An experimental investigation of the impact of biological and psychological causal explanations on anxious and depressed patients’ perception of a person with panic disorder

Abstract Background Depression is common in systemic lupus erythematosus (SLE) and is an unmeasured risk factor, yet its symptoms can be neglected in standard disease evaluations. The purpose of this study was to assess the frequency and the impact of depression on quality of life in SLE patients. We recruited 32 patients with SLE and 15 healthy control volunteers in the study. The following investigations were undertaken in each patient: clinical and rheumatologic assessment, SLE Disease Activity Index-2k (SLEDAI-2k), Beck Depression Inventory (BDI), Short-Form Health Survey (SF-36) questionnaire, and routine laboratory tests. Results There was a high percentage of depression (46.9%) in the SLE patients. Regarding quality of life (SF-36), there were significant affection of the physical and mental composite summary domains (PCS and MCS) scores in lupus patients compared with controls (P < 0.000 for both) with the same significant in depressed compared with non-depressed patients. SF-36 subscales (physical function, limit emotional, emotional wellbeing, and social function) were significantly affected in depressed lupus patients compared with non-depressed patients. There was a significant negative correlation between the score of MCS domain of SF-36 with BDI (P < 0.000) while positive correlation between SLEDAI score with depression score. In contrast, there were no significant correlations between MCS or PCS with age, duration of illness, or SLEDAI-2K. Conclusions Depression is common in SLE patients and had a negative impact on quality of life particularly on MCS domain and positive correlation with disease severity score. Trial registration This study was registered on clinical trial with registration number: NCT03165682 https://clinicaltrials.gov/ct2/show/NCT03165682 on 24 May 2017.

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Are (negative) emotions to blame for being positional? An experimental investigation of the impact of emotional states on status preferences

Journal of Behavioral and Experimental Economics ◽

10.1016/j.socec.2016.12.004 ◽

2017 ◽

Vol 67 ◽

pp. 122-130 ◽

Cited By ~ 2

Author(s):

Jérémy Celse ◽

Fabrice Galia ◽

Sylvain Max

Keyword(s):

Experimental Investigation ◽

Negative Emotions ◽

Emotional States ◽

The Impact

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Maximizing Recall of Gruesome Images for Health Effects Advertising: An Experimental Investigation

Social Marketing Quarterly ◽

10.1080/15245004.2010.522765 ◽

2010 ◽

Vol 16 (4) ◽

pp. 112-121 ◽

Cited By ~ 1

Author(s):

Brennen W. Mills ◽

Owen B. J. Carter ◽

Robert J. Donovan

Keyword(s):

Experimental Investigation ◽

Body Part ◽

The Body ◽

Advertising Effectiveness ◽

Body Parts ◽

Online Study ◽

Video Clips ◽

Video Images ◽

The Impact

The objective of this case study was to experimentally manipulate the impact on arousal and recall of two characteristics frequently occurring in gruesome depictions of body parts in smoking cessation advertisements: the presence or absence of an external physical insult to the body part depicted; whether or not the image contains a clear figure/ground demarcation. Three hundred participants (46% male, 54% female; mean age 27.3 years, SD = 11.4) participated in a two-stage online study wherein they viewed and responded to a series of gruesome 4-s video images. Seventy-two video clips were created to provide a sample of images across the two conditions: physical insult versus no insult and clear figure/ground demarcation versus merged or no clear figure/ground demarcation. In stage one, participants viewed a randomly ordered series of 36 video clips and rated how “confronting” they considered each to be. Seven days later (stage two), to test recall of each video image, participants viewed all 72 clips and were asked to identify those they had seen previously. Images containing a physical insult were consistently rated more confronting and were remembered more accurately than images with no physical insult. Images with a clear figure/ground demarcation were rated as no more confronting but were consistently recalled with greater accuracy than those with unclear figure/ground demarcation. Makers of gruesome health warning television advertisements should incorporate some form of physical insult and use a clear figure/ground demarcation to maximize image recall and subsequent potential advertising effectiveness.

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Depression and its Somatic Consequences: Allostatic Load as the Connecting Link

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.055 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S62-S62

Author(s):

B. Penninx

Keyword(s):

Health Outcomes ◽

Psychiatric Disorders ◽

Allostatic Load ◽

Cellular Aging ◽

Health Consequences ◽

Somatic Health ◽

Depressed Patients ◽

Physiological Dysregulation ◽

Increased Risk ◽

The Impact

Stress-related psychiatric disorders, such as depressive and anxiety disorders, have been associated with increased risk of overall mortality as well as with the onset of various aging-related somatic diseases. In addition to unhealthy lifestyles and poorer (self) care, various stress-related physiological processes likely contribute to these detrimental health consequences of psychiatric disorders. Considering the fact that the impact of stress-related disorders is visible on many different somatic health outcomes, it is unlikely that contributing biological systems are very specific. In fact, it is likely that multiple dysregulations of stress systems, including the immune, HPA-axis and autonomic nervous systems, but also various general proteomic or metabolomic pathways are involved. The concept of Allostatic Load (AL) emphasizes the presence of a multi-system physiological dysregulation.In this talk I will summarize what the evidence is for somatic health consequences of psychiatric conditions, with depression as an important example. Subsequently, I will provide an overview of the various stress systems that are dysregulated in depressed patients. In addition, I will provide empirical data from the Netherlands Study of Depression and Anxiety (n = 2981) that illustrate that there is evidence that depressed patients are especially at risk for a dysregulation in multiple physiological stress systems. I will also illustrate how such a state of AL can impact on basis cellular aging indicators like telomere length and epigenetic age.In sum, this talk will highlight the current state-of-evidence for an association between depressions with the onset of many adverse somatic health outcomes, and will provide insight into the contributing role of a multisystem physiological dysregulation.Disclosure of interestThe author has not supplied his declaration of competing interest.

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Experimental investigation of isothermal and reacting flow characteristics downstream of axisymmetric bluff body stabilizers under stratified or fully premixed inlet mixture conditions

10.12681/eadd/48856 ◽

2020 ◽

Author(s):

Γεώργιος Πατεράκης

Keyword(s):

Experimental Investigation ◽

Turbulent Flow ◽

Bluff Body ◽

Operating Conditions ◽

Reacting Flow ◽

Wide Range ◽

Flow Features ◽

Air Mixing ◽

The Impact ◽

Stratified Flames

The current work describes an experimental investigation of isothermal and turbulent reacting flow field characteristics downstream of axisymmetric bluff body stabilizers under a variety of inlet mixture conditions. Fully premixed and stratified flames established downstream of this double cavity premixer/burner configuration were measured and assessed under lean and ultra-lean operating conditions. The aim of this thesis was to further comprehend the impact of stratifying the inlet fuelair mixture on the reacting wake characteristics for a range of practical stabilizers under a variety of inlet fuel-air settings. In the first part of this thesis, the isothermal mean and turbulent flow features downstream of a variety of axisymmetric baffles was initially examined. The effect of different shapes, (cone or disk), blockage ratios, (0.23 and 0.48), and rim thicknesses of these baffles was assessed. The variations of the recirculation zones, back flow velocity magnitude, annular jet ejection angles, wake development, entrainment efficiency, as well as several turbulent flow features were obtained, evaluated and appraised. Next, a comparative examination of the counterpart turbulent cold fuel-air mixing performance and characteristics of stratified against fully-premixed operation was performed for a wide range of baffle geometries and inlet mixture conditions. Scalar mixing and entrainment properties were investigated at the exit plane, at the bluff body annular shear layer, at the reattachment region and along the developing wake were investigated. These isothermal studies provided the necessary background information for clarifying the combustion properties and interpreting the trends in the counterpart turbulent reacting fields. Subsequently, for selected bluff bodies, flame structures and behavior for operation with a variety of reacting conditions were demonstrated. The effect of inlet fuel-air mixture settings, fuel type and bluff body geometry on wake development, flame shape, anchoring and structure, temperatures and combustion efficiencies, over lean and close to blow-off conditions, was presented and analyzed. For the obtained measurements infrared radiation, particle image velocimetry, laser doppler velocimetry, chemiluminescence imaging set-ups, together with Fouriertransform infrared spectroscopy, thermocouples and global emission analyzer instrumentation was employed. This helped to delineate a number of factors that affectcold flow fuel-air mixing, flame anchoring topologies, wake structure development and overall burner performance. The presented data will also significantly assist the validation of computational methodologies for combusting flows and the development of turbulence-chemistry interaction models.

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