Risk factors and distribution features of level IB lymph nodes metastasis in nasopharyngeal carcinoma

Objectives: Imaging characteristis of MDCT in nasopharyngeal carcinoma. Subject and methods: Cross- sectional study in 51patients with nasopharyngeal carcinoma by MDCT at Danang Cancer Hospital from January 2013 to July 2014. Results: The findings reveal that the tumor in lateral wall (66.7%), diameter > 2cm (64.7%), hypodensity (98%), contrast- enhanced CT (62.7%). Blunting of fossa of Rosenmuller (96.1%), invasion of parapharyngeal space (62.7%), destruction of pterygoid bone (19.6%), invasion of skull base (17.6%), destruction of sphenoid bone (9.8%). Lymph nodes metastasis (96.1%), diameter (> 1- 3cm) is 58.8%. T-staging by CT showed T1 (35.3%), T2 (37.3%), T3 (17.6%) and T4 (9.8%). N- staging by CT showed N2 (66.7%), N3a- N3b (19.6%). Staging of Nasopharyngeal carcinoma: stage II-III (60.8%), stage IVA-IVB (23.5%) and stage IVC (11.8%). Conclusions: MDCT with a thinner slice thickness and high quality images is able to detect lymph nodes metastasis with small size and those in deep neck area and assess comprehensively the invasion of the tumor. Key words: Nasopharyngeal carcinoma, MDCT

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Management of malignant colon and rectal polyps (T1) after endoscopic polypectomy: analysis of pathological risk factors for lymph nodes metastasis. A retrospective multicentric observational study. POST-1 (Polypectomy Or Surgery for T1)

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2018.10.205 ◽

2019 ◽

Vol 45 (2) ◽

pp. e52-e53

Author(s):

D. Parini ◽

L. Saadeh ◽

M. Zizzo ◽

J. Sancho-Muriel ◽

L. Lorenzon ◽

...

Keyword(s):

Risk Factors ◽

Observational Study ◽

Lymph Nodes ◽

Endoscopic Polypectomy ◽

Lymph Nodes Metastasis ◽

Rectal Polyps

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Treatment outcome of nasopharyngeal carcinoma with retropharyngeal lymph nodes metastasis only and the feasibility of elective neck irradiation

Oral Oncology ◽

10.1016/j.oraloncology.2012.04.011 ◽

2012 ◽

Vol 48 (10) ◽

pp. 1045-1050 ◽

Cited By ~ 10

Author(s):

Xiaomin Ou ◽

Chunying Shen ◽

Lin Kong ◽

Xiaoshen Wang ◽

Jianhui Ding ◽

...

Keyword(s):

Treatment Outcome ◽

Nasopharyngeal Carcinoma ◽

Lymph Nodes ◽

Lymph Nodes Metastasis ◽

Neck Irradiation

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P-318 Risk Factors of Synchronous Inguinal Lymph Nodes Metastasis for Lower Rectal Cancer Involving the Anal Canal

Annals of Oncology ◽

10.1093/annonc/mdv233.314 ◽

2015 ◽

Vol 26 ◽

pp. iv93

Author(s):

R. Wang

Keyword(s):

Risk Factors ◽

Rectal Cancer ◽

Lymph Nodes ◽

Anal Canal ◽

Lower Rectal Cancer ◽

Inguinal Lymph Nodes ◽

Lymph Nodes Metastasis

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Pattern and Risk Factors of Central Compartment Lymph Node Metastasis in Papillary Thyroid Cancer: A Prospective Study from an Endocrine Surgery Centre

Journal of Thyroid Research ◽

10.1155/2012/436243 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Sudhi Agarwal ◽

Gyan Chand ◽

Sushila Jaiswal ◽

Anjali Mishra ◽

Gaurav Agarwal ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Lymph Nodes ◽

Tumour Size ◽

Central Compartment ◽

Papillary Thyroid ◽

Lymph Nodes Metastasis ◽

Lymph Nodes Dissection ◽

A Prospective Study

Lymphatic metastasis in papillary thyroid cancer (PTC) is eminent; however, the extent of central compartment lymph nodes dissection (CCD) is controversial and requires the knowledge of pattern and risk factors for central compartment lymph nodes metastasis (CCM). We did a prospective study of 47 cases with PTC who underwent total thyroidectomy (TT) with CCD with/without lateral lymph nodes dissection (LND). Clinicopathological profile including CCM as ipsilateral and contralateral was documented. On histopathology, the mean tumour size was3.57±2.42 cm 59.6% had CCM, which was bilateral in the majority (60.72%). The tumour-size was the most important predictor for lymph nodes metastasis-(P=0.018) whereas multicentricity-(P=0.002) and ipsilateral CCM-(P=0.001) were the predictors for contralateral CCM. The long-term morbidity of CCD done in primary setting is comparable with TT-alone. Bilateral CCD should be done with thyroidectomy in PTC, otherwise the risk of residual diseases and subsequent recurrence is high. The long-term morbidity is comparable in experienced hands.

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Risk Factors for Pathologically Confirmed Lymph Nodes Metastasis in Patients With Clinical T2N0M0 Stage Prostate Cancer

Frontiers in Oncology ◽

10.3389/fonc.2020.01547 ◽

2020 ◽

Vol 10 ◽

Author(s):

Ning Xu ◽

Zhi-Bin Ke ◽

Ye-Hui Chen ◽

Yu-Peng Wu ◽

Shao-Hao Chen ◽

...

Keyword(s):

Prostate Cancer ◽

Risk Factors ◽

Lymph Nodes ◽

Lymph Nodes Metastasis

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Risk Factors for Metastasis to No.253 Lymph Node for Colorectal Cancer Patients

10.21203/rs.3.rs-97658/v1 ◽

2020 ◽

Author(s):

Zhouyuan Du ◽

Dianshi Wang ◽

Yuan Li ◽

Peng Hu ◽

Chuanqing Wu ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Lymph Node ◽

Lymph Nodes ◽

Lymphovascular Invasion ◽

Perineural Invasion ◽

Radical Resection ◽

Histologic Grade ◽

Tumor Type ◽

Lymph Nodes Metastasis

Abstract Background: No.253 lymph nodes metastasis is related to poor prognosis of colorectal cancer, while the role of No.253 lymph nodes dissection in colorectal cancer is still controversial.Methods: A total of 157 patients who were received laparoscopic radical resection of colorectal cancer with preservation of the left colon artery + D3 lymph node dissection (low ligation + high dissection) in our hospital were enrolled. No.253 lymph nodes of each patients were dissected and sent for examination. Clinicaopathological factors correlated with No.253 lymph nodes metastasis, including gender, age, tumor location, tumor size, length of tumor from the anus, whether lymphovascular invasion, whether perineural invasion, tumor markers CEA, CA125 and CA199, tumor T stage, whether it is distant metastasis, the total number of lymph nodes harvested, tumor type, and histologic grade were respectively analyzed.Results: A total of 2286 lymph nodes were sent for examination, of which 557 No.253 lymph nodes were sent for examination. Among them, 5 patients had a total of 27 No.253 lymph node metastases. Preoperative CA125 level (X2=4.736, p=0.030), whether perineural invasion (X2=8.086, p<0.01), whether lymphovascular invasion (X2= 7.053, p<0.01), tumor type (X2=21.019, p<0.01), histologic grade (X2=15.315, p<0.01) were significantly correlated with positive No.253 lymph nodes metastasis. A multivariate logistic regression analysis showed that none of risk factor from above are independent risk factors for No.253 lymph node metastasis(P>0.05).Conclusion: Preoperative CA125 level, whether perineural invasion, whether lymphovascular invasion, tumor type, histologic grade were risk factors of the No.253 lymph nodes metastasis. Multivariate analysis showed that five risk factors from above were not the independent risk factor for No.253 lymph nodes metastasis. Colorectal cancer patients with the risk factors above were suggested to receive radical resection + D3 lymph node dissection.

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Development and validation of radiologic scores for guiding individualized induction chemotherapy in T3N1M0 nasopharyngeal carcinoma

European Radiology ◽

10.1007/s00330-021-08460-1 ◽

2022 ◽

Author(s):

Shan-Shan Yang ◽

Yi-Shan Wu ◽

Ya-Jun Pang ◽

Su-Ming Xiao ◽

Bao-Yu Zhang ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Nasopharyngeal Carcinoma ◽

Lymph Nodes ◽

Fdg Pet ◽

Cervical Lymph Nodes ◽

Pet Ct ◽

Risk Patients ◽

Fdg Pet Ct ◽

Ct And Mri

Abstract Objectives We aimed to develop and validate radiologic scores from [18F]FDG PET/CT and MRI to guide individualized induction chemotherapy (IC) for patients with T3N1M0 nasopharyngeal carcinoma (NPC). Methods A total of 542 T3N1M0 patients who underwent pretreatment [18F]FDG PET/CT and MRI were enrolled in the training cohort. A total of 174 patients underwent biopsy of one or more cervical lymph nodes. Failure-free survival (FFS) was the primary endpoint. The radiologic score, which was calculated according to the number of risk factors from the multivariate model, was used for risk stratification. The survival difference of patients undergoing concurrent chemoradiotherapy (CCRT) with or without IC was then compared in risk-stratified subgroups. Another cohort from our prospective clinical trial (N = 353, NCT03003182) was applied for validation. Results The sensitivity of [18F]FDG PET/CT was better than that of MRI (97.7% vs. 87.1%, p < 0.001) for diagnosing histologically proven metastatic cervical lymph nodes. Radiologic lymph node characteristics were independent risk factors for FFS (all p < 0.05). High-risk patients (n = 329) stratified by radiologic score benefited from IC (5-year FFS: IC + CCRT 83.5% vs. CCRT 70.5%; p = 0.0044), while low-risk patients (n = 213) did not. These results were verified again in the validation cohort. Conclusions T3N1M0 patients were accurately staged by both [18F]FDG PET/CT and MRI. The radiologic score can correctly identify high-risk patients who can gain additional survival benefit from IC and it can be used to guide individualized treatment of T3N1M0 NPC. Key Points • [18F]FDG PET/CT was more accurate than MRI in diagnosing histologically proven cervical lymph nodes. • Radiologic lymph node characteristics were reliable independent risk factors for FFS in T3N1M0 nasopharyngeal carcinoma patients. • High-risk patients identified by the radiologic score based on [18F]FDG PET/CT and MRI could benefit from the addition of induction chemotherapy.

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