ANTIBODY COATING ON IMPLANTABLE INTRAVASCULAR DEVICES TO SELECTIVELY CAPTURE GENETICALLY ENGINEERED CELLS FOR LOCAL DRUG DELIVERY: AN IN VITRO FEASIBILITY STUDY

2014 ◽  
Vol 30 (10) ◽  
pp. S101
Author(s):  
Q. Zhang ◽  
J. Barfield ◽  
M. Kutryk
Keyword(s):  
Drug Delivery ◽  
Feasibility Study ◽  
Genetically Engineered ◽  
Local Drug Delivery ◽  
Intravascular Devices ◽  
Antibody Coating

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

scholarly journals Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1473 ◽  
Author(s):  
Ioana A. Duceac ◽  
Liliana Verestiuc ◽  
Cristina D. Dimitriu ◽  
Vasilica Maier ◽  
Sergiu Coseri
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
In Vitro Release ◽  
Local Drug Delivery ◽  
Acrylic Polymers ◽  
Modified Chitosan ◽  
Porous Networks ◽  
Preparation Conditions ◽  
Swelling Mechanism

The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

scholarly journals Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization

2010 ◽  
Vol 11 (4) ◽  
pp. 1675-1683 ◽  
Author(s):  
Chidambaram Soundrapandian ◽  
Someswar Datta ◽  
Biswanath Kundu ◽  
Debabrata Basu ◽  
Biswanath Sa
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Local Drug Delivery ◽  
In Vitro Characterization

Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery

Circulation ◽  
1997 ◽  
Vol 96 (2) ◽  
pp. 636-645 ◽  
Author(s):  
Dorothea I. Axel ◽  
Wolfgang Kunert ◽  
Christoph Göggelmann ◽  
Martin Oberhoff ◽  
Christian Herdeg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Smooth Muscle ◽  
Local Drug Delivery ◽  
Arterial Smooth Muscle Cell ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

In vitro characterization of polyacrylamide hydrogels for application as implant coating for stimulus-responsive local drug delivery

2014 ◽  
Vol 25 (11) ◽  
pp. 1234-1241 ◽  
Author(s):  
Ingo Minrath ◽  
Daniela Arbeiter ◽  
Klaus-Peter Schmitz ◽  
Katrin Sternberg ◽  
Svea Petersen
Keyword(s):  
Drug Delivery ◽  
Local Drug Delivery ◽  
Polyacrylamide Hydrogels ◽  
In Vitro Characterization ◽  
Stimulus Responsive ◽  
Implant Coating

scholarly journals Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study

2013 ◽  
Vol 17 (4) ◽  
pp. 429 ◽  
Author(s):  
Ranganathan Vijayalashmi ◽  
SabithaManhalore Ravindranath ◽  
NadathurDoraiswamy Jayakumar ◽  
Padmalatha ◽  
SheejaH Vargheese ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Porphyromonas Gingivalis ◽  
Delivery System ◽  
In Vitro Study ◽  
Local Drug Delivery ◽  
Local Drug Delivery System ◽  
Kinetics Of

Lidocaine Loaded Ca/P Scaffolds for Bone Regeneration and Local Drug Delivery

2011 ◽  
Vol 222 ◽  
pp. 289-292 ◽  
Author(s):  
Dagnija Loca ◽  
Janis Locs ◽  
Juris Gulbis ◽  
Ilze Salma ◽  
Liga Berzina-Cimdina
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Bone Regeneration ◽  
Pore Size ◽  
Clinical Importance ◽  
Local Drug Delivery ◽  
In Vitro Dissolution ◽  
Poly Lactic Acid ◽  
Porous Scaffolds

Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350µm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.

RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery system

2005 ◽  
Vol 93 (01) ◽  
pp. 106-114 ◽  
Author(s):  
Anirban Gupta ◽  
Guofeng Huang ◽  
Brian Lestini ◽  
Sharon Sagnella ◽  
Kandice Kottke-Marchant ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Platelet Activation ◽  
Delivery System ◽  
Human Platelets ◽  
Local Drug Delivery ◽  
Activated Platelets ◽  
Contrast Microscopy ◽  
Or Gene

SummaryLocal drug delivery has become an important treatment modality for the prevention of thrombotic events following coronary angioplasty. In this study, we investigate the ability of liposomes bearing surface conjugated linear Arg-Gly-Asp (RGD) peptide (GSSSGRGD SPA) moieties to target and bind activated platelets, and the effect of such RGD-modified liposomes on platelet activation and aggregation. The binding of RGD-liposomes to human platelets was assessed by fluorescence microscopy,phase contrast microscopy and flow cytometry. The effect of RGDmodified liposomes on platelet activation and aggregation was investigated in vitro, with and without platelet agonists. RGD-liposomes were found to bind activated platelets at levels significantly greater than the control RGE-liposomes.The RGD-liposomes did not exhibit any statistically significant effect on platelet activation or aggregation.The results demonstrate the ability of the RGD-modified liposomes to target and bind activated platelets without causing significant platelet aggregation and suggests a feasible way for the development of a platelet-targeted anti-thrombogenic drug delivery system. Furthermore, the approach can be extended to the development of liposomes for other vascular targets, for application in drug delivery or gene therapy.

scholarly journals Mutual influence of incorporated drugs in a dual drug delivery coating for cardiovascular applications

2017 ◽  
Vol 3 (2) ◽  
pp. 379-382
Author(s):  
Katharina Wulf ◽  
Michael Teske ◽  
Claudia Matschegewski ◽  
Daniela Arbeiter ◽  
Thomas Eickner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mutual Influence ◽  
Local Drug Delivery ◽  
Drug Eluting Stent ◽  
Vascular Endothelial ◽  
Effective Inhibition ◽  
Drug Eluting ◽  
The Stability ◽  
Endothelial Growth Factor

AbstractFor a long-term efficient drug-eluting stent for vascular applications, the development of drug-loaded coating, combining the effective inhibition of smooth muscle cell proliferation while promoting the re-endothelialization, is a promising concept. However the mostly required simultaneous incorporation of drugs can influence decisively the stability, efficacy and release of the respective drug. Therefore, the mutual influence of a dual local drug delivery coatings based on poly(L-lactide-co-ε-caprolactone) (PLLA-co-CL) containing vascular endothelial growth factor (VEGF165) coupled to the surface and an embedded drug, such as fluorescein diacetate (FDAc) instead of Paclitaxel (PTX) on the in vitro drug release was investigated. Surprisingly, for the investigated coating the immobilized VEGF loading was enhanced and the release profile was accelerated by FDAc incorporation. Even a manifold increase for the in vitro released amounts of VEGF was detected. In contrast, the immobilization of VEGF seems to have a negligible influence on the in vitro FDAc release profiles.

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