scholarly journals Effects of Load and Contact Time on the Stability of Bimolecular Integrin-Fibrinogen Bonds Under a Constant Tensile Force

2009 ◽  
Vol 96 (3) ◽  
pp. 595a
Author(s):  
Rustem I. Litvinov ◽  
Joel S. Bennett ◽  
John W. Weisel ◽  
Henry Shuman
Author(s):  
M. X. Zhao ◽  
B. Balachandran ◽  
M. A. Davies ◽  
J. R. Pratt

Abstract In this paper, numerical and experimental investigations conducted into the dynamics and stability of partial immersion milling operations are presented. A mechanics based model is used for simulations of a wide range of milling operations and instabilities that arise due to regeneration and/or impact effects are studied. Poincaré sections are used to assess the stability of motions. The studies reveal that apart from Hopf bifurcation of a periodic motion, a period-doubling bifurcation of a periodic motion may also lead to chatter in partial immersion milling operations. Issues such as tooth contact time variation and structure of stability charts are also discussed.


2020 ◽  
Vol 108 (6) ◽  
pp. 425-431
Author(s):  
Shunyan Ning ◽  
Jie Zhou ◽  
Shichang Zhang ◽  
Wei Zhang ◽  
Yuezhou Wei

AbstractTo directly separate actinides from high level liquid waste (HLLW), a novel molecule, i. e. isoPentyl-BTBP (6,6′-bis(5,6-bis(4-methylpentyl)-1,2,4-triazin-3-yl)-2,2′-bipyridines) was synthesized and characterized. A kind of isoPentyl-BTBP/SiO2-P adsorbent was obtained by impregnating isoPentyl-BTBP into porous silica/polymer support particles SiO2-P under reduced pressure. The effect of HNO3 concentration, contact time on the adsorption of isoPentyl-BTBP/SiO2-P towards 241Am(III) and 239Pu(IV) was studied. And the stability of isoPentyl-BTBP/SiO2-P in HNO3 medium was also evaluated. It turned out that isoPentyl-BTBP/SiO2-P had much higher affinity for 241Am(III) and 239Pu(IV) over FP elements in 3 M HNO3, fast adsorption kinetics towards 239Pu(IV), excellent stability in HNO3 medium, and should be a very promising adsorbent for separating 239Pu(IV) and 241Am(III) from HLLW.


1989 ◽  
Vol 13 ◽  
pp. 140-145 ◽  
Author(s):  
Bernhard Lackinger

The fracture of a slab avalanche is a multi-phase and progressive process. The different kinds of fracture and possible scenarios of avalanche release in the form of a zip effect are shown. In the course of investigations, most importance has so far been attached to shear failure along the sliding surface. Various cases of load and their effects on the stresses, on the changes of strength, and on the stability of the inclined snow-pack are discussed. The usual simple model of the shear-stability index is unsatisfactory. The present paper deals with the complex interaction of all supporting forces of a snow slab by means of simplified geotechnical considerations. For this purpose, the acting and reacting forces of a “standard avalanche” (i.e. dead load with driving and normal component, shear force, tensile force, compressive force, and flank force) are estimated from published boundary values. Using different combinations (e.g. hard slab with high circumferential forces on a weak shear surface with low shear force), it can be shown that suspension at the crown and lower and lateral support are of great importance. This applies especially to cases with low shear forces and, consequently, with low overall stability. Despite the fact that the circumferential area of the model avalanche is only 6% of the area of the shear surface, the circumferential force in this case is more than 150% of the shear force. In a parameter study with different avalanche sizes, these results are generalized and confirmed. For the assumed strength limits, critical areas and depths of possible slab avalanches can be derived. Although the supporting shear force is the major contributor to stability, particularly with larger slabs, it can be seen from the investigations that the redistributions of stress and spatial supports and suspensions of the whole slab avalanche must not be neglected in stability analyses.


2010 ◽  
Vol 8 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Ljubomir Vlajic ◽  
Dragan Kostic

The paper presents the results of static and dynamic tests of double layered catenary of the swimming pool building roof in Leskovac. By the comparison of measured and calculated values, a potential was created to correct the mathematical model, and to verify it. Only then, the calculation model for all sorts of static and dynamic load was able to simulate the realistic behavior of the structure. In this paper, the authors presented the basic recommendations in terms of what initial tensile force should be adopted in order to control the stability of such very cost-effective girders.


2019 ◽  
Vol 9 (11) ◽  
pp. 2175 ◽  
Author(s):  
Liang Jia ◽  
Shikai He ◽  
Na Li ◽  
Wei Wang ◽  
Kai Yao

Based on the horizontal slice method (HSM) and assuming a log spiral slip surface, a method to analyze the stability of a reinforced retaining wall under seismic loads was established in this study by calculating the tensile force of the reinforcement. A parametric study was conducted on the normalized tensile force of the reinforcement, and it was observed that the normalized tensile force tends to increase with acceleration of the seismic load and the height of the backfill. Moreover, it also increases with soil unit weight, while it decreases with increased friction angle of the backfill soil, and the influence of soil cohesion on the normalized tensile force is not significant. The HSM method is proved to be suitable for analyzing the tensile force of reinforcement in retaining walls under seismic loads.


2016 ◽  
Vol 83 (4) ◽  
Author(s):  
Li-Yuan Zhang ◽  
Zi-Long Zhao ◽  
Qing-Dong Zhang ◽  
Xi-Qiao Feng

Chiral structures have many technologically significant applications in engineering. In this paper, we investigate, both theoretically and experimentally, the structural transformation from a symmetric X-shaped tensegrity to a chiral structure under uniaxial tension. When the applied tensile force exceeds a critical value, the initially achiral structure would exhibit snap-through buckling. At the critical state, the in-plane deformation mode of the tensegrity switches into an off-plane one. The critical condition of the structural transformation is provided in terms of structural parameters. An experiment was performed to validate the theoretical model. This work may not only deepen our understanding of the stability of tensegrities but also help design chiral structures for engineering applications.


2015 ◽  
Vol 2015 ◽  
pp. 1-12
Author(s):  
Yan Wang ◽  
Tao Jing ◽  
Jimei Wu ◽  
Min Xie

The stability of the moving viscoelastic plate with the piezoelectric layer subjected to uniformly distributed tangential follower force is investigated. The force excited by the piezoelectric layer due to external voltage is modeled as the follower tensile force. The differential equation of the axially moving viscoelastic rectangular plate with piezoelectric layer subjected to uniformly distributed tangential follower force is formulated on the basis of the Kirchhoff thin plate theory and the two-dimensional viscoelastic differential constitutive relation. The complex eigenvalue equations are established by the differential quadrature method. Via numerical calculation, the curves of real parts and imaginary parts of dimensionless complex frequencies versus uniformly distributed tangential follower force and dimensionless moving speed are obtained. The effects of nonconservative force, dimensionless axially moving speed, and dimensionless applied voltages on the stability of axially moving nonconservative viscoelastic plate with piezoelectric layer are analyzed.


Author(s):  
Mathilde Bonnet ◽  
Marine Dermu ◽  
Clara Roessle ◽  
Marc Bellaiche ◽  
Tarik Abarou ◽  
...  

Abstract Background Eosinophilic Esophagitis is an increasing pathology which can cause stomach symptom like dysphagia, vomiting, food blockage. The treatment consists in dietary therapy and topical corticosteroid therapy to avoid the important number of side effects of the oral corticosteroids. There is presently no available topical form adapted for treating esophageal pathology. Methods The aim of this work was to develop an oral viscous budesonide gel (OVBG). A focus on palatability was made in order to use OVBG in children. A stability indicating HLPC method able to quantify budesonide contained in our OVBG has been developed. Results Previous work of Hefner and Al. showed that xanthan gum had a longer esophageal mucosal contact time than sucralose. This encouraged the development of a xanthan gum-based formulation. This OVBG has also the advantage to facilitate compliance thanks to its taste and pleasant texture. The stability length of the preparation can be extended over a 3-months period, stored in a refrigerator at 2–8 °C. Conclusion An adapted pediatric formulation with a 3-months stability was developed. Furthermore, the formulation can be easily reproduced in community pharmacy. Regarding the increasing number of patients concerned OVBG is a good answer to a real clinical need.


Catalysts ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 836
Author(s):  
Hengshuai Li ◽  
Haiquan Hu ◽  
Chenglin Bai ◽  
Chunjiang Bao ◽  
Cailong Liu ◽  
...  

It is of practical significance to find organic metal-free catalyst materials. We propose a new graphene-like carbon nitride structure, which was able to meet these requirements well. Its primitive cell consists of eight carbon atoms and six nitrogen atoms. Hence, we called this structure g–C8N6. The stability of the structure was verified by phonon spectroscopy and molecular dynamics simulations. Then its electronic structure was calculated, and its band edge position was compared with the redox potential of water. We analyzed its optical properties and electron–hole recombination rate. After the above analysis, it is predicted that it is a suitable photocatalyst material. To improve its photocatalytic performance, two methods were proposed: applied tensile force and multilayer stacking. Our research is instructive for the photocatalytic application of this kind of materials.


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