scholarly journals Parsing Heterogeneity in Mood Disorders: The Challenges of Modeling Stable Mood Disorder–Related Functional Connectomes

2022 ◽  
Vol 7 (1) ◽  
pp. 7-9
Author(s):  
Emily L. Belleau
Keyword(s):  
Mood Disorder ◽  
Mood Disorders

Obtaining a Family Psychiatric History: Is it Worth the Effort?

1993 ◽  
Vol 38 (9) ◽  
pp. 590-594 ◽  
Author(s):  
Ronald A. Remick ◽  
Adele D. Sadovnick ◽  
Boris Gimbarzevsky ◽  
Raymond W. Lam ◽  
Athanasios P. Zis ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Medical Records ◽  
Psychiatric History ◽  
First Degree Relatives ◽  
History Of ◽  
Generated Family ◽  
Index Cases

The purpose of this study was to determine whether, for first-degree relatives of patients presenting to a mood disorders clinic, family history information on psychiatric conditions collected by a psychiatrist and incorporated into the patient's medical records is as informative as that gathered during an interview specifically designed to collect family history data. The study group consisted of 472 first-degree relatives of 78 randomly selected index cases from a large mood disorders genetic database. Family history of psychiatric disorders recorded in regular psychiatric medical records (“clinician history”), and data obtained by a genetic counsellor administering specific family psychiatric history questionnaires to patients and multiple family informants (“family history”) were compared using a kappa statistic. Good agreement between the two methods on the presence or absence of a psychiatric disorder was found among first-degree relatives of index cases, but poor agreement was found with respect to the presence or absence of a specific mood disorder diagnosis(es) in a relative. The results suggest that a clinician-generated family psychiatric history is sensitive to the presence or absence of a psychiatric disorder when compared to a more structured detailed genetic interview. However, for research purposes, a clinician-generated family psychiatric history of a specific mood disorder diagnosis, without supporting collateral information, may not be reliable for use in supporting a mood disorder diagnosis in a patient and/or his relatives.

scholarly journals Kleptomania, mood disorder and lithium

1992 ◽  
Vol 50 (4) ◽  
pp. 543-546 ◽  
Author(s):  
Fábio Lopes Rocha ◽  
Maria Elizabete Guimarães Rocha
Keyword(s):  
Major Depression ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Pharmacological Treatment ◽  
Lithium Therapy ◽  
Bipolar Mood Disorder

Kleptomania has been found in association with major depression in a fairly large number of reports in recent years. We describe a patient with concurrent DSM-III-R Bipolar Mood Disorder and Kleptomania, whose symptoms remitted completely, apparently in response to lithium therapy, which raised the possibility that pharmacological treatment may benefit kleptomania. Further studies are needed to establish the possible relationship between kleptomania, mood disorders and lithium therapy.

The Prevention of Suicide in Patients with Recurrent Mood Disorder

1992 ◽  
Vol 6 (2_suppl) ◽  
pp. 334-339
Author(s):  
Malcolm Peet
Keyword(s):  
Mood Disorder ◽  
Mood Disorders ◽  
Health Workers ◽  
Lithium Treatment ◽  
Term Treatment ◽  
Mental Health Workers ◽  
Long Term Treatment ◽  
Reduced Rate ◽  
Commit Suicide

Recurrent mood disorder carries a risk of suicide of ~ 15%. Patients who do commit suicide have often received inadequate antidepressant or prophylactic lithium treatment. Long-term treatment with lithium normalizes the excess mortality associated with recurrent mood disorders, including that from suicide. A reduced availability of the most lethal methods of suicide may contribute epidemiologically to a reduced rate of suicide, and therefore the differences in overdose toxicity between antidepressants may be pertinent. Education of mental health workers regarding the effective treatment of mood disorders can help to reduce the rate of suicide. Patient education and psychological support can lead to improved compliance with prophylactic medication and early detection of relapse, but more formal psychotherapy does not appear to be helpful. Specialized mood disorder clinics lead to better patient care than is possible in a routine psychiatric out-patient clinic.

Comorbidity of dsm-iii-r personality disorders in schizophrenic and unipolar mood disorders: a comparative study

1997 ◽  
Vol 12 (6) ◽  
pp. 316-318 ◽  
Author(s):  
P Oulis ◽  
L Lykouras ◽  
J Hatzimanolis ◽  
V Tomaras
Keyword(s):  
Personality Disorder ◽  
Mental Disorders ◽  
Comparative Study ◽  
Mood Disorder ◽  
Personality Disorders ◽  
Mood Disorders ◽  
Clinical Interview ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Patient Groups

SummaryWe investigated the overall prevalence and the differential comorbidity of Diagnostic and Statistical Manual (DSM)-III-R personality disorders in 166 remitted or recovered patients with schizophrenic (n = 102) or unipolar mood disorder (n = 64). Over 60% of both patient groups met the DSM-III-R criteria of at least one DSM-III-R personality disorder as assessed by means of the Structured Clinical Interview for DSM-III-R (SCID-II-R), receiving on average 3.1 personality diagnoses. Neither DSM-III-R categories of personality disorders, nor scores on its three clusters A, B and C, nor total score on SCID-II-R differed significantly across the two groups. In conclusion, DSM-III-R personality disorders, although highly prevalent in schizophrenic and unipolar mood disorders, lack any specificity with respect to these categories of mental disorders.

scholarly journals Mood Disorders in Late Life: A Population-based Analysis of Prevalence, Risk Factors, and Consequences in Community-dwelling Older Adults in Ontario: Troubles de l’humeur en âge avancé : Une analyse dans la population de la prévalence, des facteurs de risque et des conséquences chez des adultes âgés vivant en milieu communautaire en Ontario

2020 ◽  
Vol 65 (9) ◽  
pp. 630-640
Author(s):  
Rachel Strauss ◽  
Paul Kurdyak ◽  
Richard H. Glazier
Keyword(s):  
Risk Factors ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Potential Risk ◽  
Late Life ◽  
Population Based ◽  
Community Dwelling ◽  
Self Report ◽  
Term Care ◽  
Potential Risk Factors

Objective: Mental health issues in late life are a growing public health challenge as the population aged 65 and older rapidly increases worldwide. An updated understanding of the causes of mood disorders and their consequences in late life could guide interventions for this underrecognized and undertreated problem. We undertook a population-based analysis to quantify the prevalence of mood disorders in late life in Ontario, Canada, and to identify potential risk factors and consequences. Method: Individuals aged 65 or older participating in 4 cycles of a nationally representative survey were included. Self-report of a diagnosed mood disorder was used as the outcome measure. Using linked administrative data, we quantified associations between mood disorder and potential risk factors such as demographic/socioeconomic factors, substance use, and comorbidity. We also determined associations between mood disorders and 5-year outcomes including health service utilization and mortality. Results: The prevalence of mood disorders was 6.1% (4.9% among males, 7.1% among females). Statistically significant associations with mood disorders included younger age, female sex, food insecurity, chronic opioid use, smoking, and morbidity. Individuals with mood disorders had increased odds of all consequences examined, including placement in long-term care (adjusted odds ratio [OR] =2.28; 95% confidence interval [CI], 1.71 to 3.02) and death (adjusted OR = 1.35; 95% CI, 1.13 to 1.63). Conclusions: Mood disorders in late life were strongly correlated with demographic and social/behavioral factors, health care use, institutionalization, and mortality. Understanding these relationships provides a basis for potential interventions to reduce the occurrence of mood disorders in late life and their consequences.

Anxiety disorders comorbidity in mood disorder subgroups: data from a mood disorders clinic

2001 ◽  
Vol 67 (1-3) ◽  
pp. 167-173 ◽  
Author(s):  
Boghos I Yerevanian ◽  
Ralph J Koek ◽  
Swarnalatha Ramdev
Keyword(s):  
Anxiety Disorders ◽  
Mood Disorder ◽  
Mood Disorders

scholarly journals Mental Health in the Cree Peoples of Northern Quebec: Relationships Among Trauma, Familial Psychological Distress, and Mood or Anxiety Disorders

2018 ◽  
Vol 64 (3) ◽  
pp. 180-189
Author(s):  
Laura M. Heath ◽  
Jill Torrie ◽  
Kathryn J. Gill
Keyword(s):  
Mental Health ◽  
Sexual Abuse ◽  
Psychological Distress ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Emotional Abuse ◽  
Substance Dependence ◽  
Physical And Mental Health ◽  
Parental History ◽  
History Of

Objective: This study examined the physical and mental health of Cree adults, as well as the personal, clinical, and environmental factors associated with the presence of lifetime anxiety and mood disorders. Methods: Mental health was assessed using the computerised version of the Diagnostic Interview Schedule (CDIS-IV), and standardised instruments were used to assess physical health, addiction severity, and psychological distress in 506 randomly selected participants from 4 Northern Cree communities in Quebec. Results: Overall, 46.1% of participants reported chronic medical problems, 42.1% were current smokers and 34.5% met the DSM-IV criteria for an anxiety or mood disorder. Individuals with an anxiety or mood disorder were younger, predominantly female, and with higher educational levels, and a large proportion (47.7%) met the lifetime criteria for substance dependence. Hierarchical regression determined that anxiety or mood disorders were associated with serious problems getting along with parents, a history of physical and sexual abuse, and a lifetime diagnosis of substance dependence. Overall, 29.7% of Cree adults reported sexual abuse, 47.1% physical abuse, and 52.9% emotional abuse. Conclusions: This study highlights the high rates of physical and mental health problems in Cree communities and the association among parental history of psychological problems, history of abuse, and psychological distress. Participants expressed a desire for additional medical and psychological treatments to address the patterns of abuse, trauma, and mental disorders that are burdening the Cree communities in Northern Quebec.

scholarly journals Toward Effective Early Intervention and Prevention Strategies for Major Affective Disorders: A Review of Antecedents and Risk Factors

2000 ◽  
Vol 45 (4) ◽  
pp. 340-348 ◽  
Author(s):  
Anne Duffy
Keyword(s):  
Risk Factors ◽  
Early Intervention ◽  
Family History ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Relevant Literature ◽  
Positive Family History ◽  
Prevention Strategies ◽  
Sociological Factors ◽  
Treatment And Prevention

Objective: To review critically the literature pertaining to riskfactors and antecedent symptoms and syndromes in order to determine an empirically based strategy for early treatment and prevention of major mood episodes. Method: The relevant literature is summarized, with particular emphasis on early-onset (child and adolescent) mood disorders. Results: A complex interaction between biological, psychological, and sociological factors contributes to the development of a major mood disorder. Having a positive family history of mood disorder (bipolar and unipolar) and being female (unipolar) are the strongest, most reliable risk factors. There is continuity between adolescent and adult mood disorders, and subsyndromal mood disturbance in adolescents has clinical and public health significance. However, more longitudinal study is required to reliably map the course and predictive importance of mood disorders in very young children. Conclusions: Substantial evidence supports the effectiveness of early intervention and prevention efforts in children at risk for mood disorders (identified as having affected family members) and in adolescents manifesting significant mood symptoms and syndromes (especially if associated with a positive family history). However, the current level of understanding regarding the etiological significance and mechanism of risk factors associated with mood disorders does not support broad community-based primary prevention strategies in unselected populations.

scholarly journals The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Richard J. Shaw ◽  
Daniel Mackay ◽  
Jill P. Pell ◽  
Sandosh Padmanabhan ◽  
David S. Bailey ◽  
...  
Keyword(s):  
Mood Disorder ◽  
Mood Disorders ◽  
Cox Regression ◽  
Previous History ◽  
Area Deprivation ◽  
Antihypertensive Medications ◽  
Healthcare Data ◽  
Increased Risk ◽  
History Of ◽  
New Onset

Abstract Background Recent work suggests that antihypertensive medications may be useful as repurposed treatments for mood disorders. Using large-scale linked healthcare data we investigated whether certain classes of antihypertensive, such as angiotensin antagonists (AAs) and calcium channel blockers, were associated with reduced risk of new-onset major depressive disorder (MDD) or bipolar disorder (BD). Method Two cohorts of patients treated with antihypertensives were identified from Scottish prescribing (2009–2016) and hospital admission (1981–2016) records. Eligibility for cohort membership was determined by a receipt of a minimum of four prescriptions for antihypertensives within a 12-month window. One treatment cohort (n = 538 730) included patients with no previous history of mood disorder, whereas the other (n = 262 278) included those who did. Both cohorts were matched by age, sex and area deprivation to untreated comparators. Associations between antihypertensive treatment and new-onset MDD or bipolar episodes were investigated using Cox regression. Results For patients without a history of mood disorder, antihypertensives were associated with increased risk of new-onset MDD. For AA monotherapy, the hazard ratio (HR) for new-onset MDD was 1.17 (95% CI 1.04–1.31). Beta blockers' association was stronger (HR 2.68; 95% CI 2.45–2.92), possibly indicating pre-existing anxiety. Some classes of antihypertensive were associated with protection against BD, particularly AAs (HR 0.46; 95% CI 0.30–0.70). For patients with a past history of mood disorders, all classes of antihypertensives were associated with increased risk of future episodes of MDD. Conclusions There was no evidence that antihypertensive medications prevented new episodes of MDD but AAs may represent a novel treatment avenue for BD.

scholarly journals Using resting-state intrinsic network connectivity to identify suicide risk in mood disorders

2019 ◽  
Vol 50 (14) ◽  
pp. 2324-2334 ◽  
Author(s):  
Jonathan P. Stange ◽  
Lisanne M. Jenkins ◽  
Stephanie Pocius ◽  
Kayla Kreutzer ◽  
Katie L. Bessette ◽  
...  
Keyword(s):  
Mood Disorder ◽  
Mood Disorders ◽  
Resting State ◽  
Suicide Risk ◽  
Network Connectivity ◽  
Resting State Fmri ◽  
Neural Substrates ◽  
Resting State Functional Connectivity ◽  
Promising Tool ◽  
History Of

AbstractBackgroundLittle is known about the neural substrates of suicide risk in mood disorders. Improving the identification of biomarkers of suicide risk, as indicated by a history of suicide-related behavior (SB), could lead to more targeted treatments to reduce risk.MethodsParticipants were 18 young adults with a mood disorder with a history of SB (as indicated by endorsing a past suicide attempt), 60 with a mood disorder with a history of suicidal ideation (SI) but not SB, 52 with a mood disorder with no history of SI or SB (MD), and 82 healthy comparison participants (HC). Resting-state functional connectivity within and between intrinsic neural networks, including cognitive control network (CCN), salience and emotion network (SEN), and default mode network (DMN), was compared between groups.ResultsSeveral fronto-parietal regions (k > 57, p < 0.005) were identified in which individuals with SB demonstrated distinct patterns of connectivity within (in the CCN) and across networks (CCN-SEN and CCN-DMN). Connectivity with some of these same regions also distinguished the SB group when participants were re-scanned after 1–4 months. Extracted data defined SB group membership with good accuracy, sensitivity, and specificity (79–88%).ConclusionsThese results suggest that individuals with a history of SB in the context of mood disorders may show reliably distinct patterns of intrinsic network connectivity, even when compared to those with mood disorders without SB. Resting-state fMRI is a promising tool for identifying subtypes of patients with mood disorders who may be at risk for suicidal behavior.

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