunum. Encapsulation of TTO also improved antioxidant indexes and decreased liver injury and inflammation accordingly (p < 0.05). Encapsulated TTO-treated pigs had higher abundance of beneficial Clostridium_sensu_stricto_1 and lower the abundance of harmful Escherichia–Shigella in cecal and colonic digesta (p < 0.05). Our results demonstrated TTO benefits on improving growth performance of weaned pigs and further proved that encapsulation of TTO was superior to its unencapsulated counterpart at multiples. Encapsulated TTO was similar to the PC group and could be potentially an alternative of feed antibiotics for weaned pigs.

scholarly journals Supplementation with Exogenous Catalase from Penicillium notatum in the Diet Ameliorates Lipopolysaccharide-Induced Intestinal Oxidative Damage through Affecting Intestinal Antioxidant Capacity and Microbiota in Weaned Pigs

2021 ◽  
Author(s):  
Jiali Chen ◽  
Fuchang Li ◽  
Weiren Yang ◽  
Shuzhen Jiang ◽  
Yang Li
Keyword(s):  
Oxidative Damage ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Weaned Pigs ◽  
Penicillium Notatum

Exogenous CAT derived from microorganisms has been widely used in food, medicine, and other industries. Recent study also found that exogenous CAT supplementation could improve growth performance and antioxidant capacity of weaned pigs.

scholarly journals Influences of Selenium-Enriched Yeast on Growth Performance, Immune Function, and Antioxidant Capacity in Weaned Pigs Exposure to Oxidative Stress

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Lei Liu ◽  
Daiwen Chen ◽  
Bing Yu ◽  
Yuheng Luo ◽  
Zhiqing Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Antioxidant Capacity ◽  
Immune Function ◽  
Growth Performance ◽  
Nuclear Factor ◽  
Serum Concentrations ◽  
Immune Functions ◽  
Weaned Pigs ◽  
Tnf Α

This study elucidated the function role of dietary selenium-enriched yeast (SeY) supplementation on growth performance, immune function, and antioxidant capacity in weaned pigs exposure to oxidative stress. Thirty-two similarity weight pigs were randomly divided into four treatments: (1) nonchallenged control, (2) control+SeY, (3) control+diquat, and (4) control+SeY+diquat. The period of experiment was 21 days; on day 16, pigs were injected with diquat or sterile saline. Results revealed that oxidative stress was notably detrimental to the growth performance of piglets, but SeY supplementation ameliorated this phenomenon, which might be regarding the increasing of body antioxidant capacity and immune functions. In details, SeY supplementation improved the digestibility of crude protein (CP), ash, and gross energy (GE). Moreover, the serum concentrations of proinflammatory cytokines (TNF-α, IL-1β, and IL-6), glutamic-pyruvic transaminase(GPT), and glutamic-oxaloacetic transaminase (GOT) were reduced via SeY supplemented, and serum concentrations of immunoglobulins A (IgA), IgG, and activities of antioxidant enzymes such as the superoxide dismutase (SOD), catalase (CAT) ,and glutathione peroxidase (GSH-Px) were improved in the diquat-challenged pigs ( P < 0.05 ). In addition, SeY supplementation acutely enhanced the activities of these antioxidant enzymes in the liver and thymus upon diquat challenge, which involved with the upregulation of the critical genes related antioxidant signaling such as the nuclear factor erythroid-derived 2-related factor 2 (Nrf-2) and heme oxygenase-1 (HO-1) ( P < 0.05 ). Importantly, we also found that SeY supplementation apparently reduced the malondialdehyde (MDA) concentrations in the liver, thymus, and serum ( P < 0.05 ). Specifically, the expression levels of TNF-α, IL-6, IL-1β, Toll-like receptor 4 (TLR-4), and nuclear factor-κB (NF-κB) in the liver and thymus were downregulated by SeY upon diquat challenge. These results suggested that SeY can attenuate oxidative stress-induced growth retardation, which was associated with elevating body antioxidant capacity, immune functions, and suppressed inflammatory response.

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