Association of serum vitamin D status with dietary intake and sun exposure in adults

AbstractObjectiveTo assess vitamin D status among Cypriot adolescents and investigate potential determinants including BMI and body fat percentage (BF%).DesignParticipants had cross-sectional assessments of serum vitamin D, physical activity, dietary vitamin D intake and sun exposure. Linear and logistic regression models were used to explore the associations of vitamin D with potential predictors.SettingHospitals, Cyprus, November 2007–May 2008.SubjectsAdolescents (n 671) aged 16–18 years.ResultsMean serum vitamin D was 22·90 (sd 6·41) ng/ml. Only one in ten children had sufficient levels of vitamin D (≥30 ng/ml), while the prevalence of vitamin D deficiency (12–20 ng/ml) and severe deficiency (<12 ng/ml) was 31·7 % and 4·0 %, respectively. Lower vitamin D was associated with winter and spring season, female gender, reduced sun exposure in winter and darker skin. Participants with highest BMI and BF% when compared with a middle reference group had increased adjusted odds of vitamin D insufficiency (OR = 3·00; 95 % CI 1·21, 7·45 and OR = 5·02; 95 % CI 1·80, 13·97, respectively). A similar pattern, although not as strong, was shown for vitamin D deficiency with BF% (OR = 1·81; 95 % CI 1·04, 3·16) and BMI (OR = 1·51; 95 % CI 0·85, 2·67). Participants in the lowest BMI and BF% groups also displayed compromised vitamin D status, suggesting a U-shaped association.ConclusionsVitamin D deficiency in adolescence is very prevalent in sunny Cyprus, particularly among females, those with darker skin and those with reduced sun exposure in winter. Furthermore, vitamin D status appears to have a U-shaped association with adiposity measures.

Download Full-text

DIETARY INTAKE AND SUN EXPOSURE RELATED TO VITAMIN D CONCENTRATION IN THALASSEMIA PATIENTS: A LITERATURE REVIEW

Media Gizi Indonesia ◽

10.20473/mgi.v16i3.238-247 ◽

2021 ◽

Vol 16 (3) ◽

pp. 238

Author(s):

Yesi Herawati ◽

Gaga Irawan Nugraha ◽

Dida Akhmad Gurnida

Keyword(s):

Vitamin D ◽

Literature Review ◽

Dietary Intake ◽

Serum Vitamin ◽

Sun Exposure ◽

High Serum ◽

Liver Protein ◽

Thalassemia Patient ◽

Serum Vitamin D ◽

Bone Minerals

Vitamin D has an important role in calcium homeostasis and bone minerals during rapid growth periods. Several studies have shown that deﬁciency of vitamin D occurs in thalassemia patient. The study used literature review to determine relation of dietary intake and sun exposure with vitamin D concentration in thalassemia patiens in 29 literatures. Those literatures were taken from books and articles published from 2010 to 2019 with the keywords “thalassemia”, “dietary intake”, “sun exposure” and “vitamin D” using database in Pubmed, Google Scholar and Medline. The results of 29 literatures showed that vitamin D deﬁciency is caused by reduced dietary intake and impaired vitamin D hydroxylation in the liver due to hemochromatosis resulting in high serum ferritin. Source of vitamin D comes from endogenous synthesis with sunlight exposure and little dietary source of vitamin D2 and vitamin D3. Another food intake can also aﬀect serum vitamin D concentration, mainly fat and protein intake. Vitamin D is fat soluble vitamin, it can be stored in the fat for later metabolized in the liver. Protein is required to transport vitamin D to blood circulation, enzyme formation and vitamin D receptor (VDR). Thalassemia patients need to increase of macro and micronutrients requirement. Low Hb concentration causes fatigue, tired easily and decreased appetite. A lot of research on thalassemia children found that intake of energy and protein were lower than recommended and lack of sun exposure. These conditions will aﬀect to vitamin D concentration. A comprehensive understanding in the relationship of dietary intake and sun exposure to vitamin D concentration in thalassemia patients is explained in this mini review. Maintaining normal vitamin D concentration through adequate dietary intake and sun exposure are very important to optimize growth in thalassemia patients.

Download Full-text

Sun Exposure Guidelines and Serum Vitamin D Status in Denmark: The StatusD Study

Nutrients ◽

10.3390/nu8050266 ◽

2016 ◽

Vol 8 (5) ◽

pp. 266 ◽

Cited By ~ 17

Author(s):

Louise Hansen ◽

Anne Tjønneland ◽

Brian Køster ◽

Christine Brot ◽

Rikke Andersen ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Sun Exposure ◽

Vitamin D Status ◽

Serum Vitamin D

Download Full-text

Validation of a Method to Predict Serum Vitamin D from Sun Exposure, Skin Reflectance & Dietary Intake in Overweight and Obese Subjects

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.996.7 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Brian D Piccolo ◽

Laura Hall ◽

Charles Stephensen ◽

Erik Gertz ◽

Leslie Woodhouse ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

Serum Vitamin ◽

Sun Exposure ◽

Serum Vitamin D ◽

Skin Reflectance ◽

Obese Subjects

Download Full-text

Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

Nutrients ◽

10.3390/nu13113747 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3747

Author(s):

María José Toribio ◽

Feliciano Priego-Capote ◽

Beatriz Pérez-Gómez ◽

Nerea Fernández de Larrea-Baz ◽

Emma Ruiz-Moreno ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Premenopausal Women ◽

Sun Exposure ◽

Individual Characteristics ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Nulliparous Women ◽

Diagnostic Center

The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39–50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE–LC–MS/MS platform. The association between participant’s characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.

Download Full-text

A genomewide association study identified CYP2J2 as a gene controlling serum vitamin D status in beef cattle1,2

Journal of Animal Science ◽

10.2527/jas.2012-6020 ◽

2013 ◽

Vol 91 (8) ◽

pp. 3549-3556 ◽

Cited By ~ 8

Author(s):

E. Casas ◽

R. J. Leach ◽

T. A. Reinhardt ◽

R. M. Thallman ◽

J. D. Lippolis ◽

...

Keyword(s):

Vitamin D ◽

Association Study ◽

Serum Vitamin ◽

Vitamin D Status ◽

Genomewide Association Study ◽

Serum Vitamin D ◽

Genomewide Association

Download Full-text

Influence of serum vitamin D status on severe sarcopenia among female patients with rheumatoid arthritis: the KURAMA database

10.21203/rs.3.rs-697981/v1 ◽

2021 ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Muscle Mass ◽

Gait Speed ◽

Serum Vitamin ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Increased Risk ◽

Vitamin D Levels ◽

High Prevalence

Abstract Sarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum vitamin D (25(OH)D) affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 Patients (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait-speed. Furthermore, multiple regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08). In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH) status. In conclusion, vitamin D levels are associated with severe sarcopenia and its components, and modification of vitamin D status including vitamin D supplementation may play a role in improving sarcopenia in RA.

Download Full-text