scholarly journals Serum Vitamin D Levels Predict 30-day Readmission Rate and Length of Stay in Hospitalized Patients with an Acute Heart Failure Syndrome due to Reduced Ejection Fraction

2017 ◽  
Vol 23 (8) ◽  
pp. S82
Author(s):  
Fadi Ghrair ◽  
Hassan Alkhawam ◽  
Anwar Zaitoun ◽  
Feras Zaiem ◽  
Amir Sara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Length Of Stay ◽  
Ejection Fraction ◽  
Acute Heart Failure ◽  
Readmission Rate ◽  
Serum Vitamin ◽  
Reduced Ejection Fraction ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract P010: Serum Vitamin D and Risk of Heart Failure: Prospective Results From the Moli-sani Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Simona Costanzo ◽  
Amalia De Curtis ◽  
Augusto Di Castelnuovo ◽  
Mariarosaria Persichillo ◽  
Maria B Donati ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Multivariable Analysis ◽  
Serum Vitamin ◽  
C Reactive Protein ◽  
Baseline Serum ◽  
Serum Vitamin D ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Incident Cases

Introduction: Vitamin D deficiency has been associated with the progression of heart failure (HF) and Vitamin D supplementation may have protective effects in patients with HF. However, little is known on the predictive value of circulating Vitamin D levels on HF risk. Hypothesis: Low serum Vitamin D levels are associated with incident HF in a large prospective cohort of Italian adults. Methods: We analyzed 18,689 (48.4% men, age ≥35 years) HF-free individuals randomly recruited from the general population of the Moli-sani study, for whom complete data on HF and serum Vitamin D were available. Vitamin D was measured on serum by an immunoassay in the central laboratory of European BiomarCaRE project (Abbott Architect 25-OH Vitamin D, Wiesbaden, Germany). The cohort was followed up for a median of 4.2 years (80,849 person-years). Baseline serum Vitamin D was categorized in deficient/insufficient, hypovitaminosis, and normal (Table). Incident cases of HF were identified by linkage with the regional archive of hospital discharges. Hazard ratios (HRs) were calculated using Cox-proportional hazard models. Results: Subjects with normal, hypo or insufficient levels of Vitamin D were 12.2%, 79.6% and 8.2%, respectively. We identified 412 incident cases of HF. The incidence of HF was 1.1%, 2.2% and 3.9%, respectively in subjects with normal, hypo and insufficient levels of Vitamin D. After a multivariable analysis, considering a large panel of potential covariates, individuals with deficient/insufficient levels of serum Vitamin D showed a higher risk of developing HF (HR: 1.78, 95% CI: 1.07-2.97) than those with normal levels. Further adjustment for C-Reactive Protein did not modify the association (Table). Conclusions: Deficiency of Vitamin D is associated with a significantly higher risk of HF in a general adult population. This association was not explained by an inflammatory marker such as C-Reactive Protein.

Low Serum Vitamin D Levels are Associated with Patients with Acute Decompensated Heart Failure

2014 ◽  
Vol 20 (10) ◽  
pp. S181
Author(s):  
Tetsuro Miyazaki ◽  
Shoko Suda ◽  
Takatoshi Kasai ◽  
Takao Kato ◽  
Masaru Hiki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Acute Decompensated Heart Failure ◽  
Serum Vitamin ◽  
Decompensated Heart Failure ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

scholarly journals Study to determine serum vitamin D levels in patients with congestive heart failure

2019 ◽  
Vol 7 (12) ◽  
pp. 4762
Author(s):  
Nishant Wadhera ◽  
Geetika Kalra ◽  
Abhishek Gupta ◽  
Saurabh Singhal ◽  
S. K. Jha
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Congestive Heart Failure ◽  
Venous Pressure ◽  
Clinical Manifestations ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Mean

Background: It was to evaluate the association of serum levels of vitamin D in patients with congestive heart failure.Methods: The present study was conducted in the department of Medicine at Chattrapati Shivaji Subharti Hospital among 100 patients, aged 18 years and above diagnosed as congestive heart failure on the basis of clinical and echocardiographic evidence. Clinical manifestations looked for CHF were: Dyspnea, orthopnea, acute pulmonary edema, cerebral symptoms, cheyne-stokes respiration, cyanosis, sinus tachycardia, raised jugular venous pressure, congestive hepatomegaly and pedal edema. In the present study deficiency/ insufficiency of vitamin D was considered when the presence of levels of 25-hydroxyvitamin D was <30 ng/ml. Laboratory tests performed to diagnose congestive heart failure and serum vitamin D levels were complete blood count, KFT (urea, serum creatinine), serum electrolytes, ECG, chest X ray and echocardiogram. Data were tabulated and examined using the statistical package for Social Sciences Version 22.0.Results: When data was assessed for comparison in relation to NHYA grades and vitamin D levels, it was found to be statistically significant. The Mean±SD scores of serum urea (mg/dL) was found to be 44.7±56.4, 47.3±63.8 and 36.4± 18.3 in whole study sample, vitamin D levels <30 and vitamin D levels >30 respectively with statistically significant difference. The Mean±SD scores of CPK MB (IU/L) was found to be 33.1±20.8 and 18.6±13.3 among the subjects having vitamin D levels <30 and vitamin D levels >30 respectively with statistically significant difference.Conclusions: The results of the present study suggest that low levels of vitamin D may adversely affect the cardiovascular system.

ID: 14: DIGITALIS INCREASES THE 30-DAY READMISSION RATE IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION

2016 ◽  
Vol 64 (4) ◽  
pp. 924.1-924
Author(s):  
H Alkhawam ◽  
J Sall ◽  
JJ Lieber ◽  
TJ Vittorio
Keyword(s):  
Heart Failure ◽  
Mortality Rate ◽  
Length Of Stay ◽  
Ejection Fraction ◽  
Readmission Rate ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Reduced Ejection Fraction ◽  
Treatment Groups ◽  
Patients With Heart Failure

IntroductionDigitalis has been used for over 200 years to treat patients with heart failure (HF). Evidence from clinical trials supports the use of digitalis in patients with HF due to left ventricular (LV) systolic dysfunction, particularly in patients with more advanced symptoms. However, there is no evidence that digitalis improves survival.HypothesisWe evaluated the role of digitalis use in the 30-day readmission rate, mortality rate and length of stay (LOS) in patients with heart failure and reduced ejection fraction (HFrEF).MethodsWe performed a retrospective chart analysis of 1,616 patients who were admitted to the hospital from 2005 to 2012 due to decompensated HF. 781 patients had HFrEF. The medications of all 781 patients with HFrEF were reviewed. The HFrEF patients were divided into two groups: digitalis-treated and non-digitalis treated. The 30-day readmission rate, mortality rate and LOS were subsequently determined.ResultsOf the 781 patients with HFrEF, 196 (25%) did receive digitalis treatment versus 584 (75%) did not receive Digitalis treatment. After the other medications in each group were standardized, the digitalis-treatment HFrEF group had a higher 30-day readmission rate compared to the non-digitalis treatment HFrEF group (OR: 1.5, 95% CI: 1.1–2.2, p=0.04). The morality rate and LOS between the digitalis-treatment and non-digitalis treatment groups did not differ (p=0.7 and 0.4, respectively).ConclusionOur study confirmed that digitalis use in HFrEF does not improve the survival rate and length of stay. However, our study showed that digitalis use can increase the 30-day readmission rate.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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