Antioxidant compounds from Annona crassiflora fruit peel reduce lipid levels and oxidative damage and maintain the glutathione defense in hepatic tissue of Triton WR-1339-induced hyperlipidemic mice

2021 ◽  
Vol 142 ◽  
pp. 112049 ◽  
Author(s):  
Letícia Pereira Afonso Ramos ◽  
Allisson Benatti Justino ◽  
Natália Tavernelli ◽  
André Lopes Saraiva ◽  
Rodrigo Rodrigues Franco ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Hepatic Tissue ◽  
Antioxidant Compounds ◽  
Lipid Levels ◽  
Fruit Peel ◽  
Triton Wr 1339 ◽  
Annona Crassiflora

scholarly journals Characterization, Stability, and Bioaccessibility of Betalain and Phenolic Compounds from Opuntia stricta var. Dillenii Fruits and Products of Their Industrialization

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1593
Author(s):  
Iván Gómez-López ◽  
Gloria Lobo-Rodrigo ◽  
María P. Portillo ◽  
M. Pilar Cano
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Acids ◽  
Total Phenolic ◽  
Antioxidant Compounds ◽  
Gastrointestinal Digestion ◽  
Fruit Peel ◽  
Full Characterization ◽  
In Vitro Gastrointestinal Digestion ◽  
Quercetin Glycoside

The aim of the present study was the full characterization, quantification, and determination of the digestive stability and bioaccessibility of individual betalain and phenolic compounds of Opuntia stricta, var. Dillenii fresh fruits (peel, pulp, and whole fruit) and of the products of the industrialization to obtain jam (raw pressed juice (product used for jam formulation), by-product (bagasse), and frozen whole fruit (starting material for jam production)). Opuntia stricta var. Dillenii fruits and products profile showed 60 betalain and phenolic compounds that were identified and quantified by HPLC-DAD-ESI/MS and HPLC-DAD-MS/QTOF, being 25 phenolic acids (including isomers and derivatives), 12 flavonoids (including glycosides), 3 ellagic acids (including glycosides and derivative), and 20 betanins (including degradation compounds). In vitro gastrointestinal digestion was performed by INFOGEST® protocol. Fruit pulp showed the greater content of total betalains (444.77 mg/100 g f.w.), and jam only showed very low amounts of two betanin degradation compounds, Cyclo-dopa-5-O-β-glucoside (and its isomer) (0.63 mg/100 f.w.), and two Phyllocactin derivatives (1.04 mg/100 g f.w.). Meanwhile, fruit peel was the richer tissue in total phenolic acids (273.42 mg/100 g f.w.), mainly in piscidic acid content and total flavonoids (7.39 mg/100 g f.w.), isorhamnetin glucoxyl-rhamnosyl-pentoside (IG2) being the most abundant of these compounds. The stability of betalains and phenolic compounds during in vitro gastrointestinal digestion is reported in the present study. In Opuntia stricta var. Dillenii pulp (the edible fraction of the fresh fruit), the betanin bioaccessibility was only 22.9%, and the flavonoid bioaccessibility ranged from 53.7% to 30.6%, depending on the compound. In non-edible samples, such as peel sample (PE), the betanin bioaccessibility was 42.5% and the greater bioaccessibility in flavonoids was observed for quercetin glycoside (QG1) 53.7%, the fruit peel being the most interesting material to obtain antioxidant extracts, attending to its composition on antioxidant compounds and their bioaccessibilities.

Peel of araticum fruit (Annona crassiflora Mart.) as a source of antioxidant compounds with α-amylase, α-glucosidase and glycation inhibitory activities

2016 ◽  
Vol 69 ◽  
pp. 167-182 ◽  
Author(s):  
Allisson B. Justino ◽  
Mariana N. Pereira ◽  
Danielle D. Vilela ◽  
Leonardo G. Peixoto ◽  
Mário M. Martins ◽  
...  
Keyword(s):  
Antioxidant Compounds ◽  
Inhibitory Activities ◽  
Annona Crassiflora

Protective Mechanisms of Quercetin on Cisplatin Induced Oxidative Damage in Hepatic Tissue of Wistar Rats

2017 ◽  
Vol 88 (4) ◽  
pp. 1399-1407 ◽  
Author(s):  
Pawan K. Verma ◽  
Rajinder Raina ◽  
Shahid Prawez ◽  
Mudasir Sultana ◽  
Maninder Singh ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Hepatic Tissue ◽  
Protective Mechanisms

LC–MS/MS methods for the detection of isoprostanes (iPF2α-III and 8,12-iso-iPF2α-VI) as biomarkers of CCl4-induced oxidative damage to hepatic tissue

2008 ◽  
Vol 861 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Tina Sicilia ◽  
Angela Mally ◽  
Ute Schauer ◽  
Axel Pähler ◽  
Wolfgang Völkel
Keyword(s):  
Oxidative Damage ◽  
Hepatic Tissue

A mechanism-based pharmacological evaluation of efficacy of Flacourtia indica in management of dyslipidemia and oxidative stress in hyperlipidemic rats

2016 ◽  
Vol 27 (2) ◽  
Author(s):  
Shiv Vardan Singh ◽  
Atul Shrivastava ◽  
Jyotshna ◽  
Upma Chaturvedi ◽  
Subhash Chandra Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plasma Lipid ◽  
Antioxidant Potential ◽  
Lipid Levels ◽  
Pharmacological Evaluation ◽  
Triton Wr 1339 ◽  
Intraperitoneal Dose ◽  
And Oxidative Stress

AbstractHyperlipidemia was induced by a single intraperitoneal dose of Triton WR-1339 in Charles Foster rats. The plasma lipid levels were estimated in control and treated groups. The antioxidant potential ofTheThese finding suggest that

scholarly journals Effect of Rambutan Fruit Peel Extract on Total Sperm Counts of Wistar Rats With Obesity

Biota ◽  
2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Kerin Victoria Sipahutar ◽  
Yudhi Nugraha ◽  
Cut Fauziah
Keyword(s):  
Wistar Rats ◽  
Semen Quality ◽  
Sperm Count ◽  
Control Group ◽  
Antioxidant Compounds ◽  
P Value ◽  
High Fat ◽  
Fruit Peel ◽  
Group I ◽  
Peel Extract

Obesity caused by a high-fat diet leads to an altered reproductive hormonal profile, including impaired semen quality. Antioxidants can overcome these conditions. One of the well-known sources of antioxidants is in the rambutan fruit peel extract. This research aimed to figure the effect of rambutan fruit peel extract towards total sperm count in Wistar rats induced with high-fat feed. The study design used post-test only control group,  subjects were 30 male Wistar rats divided into five groups: Group I (Positive Control) was given high-fat feed, Group II (Treatment Control Group) was given 15mg/kg BW rambutan fruit peel extract, whereas group III, IV, V (Treatment Group) were given an extract of rambutan skin with a dosage of 15, 30, and 60 mg/kg BW, respectively. Treatment was administered for 81 days. This study showed that rambutan fruit peel extract with doses of 15, 30, and 60 mg/kg BW has significantly increased total sperm count in Wistar rats induced with high-fat feed. The outcome using Kruskal Wallis shows a result of p-value 0,010 (CI 95%). Antioxidant compounds found in rambutan fruit peel extract significantly increase total sperm count in Wistar rats induced with high-fat feed, with the highest efficacy on the dose of 15mg/kg BW.   Keywords: Fruit Peel Rambutan Extract; ; ; 

scholarly journals Bioactive compounds content of Snake Fruit Peel, Aloe Vera, and Stevia Extracts as Raw Material of Functional Drinks

2020 ◽  
Vol 1 (1) ◽  
pp. 34
Author(s):  
Amalya Nurul Khairi ◽  
Nurkhasanah Nurkhasanah
Keyword(s):  
Bioactive Compounds ◽  
Aloe Vera ◽  
Total Phenol ◽  
Raw Material ◽  
Antioxidant Compounds ◽  
Fruit Peel ◽  
Two Factors ◽  
Phenol Composition ◽  
Functional Drink ◽  
Peel Extract

The objective of the research is to analyze the content of the bioactive compounds of extracts made of snake fruit skin, Aloe vera, and Stevia as materials to make functional drinks. Salacca zalacca (Gaert.) Voss. cultivar has flavonoid, tannin, and a bit of alkaloid on its fruit peel. Aloe vera and Stevia also known to have antioxidant compounds. Aloe vera controls the metabolism of carbohydrates and maintaining homeostasis of glucose. The research methods are divided into steps: 1) the extraction of Snake fruit peel, Aloe vera, and Stevia; 2) the formulation of the functional drink; 3)the evaluation of antioxidant, total phenol, and tannin levels of the formulated extracts. The research used Randomized Group Design (RGD) of two factors, and each factor consists of 4 levels and 2 levels. Factor I=the ratio of snake fruit peel:Aloe vera extract (10:90 (v/v); 30:70 (v/v); 70:30 (v/v); 90:10 (v/v)) and factor II= addition of Stevia filtrate (2%; 4%) (v/v total). The best nutrient of the formulated functional drink is obtained by the composition of 90% snake fruit peel extract, 10% aloe vera, and 4% stevia. The snake fruit peel extract significantly affects the antioxidant activity and total phenol composition, aloe vera extract has an insignificant effect on active compounds, and stevia affects the tannin level of the functional drink.

scholarly journals Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jonna Weisell ◽  
Anna-Kaisa Ruotsalainen ◽  
Juha Näpänkangas ◽  
Matti Jauhiainen ◽  
Jaana Rysä
Keyword(s):  
Aortic Valve ◽  
Body Weight Gain ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Hepatic Tissue ◽  
Lipid Levels ◽  
Calcific Aortic Valve Disease ◽  
Beneficial Effects ◽  
Valvular Calcification ◽  
Cytokines And Chemokines

AbstractIn calcific aortic valve disease (CAVD) progressive valvular calcification causes aortic valve dysfunction. CAVD has several risk factors such as age and dyslipidemia. Vitamin K was shown to inhibit vascular calcification in mice and valvular calcification in patients with CAVD. We studied the effect of menaquinone 4 (MK4/vitamin K2) on valvular calcification in the hypercholesterolemic mouse model of CAVD. LDLr−/−ApoB100/100 male mice were fed with a Western diet for 5 months, with (n = 10) or without (n = 10) added 0.2 mg/g MK4. Body weight gain was followed weekly. Morphology of aortic valves and liver was assessed with immunohistochemistry. Plasma cholesterol levels and cytokines from hepatic tissue were assessed in the end of the study. Hepatic gene expression of lipid metabolism regulating genes were assessed after 18 h diet. MK4 exacerbated the lipoprotein lipid profile without affecting aortic valve morphology in hypercholesterolemic LDLr−/− ApoB100/100 mice. The MK4-containing WD diet increased plasma levels of LDL and triglycerides, hepatic steatosis, and mRNA expression of genes required for triglyceride and cholesterol synthesis. MK4 diminished levels of several cytokines and chemokines in liver, including IL-6, TNFα and MCP1, as measured by hepatic cytokine array. Consequently, MK4 may exert non-beneficial effects on circulating lipid levels, especially in hypercholesterolemic individuals.

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